{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:14:17Z","timestamp":1783754057322,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.micpath.2026.108591","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T23:46:27Z","timestamp":1779752787000},"page":"108591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Antifungal activity of Tetradenia riparia essential oil against dermatophytes: effects of nanoencapsulation and molecular docking insights into CYP51 interaction"],"prefix":"10.1016","volume":"217","author":[{"given":"Regina Yasuko","family":"Makimori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3477-6299","authenticated-orcid":false,"given":"Eliana Harue","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Meireles","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Firmino","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Catuzo Canonico","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilda Cristiani","family":"Gazim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Vataru","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia","family":"Ueda-Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-397X","authenticated-orcid":false,"given":"Benedito Prado Dias","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108591_bib1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/pathogens13080657","article-title":"Host\u2013pathogen interaction and resistance mechanisms in dermatophytes","volume":"13","author":"Dubljanin","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.micpath.2026.108591_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.107622","article-title":"Antifungal resistance in dermatophytes: essential oil-based nanoformulations as new generation therapeutics","volume":"205","author":"Yadav","year":"2025","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2026.108591_bib3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bjp.2014.10.014","article-title":"Antifungal activity and mechanism of action of monoterpenes","volume":"24","author":"Miron","year":"2014","journal-title":"Rev Bras Pharmacogn"},{"key":"10.1016\/j.micpath.2026.108591_bib4","series-title":"Microbial Pathogens. Badajoz","first-page":"1364","article-title":"Nanotechnology as an approach for essential-oil-based formulations","author":"S\u00e3o-Pedro","year":"2013"},{"key":"10.1016\/j.micpath.2026.108591_bib5","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.3390\/molecules15085509","article-title":"Seasonal variation, chemical composition, analgesic and antimicrobial activities of Tetradenia riparia essential oil","volume":"15","author":"Gazim","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.micpath.2026.108591_bib6","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.9734\/EJMP\/2014\/11370","article-title":"Antimicrobial activity of Tetradenia riparia Lamiaceae, a medicinal plant from Tanzania","volume":"4","author":"Njau","year":"2014","journal-title":"Eur. J. Med. Plants"},{"key":"10.1016\/j.micpath.2026.108591_bib7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijpharm.2014.12.069","article-title":"Essential oils: from extraction to encapsulation","volume":"483","author":"El-Asbahani","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.micpath.2026.108591_bib8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mycmed.2015.09.003","article-title":"Antidermatophytic activity of hydroalcoholic extracts from rosmarinus officinalis and Tetradenia riparia","volume":"24","author":"Endo","year":"2015","journal-title":"J. Mycol. Med."},{"key":"10.1016\/j.micpath.2026.108591_bib9","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1128\/AAC.39.12.2610","article-title":"Demonstration of synergy with fluconazole and NSAIDs against Candida albicans","volume":"39","author":"Scott","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2026.108591_bib10","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1128\/AAC.44.9.2373-2381.2000","article-title":"Potent synergism of fluconazole and cyclosporine in Candida albicans","volume":"44","author":"Marchetti","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2026.108591_bib11","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.3390\/polym14245495","article-title":"Biotechnological applications of nanoencapsulated essential oils: a review","volume":"14","author":"Albuquerque","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.micpath.2026.108591_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fmed.2016.00011","article-title":"Emerging threats in antifungal-resistant fungal pathogens","volume":"3","author":"Sanglard","year":"2016","journal-title":"Front. Med."},{"key":"10.1016\/j.micpath.2026.108591_bib13","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.3390\/molecules200713384","article-title":"Molecular docking and structure-based drug design strategies","volume":"20","author":"Ferreira","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.micpath.2026.108591_bib14","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2174\/1568026614666140929124445","article-title":"Structure-based virtual screening for drug discovery: principles, applications and recent advances","volume":"14","author":"Lionta","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.micpath.2026.108591_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108591_bib16","series-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi","year":"2017"},{"key":"10.1016\/j.micpath.2026.108591_bib19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.micpath.2026.108591_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2026.108591_bib18","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2026.108591_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/futurepharmacol6010004","article-title":"Preparation, characterization, and antibiofilm effect of free and nanoencapsulated Tetradenia riparia essential oil","volume":"6","author":"Makimori","year":"2026","journal-title":"Future Pharmacol"},{"key":"10.1016\/j.micpath.2026.108591_bib21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.phymed.2011.07.005","article-title":"In vitro antifungal, anti-elastase and anti-keratinase activity of essential oils against Aspergillus fumigatus and Trichophyton rubrum","volume":"19","author":"Khan","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1016\/j.micpath.2026.108591_bib22","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/j.fct.2009.07.025","article-title":"Antioxidant and antidermatophytic activities of essential oil of Magnolia liliflora","volume":"47","author":"Bajpai","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.micpath.2026.108591_bib23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2133.1992.tb00001.x","article-title":"Terbinafine: mode of action and properties of squalene epoxidase inhibition","volume":"126","author":"Ryder","year":"1992","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.micpath.2026.108591_bib24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1128\/AAC.40.2.443","article-title":"Characterization of squalene epoxidase activity from Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents","volume":"40","author":"Favre","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2026.108591_bib25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s12879-015-1240-1","article-title":"An ultrastructural study of Trichophyton rubrum induced onychomycosis","volume":"15","author":"Yue","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.micpath.2026.108591_bib26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3390\/molecules28010435","article-title":"Immune defences: a view from the side of essential oils","volume":"28","author":"Tullio","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.micpath.2026.108591_bib27","first-page":"388","article-title":"Antifungal activity of Melaleuca alternifolia essential oil","volume":"9","author":"Nenoff","year":"1996","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.micpath.2026.108591_bib28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10156-006-0474-7","article-title":"Vapor activity of essential oils against Trichophyton mentagrophytes","volume":"12","author":"Inouye","year":"2006","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.micpath.2026.108591_bib29","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3390\/antibiotics13090892","article-title":"Nail lacquer containing essential oils and silver nanoparticles for onychomycosis: development and antifungal evaluation","volume":"13","author":"Scandorieiro","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/j.micpath.2026.108591_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.nano.2005.12.003","article-title":"Nanoencapsulation I: methods for preparation of polymeric nanoparticles","volume":"2","author":"Reis","year":"2006","journal-title":"Nanomedicine"},{"key":"10.1016\/j.micpath.2026.108591_bib32","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.phymed.2008.06.008","article-title":"Synergism between natural products and antibiotics","volume":"15","author":"Hemaiswarya","year":"2008","journal-title":"Phytomedicine"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026003177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026003177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:39:56Z","timestamp":1783751996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026003177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":31,"alternative-id":["S0882401026003177"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108591","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antifungal activity of Tetradenia riparia essential oil against dermatophytes: effects of nanoencapsulation and molecular docking insights into CYP51 interaction","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108591"}}