{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:57:00Z","timestamp":1787788620108,"version":"build-2784847793"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["IF200207"],"award-info":[{"award-number":["IF200207"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"UGC","doi-asserted-by":"publisher","award":["F.4-5\/236 FRP ( 2015 ) BSR"],"award-info":[{"award-number":["F.4-5\/236 FRP ( 2015 ) BSR"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"ICMR","doi-asserted-by":"publisher","award":["P-16\/ECD\/Adhoc\/49\/2022-23"],"award-info":[{"award-number":["P-16\/ECD\/Adhoc\/49\/2022-23"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"ICMR","doi-asserted-by":"publisher","award":["EMDR\/SG\/16\/2024-01-04453"],"award-info":[{"award-number":["EMDR\/SG\/16\/2024-01-04453"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.micpath.2026.108275","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T23:46:56Z","timestamp":1767397616000},"page":"108275","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Fecal microbiota transplantation attenuates neuropathic pain in rats via gut microbiota-mediated immunomodulation of ion channels and nociceptors"],"prefix":"10.1016","volume":"212","author":[{"given":"Meghana","family":"Allani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Juyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Chandra Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8491-2255","authenticated-orcid":false,"given":"Vinod","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.micpath.2026.108275_bib1","first-page":"1599","article-title":"Neuropathic pain: an updated grading system for research and clinical practice","volume":"157","author":"Finnerup","year":"2016"},{"issue":"18","key":"10.1016\/j.micpath.2026.108275_bib2","first-page":"6028","article-title":"Neuropathic pain in the emergency setting: diagnosis and management","volume":"12","author":"Doneddu","year":"2023"},{"key":"10.1016\/j.micpath.2026.108275_bib3","series-title":"Clinical Pain Management: Current Practice and Recent Innovations in Research","author":"Wang","year":"2024"},{"key":"10.1016\/j.micpath.2026.108275_bib4","series-title":"StatPearls [Internet]","article-title":"WHO analgesic ladder","author":"Anekar","year":"2023"},{"issue":"2","key":"10.1016\/j.micpath.2026.108275_bib5","first-page":"203","article-title":"Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention","volume":"22","author":"Volkow","year":"2023"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib6","first-page":"1","article-title":"Neuropathic pain: a maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib7","first-page":"155","article-title":"Pathology of pain and its implications for therapeutic interventions","volume":"9","author":"Cao","year":"2024"},{"issue":"6","key":"10.1016\/j.micpath.2026.108275_bib8","first-page":"492","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020"},{"issue":"11","key":"10.1016\/j.micpath.2026.108275_bib9","article-title":"Gut microbiota dysbiosis and neurological function recovery after intracerebral hemorrhage: an analysis of clinical samples","volume":"12","author":"Wang","year":"2024"},{"key":"10.1016\/j.micpath.2026.108275_bib10","article-title":"Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate parkinson's disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial","volume":"71","author":"Bruggeman","year":"2024"},{"issue":"5","key":"10.1016\/j.micpath.2026.108275_bib11","first-page":"1075","article-title":"A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric NO-dependent and gut-brain axis mechanism","volume":"25","author":"Grasset","year":"2017"},{"issue":"20","key":"10.1016\/j.micpath.2026.108275_bib12","first-page":"3655","article-title":"Fecal microbiota transplantation-mediated rebalancing of the gut\u2013brain axis alleviates cisplatin-induced neuropathic pain","volume":"15","author":"Rani","year":"2024"},{"key":"10.1016\/j.micpath.2026.108275_bib13","series-title":"The Role of the microbiota\u2013gut\u2013brain Axis in methamphetamine-induced Neurotoxicity: Disruption of Microbial Composition and short-chain Fatty Acid Metabolism","author":"Chen","year":"2024"},{"key":"10.1016\/j.micpath.2026.108275_bib14","volume":"vol. 14","author":"Kasarello","year":"2023"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib15","article-title":"Changes in gut microbiota in the acute phase after spinal cord injury correlate with severity of the lesion","volume":"11","author":"Bazzocchi","year":"2021"},{"issue":"2","key":"10.1016\/j.micpath.2026.108275_bib16","first-page":"423","article-title":"Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease","volume":"165","author":"Kashyap","year":"2024"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib17","first-page":"57","article-title":"Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain","volume":"9","author":"Yang","year":"2019"},{"issue":"11","key":"10.1016\/j.micpath.2026.108275_bib18","first-page":"2109","article-title":"Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats","volume":"40","author":"Liu","year":"2012"},{"issue":"21\u201322","key":"10.1016\/j.micpath.2026.108275_bib19","first-page":"1441","article-title":"Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats","volume":"73","author":"Jin","year":"2010"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib20","first-page":"87","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988"},{"key":"10.1016\/j.micpath.2026.108275_bib21","article-title":"Inhibition of pan-Aurora kinase attenuates evoked and ongoing pain in nerve injured rats via regulating KIF17-NR2B mediated signaling","volume":"106","author":"Uniyal","year":"2022"},{"issue":"24","key":"10.1016\/j.micpath.2026.108275_bib23","first-page":"9613","article-title":"AhR activation leads to alterations in the gut microbiome with consequent effect on induction of myeloid derived suppressor cells in a CXCR2-dependent manner","volume":"21","author":"Neamah","year":"2020"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib24","article-title":"Enrichment of lactic acid\u2010producing bacteria in the fecal microbiota of patients with ulcerative colitis in North India","volume":"2023","author":"Juyal","year":"2023"},{"issue":"21","key":"10.1016\/j.micpath.2026.108275_bib25","first-page":"2957","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Mago\u010d","year":"2011"},{"key":"10.1016\/j.micpath.2026.108275_bib26","series-title":"VSEARCH: a Versatile Open Source Tool for Metagenomics","volume":"vol. 4","author":"Rognes","year":"2016"},{"issue":"19","key":"10.1016\/j.micpath.2026.108275_bib27","first-page":"2460","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010"},{"issue":"16","key":"10.1016\/j.micpath.2026.108275_bib28","first-page":"5261","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007"},{"key":"10.1016\/j.micpath.2026.108275_bib29","first-page":"1","volume":"vol. 12","author":"Segata","year":"2011"},{"issue":"8","key":"10.1016\/j.micpath.2026.108275_bib30","first-page":"6089","article-title":"Dermorphin [D-Arg2, Lys4](1-4) amide alleviates frostbite-induced pain by regulating TRP channel-mediated microglial activation and neuroinflammation","volume":"61","author":"Ummadisetty","year":"2024"},{"issue":"7","key":"10.1016\/j.micpath.2026.108275_bib31","first-page":"965","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015"},{"issue":"2","key":"10.1016\/j.micpath.2026.108275_bib32","article-title":"Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK biobank","volume":"8","author":"Baskozos","year":"2023"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib33","first-page":"1","volume":"3","author":"Colloca","year":"2017","journal-title":"Neuropathic pain"},{"key":"10.1016\/j.micpath.2026.108275_bib34","series-title":"Neuropathic Pain: Mechanisms and Therapeutic Strategies","volume":"vol. 11","author":"Petroianu","year":"2023"},{"issue":"3","key":"10.1016\/j.micpath.2026.108275_bib35","first-page":"1448","article-title":"Immune actions on the peripheral nervous system in pain","volume":"22","author":"Liu","year":"2021"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib36","first-page":"27","article-title":"Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation","volume":"7","author":"Romano","year":"2021"},{"key":"10.1016\/j.micpath.2026.108275_bib37","series-title":"Current Perspectives on Gut Microbiome Dysbiosis and Depression","first-page":"1328","volume":"vol. 37","author":"Capuco","year":"2020"},{"key":"10.1016\/j.micpath.2026.108275_bib38","volume":"vol. 90","author":"Liu","year":"2023"},{"key":"10.1016\/j.micpath.2026.108275_bib39","article-title":"The gut-brain axis and beyond: microbiome control of spinal cord injury pain in humans and rodents","volume":"9","author":"Bannerman","year":"2021"},{"issue":"5","key":"10.1016\/j.micpath.2026.108275_bib40","first-page":"1076","article-title":"Alterations in gut microbiota are related to metabolite profiles in spinal cord injury","volume":"18","author":"Kang","year":"2023"},{"issue":"18","key":"10.1016\/j.micpath.2026.108275_bib41","first-page":"9368","article-title":"Supplementation with Bifidobacterium animalis subsp. lactis MH-022 for remission of motor impairments in a 6-OHDA-induced parkinson's disease rat model by reducing inflammation, reshaping the gut microbiome, and fostering specific microbial taxa","volume":"15","author":"Tsao","year":"2024"},{"key":"10.1016\/j.micpath.2026.108275_bib42","series-title":"Bifidobacterium animalis in Combination with Human Origin of Lactobacillus plantarum Ameliorate Neuroinflammation in Experimental Model of Multiple Sclerosis by Altering CD4+ T Cell Subset Balance","first-page":"1535","volume":"vol. 95","author":"Salehipour","year":"2017"},{"key":"10.1016\/j.micpath.2026.108275_bib43","article-title":"Vitamin A supplementation ameliorates ulcerative colitis in gut microbiota\u2013dependent manner","volume":"148","author":"Pang","year":"2021"},{"key":"10.1016\/j.micpath.2026.108275_bib44","series-title":"Genome Insight and Probiotic Potential of Three Novel Species of the Genus Corynebacterium","volume":"vol. 14","author":"Shamsuzzaman","year":"2023"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib45","article-title":"Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome","volume":"9","author":"Nozu","year":"2019"},{"issue":"1","key":"10.1016\/j.micpath.2026.108275_bib46","article-title":"Short-chain fatty acid, butyrate prevents morphine-and paclitaxel-induced nociceptive hypersensitivity","volume":"13","author":"Jessup","year":"2023"},{"issue":"42","key":"10.1016\/j.micpath.2026.108275_bib47","first-page":"26482","article-title":"Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice","volume":"117","author":"Bonomo","year":"2020"},{"issue":"7973","key":"10.1016\/j.micpath.2026.108275_bib48","first-page":"381","article-title":"Synergy and oxygen adaptation for development of next-generation probiotics","volume":"620","author":"Khan","year":"2023"},{"issue":"2","key":"10.1016\/j.micpath.2026.108275_bib49","first-page":"138","article-title":"Animal models-mimicking the pain of trigeminal neuralgia","volume":"54","author":"Gupta","year":"2022"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102600001X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102600001X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:55:10Z","timestamp":1777575310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240102600001X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":48,"alternative-id":["S088240102600001X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108275","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fecal microbiota transplantation attenuates neuropathic pain in rats via gut microbiota-mediated immunomodulation of ion channels and nociceptors","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108275","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108275"}}