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Investig."},{"key":"10.1016\/j.micpath.2026.108654_bib70","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-3024.1995.tb00969.x","article-title":"Toxocara canis adult worm antigen induces proliferative response of healthy human peripheral blood mononuclear cells","volume":"17","author":"Inuo","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib71","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-3024.1995.tb01006.x","article-title":"B cell mitogenic activity of Toxocara canis adult worm antigen","volume":"17","author":"Wang","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib72","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/pim.12143","article-title":"Visceral larva migrans syndrome: analysis of serum cytokine levels in children with hepatic lesions confirmed in radiological findings","volume":"36","author":"Mazur-Melewska","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib73","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0166-6851(86)90035-6","article-title":"Biochemical properties of larval excretory-secretoryglycoproteins of the parasitic nematode Toxocara canis","volume":"18","author":"Meghji","year":"1986","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.micpath.2026.108654_bib74","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1073\/pnas.93.4.1665","article-title":"An abundantly expressed mucin-like protein from Toxocara canis infective larvae: the precursor of the larval surface coat glycoproteins","volume":"93","author":"Gems","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.micpath.2026.108654_bib75","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0014-4894(92)90122-Q","article-title":"Toxocara canis: monoclonal antibodies to carbohydrate epitopes of secreted (TES) antigens localize to different secretion-related structures in infective larvae","volume":"75","author":"Page","year":"1992","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micpath.2026.108654_bib76","doi-asserted-by":"crossref","first-page":"18517","DOI":"10.1074\/jbc.270.31.18517","article-title":"An abundant, trans-spliced mRNA from Toxocara canis infective larvae encodes a 26-kDa protein with homology to phosphatidylethanolamine-binding proteins","volume":"270","author":"Gems","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2026.108654_bib77","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molbiopara.2016.09.002","article-title":"Proteomic analysis of Toxocara canis excretory and secretory (TES) proteins","volume":"211","author":"Sperotto","year":"2017","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.micpath.2026.108654_bib78","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.vetpar.2018.06.015","article-title":"The somatic proteins of Toxocara canis larvae and excretory-secretory products revealed by proteomics","volume":"259","author":"da Silva","year":"2018","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.micpath.2026.108654_bib79","doi-asserted-by":"crossref","DOI":"10.1590\/s1984-29612022056","article-title":"Acute and chronic immunomodulatory response mechanisms against Toxocara canis larvae infection in mice","volume":"31","author":"Borchard","year":"2022","journal-title":"Rev. Bras. Parasitol. Vet."},{"key":"10.1016\/j.micpath.2026.108654_bib80","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fimmu.2014.00603","article-title":"TH1\/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism?","volume":"5","author":"Muraille","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib81","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1007\/s00436-019-06405-8","article-title":"Cytokine production and signalling in human THP-1 macrophages is dependent on Toxocara canis glycans","volume":"118","author":"D\u0142ugosz","year":"2019","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micpath.2026.108654_bib82","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib83","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12192-012-0356-0","article-title":"Extracellular HSP27 acts as asignaling molecule to activate NF-\u03ba B in macrophages","volume":"18","author":"Salari","year":"2013","journal-title":"Cell Stress Chaperones"},{"issue":"2","key":"10.1016\/j.micpath.2026.108654_bib84","first-page":"5088","article-title":"Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation","volume":"282","author":"Voss","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2026.108654_bib85","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.2741\/3387","article-title":"Regulation of monocytes and macrophages cell fate M","volume":"14","author":"Gonzalez-Mejia","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.micpath.2026.108654_bib86","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1017\/S0031182020000347","article-title":"Heat shock protein 70 (Hsp70) in Schistosoma mansoni and its role in decreased adult worm sensitivity to praziquantel","volume":"147","author":"Abou-El-Naga","year":"2020","journal-title":"Parasitology"},{"key":"10.1016\/j.micpath.2026.108654_bib87","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1189\/jlb.0109005","article-title":"Heat shock proteins and immune system","volume":"85","author":"Tsan","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.micpath.2026.108654_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010734","article-title":"The non-glycosylated protein of Toxocara canis MUC-1 interacts with proteins of murine macrophages","volume":"16","author":"Zhou","year":"2022","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2026.108654_bib89","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2026.108654_bib90","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell migration: integrating signals from front to back","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.micpath.2026.108654_bib91","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1038\/s41467-018-06756-3","article-title":"Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing","volume":"9","author":"Sheng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2026.108654_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.molbiopara.2025.111720","article-title":"Lipid transport proteins in Toxocara canis: host lipid acquisition and immune modulation","volume":"265","author":"Abou-El-Naga","year":"2026","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.micpath.2026.108654_bib93","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.imbio.2011.10.004","article-title":"Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2","volume":"217","author":"Popova","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.micpath.2026.108654_bib94","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3390\/pathogens10080949","article-title":"Identification of Toxocara canis antigen interacting partners by yeast two-hybrid assay and a putative mechanism of these host-parasite interactions","volume":"10","author":"D\u0142ugosz","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.micpath.2026.108654_bib95","doi-asserted-by":"crossref","DOI":"10.1111\/pim.13010","article-title":"The immunomodulatory effects of the C-type lectin protein of Toxocara canis on experimental autoimmune encephalomyelitis","volume":"45","author":"Etebar","year":"2023","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib96","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.209551","article-title":"A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability","volume":"131","author":"Fisher","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.micpath.2026.108654_bib97","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3390\/pathogens10030321","article-title":"Toxocara canis and Toxocara cati somatic and excretory-secretory antigens are recognised by C-Type lectin receptors","volume":"10","author":"Raulf","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.micpath.2026.108654_bib98","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00436-024-08212-2","article-title":"C-type lectin 4 of Toxocara canis activates NF-\u0138B and MAPK pathways by modulating NOD1\/2 and RIP2 in murine macrophages in vitro","volume":"123","author":"Wu","year":"2024","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micpath.2026.108654_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2021.108152","article-title":"Excretory\/secretory proteins of adult Toxocara canis induce changes in the expression of proteins involved in the NOD1-RIP2-NF-\u03baB pathway and modulate cytokine production in mouse macrophages","volume":"229","author":"Li","year":"2021","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micpath.2026.108654_bib100","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1398-9995.2006.01089.x","article-title":"A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils","volume":"61","author":"Logan","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.micpath.2026.108654_bib101","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3389\/fmicb.2017.01834","article-title":"Recombinant Trichinella pseudospiralis serine protease inhibitors alter macrophage polarization In Vitro","volume":"8","author":"Xu","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2026.108654_bib102","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.3389\/fimmu.2019.02375","article-title":"Macrophage migration inhibitory factor (MIF) is essential for type 2 effector cell immunity to an intestinal helminth parasite","volume":"10","author":"Filbey","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib103","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74121-w","article-title":"Genetic regulation of gene expression of MIF family members in lung tissue","volume":"10","author":"Florez-Sampedro","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108654_bib104","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.0105-2896.2005.00310.x","article-title":"The lysosomal cysteine proteases in MHC class II antigen presentation","volume":"207","author":"Hsing","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micpath.2026.108654_bib105","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0960-9822(01)00118-X","article-title":"Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing","volume":"11","author":"Manoury","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.micpath.2026.108654_bib106","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1007\/s00436-014-4064-9","article-title":"Cloning, expression and characterisation of a type II cystatin from Schistosoma japonicum, which could regulate macrophage activation","volume":"113","author":"Yang","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micpath.2026.108654_bib107","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.4049\/jimmunol.180.6.4265","article-title":"Helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages","volume":"180","author":"Schnoeller","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib108","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007817","article-title":"Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism","volume":"15","author":"Liu","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2026.108654_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2022.106467","article-title":"Emerging roles for extracellular vesicles in Schistosoma infection","volume":"232","author":"Abou-El-Naga","year":"2022","journal-title":"Acta Trop."},{"key":"10.1016\/j.micpath.2026.108654_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009866","article-title":"Schistosoma mansoni egg-derived extracellular vesicles: a promising vaccine candidate against murine schistosomiasis","volume":"15","author":"Mossallam","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2026.108654_bib111","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.micpath.2026.108654_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2021.110632","article-title":"Review: schistosoma mansoni phosphatidylinositol 3 kinase (PI3K)\/Akt\/mechanistic target of rapamycin (mTOR) signaling pathway","volume":"256","author":"Abou-El-Naga","year":"2021","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.micpath.2026.108654_bib113","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1038\/ncomms3834","article-title":"The TSCmTOR pathway regulates macrophage polarization","volume":"4","author":"Byles","year":"2013","journal-title":"Nat. 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Initial events","volume":"93","author":"Kayes","year":"1978","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.micpath.2026.108654_bib120","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0020-7519(90)90117-6","article-title":"The in vitro adherence of murine eosinophils, neutrophils and non-induced and induced macrophages to infective larvae of Toxocara canis (Nematoda, Ascarididae)","volume":"20","author":"Lombardi","year":"1990","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micpath.2026.108654_bib121","first-page":"245","article-title":"A study on patients with eosinophilia of suspected parasitic origin","volume":"25","author":"el Zawawy","year":"1995","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"10.1016\/j.micpath.2026.108654_bib122","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-3024.1984.tb00779.x","article-title":"Characterization of surface and excretory-secretory antigens of Toxocara canis infective larvae","volume":"6","author":"Maizels","year":"1984","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib123","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00436-004-1233-2","article-title":"Enhanced expression of transforming growth factor-beta1 in inflammatory cells and secretory granules in Paneth cells in the small intestine of mice infected with Toxocara canis","volume":"94","author":"Fan","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micpath.2026.108654_bib124","first-page":"189","article-title":"In vivo inhibition of inducible nitric oxide and evaluation of the brain tissue damage induced by Toxocara canis larvae in experimentally infected mice","volume":"47","author":"Gargili","year":"2004","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.micpath.2026.108654_bib125","first-page":"326","article-title":"Inhibition of inducible nitric oxide synthase in murine visceral larva migrans: effects on lung and liver damage","volume":"49","author":"Demirci","year":"2006","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.micpath.2026.108654_bib126","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-3024.2002.00598.x","article-title":"In vivo inhibition of inducible nitric oxide synthase decreases lung injury induced by Toxocara canis in experimentally infected rats","volume":"24","author":"Espinoza","year":"2002","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib127","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1365-3024.2002.00468.x","article-title":"Toxocara canis antigens stimulate the production of nitric oxide and prostaglandin E2 by rat alveolar macrophages","volume":"24","author":"Espinoza","year":"2002","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib128","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2016.08.006","article-title":"Tissue-specific contribution of macrophages to wound healing","volume":"61","author":"Minutti","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.micpath.2026.108654_bib129","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1365-3024.2001.00387.x","article-title":"Suppression of macrophage interleukin-12 and tumour necrosis factor-alpha production in mice infected with Toxocara canis","volume":"23","author":"Kuroda","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2026.108654_bib130","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.actatropica.2007.11.005","article-title":"Enhanced expression of transforming growth factor-beta 1 in inflammatory cells, alpha-smooth muscle actin in stellate cells, and collagen accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice","volume":"105","author":"Wu","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.micpath.2026.108654_bib131","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166433","article-title":"Alternatively activated (M2) macrophage phenotype is inducible by endothelin-1 in cultured human macrophages","volume":"11","author":"Soldano","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2026.108654_bib132","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pupt.2012.02.001","article-title":"Elastin in asthma","volume":"25","author":"Reddel","year":"2012","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.micpath.2026.108654_bib133","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00436-004-1271-9","article-title":"Induction of matrix metalloproteinase-9 in mice during Toxocara canis larvae migration","volume":"95","author":"Lai","year":"2005","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micpath.2026.108654_bib134","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00436-018-06196-4","article-title":"Matrix metalloproteinase-2 and matrix metalloproteinase-9 in mice with ocular toxocariasis","volume":"118","author":"Shyu","year":"2019","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micpath.2026.108654_bib135","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jmii.2020.07.022","article-title":"Matrix metalloproteinases activation in Toxocara canis induced pulmonary pathogenesis","volume":"54","author":"Lu","year":"2021","journal-title":"J. Microbiol. Immunol. 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