{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:16:23Z","timestamp":1786994183887,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Malaysia Ministry of Higher Education","doi-asserted-by":"publisher","award":["600-IRMI\/FRGS 5\/3 (417\/2019"],"award-info":[{"award-number":["600-IRMI\/FRGS 5\/3 (417\/2019"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.micpath.2026.108613","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:30:55Z","timestamp":1780759855000},"page":"108613","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Structural, proteomic, and metabolomic insights into the antibacterial efficacy of nalidixic acid against Corynebacterium pseudotuberculosis"],"prefix":"10.1016","volume":"217","author":[{"given":"Anati Abd Rashid","family":"Syaida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Izwan Mohammad","family":"Yusof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faez Firdaus Abdullah","family":"Jesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Salleh","family":"Rofiee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Fakharul Zaman Raja","family":"Yahya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108613_bib1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3201\/eid0809.020063","article-title":"Biofilms: microbial life in surfaces","volume":"8","author":"Donlan","year":"2002","journal-title":"J Emerg Infect Dis"},{"key":"10.1016\/j.micpath.2026.108613_bib2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1590\/S1413-86702008000600016","article-title":"Biofilms: microbes and disease","volume":"12","author":"Aparna","year":"2008","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.micpath.2026.108613_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/nano11010082","article-title":"Nanotheranostics: a possible solution for drug-resistance Staphylococcus aureus and their biofilms?","volume":"11","author":"Mosselhy","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.micpath.2026.108613_bib4","first-page":"60","article-title":"Biofilms of pathogenic bacteria and emerging antibiofilm strategies","volume":"6","author":"Aransiola","year":"2022","journal-title":"Rev. Cien. Salud."},{"key":"10.1016\/j.micpath.2026.108613_bib5","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tim.2020.03.016","article-title":"Biofilm matrixome: extracellular components in structured microbial communities","volume":"28","author":"Karygianni","year":"2020","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micpath.2026.108613_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1625356","article-title":"Biofilms and multidrug resistance: an emerging crisis and the need for multidisciplinary interventions","volume":"13","author":"Yahya","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.micpath.2026.108613_bib7","first-page":"349","article-title":"Transcriptome analysis of Corynebacterium pseudotuberculosis biovar equi in two conditions of the environmental stress","volume":"667","author":"Gomide","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.micpath.2026.108613_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2020.10.022","article-title":"Biochemical composition, morphology and antimicrobial susceptibility pattern of Corynebacterium pseudotuberculosis biofilm","volume":"33","author":"Yaacob","year":"2021","journal-title":"J. King Saud Univ. Sci."},{"key":"10.1016\/j.micpath.2026.108613_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1051\/vetres:2005056","article-title":"Corynebacterium pseudotuberculosis: microbiology, biochemical properties, pathogenesis and molecular studies of virulence","volume":"37","author":"Dorella","year":"2006","journal-title":"J Vet Res"},{"key":"10.1016\/j.micpath.2026.108613_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jcpa.2018.04.003","article-title":"Caseous lymphadenitis caused by Corynebacterium pseudotuberculosis in alpine chamois (rupicapra r. rupicapra): a review of 98 cases","volume":"161","author":"Domenis","year":"2018","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.micpath.2026.108613_bib11","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1128\/jb.89.4.1068-1074.1965","article-title":"Mechanism of action of nalidixic acid of Escherichia coli","volume":"89","author":"Goss","year":"1965","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micpath.2026.108613_bib12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejmech.2005.09.002","article-title":"Synthesis and evaluation of new quinazolone derivatives of nalidixic acid as potential antibacterial and antifungal agents","volume":"41","author":"Grover","year":"2006","journal-title":"Eur J Med Chem Rep"},{"key":"10.1016\/j.micpath.2026.108613_bib13","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1747-0285.2011.01316.x","article-title":"Synthesis of novel nalidixic acid-based 1,3,4-Thiadiazole and 1,3,4-Oxadiazole derivatives as potent antibacterial agents","volume":"79","author":"Aggarwal","year":"2012","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.micpath.2026.108613_bib14","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1016\/j.bmcl.2015.07.071","article-title":"Re-Engineering nalidixic acid's chemical scaffold: a step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens","volume":"25","author":"Peraman","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.micpath.2026.108613_bib15","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/jac\/dku078","article-title":"Impact of quinolone-resistance acquisition on biofilm production and fitness in Salmonella enterica","volume":"69","author":"F\u00e0brega","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2026.108613_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41522-020-0116-3","article-title":"The insect antimicrobial peptide cecropin A disrupts uropathogenic Escherichia coli biofilms","volume":"6","author":"Kalsy","year":"2020","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.micpath.2026.108613_bib17","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/lam.13550","article-title":"Subinhibitory concentrations of nalidixic acid alter bacterial physiology and induce anthropogenic resistance in a commensal strain of Escherichia coli in vitro","volume":"73","author":"Chadha","year":"2021","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.micpath.2026.108613_bib18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00284-024-03863-x","article-title":"Novel fabrication of bio-polymeric nanogel loaded with nalidixic acid formulations for the effective prevention of bacterial pathogens leading urinary tract infection and its biosafety evaluation","volume":"81","author":"Yang","year":"2024","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.micpath.2026.108613_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.55230\/mabjournal.v53i1.2808","article-title":"Antibiofilm efficacy and mode of action of Etlingera elatior extracts against Staphylococcus aureus","volume":"53","author":"Hamdan","year":"2024","journal-title":"Malays. Appl. Biol."},{"key":"10.1016\/j.micpath.2026.108613_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.55230\/mabjournal.v51i4.10","article-title":"Antibacterial and antibiofilm activities of Swietenia macrophylla king ethanolic extract against foodborne pathogens","volume":"51","author":"Man","year":"2022","journal-title":"Malays. Appl. Biol."},{"key":"10.1016\/j.micpath.2026.108613_bib21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s10930-017-9719-9","article-title":"Subtractive protein profiling of Salmonella typhimurium biofilm treated with DMSO","volume":"36","author":"Yahya","year":"2017","journal-title":"Protein J."},{"key":"10.1016\/j.micpath.2026.108613_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2021.126911","article-title":"Integrating transcriptomics and metabolomics analysis on Kojic acid combating Acinetobacter baumannii biofilm and its potential roles","volume":"254","author":"Li","year":"2022","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.micpath.2026.108613_bib70","doi-asserted-by":"crossref","first-page":"97","DOI":"10.17509\/ijost.v4i1.15806","article-title":"How to read and interpret FTIR spectroscope of organic material","volume":"4","author":"Nandiyanto","year":"2019","journal-title":"IJoST"},{"key":"10.1016\/j.micpath.2026.108613_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114341","article-title":"Matrix matters: how extracellular substances shape biofilm structure and mechanical properties","volume":"246","author":"Hasan","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.micpath.2026.108613_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1155\/2009\/892569","article-title":"Fourier transform infrared Spectroscopy of dental unit water line biofilm bacteria","volume":"23","author":"Liaqat","year":"2009","journal-title":"J Spectrosc"},{"key":"10.1016\/j.micpath.2026.108613_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234870","article-title":"Microcultivation and FTIR spectroscopy-based screening revealed a nutrient-induced Co-Production of high-value metabolites in oleaginous Mucoromycota fungi","volume":"15","author":"Dzurendova","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2026.108613_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120237","article-title":"Biofilm-Mediated decolorization, degradation and detoxification of synthetic effluent by novel biofilm-producing bacteria isolated from textile dyeing effluent","volume":"314","author":"Haque","year":"2022","journal-title":"Environ Pollut"},{"key":"10.1016\/j.micpath.2026.108613_bib38","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.saa.2009.11.026","article-title":"Analysis of changes in attenuated total reflection of FTIR fingerprints of Pseudomonas fluorescens from planktonic stated to nascent biofilm State","volume":"75","author":"Quil\u00e8s","year":"2010","journal-title":"Spectrolchim Acta A Mol Biomol Spectrosc"},{"key":"10.1016\/j.micpath.2026.108613_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioflm.2023.100141","article-title":"Investigating the chemical pathways to the formation of a single biofilm using Infrared spectroscopy","volume":"6","author":"Crisp","year":"2023","journal-title":"Biofilm"},{"key":"10.1016\/j.micpath.2026.108613_bib75","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/08927014.2014.915956","article-title":"On the production of glycogen by Pseudomonas fluorescens during biofilm development: an in situ Study by attenuated total reflection-infrared with chemometrics","volume":"30","author":"Quil\u00e8s","year":"2014","journal-title":"Biofouling"},{"key":"10.1016\/j.micpath.2026.108613_bib76","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1021\/ac9015424","article-title":"Real-Time chemical imaging of bacterial activity in biofilms using open-channel microfluidics and Synchrotron FTIR spectromicroscopy","volume":"81","author":"Holman","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.micpath.2026.108613_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180680","article-title":"FTIR spectroscopy of whole cells for monitoring of yeast apoptosis mediated by p53 over-expression and its suppression by Nigella sativa extracts","volume":"12","author":"Mihoubi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2026.108613_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.614011","article-title":"Comparative proteomic analyses between biofilm-forming and non-biofilm-forming strains of Corynebacterium pseudotuberculosis isolated from goats","volume":"8","author":"S\u00e1","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.micpath.2026.108613_bib24","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16751","article-title":"Activity of biogenic silver nanoparticles in planktonic and biofilm-associated Corynebacterium pseudotuberculosis","volume":"12","author":"Santos","year":"2024","journal-title":"PeerJ"},{"key":"10.1016\/j.micpath.2026.108613_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1574-6941.2011.01087.x","article-title":"Trade-Off between oxygen and iron acquisition in bacterial cells at the air-liquid interface","volume":"77","author":"Yamamoto","year":"2011","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.micpath.2026.108613_bib26","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1061\/(ASCE)0733-9372(2003)129:6(576)","article-title":"Efficacy of biofilms under toxic conditions","volume":"129","author":"Gheewala","year":"2003","journal-title":"J Environmen Eng"},{"key":"10.1016\/j.micpath.2026.108613_bib27","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1007\/s00253-016-7396-9","article-title":"Is biofilm removal properly assessed? Comparison of different quantification methods in a 96-Well plate System","volume":"100","author":"Stiefel","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2026.108613_bib28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijantimicag.2016.05.008","article-title":"Synergistic antibiofilm efficacy of various commercial antiseptics, enzymes and EDTA: a Study of Pseudomonas aeruginosa and Staphylococcus aureus biofilms","volume":"48","author":"Lefebvre","year":"2016","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2026.108613_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.46754\/jssm.2022.4.004","article-title":"Inhibition of Corynebacterium pseudotuberculosis biofilm by DNA synthesis and protein synthesis inhibitors","volume":"17","author":"Rashid","year":"2022","journal-title":"JSSM"},{"issue":"1","key":"10.1016\/j.micpath.2026.108613_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2174\/187152107779314179","article-title":"Activities of quinolones against obligately anaerobic bacteria","volume":"6","author":"Schaumann","year":"2007","journal-title":"Anti-Infect. Agents Med. Chem."},{"key":"10.1016\/j.micpath.2026.108613_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mimet.2013.12.011","article-title":"Optimization of resazurin-based viability staining for quantification of microbial biofilms","volume":"98","author":"Van den Driessche","year":"2014","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.micpath.2026.108613_bib32","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00253-009-1879-x","article-title":"Fluorescent assay based on resazurin for detection of activity of disinfectants against bacterial biofilm","volume":"82","author":"Mariscal","year":"2009","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2026.108613_bib33","doi-asserted-by":"crossref","DOI":"10.1021\/acs.molpharmaceut.9b00080","article-title":"Spray-Dried particles of nitric oxide-modified glutathione for the treatment of chronic lung infection","volume":"16","author":"Das","year":"2019","journal-title":"Mol Pharmaceutics"},{"key":"10.1016\/j.micpath.2026.108613_bib34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ja.2012.49","article-title":"Combining biofilm matrix measurements with biomass and viability assays in susceptibility assessments of antimicrobials against Staphylococcus aureus biofilms","volume":"65","author":"Skogman","year":"2012","journal-title":"J. Antibiot."},{"key":"10.1016\/j.micpath.2026.108613_bib35","doi-asserted-by":"crossref","DOI":"10.1007\/s11270-024-07548-w","article-title":"Analyzing the growth and characteristics of Pseudomonas aeruginosa biofilm and estimating its Cr(VI) removing potential from water","volume":"235","author":"Mehra","year":"2024","journal-title":"Water Air Soil Pollut"},{"key":"10.1016\/j.micpath.2026.108613_bib36","first-page":"45","article-title":"Structural and proteomic insights into the antibiofilm efficacy of DMSO on Corynebacterium pseudotuberculosis","volume":"33","author":"Syaida","year":"2025","journal-title":"AsPac J Biol Biotechnol"},{"key":"10.1016\/j.micpath.2026.108613_bib39","first-page":"857","article-title":"The structure of Phosphate-Bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid","volume":"F65","author":"Kozlov","year":"2009","journal-title":"Acta Cryst"},{"key":"10.1016\/j.micpath.2026.108613_bib40","first-page":"881","article-title":"Structure of Staphylococcus aureus Adenylosuccinate Lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery","volume":"D66","author":"Fyfe","year":"2010","journal-title":"Acta Cryst"},{"key":"10.1016\/j.micpath.2026.108613_bib41","doi-asserted-by":"crossref","first-page":"11829","DOI":"10.1074\/jbc.M117.787994","article-title":"Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design","volume":"292","author":"Chitty","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2026.108613_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jsb.2018.01.006","article-title":"Structure of the Bacillus anthracis dTDP-L-Rhamnose biosynthetic pathway enzyme: dtdp-\u03b1-d-glucose 4,6-Dehydratase, RfbB","volume":"202","author":"Gokey","year":"2018","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.micpath.2026.108613_bib43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ab.2016.01.004","article-title":"A 96-well microtiter plate assay for high-throughput screening of Mycobacterium tuberculosis dTDP-D-Glucose 4,6-Dehydratase inhibitors","volume":"498","author":"Shi","year":"2016","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.micpath.2026.108613_bib44","first-page":"951","article-title":"Streptococcal dTDP-L-Rhamnose biosynthesis enzymes: functional characterization and lead compound identification","volume":"111","author":"van der Beek","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.micpath.2026.108613_bib45","doi-asserted-by":"crossref","DOI":"10.1039\/C8RA02315H","article-title":"Effect of Metabolic Uncoupler, 3, 3\u2019, 4\u2019, 5 \u2013 tetrachlorosalicylanilide (TCS) on Bacillus subtilis: Biofilm formation, flocculability and surface Characteristics","volume":"8","author":"Feng","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.micpath.2026.108613_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-24380-5","article-title":"HadD, A novel fatty acid synthase type II protein, is essential for Alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness","volume":"8","author":"Lefebvre","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108613_bib47","series-title":"Foodborne Bacterial Pathogens","article-title":"Characterization of bacterial membrane fatty acid profiles for biofilm cells","author":"Dubois-Brissonnet","year":"2025"},{"key":"10.1016\/j.micpath.2026.108613_bib48","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1099\/mic.0.051243-0","article-title":"CcpA coordinates central metabolism and biofilm form in Staphylococcus epidermis","volume":"157","author":"Sadykov","year":"2011","journal-title":"Microbiology"},{"key":"10.1016\/j.micpath.2026.108613_bib49","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1099\/mic.0.2008\/019828-0","article-title":"Effect of carbon source availability and growth phase on expression of Corynebacterium glutamicum genes involved in the tricarboxylic acid cycle and glyoxylate bypass","volume":"154","author":"Han","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.micpath.2026.108613_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/biot.201700612","article-title":"Integrated analysis of the transcriptome and metabolome of Corynebacterium glutamicum during penicillin-induced glutamic acid production","volume":"13","author":"Hirasawa","year":"2018","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.micpath.2026.108613_bib51","article-title":"Pseudomonas fluorescens Pfo-1 leads to reduced biofilm Formation and a reduction in cell size of surface-attached but not planktonic cells","volume":"2016","author":"Yoshioka","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.micpath.2026.108613_bib52","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1042\/BCJ20240338","article-title":"Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8","volume":"481","author":"Samarakoon","year":"2024","journal-title":"Biochem. J."},{"key":"10.1016\/j.micpath.2026.108613_bib53","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3182\/20140824-6-ZA-1003.01325","article-title":"Modeling framework for investigating the influence of amino acids on the planktonic-biofilm transition of Pseudomonas aeruginosa","volume":"47","author":"Xu","year":"2014","journal-title":"IFAC Proc. Vol."},{"key":"10.1016\/j.micpath.2026.108613_bib54","article-title":"An integrated modeling and experimental approach to Study the influence of environmental nutrients on biofilm Formation of Pseudomonas aeruginosa","volume":"2015","author":"Xu","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.micpath.2026.108613_bib55","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1177\/0022034517707512","article-title":"Arginine improves pH homeostasis via metabolism and microbiome modulation","volume":"96","author":"Agnello","year":"2017","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.micpath.2026.108613_bib56","article-title":"Nutrient sensing and biofilm modulation: the example of L-Arginine in Pseudomonas","volume":"23","author":"Rossi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2026.108613_bib57","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00297-21","article-title":"Putrescine and its metabolic precursor arginine promote biofilm and c-di-GMP synthesis in Pseudomonas aeruginosa","volume":"204","author":"Liu","year":"2022","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micpath.2026.108613_bib58","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnad077","article-title":"The phosphodiesterase RmcA contributes to the adaptation of Pseudomonas putida to L-Arginine","volume":"370","author":"Scribani-Rossi","year":"2023","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micpath.2026.108613_bib59","doi-asserted-by":"crossref","first-page":"21185","DOI":"10.1074\/jbc.M115.644401","article-title":"Arginine-Ornithine antiporter Arcd Controls arginine metabolism and interspecies biofilm development of Streptococcus gordonii","volume":"290","author":"Sakanaka","year":"2015","journal-title":"JBC"},{"key":"10.1016\/j.micpath.2026.108613_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.resmic.2020.103796","article-title":"Proteomic comparison of biofilm vs. planktonic Staphyloccus epidermis cells suggests key metabolic differences between these conditions","volume":"172","author":"Mart\u00ednez-Garc\u00eda","year":"2021","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.micpath.2026.108613_bib61","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3923\/tb.2014.19.26","article-title":"In Silico analysis of essential tricarboxylic acid cycle enzymes from biofilm-forming bacteria","volume":"7","author":"Yahya","year":"2014","journal-title":"Trends in Bioinformatics"},{"key":"10.1016\/j.micpath.2026.108613_bib62","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1126\/science.1188628","article-title":"D-Amino acids trigger biofilm disassembly","volume":"328","author":"Kolodkin-Gal","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.micpath.2026.108613_bib63","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.micpath.2015.07.009","article-title":"The effects of D-Tyrosine combined with Amikacin on the biofilms of Pseudomonas aeruginosa","volume":"86","author":"She","year":"2015","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2026.108613_bib64","article-title":"D-Amino acids inhibit biofilm Formation in Staphyloccoccus epidermis strains from ocular infections","volume":"63","author":"Ram\u00f3n-Per\u00e9z","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2026.108613_bib65","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2166\/wst.2021.623","article-title":"Effect of different D-Amino acids on biofilm Formation of mixed microorganisms","volume":"85","author":"Su","year":"2022","journal-title":"Water Sci. Technol."},{"issue":"6","key":"10.1016\/j.micpath.2026.108613_bib66","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/mSystems.00986-20","article-title":"Proteomic and systematic functional profiling unveils citral targeting antibiotic resistance, antioxidant defense, and biofilm-associated two-component systems of Acinetobacter baumannii to encumber biofilm and virulence traits","volume":"5","author":"Selvaraj","year":"2020","journal-title":"mSystems"},{"key":"10.1016\/j.micpath.2026.108613_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1598098","article-title":"Identification of the malonylation modification in Staphylococcus aureus and insight into the regulators in biofilm formation","volume":"16","author":"Yu","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2026.108613_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2025.117487","article-title":"TMT-based quantitative proteomics and non-targeted metabolomics reveal the antibacterial mechanism of rhein against Bacillus cereus and its potential application as a food preservative","volume":"218","author":"Li","year":"2025","journal-title":"LWT"},{"issue":"2","key":"10.1016\/j.micpath.2026.108613_bib69","article-title":"Treatment with the combined antimicrobials triggers proteomic changes in P. aeruginosa-C. albicans polyspecies biofilms","volume":"48","author":"Isa","year":"2022","journal-title":"Sci. Asia"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026003396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026003396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:34:54Z","timestamp":1783751694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026003396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":77,"alternative-id":["S0882401026003396"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108613","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural, proteomic, and metabolomic insights into the antibacterial efficacy of nalidixic acid against Corynebacterium pseudotuberculosis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108613","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108613"}}