{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:14:12Z","timestamp":1783754052392,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.micpath.2026.108607","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:28:03Z","timestamp":1780417683000},"page":"108607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The porcine-derived compound Bacillus alleviates piglet infection with porcine epidemic diarrhea virus by reshaping the intestinal barrier and microbial balance"],"prefix":"10.1016","volume":"217","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1361-8107","authenticated-orcid":false,"given":"Yuzhu","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108607_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2478\/jvetres-2020-0050","article-title":"Animal coronaviruses in the light of COVID-19","volume":"64","author":"Doma\u0144ska-Blicharz","year":"2020","journal-title":"J. Veterinary Res."},{"key":"10.1016\/j.micpath.2026.108607_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198045","article-title":"Porcine epidemic diarrhea virus (PEDV): an update on etiology, transmission, pathogenesis, and prevention and control","volume":"286","author":"Jung","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.micpath.2026.108607_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.virusres.2016.09.003","article-title":"From the field to the lab - an European view on the global spread of PEDV","volume":"226","author":"Choudhury","year":"2016","journal-title":"Virus Res."},{"key":"10.1016\/j.micpath.2026.108607_bib4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12985-015-0421-2","article-title":"Porcine epidemic diarrhea virus: an emerging and re-emerging epizootic swine virus","volume":"12","author":"Lee","year":"2015","journal-title":"Virol. J."},{"key":"10.1016\/j.micpath.2026.108607_bib5","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00737-13","article-title":"Origin, evolution, and genotyping of emergent porcine epidemic diarrhea virus strains in the United States","volume":"4","author":"Huang","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.micpath.2026.108607_bib6","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1128\/JVI.00430-15","article-title":"Receptor usage and cell entry of porcine epidemic diarrhea coronavirus","volume":"89","author":"Liu","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2026.108607_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13578-017-0183-1","article-title":"Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics","volume":"7","author":"He","year":"2017","journal-title":"Cell Biosci."},{"key":"10.1016\/j.micpath.2026.108607_bib8","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/14787210.2022.2128765","article-title":"Lactic acid bacteria: prominent player in the fight against human pathogens","volume":"20","author":"Saha","year":"2022","journal-title":"Expert Rev. Anti-infect. Ther."},{"key":"10.1016\/j.micpath.2026.108607_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.rvsc.2021.07.002","article-title":"Inhibitory effects of Lactobacillus plantarum metabolites on porcine epidemic diarrhea virus replication","volume":"139","author":"Huang","year":"2021","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.micpath.2026.108607_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0286944","article-title":"Isolation, functional evaluation, and fermentation process optimization of probiotic Bacillus coagulans","volume":"18","author":"Xu","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2026.108607_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1273589","article-title":"Isolation, identification, and pathogenicity of porcine epidemic diarrhea virus","volume":"14","author":"Sun","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2026.108607_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01063-23","article-title":"Genetic signatures associated with the virulence of porcine epidemic diarrhea virus AH2012\/12","volume":"97","author":"Peng","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2026.108607_bib13","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/ani14020294","article-title":"Porcine epidemic diarrhea virus: etiology, epidemiology, antigenicity, and control strategies in China","volume":"14","author":"Lei","year":"2024","journal-title":"Animals : Open Access J. MDPI"},{"key":"10.1016\/j.micpath.2026.108607_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12985-023-01961-z","article-title":"A new PEDV strain CH\/HLJJS\/2022 can challenge current detection methods and vaccines","volume":"20","author":"Yao","year":"2023","journal-title":"Virol. J."},{"key":"10.1016\/j.micpath.2026.108607_bib15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.virol.2020.07.001","article-title":"Acute porcine epidemic diarrhea virus infection reshapes the intestinal microbiota","volume":"548","author":"Yang","year":"2020","journal-title":"Virology"},{"key":"10.1016\/j.micpath.2026.108607_bib16","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1021\/acs.jnatprod.9b00110","article-title":"Bioactive secondary metabolites from bacillus subtilis: a comprehensive review","volume":"82","author":"Kaspar","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.micpath.2026.108607_bib17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3390\/ani15040470","article-title":"In vitro and in vivo evaluation of bacillus strains as prophylactic agents against porcine epidemic diarrhea virus","volume":"15","author":"Chen","year":"2025","journal-title":"Animals : Open Access J. MDPI"},{"key":"10.1016\/j.micpath.2026.108607_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111675","article-title":"Bacillus amyloliquefaciens SC06 alleviated intestinal damage induced by inflammatory via modulating intestinal microbiota and intestinal stem cell proliferation and differentiation","volume":"130","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.micpath.2026.108607_bib19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nri2729","article-title":"Effector and regulatory B cells: modulators of CD4+ T cell immunity","volume":"10","author":"Lund","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micpath.2026.108607_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.605024","article-title":"All about the RNA: interferon-stimulated genes that interfere with viral RNA processes","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2026.108607_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56391-1","article-title":"Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108607_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.14798","article-title":"Tight junction proteins occludin and ZO-1 as regulators of epithelial proliferation and survival","volume":"1514","author":"Kuo","year":"2022","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.micpath.2026.108607_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1409111","article-title":"Editorial: IgA and mucosal immunity in vaccinology and in protection from infection","volume":"14","author":"Carsetti","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2026.108607_bib24","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026003335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026003335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:39:35Z","timestamp":1783751975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026003335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":24,"alternative-id":["S0882401026003335"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108607","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The porcine-derived compound Bacillus alleviates piglet infection with porcine epidemic diarrhea virus by reshaping the intestinal barrier and microbial balance","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108607","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108607"}}