{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:53:35Z","timestamp":1788836015700,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000303","name":"Inspire Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002473","name":"Dongshin University","doi-asserted-by":"publisher","award":["DSU-REG\/2022-2023\/618"],"award-info":[{"award-number":["DSU-REG\/2022-2023\/618"]}],"id":[{"id":"10.13039\/501100002473","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002473","name":"Dongshin University","doi-asserted-by":"publisher","award":["IF210106"],"award-info":[{"award-number":["IF210106"]}],"id":[{"id":"10.13039\/501100002473","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.micpath.2025.108262","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:52:42Z","timestamp":1766508762000},"page":"108262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Combination of endolysin LysK04 and cinnamaldehyde potentially inhibits Gram-negative pathogens via outer membrane disruption and peptidoglycan hydrolysis"],"prefix":"10.1016","volume":"211","author":[{"given":"Harshitha","family":"N","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrija","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijith","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Rout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil S.","family":"More","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-9810","authenticated-orcid":false,"given":"Susweta Das","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2025.108262_bib1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/antibiotics10020124","article-title":"Phage-encoded endolysins","volume":"10","author":"Abdelrahman","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.micpath.2025.108262_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2217\/fmb.15.8","article-title":"Breaking barriers: expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria","volume":"10","author":"Briers","year":"2015","journal-title":"Future Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0304-4157(83)90014-X","article-title":"Molecular architecture and functioning of the outer membrane of Escherichia coli and other gram-negative bacteria","volume":"737","author":"Lugtenberg","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.micpath.2025.108262_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2024.102433","article-title":"Gram-negative endolysins: overcoming the outer membrane obstacle","volume":"78","author":"Sisson","year":"2024","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib5","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.biotechadv.2017.12.009","article-title":"Synthetic biology of modular endolysins","volume":"36","author":"Gerstmans","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.micpath.2025.108262_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fmicb.2017.00293","article-title":"A novel antimicrobial endolysin, LysPA26, against Pseudomonas aeruginosa","volume":"8","author":"Guo","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1080\/08927014.2023.2265817","article-title":"Combined antimicrobial effect of phage-derived endolysin and depolymerase against biofilm-forming Salmonella Typhimurium","volume":"39","author":"Kim","year":"2023","journal-title":"Biofouling"},{"key":"10.1016\/j.micpath.2025.108262_bib8","doi-asserted-by":"crossref","first-page":"7470","DOI":"10.1038\/s41598-023-33822-8","article-title":"Antibacterial activity of vB_AbaM_PhT2 phage hydrophobic amino acid fusion endolysin, combined with colistin against Acinetobacter baumannii","volume":"13","author":"Sitthisak","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2025.108262_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134670","article-title":"Synergism of colistin and globular endolysins against multidrug-resistant gram-negative bacteria","volume":"278","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2025.108262_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1385261","article-title":"Endolysins: a new antimicrobial agent against antimicrobial resistance. Strategies and opportunities in overcoming the challenges of endolysins against Gram-negative bacteria","volume":"15","author":"Khan","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.micpath.2025.108262_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.afres.2024.100581","article-title":"Exploring synergistic effects of essential oils compounds with antibiotics and biocides against multidrug-resistant foodborne pathogens","volume":"4","author":"Caballero G\u00f3mez","year":"2024","journal-title":"Appl. Food Res."},{"key":"10.1016\/j.micpath.2025.108262_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12929-019-0561-6","article-title":"Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria","volume":"26","author":"Farrag","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.micpath.2025.108262_bib13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12906-016-1147-4","article-title":"Medicinal attributes of major phenylpropanoids present in cinnamon","volume":"16","author":"Sharma","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.micpath.2025.108262_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.01011","article-title":"Trans-cinnamaldehyde and eugenol increase Acinetobacter baumannii sensitivity to beta-lactam antibiotics","volume":"9","author":"Karumathil","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib15","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1128\/AAC.01372-13","article-title":"Improving the lethal effect of Cpl-7, a pneumococcal phage lysozyme with broad bactericidal activity, by inverting the net charge of its cell wall-binding module","volume":"57","author":"D\u00edez-Mart\u00ednez","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2025.108262_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2023.110187","article-title":"Synergistic antimicrobial activity of essential oils in combination with phage endolysin against Salmonella Typhimurium in cooked ground beef","volume":"157","author":"Kim","year":"2024","journal-title":"Food Control"},{"key":"10.1016\/j.micpath.2025.108262_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.resmic.2023.104104","article-title":"Evaluating the efficacy of endolysins and membrane permeabilizers against Vibrio parahaemolyticus in marine conditions","volume":"174","author":"Zerme\u00f1o-Cervantes","year":"2023","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2019.104405","article-title":"A review of cinnamaldehyde and its derivatives as antibacterial agents","volume":"139","author":"Doyle","year":"2019","journal-title":"Fitoterapia"},{"key":"10.1016\/j.micpath.2025.108262_bib19","article-title":"Advances in pharmacological effects and mechanism of action of cinnamaldehyde","volume":"15","author":"Guo","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.micpath.2025.108262_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2025.120503","article-title":"Hydrogel integrating CBEO-CINcocktail (Cinnamomum pauciflorum Nees bark oil enriched with cinnamaldehyde) loaded nanosponges exhibited potent antibacterial activity against carbapenem resistant bacterial pathogens - in vitro and in vivo evaluation","volume":"225","author":"Das Mitra","year":"2025","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.micpath.2025.108262_bib21","first-page":"1","article-title":"Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens","volume":"4","author":"Li","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.micpath.2025.108262_bib22","article-title":"Molecular detection of the New Delhi metallo-\u03b2-lactamase clinical variant with double mutation-V88L and M154L in Escherichia coli isolates from South India","volume":"21","author":"Mitra","year":"2020","journal-title":"Gene Rep."},{"key":"10.1016\/j.micpath.2025.108262_bib23","article-title":"NIHR global health research unit on genomic surveillance - india consortium, geographical distribution, disease association and diversity of Klebsiella pneumoniae K\/L and O antigens in India: roadmap for vaccine development","volume":"10","author":"Shamanna","year":"2024","journal-title":"Microb. Genom."},{"key":"10.1016\/j.micpath.2025.108262_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140887","article-title":"Development of a lytic bacteriophage BPK01 impregnated biopolymer (chitosan) hydrogel for combating high-risk strains of carbapenem resistant Klebsiella pneumoniae (CRKP) pathogens- in vitro and in vivo evaluation","volume":"304","author":"Harshitha","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2025.108262_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00506-22","article-title":"A lysozyme murein hydrolase with broad-spectrum antibacterial activity from enterobacter phage myPSH1140","volume":"66","author":"Ramesh","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2025.108262_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.146105","article-title":"Improved lytic action of engineered phage-encoded endolysin and docking insights into its action on bacterial peptidoglycan","volume":"320","author":"Rani","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2025.108262_bib27","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1128\/AEM.02235-13","article-title":"Characterization of AmiBA2446, a novel bacteriolytic enzyme active against bacillus species","volume":"79","author":"Mehta","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.00208","article-title":"Structural and enzymatic characterization of ABgp46, a novel phage endolysin with broad anti-gram-negative bacterial activity","volume":"7","author":"Oliveira","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib29","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/s41598-022-05361-1","article-title":"Synthetic antimicrobial peptides as enhancers of the bacteriolytic action of staphylococcal phage endolysins","volume":"12","author":"Gouveia","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2025.108262_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129493","article-title":"Unveiling the mechanism of bactericidal activity of a cecropin A-fused endolysin LNT113","volume":"260","author":"Cho","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2025.108262_bib31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12929-024-01027-4","article-title":"Antimicrobial peptide thanatin fused endolysin PA90 (Tha-PA90) for the control of Acinetobacter baumannii infection in mouse model","volume":"31","author":"Lim","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.micpath.2025.108262_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.107068","article-title":"Anti-bacteria, anti-biofilm, and anti-virulence activity of the synthetic compound MTEBT-3 against carbapenem-resistant Klebsiella pneumoniae strains ST3984","volume":"197","author":"Zhang","year":"2024","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2025.108262_bib33","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00203-024-04003-6","article-title":"Assessing the synergistic potential of bacteriophage endolysins and antimicrobial peptides for eradicating bacterial biofilms","volume":"206","author":"Tyagi","year":"2024","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib34","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1099\/mic.0.000613","article-title":"Stress responses, outer membrane permeability control and antimicrobial resistance in Enterobacteriaceae","volume":"164","author":"Dam","year":"2018","journal-title":"Microbiology"},{"key":"10.1016\/j.micpath.2025.108262_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijfoodmicro.2016.12.007","article-title":"Endolysin LysSA97 is synergistic with carvacrol in controlling Staphylococcus aureus in foods","volume":"244","author":"Chang","year":"2017","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1603380","article-title":"Endolysins and membrane-active peptides: innovative engineering strategies against gram-negative bacteria","volume":"16","author":"Wojciechowska","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2025.108262_bib37","series-title":"Birmingham","article-title":"Cinnamaldehyde increases the susceptibility of quorum-sensing-mediated biofilms to conventional antibiotics","author":"Gyamfi-Brobbey","year":"2015"},{"key":"10.1016\/j.micpath.2025.108262_bib38","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s11033-025-10564-6","article-title":"Antibacterial and antibiofilm efficacy of eugenol, carvacrol, and cinnamaldehyde against colistin-resistant Klebsiella pneumoniae","volume":"52","author":"Kashi","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.micpath.2025.108262_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115946","article-title":"Deciphering the inhibitory mechanisms of cinnamaldehyde on biofilm formation of Listeria monocytogenes and implement these strategies to control its transfer to beef surfaces","volume":"204","author":"Yang","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.micpath.2025.108262_bib40","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1099\/mic.0.050336-0","article-title":"The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited","volume":"157","author":"Hsu","year":"2011","journal-title":"Microbiol. Read. Engl."},{"key":"10.1016\/j.micpath.2025.108262_bib41","article-title":"Investigating the potential of endolysin loaded chitosan nanoparticles in the treatment of pneumococcal pneumonia","volume":"61","author":"Gondil","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.micpath.2025.108262_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118605","article-title":"DEAE-chitosan nanoparticles as a pneumococcus-biomimetic material for the development of antipneumococcal therapeutics","volume":"273","author":"V\u00e1zquez","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.micpath.2025.108262_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154973","article-title":"Evolving biofilm inhibition and eradication in clinical settings through plant-based antibiofilm agents","volume":"119","author":"Silva","year":"2023","journal-title":"Phytomedicine"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025009878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025009878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:56:22Z","timestamp":1777575382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025009878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":43,"alternative-id":["S0882401025009878"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.108262","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination of endolysin LysK04 and cinnamaldehyde potentially inhibits Gram-negative pathogens via outer membrane disruption and peptidoglycan hydrolysis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.108262","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108262"}}