{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:02:41Z","timestamp":1771470161159,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.micpath.2026.108303","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:24:50Z","timestamp":1768350290000},"page":"108303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Diagnostic and pathological characterization of senecavirus A-associated epidemic transient neonatal losses in swine"],"prefix":"10.1016","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1186-6518","authenticated-orcid":false,"given":"Eduarda Ribeiro","family":"Braga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-7072","authenticated-orcid":false,"given":"Emanoelly Machado Sousa","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3926-9491","authenticated-orcid":false,"given":"Anderson Hentz","family":"Gris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Groeltz-Thrush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-7762","authenticated-orcid":false,"given":"Pablo E.","family":"Pi\u00f1eyro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108303_bib1","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1080\/15548627.2023.2293442","article-title":"Senecavirus A induces mitophagy to promote self-replication through direct interaction of 2C protein with K27-linked ubiquitinated TUFM catalyzed by RNF185","volume":"20","author":"Chen","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.micpath.2026.108303_bib2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12917-017-0967-x","article-title":"An indirect enzyme-linked immunosorbent assay for the identification of antibodies to senecavirus A in swine","volume":"13","author":"Dvorak","year":"2017","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.micpath.2026.108303_bib3","doi-asserted-by":"crossref","DOI":"10.4142\/jvs.22307","article-title":"Prevalence of senecavirus A in pigs from 2014 to 2020: a global systematic review and meta-analysis","volume":"24","author":"Ran","year":"2023","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.micpath.2026.108303_bib4","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.vaccine.2022.02.018","article-title":"Efficacy of an inactivated senecavirus A vaccine in weaned pigs and mature sows","volume":"40","author":"Buckley","year":"2022","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2026.108303_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.567792","article-title":"A 5-Year review of senecavirus A in China since its emergence in 2015","volume":"7","author":"Liu","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.micpath.2026.108303_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2024.110248","article-title":"Evidence of vertical transmission of senecavirus A in naturally infected sows","volume":"600","author":"Schaefer","year":"2024","journal-title":"Virology"},{"key":"10.1016\/j.micpath.2026.108303_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/tbed.12598","article-title":"Systematic epidemiological investigations of cases of senecavirus A in US swine breeding herds","volume":"64","author":"Baker","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.micpath.2026.108303_bib8","first-page":"495","article-title":"A review on pathological and diagnostic aspects of emerging viruses\u2014senecavirus A, torque teno sus virus and linda virus\u2014in swine","volume":"9","author":"Hawko","year":"2022","journal-title":"Vet. Sci."},{"key":"10.1016\/j.micpath.2026.108303_bib9","first-page":"84","article-title":"Idiopathic vesicular disease in swine in Manitoba","volume":"49","author":"Pasma","year":"2008","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.micpath.2026.108303_bib10","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1111\/tbed.12669","article-title":"Emergence and whole-genome sequence of senecavirus A in Colombia","volume":"64","author":"Sun","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.micpath.2026.108303_bib11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/tbed.12654","article-title":"The first detection of senecavirus A in pigs in Thailand, 2016","volume":"65","author":"Saeng-Chuto","year":"2018","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.micpath.2026.108303_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/MRA.01247-18","article-title":"First detection and genome sequence of senecavirus A in Vietnam","volume":"8","author":"Arzt","year":"2019","journal-title":"Microbiol Resour Announc"},{"key":"10.1016\/j.micpath.2026.108303_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/00480169.1987.35369","article-title":"A vesiculo-bullous disease in pigs resembling foot and mouth disease. I. Field cases","volume":"35","author":"Montgomery","year":"1987","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/j.micpath.2026.108303_bib14","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/tbed.12557","article-title":"The first identification and complete genome of senecavirus A affecting pig with idiopathic vesicular disease in China","volume":"64","author":"Wu","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.micpath.2026.108303_bib15","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3201\/eid2207.151583","article-title":"Clinical manifestations of senecavirus A infection in neonatal pigs, Brazil, 2015","volume":"22","author":"Leme","year":"2016","journal-title":"Emerging Infectious Disease journal"},{"key":"10.1016\/j.micpath.2026.108303_bib16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/tbed.12516","article-title":"Neonatal mortality, vesicular lesions and lameness associated with senecavirus A in a U.S. sow farm","volume":"63","author":"Canning","year":"2016","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.micpath.2026.108303_bib17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/tbed.12410","article-title":"Identification and complete genome of Seneca valley virus in vesicular fluid and sera of pigs affected with idiopathic vesicular disease, Brazil","volume":"62","author":"Vannucci","year":"2015","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.micpath.2026.108303_bib18","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1128\/JCM.00710-16","article-title":"Serological and molecular detection of senecavirus A associated with an outbreak of swine idiopathic vesicular disease and neonatal mortality","volume":"54","author":"Gimenez-Lirola","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2026.108303_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/0300985816653990","article-title":"Senecavirus A","volume":"54","author":"Segales","year":"2017","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.micpath.2026.108303_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16407-0","article-title":"Histopathological, immunohistochemical, and ultrastructural evidence of spontaneous senecavirus A-induced lesions at the choroid plexus of newborn piglets","volume":"7","author":"Oliveira","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108303_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.105022","article-title":"Seneca valley virus induces immunodepressionin suckling piglets by selective apoptosis of B lymphocytes","volume":"158","author":"Oliveira","year":"2021","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2026.108303_bib22","article-title":"Senecavirus A as an oncolytic virus: prospects, challenges and development directions","volume":"12","author":"Luo","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.micpath.2026.108303_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00363","article-title":"Senecavirus A 3C protease mediates host cell apoptosis late in infection","volume":"10","author":"Fernandes","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2026.108303_bib24","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00705-017-3630-8","article-title":"Quantitative analysis of senecavirus A in tissue samples from naturally infected newborn piglets","volume":"163","author":"Dall Agnol","year":"2018","journal-title":"Arch. Virol."},{"key":"10.1016\/j.micpath.2026.108303_bib25","article-title":"Epidemiological monitoring and genetic variation analysis of pathogens associated with porcine viral diarrhea in southern China from 2021 to 2023","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2026.108303_bib26","article-title":"Advances in the differential molecular diagnosis of vesicular disease pathogens in swine","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2026.108303_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198038","article-title":"Comprehensive review on immunopathogenesis, diagnostic and epidemiology of senecavirus A","volume":"286","author":"Houston","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.micpath.2026.108303_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01717-17","article-title":"Adaptive immune responses following senecavirus A infection in pigs","volume":"92","author":"Maggioli","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2026.108303_bib29","doi-asserted-by":"crossref","DOI":"10.1177\/10406387221084054","article-title":"Persistence and shedding of senecavirus A in naturally infected boars","author":"Sturos","year":"2022","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.micpath.2026.108303_bib30","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1099\/jgv.0.000631","article-title":"Pathogenesis of senecavirus A infection in finishing pigs","volume":"97","author":"Joshi","year":"2016","journal-title":"J. Gen. Virol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102600029X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102600029X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:22:11Z","timestamp":1769858531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240102600029X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":30,"alternative-id":["S088240102600029X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108303","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic and pathological characterization of senecavirus A-associated epidemic transient neonatal losses in swine","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108303"}}