{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:54:34Z","timestamp":1777874074845,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.micpath.2026.108417","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T17:47:35Z","timestamp":1772473655000},"page":"108417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Boesenbergia rotunda extract decreases biofilm formation and host-pathogen interaction of bloodstream-isolated Candida albicans by interfering with biomolecule composition and metabolomics adaptation"],"prefix":"10.1016","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-1869","authenticated-orcid":false,"given":"Jamras","family":"Kanchanapiboon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasiwan","family":"Tuntoaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3168-4534","authenticated-orcid":false,"given":"Subhadhcha","family":"Poonsatha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnatchai","family":"Maiuthed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pattarawit","family":"Rukthong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanjana","family":"Thumanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supatcharee","family":"Siriwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudaluck","family":"Thunyaharn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detmontree","family":"Wachisuthon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apirak","family":"Sakpetch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilailuk","family":"Chuennangchee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108417_bib2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.55374\/jseamed.v5i2.96","article-title":"Activity of triazoles and echinocandins against Candida bloodstream isolates at Phramongkutklao hospital, Thailand","volume":"5","author":"Thunyaharn","year":"2021","journal-title":"Southeast Asian Med. Res."},{"key":"10.1016\/j.micpath.2026.108417_bib3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/jof9030353","article-title":"Characterization of virulence factors in Candida species causing candidemia in a tertiary care hospital in Bangkok, Thailand","volume":"9","author":"Saiprom","year":"2023","journal-title":"J. Fungi"},{"key":"10.1016\/j.micpath.2026.108417_bib4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1590\/0037-8682-0045-2013","article-title":"Determination of germ tube, phospholipase, and proteinase production by bloodstream isolates of Candida albicans","volume":"46","author":"Mattei","year":"2013","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.micpath.2026.108417_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.resmic.2022.104009","article-title":"Metabolomics profiling of culture medium reveals association of methionine and vitamin B metabolisms with virulent phenotypes of clinical bloodstream-isolated Candida albicans","volume":"174","author":"Kanchanapiboon","year":"2023","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.micpath.2026.108417_bib6","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1038\/s41598-020-60792-y","article-title":"Virulence assessment of six major pathogenic Candida species in the mouse model of invasive candidiasis caused by fungal translocation","volume":"10","author":"Hirayama","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108417_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9870679","article-title":"Antifungal resistance, metabolic routes as drug targets, and new antifungal agents: an overview about endemic dimorphic fungi","volume":"2017","author":"Parente-Rocha","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.micpath.2026.108417_bib8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/jof8070723","article-title":"Metabolic plasticity of Candida albicans in response to different environmental conditions","volume":"8","author":"Gallo","year":"2022","journal-title":"Fungi"},{"key":"10.1016\/j.micpath.2026.108417_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00203-006-0094-8","article-title":"FTIR spectroscopy as a potential tool to analyse structural modifications during morphogenesis of Candida albicans","volume":"185","author":"Adt","year":"2006","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.micpath.2026.108417_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01333-14","article-title":"Novel entries in a fungal biofilm matrix encyclopedia","volume":"5","author":"Zarnowski","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.micpath.2026.108417_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/jof11020093","article-title":"Fungal metabolomics: a comprehensive approach to understanding pathogenesis in humans and identifying potential therapeutics","volume":"11","author":"Alves","year":"2025","journal-title":"J. Fungi (Basel)"},{"key":"10.1016\/j.micpath.2026.108417_bib12","first-page":"93","article-title":"Ethnobotanical survey of the ginger family in selected Malay villages in Peninsular Malaysia, Malays","volume":"19","author":"Ibrahim","year":"2000","journal-title":"J. Sci."},{"key":"10.1016\/j.micpath.2026.108417_bib13","series-title":"Thai Herbal Pharmacopoeia 2021 Supplement 2022","year":"2022"},{"key":"10.1016\/j.micpath.2026.108417_bib14","series-title":"Medicinal Plant Information Center","article-title":"Thai medicinal plants recommended for primary health care system","author":"Bunyapraphatsara","year":"1992"},{"key":"10.1016\/j.micpath.2026.108417_bib15","series-title":"Traditional Medicine in Asia","first-page":"47","article-title":"Traditional system of medicine in Indonesia","author":"Handayani","year":"2002"},{"key":"10.1016\/j.micpath.2026.108417_bib16","first-page":"59","article-title":"Oral antipathogenic and antiviral properties of Boesenbergia rotunda (L.) Mansf. extracts with panduratin A as active compound","volume":"14","author":"Sanguansermsri","year":"2024","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.micpath.2026.108417_bib17","first-page":"909","article-title":"Antioxidant, antimicrobial and wound healing activities of Boesenbergia rotunda","volume":"7","author":"Jitvaropas","year":"2012","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.micpath.2026.108417_bib18","first-page":"278","article-title":"Safety and pharmacokinetics study of Boesenbergia rotunda (L.) Mansf. capsules in healthy volunteers: a phase 1 clinical study","volume":"22","author":"Teerachaisakul","year":"2024","journal-title":"J. Thai Trad. Alt. Med."},{"key":"10.1016\/j.micpath.2026.108417_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113193","article-title":"Boesenbergia rotunda extract inhibits Candida albicans biofilm formation by pinostrobin and pinocembrin","volume":"261","author":"Kanchanapiboon","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.micpath.2026.108417_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S1995-7645(10)60066-1","article-title":"Inhibition of candida adhesion to denture acrylic by Boesenbergia pandurata","volume":"3","author":"Sroisiri","year":"2010","journal-title":"Asian Pac. J. Tropical Med."},{"key":"10.1016\/j.micpath.2026.108417_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2334\/josnusd.51.87","article-title":"Activity of panduratin A isolated from Kaempferia pandurata Roxb. against multi-species oral biofilms in vitro","volume":"51","author":"Yanti","year":"2009","journal-title":"Oral Sci."},{"key":"10.1016\/j.micpath.2026.108417_bib22","article-title":"Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans","volume":"23","author":"Mogavero","year":"2021","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.micpath.2026.108417_bib23","article-title":"Method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts","volume":"7.4","author":"Guinea","year":"2023"},{"key":"10.1016\/j.micpath.2026.108417_bib24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/1567-1364.12068","article-title":"Clinical isolates and laboratory reference Candida species and strains have varying abilities to form biofilms","volume":"13","author":"Alnuaimi","year":"2013","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.micpath.2026.108417_bib25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3389\/fimmu.2017.00629","article-title":"Candida albicans yeast, pseudohyphal, and hyphal morphogenesis differentially affects immune recognition","volume":"8","author":"Mukaremera","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2026.108417_bib26","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3389\/fmicb.2017.01235","article-title":"Candida albicans: the ability to invade epithelial cells and survive under oxidative stress is unlinked to hyphal length","volume":"8","author":"Maza","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2026.108417_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/femsyr\/fow058","article-title":"Assessing physio-macromolecular effects of lactic acid on Zygosaccharomyces bailii cells during microaerobic fermentation","volume":"16","author":"Kuanyshev","year":"2016","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.micpath.2026.108417_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-24935-7","article-title":"Bioenhancing effects of piperine and curcumin on triterpenoid pharmacokinetics and neurodegenerative metabolomes from Centella asiatica extract in beagle dogs","volume":"12","author":"Boonyarattanasoonthorn","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108417_bib29","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2026.108417_bib30","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.micinf.2016.01.002","article-title":"Candida albicans biofilms: development, regulation, and molecular mechanisms","volume":"18","author":"Gulati","year":"2016","journal-title":"Microb. Infect."},{"key":"10.1016\/j.micpath.2026.108417_bib31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ijantimicag.2012.01.009","article-title":"Effects of sub-minimum inhibitory concentrations of antimicrobial agents on Streptococcus mutans biofilm formation","volume":"39","author":"Dong","year":"2012","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2026.108417_bib32","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3390\/antibiotics10070874","article-title":"Subinhibitory antibiotic concentrations enhance biofilm formation of clinical Enterococcus faecalis isolates","volume":"10","author":"Bernardi","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.micpath.2026.108417_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005867","article-title":"The missing link between Candida albicans hyphal morphogenesis and host cell damage","volume":"12","author":"Wilson","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2026.108417_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001181","article-title":"Host cell invasion and virulence mediated by Candida albicans Ssa1","volume":"6","author":"Sun","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2026.108417_bib35","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1038\/s41467-021-24095-8","article-title":"Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain","volume":"12","author":"Dunker","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2026.108417_bib36","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1128\/JCM.41.3.954-959.2003","article-title":"Use of Fourier-transform infrared spectroscopy for typing of Candida albicans strains isolated in intensive care units","volume":"41","author":"Sandt","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2026.108417_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214067","article-title":"Metabolomic and proteomic changes in Candida albicans biofilm in response to zosteric acid treatment","volume":"23","author":"Catt\u00f2","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2026.108417_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.636834","article-title":"Transcriptomic and metabolomic analysis revealed roles of Yck2 in carbon metabolism and morphogenesis of Candida albicans","volume":"11","author":"Liboro","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2026.108417_bib39","article-title":"An integrated transcriptomic and metabolomic approach to investigate the heterogeneous Candida albicans biofilm phenotype","volume":"5","author":"Delaney","year":"2023","journal-title":"Biofilms"},{"key":"10.1016\/j.micpath.2026.108417_bib40","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.1074\/jbc.M113.517672","article-title":"Candida albicans utilizes a modified \u03b2-oxidation pathway for the degradation of toxic propionyl-CoA","volume":"289","author":"Otzen","year":"2014","journal-title":"J. Biol. Chem."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026001439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026001439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:58:54Z","timestamp":1777575534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026001439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":39,"alternative-id":["S0882401026001439"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108417","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Boesenbergia rotunda extract decreases biofilm formation and host-pathogen interaction of bloodstream-isolated Candida albicans by interfering with biomolecule composition and metabolomics adaptation","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108417","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108417"}}