{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:20:09Z","timestamp":1790875209241,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470562"],"award-info":[{"award-number":["32470562"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["CAAS-SHVRI-2025-2"],"award-info":[{"award-number":["CAAS-SHVRI-2025-2"]}],"id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["25S11909300"],"award-info":[{"award-number":["25S11909300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012428","name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800202"],"award-info":[{"award-number":["2022YFD1800202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.micpath.2026.108505","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:20:26Z","timestamp":1776237626000},"page":"108505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["BEZ235 inhibits Cryptosporidium parvum infection in mice by targeting the PI3K-NF-\u03baB-c-MYB\/BCL2A1 axis to restore host cell apoptosis"],"prefix":"10.1016","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-1523","authenticated-orcid":false,"given":"Shasha","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiancong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxiang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongsheng","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2079-9361","authenticated-orcid":false,"given":"Zhaoguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108505_bib1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/QAD.0b013e3283437e88","article-title":"Cryptosporidiosis in patients with HIV\/AIDS","volume":"25","author":"O'Connor","year":"2011","journal-title":"AIDS"},{"key":"10.1016\/j.micpath.2026.108505_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002831","article-title":"Distribution and clinical manifestations of Cryptosporidium species and subtypes in HIV\/AIDS patients in Ethiopia","volume":"8","author":"Adamu","year":"2014","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2026.108505_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1473-3099(14)70772-8","article-title":"A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium","volume":"15","author":"Checkley","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.micpath.2026.108505_bib4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/00001432-200412000-00008","article-title":"New drugs and treatment for cryptosporidiosis","volume":"17","author":"Smith","year":"2004","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.micpath.2026.108505_bib5","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1086\/428839","article-title":"Nitazoxanide: a new thiazolide antiparasitic agent","volume":"40","author":"Fox","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micpath.2026.108505_bib6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00281-021-00875-8","article-title":"Management of cell death in parasitic infections","volume":"43","author":"Bosurgi","year":"2021","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.micpath.2026.108505_bib7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s13071-019-3529-1","article-title":"Toxoplasma gondii ROP18 inhibits human glioblastoma cell apoptosis through a mitochondrial pathway by targeting host cell P2X1","volume":"12","author":"Zhou","year":"2019","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.micpath.2026.108505_bib8","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1038\/cdd.2016.101","article-title":"Leishmania donovani inhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of beta-catenin and FOXO-1","volume":"23","author":"Gupta","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.micpath.2026.108505_bib9","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1007\/s00436-020-06738-9","article-title":"Effects of the PI3K\/Akt signaling pathway on the apoptosis of early host cells infected with Eimeria tenella","volume":"119","author":"Zhang","year":"2020","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micpath.2026.108505_bib10","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1128\/IAI.00955-08","article-title":"Biphasic modulation of apoptotic pathways in Cryptosporidium parvum-Infected human intestinal epithelial cells","volume":"77","author":"Liu","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2026.108505_bib11","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1086\/528374","article-title":"Cryptosporidium infection of human intestinal epithelial cells increases expression of osteoprotegerin: a novel mechanism for evasion of host defenses","volume":"197","author":"Castellanos-Gonzalez","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micpath.2026.108505_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12449","article-title":"Protective efficacy of recombinant Cryptosporidium parvum CpPRP1 sushi domain against C. tyzzeri infection in mice","volume":"39","author":"Huang","year":"2017","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2026.108505_bib13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2307\/3282084","article-title":"Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients","volume":"73","author":"Arrowood","year":"1987","journal-title":"J. Parasitol."},{"key":"10.1016\/j.micpath.2026.108505_bib14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s13071-022-05415-3","article-title":"MiR-942-5p targeting the IFI27 gene regulates HCT-8 cell apoptosis via a TRAIL-dependent pathway during the early phase of Cryptosporidium parvum infection","volume":"15","author":"Xie","year":"2022","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.micpath.2026.108505_bib15","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1128\/IAI.00308-08","article-title":"Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin","volume":"76","author":"Liu","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2026.108505_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/srep28446","article-title":"Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer","volume":"6","author":"Azim","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108505_bib17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s12031-017-0991-0","article-title":"C-myb plays an essential role in the protective function of IGF-1 on cytotoxicity induced by Abeta(25-35) via the PI3K\/Akt pathway","volume":"63","author":"Zhang","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.micpath.2026.108505_bib18","doi-asserted-by":"crossref","DOI":"10.1186\/bcr2614","article-title":"MYB suppresses differentiation and apoptosis of human breast cancer cells","volume":"12","author":"Drabsch","year":"2010","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.micpath.2026.108505_bib19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.20041924","article-title":"The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival","volume":"201","author":"Mandal","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micpath.2026.108505_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113539","article-title":"Inhibitors of BCL2A1\/Bfl-1 protein: potential stock in cancer therapy","volume":"220","author":"Li","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.micpath.2026.108505_bib21","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1101\/gad.13.4.382","article-title":"The prosurvival Bcl-2 homolog Bfl-1\/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis","volume":"13","author":"Zong","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.micpath.2026.108505_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00405-013-2537-6","article-title":"Outcome of patients treated with palliative weekly paclitaxel plus cetuximab in recurrent head and neck cancer after failure of platinum-based therapy","volume":"271","author":"Sosa","year":"2014","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.micpath.2026.108505_bib23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1631\/jzus.B2100877","article-title":"Toxoplasma gondii infection induces cell apoptosis via multiple pathways revealed by transcriptome analysis","volume":"23","author":"Du","year":"2022","journal-title":"J. Zhejiang Univ. - Sci. B"},{"key":"10.1016\/j.micpath.2026.108505_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006646","article-title":"Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner","volume":"12","author":"Abhishek","year":"2018","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2026.108505_bib25","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.3382\/ps\/pev293","article-title":"Relationship between Eimeria tenella development and host cell apoptosis in chickens","volume":"94","author":"Zhang","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.micpath.2026.108505_bib26","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3382\/ps\/pew496","article-title":"Dynamic expression of death receptor adapter proteins tradd and fadd in Eimeria tenella-induced host cell apoptosis","volume":"96","author":"Xu","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.micpath.2026.108505_bib27","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1158\/1535-7163.MCT-08-0017","article-title":"Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase\/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity","volume":"7","author":"Maira","year":"2008","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.micpath.2026.108505_bib28","doi-asserted-by":"crossref","first-page":"22299","DOI":"10.1073\/pnas.0905152106","article-title":"Specific apoptosis induction by the dual PI3K\/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells","volume":"106","author":"Brachmann","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.micpath.2026.108505_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025132","article-title":"The dual PI3K\/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer","volume":"6","author":"Roper","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2026.108505_bib30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/aps.2013.22","article-title":"NVP-BEZ235, a novel dual PI3K\/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro","volume":"34","author":"Wang","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.micpath.2026.108505_bib31","first-page":"714","article-title":"Anti-tumor efficacy of BEZ235 is complemented by its anti-angiogenic effects via downregulation of PI3K-mTOR-HIF1alpha signaling in HER2-defined breast cancers","volume":"6","author":"Dey","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.micpath.2026.108505_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001297","article-title":"The susceptibility of trypanosomatid pathogens to PI3\/mTOR kinase inhibitors affords a new opportunity for drug repurposing","volume":"5","author":"Diaz-Gonzalez","year":"2011","journal-title":"PLoS Neglected Trop. Dis."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026002317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026002317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T11:15:50Z","timestamp":1779016550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026002317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"alternative-id":["S0882401026002317"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108505","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BEZ235 inhibits Cryptosporidium parvum infection in mice by targeting the PI3K-NF-\u03baB-c-MYB\/BCL2A1 axis to restore host cell apoptosis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108505","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108505"}}