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(Oxf.)"},{"key":"10.1016\/j.micpath.2025.108267_bib99","first-page":"245","article-title":"A study on patients with eosinophilia of suspected parasitic origin, J. Egypt","volume":"25","author":"el Zawawy","year":"1995","journal-title":"Soc. Parasitol."},{"key":"10.1016\/j.micpath.2025.108267_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.583824","article-title":"Basophils and eosinophils in Nematode infections","volume":"11","author":"Obata-Ninomiya","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2025.108267_bib101","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nm.2628","article-title":"An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection","volume":"18","author":"Chen","year":"2012","journal-title":"Nat. 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