{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:54:19Z","timestamp":1777874059796,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022851","name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Bioanal\u00edtica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.micpath.2026.108292","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:40:45Z","timestamp":1768030845000},"page":"108292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effect of antibody-dependent enhancement on the development of the offspring of mice infected by Zika virus: Analysis of the brain transcriptome"],"prefix":"10.1016","volume":"212","author":[{"given":"Let\u00edcia Maria Soares","family":"Azevedo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Lisboa","family":"Rios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Nadur Arantes","family":"Diniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha Neves","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00ednthia Firmo","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Cunha","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidyleison Neves","family":"Camargos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-5422","authenticated-orcid":false,"given":"Ant\u00f4nio Lucio","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-6746","authenticated-orcid":false,"given":"Frederico","family":"Soriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-3008","authenticated-orcid":false,"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian Vasconcelos","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele G.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108292_bib1","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2019.1707125","article-title":"Increased temperatures reduce the vectorial capacity of Aedes mosquitoes for Zika v\u00edrus","volume":"9","author":"Onyango","year":"2020","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.micpath.2026.108292_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12985-016-0623-2","article-title":"Zika Virus on a spreading Spree: what we now know that was unknown in the 1950's","volume":"13","author":"Basu","year":"2016","journal-title":"Virol. J."},{"key":"10.1016\/j.micpath.2026.108292_bib3","first-page":"290","article-title":"Preventing transmission of zika virus in labor and delivery settings through implementation of standard Precautions - united States","volume":"65","author":"Olson","year":"2016","journal-title":"Informe Semanal de Morbilidad y Mortalidad (MMWR)"},{"issue":"5","key":"10.1016\/j.micpath.2026.108292_bib4","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika virus infection during pregnancy in mice causes placental damage and fetal demise","volume":"165","author":"Miner","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.micpath.2026.108292_bib5","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/cid\/ciw878","article-title":"Zika virus infects human fetal brain microglia and induces inflammation","volume":"64","author":"Lum","year":"2017","journal-title":"Clin. Infect. Dis."},{"issue":"19","key":"10.1016\/j.micpath.2026.108292_bib6","article-title":"Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869","volume":"4","author":"Huang","year":"2018","journal-title":"Cell Discov."},{"issue":"12","key":"10.1016\/j.micpath.2026.108292_bib7","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1001\/jamaneurol.2016.3720","article-title":"Congenital Zika virus infection beyond neonatal Microcephal","volume":"73","author":"Melo","year":"2016","journal-title":"JAMA Neurol."},{"issue":"10","key":"10.1016\/j.micpath.2026.108292_bib8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micpath.2026.108292_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008984","article-title":"Congenital abnormalities associated with Zika virus infection\u2013Dengue as potential co-factor? A systematic review","author":"Petzold","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2026.108292_bib10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aal4365","article-title":"Enhancement of Zika v\u00edrus pathogenesis by preexisting antiflavivirus immunity","volume":"356","author":"Bardina","year":"2017","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.micpath.2026.108292_bib11","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni.3515","article-title":"Dengue v\u00edrus serocross-reactivity drives antibody-dependent enhancement of infection with zika virus","volume":"17","author":"Dejnirattisai","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micpath.2026.108292_bib12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1186\/s12879-021-06482-0","article-title":"A fatal case report of antibody-dependent enhancement of dengue virus type 1 following remote Zika virus infection","volume":"21","author":"Bonheur","year":"2021","journal-title":"BMC Infect. Dis."},{"issue":"7","key":"10.1016\/j.micpath.2026.108292_bib13","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00705-013-1645-3","article-title":"Secondary infection as a risk factor for dengue hemorrhagic fever\/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection","volume":"158","author":"Guzman","year":"2013","journal-title":"Arch. Virol."},{"key":"10.1016\/j.micpath.2026.108292_bib14","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ebiom.2019.05.014","article-title":"In-depth characterization of congenital Zika syndrome in immunocompetent mice: antibodydependent enhancement and an antiviral peptide therapy","volume":"44","author":"Camargos","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.micpath.2026.108292_bib15","series-title":"Immunochemical Protocols","first-page":"113","article-title":"Purification of monoclonal antibodies","author":"Page","year":"1998"},{"issue":"4","key":"10.1016\/j.micpath.2026.108292_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00430-014-0334-5","article-title":"Subversion of early innate antiviral responses during antibody- dependent enhancement of Dengue virus infection induces severe disease in immunocompetent mice","volume":"203","author":"Costa","year":"2014","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.micpath.2026.108292_bib17","first-page":"1","article-title":"Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide","author":"Jackman","year":"2018","journal-title":"Nat. Mater."},{"issue":"1","key":"10.1016\/j.micpath.2026.108292_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNAseq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"24","key":"10.1016\/j.micpath.2026.108292_bib19","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1093\/bioinformatics\/btt558","article-title":"STAR: an integrated solution to management and visualization of sequencing data","volume":"29","author":"Wang","year":"2013","journal-title":"Bioinformatics"},{"issue":"17","key":"10.1016\/j.micpath.2026.108292_bib20","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1093\/bioinformatics\/btv300","article-title":"GOplot: an R package for visually combining expression data with functional analysis: Fig. 1","volume":"31","author":"Walter","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2026.108292_bib21","article-title":"A protocol for using gene set enrichment analysis to identify the appropriate animal model for translational research","volume":"126","author":"Weidner","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.micpath.2026.108292_bib22","series-title":"Ggplot Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"issue":"supl. 6","key":"10.1016\/j.micpath.2026.108292_bib23","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2164-16-S6-S3","article-title":"RAP: RNA-Seq Analysis Pipeline, a new cloud-based NGS web application","volume":"16","author":"D\u2019antonio","year":"2015","journal-title":"BMC Genom."},{"issue":"2","key":"10.1016\/j.micpath.2026.108292_bib24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/bfgp\/elu035","article-title":"Measuring differential gene expression with RNAseq: challenges and strategies for data analysis","volume":"14","author":"Finotello","year":"2015","journal-title":"Brief. Funct. Genom."},{"key":"10.1016\/j.micpath.2026.108292_bib25","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.12688\/f1000research.9005.1","article-title":"RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR","volume":"5","author":"Law","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.micpath.2026.108292_bib26","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.12688\/f1000research.12544.1","article-title":"Easy and efficient ensemble gene set testing with EGSEA","volume":"6","author":"Alhamdoosh","year":"2017","journal-title":"F1000Research"},{"issue":"1","key":"10.1016\/j.micpath.2026.108292_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13059-016-0881-8","article-title":"A survey of best practices for RNA-seq data analysis","volume":"17","author":"Conesa","year":"2016","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108292_bib28","doi-asserted-by":"crossref","first-page":"11.14.1","DOI":"10.1002\/0471250953.bi1114s51","article-title":"Mapping RNA-seq reads with STAR","volume":"51","author":"Dobin","year":"2015","journal-title":"Curr. Protoc. Bioinform."},{"issue":"2","key":"10.1016\/j.micpath.2026.108292_bib29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with highthroughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"9966","key":"10.1016\/j.micpath.2026.108292_bib30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"Guzman","year":"2015","journal-title":"Lancet"},{"issue":"6365","key":"10.1016\/j.micpath.2026.108292_bib31","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.micpath.2026.108292_bib32","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.chom.2018.10.008","article-title":"Cross-Reactive Dengue virus antibodies Augment Zika virus infection of human placental macrophages","volume":"24","author":"Zimmerman","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micpath.2026.108292_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ijid.2020.01.031","article-title":"An epidemiological survey of the current status of Zika and the immune interaction between dengue and Zika infection in Southern Taiwan","volume":"93","author":"Wang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"issue":"10015","key":"10.1016\/j.micpath.2026.108292_bib34","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0140-6736(16)00006-4","article-title":"Zika virus in Brazil and macular atrophy in a child with microcephaly","volume":"387","author":"Ventura","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.micpath.2026.108292_bib35","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.3390\/v14122776","article-title":"Comparative analysis of In vitro models to Study antibody-dependent enhancement of zika virus infection","volume":"14","author":"Langerak","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.micpath.2026.108292_bib36","doi-asserted-by":"crossref","first-page":"21604","DOI":"10.1038\/s41598-020-78735-y","article-title":"Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats","volume":"10","author":"Bobermin","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108292_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.89854","article-title":"Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b\/C1ql2\/Nrxn(25b+) pathway","volume":"12","author":"Koumoundourou","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.micpath.2026.108292_bib38","first-page":"68","article-title":"Molecular identification and characterisation of a novel chicken leukocyte immunoglobulin-like receptor A5","author":"Truong","year":"2020","journal-title":"Molecular, Cellular Develop. Biol."},{"key":"10.1016\/j.micpath.2026.108292_bib39","first-page":"467","article-title":"Interferon-inducible protein (IFI) 16 regulates Chikungunya and Zika virus infection in human skin fibroblasts","volume":"18","author":"Wichit","year":"2019","journal-title":"EXCLI J"},{"issue":"3","key":"10.1016\/j.micpath.2026.108292_bib40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00430-015-0445-7","article-title":"Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase","volume":"205","author":"Tappe","year":"2016","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.micpath.2026.108292_bib41","doi-asserted-by":"crossref","DOI":"10.1007\/s12016-016-8554-7","article-title":"Zika virus infection: current concerns and perspectives","author":"Maharajan","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.micpath.2026.108292_bib42","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.virol.2016.03.006","article-title":"The South Pacific epidemic strain of Zika virus replicates efficiently in human epithelial A549 cells leading to IFN-\u03b2 production and apoptosis induction","volume":"493","author":"Frumence","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.micpath.2026.108292_bib43","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/s41467-024-45794-y","article-title":"The gut ileal mucosal virome is disturbed in patients with Crohn's disease and exacerbates intestinal inflammation in mice","volume":"15","author":"Cao","year":"2024","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.micpath.2026.108292_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112341","article-title":"PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection","volume":"42","author":"Baran","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.micpath.2026.108292_bib45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/pathogens11020193","article-title":"Pathogenic infections during pregnancy and the consequences for fetal brain development","volume":"11","author":"Jash","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.micpath.2026.108292_bib46","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1172\/JCI200522877","article-title":"Essential role of RSK2 in c-Fos-dependent osteosarcoma development","volume":"115","author":"David","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.micpath.2026.108292_bib47","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.4049\/jimmunol.1003505","article-title":"Regulation of GATA-3 expression during CD4 lineage differentiation","volume":"186","author":"Gimferrer","year":"2011","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.micpath.2026.108292_bib48","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1567-133X(03)00124-8","article-title":"Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3","volume":"3","author":"Polvani","year":"2003","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.micpath.2026.108292_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn6836","article-title":"Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-\u00e0-go-go\u2013related gene) K+ channel subunits","volume":"10","author":"Schwarz","year":"2024","journal-title":"Sci. Adv."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026000185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026000185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:54:52Z","timestamp":1777575292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026000185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":49,"alternative-id":["S0882401026000185"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108292","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of antibody-dependent enhancement on the development of the offspring of mice infected by Zika virus: Analysis of the brain transcriptome","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108292"}}