{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:27:57Z","timestamp":1786487277654,"version":"build-2736575974"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["WM3064"],"award-info":[{"award-number":["WM3064"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LQN26C010002"],"award-info":[{"award-number":["LQN26C010002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010213","name":"South China Sea Institute of Oceanology, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010213","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009106","name":"Zhejiang Wanli University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009106","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.micpath.2026.108677","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:37:08Z","timestamp":1783093028000},"page":"108677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["AroC as a key virulence factor and live-attenuated vaccine target in Pseudomonas plecoglossicida"],"prefix":"10.1016","volume":"218","author":[{"given":"Yingchao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0917-5859","authenticated-orcid":false,"given":"Ping","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6755-9234","authenticated-orcid":false,"given":"Zhijuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-0171","authenticated-orcid":false,"given":"Jigang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1554-250X","authenticated-orcid":false,"given":"Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108677_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1099\/00207713-50-1-83","article-title":"Pseudomonas plecoglossicida sp. Nov., the causative agent of bacterial haemorrhagic ascites of ayu, Plecoglossus altivelis","volume":"50","author":"Nishimori","year":"2000","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib2","doi-asserted-by":"crossref","first-page":"952","DOI":"10.24272\/j.issn.2095-8137.2022.216","article-title":"Transcriptomic and metabolomic insights into the role of the flgK gene in the pathogenicity of Pseudomonas plecoglossicida to orange-spotted grouper (Epinephelus coioides)","volume":"43","author":"Yuan","year":"2022","journal-title":"Zool. Res."},{"key":"10.1016\/j.micpath.2026.108677_bib3","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.3390\/ani14233401","article-title":"Mucosal exosome proteomics of hybrid grouper Epinephelus fuscoguttatus \u2640 \u00d7 E. lanceolatus \u2642 infected by Pseudomonas plecoglossicida","volume":"14","author":"Yang","year":"2024","journal-title":"Animals"},{"key":"10.1016\/j.micpath.2026.108677_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105488","article-title":"Pathogenicity of fish pathogen Pseudomonas plecoglossicida and preparation of its inactivated vaccine","volume":"166","author":"Yan","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2026.108677_bib5","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/jfd.13206","article-title":"An outbreak of visceral white nodules disease caused by Pseudomonas plecoglossicida at a water temperature of 12 \u00b0C in cultured large yellow croaker (Larimichthys crocea) in China","volume":"43","author":"Li","year":"2020","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.micpath.2026.108677_bib6","article-title":"Petroleum-degrading enzymes: bioremediation and new prospects","author":"Peixoto","year":"2021","journal-title":"Enzym. Res."},{"key":"10.1016\/j.micpath.2026.108677_bib7","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1016\/j.vaccine.2022.08.075","article-title":"Modern biotechnological strategies for vaccine development in aquaculture - prospects and challenges","volume":"40","author":"Jose Priya","year":"2022","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2026.108677_bib8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3390\/md15060158","article-title":"The rising tide of antimicrobial resistance in aquaculture: sources, sinks and solutions","volume":"15","author":"Watts","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.micpath.2026.108677_bib9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/vaccines13020202","article-title":"Advances and challenges in Aeromonas hydrophila vaccine development: immunological insights and future perspectives","volume":"13","author":"Miryala","year":"2025","journal-title":"Vaccines"},{"key":"10.1016\/j.micpath.2026.108677_bib10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.fsi.2019.04.066","article-title":"Progress, challenges and opportunities in fish vaccine development","volume":"90","author":"Adams","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib11","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.14202\/vetworld.2019.1806-1815","article-title":"Live vaccines against bacterial fish diseases: a review","volume":"12","author":"Mohd-Aris","year":"2019","journal-title":"Vet. World"},{"key":"10.1016\/j.micpath.2026.108677_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109836","article-title":"Evaluation of the safety, immunogenicity and protective effect of an attenuated Pseudomonas plecoglossicida strain \u0394gacS as the live vaccine for the large yellow croaker (Larimichthys crocea)","volume":"153","author":"Kang","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2019.734629","article-title":"Acquisition of a type VI secretion system is critical for Pseudomonas plecoglossicida induced granulomas in fish internal organs","volume":"516","author":"Tao","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.micpath.2026.108677_bib14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.fsi.2019.02.028","article-title":"Phenotypic characterization, virulence, and immunogenicity of Pseudomonas plecoglossicida rpoE knock-down strain","volume":"87","author":"Huang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1040336","article-title":"Current status and development prospects of aquatic vaccines","volume":"13","author":"Du","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/aah.10215","article-title":"The bacterial pathogen Pseudomonas plecoglossicida, its epidemiology, virulence factors, vaccine development, and host-pathogen interactions","volume":"36","author":"Mao","year":"2024","journal-title":"J. Aquat. Anim. Health"},{"key":"10.1016\/j.micpath.2026.108677_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109752","article-title":"A novel small non-coding RNA 562 mediates the virulence of Pseudomonas plecoglossicida by regulating the expression of fliP, a key component of flagella T3SS","volume":"151","author":"He","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22669","article-title":"Comparative secretome analysis reveals cross-talk between type III secretion system and flagella assembly in Pseudomonas plecoglossicida","volume":"9","author":"Qin","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.micpath.2026.108677_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.720967","article-title":"The effect of tonB gene on the virulence of Pseudomonas plecoglossicida and the immune response of Epinephelus coioides","volume":"12","author":"Hu","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib20","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrmicro2351","article-title":"Carbon metabolism of intracellular bacterial pathogens and possible links to virulence","volume":"8","author":"Eisenreich","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib21","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3390\/molecules23061371","article-title":"Review on abyssomicins: inhibitors of the chorismate pathway and folate biosynthesis","volume":"23","author":"Sadaka","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.micpath.2026.108677_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2022.104955","article-title":"AroC, a chorismate synthase, is required for the formation of Edwardsiella tarda biofilms","volume":"24","author":"Liu","year":"2022","journal-title":"Microb. Infect."},{"key":"10.1016\/j.micpath.2026.108677_bib23","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10930-020-09923-y","article-title":"Biophysical and in-silico studies of phytochemicals targeting chorismate synthase from drug-resistant Moraxella catarrhalis","volume":"39","author":"Neetu","year":"2020","journal-title":"Protein J."},{"key":"10.1016\/j.micpath.2026.108677_bib24","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.micres.2011.11.002","article-title":"Functional analysis of the aroC gene encoding chorismate synthase from Xanthomonas oryzae pathovar oryzae","volume":"167","author":"Song","year":"2012","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.micpath.2026.108677_bib25","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00203-025-04482-1","article-title":"The AroC gene is required for pathogenicity and antibiotic sensitivity in Edwardsiella tarda strain ET13","volume":"207","author":"Hassan","year":"2025","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.106597","article-title":"Deletion of speA and aroC genes impacts the pathogenicity of Vibrio anguillarum in spotted sea bass","volume":"189","author":"Xie","year":"2024","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2026.108677_bib27","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1472-765X.2011.03126.x","article-title":"Search for live attenuated vaccine candidate against edwardsiellosis by mutating virulence-related genes of fish pathogen Edwardsiella tarda","volume":"53","author":"Xiao","year":"2011","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00586-13","article-title":"Draft genome sequence of Pseudomonas plecoglossicida strain NB2011, the causative agent of white nodules in large yellow croaker (Larimichthys crocea)","volume":"1","author":"Mao","year":"2013","journal-title":"Genome Announc."},{"key":"10.1016\/j.micpath.2026.108677_bib29","doi-asserted-by":"crossref","first-page":"D723","DOI":"10.1093\/nar\/gkac976","article-title":"The IMG\/M data management and analysis system v.7: content updates and new features","volume":"51","author":"Chen","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2026.108677_bib30","doi-asserted-by":"crossref","first-page":"D499","DOI":"10.1093\/nar\/gkaf1023","article-title":"SMART v10: three decades of the protein domain annotation resource","volume":"54","author":"Letunic","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2026.108677_bib31","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/bib\/bbx108","article-title":"MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization","volume":"20","author":"Katoh","year":"2019","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.micpath.2026.108677_bib32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/bioinformatics\/15.4.305","article-title":"ESPript: analysis of multiple sequence alignments in PostScript","volume":"15","author":"Gouet","year":"1999","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2026.108677_bib33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00239-025-10287-z","article-title":"Mega 12.1: cross-platform release for macOS and linux operating systems","volume":"94","author":"Stecher","year":"2026","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.micpath.2026.108677_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1458976","article-title":"Identification and characterization of LuxR solo homolog PplR in pathogenic Pseudomonas plecoglossicida NB2011","volume":"14","author":"Li","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12934-015-0194-8","article-title":"Development of an efficient conjugation-based genetic manipulation system for Pseudoalteromonas","volume":"14","author":"Wang","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.micpath.2026.108677_bib36","article-title":"Identification of Aeromonas hydrophila PS-1 and GFP-labeled tracking of its infection in Pelodiscus sinensis","volume":"610","author":"Dai","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.micpath.2026.108677_bib37","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.micpath.2026.108677_bib38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.fsi.2022.06.034","article-title":"Characterization of 4 deletion mutants of Pseudomonas plecoglossicida and their potential for live attenuated vaccines in large yellow croaker (Larimichthys crocea)","volume":"127","author":"Li","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib39","first-page":"211","article-title":"The fliA gene of Pseudomonas plecoglossicida is involved in motility, adhesion, and virulence","volume":"72","author":"Zhang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib40","article-title":"Construction and biological characterization of three virulence-related gene deletion mutants of Pseudomonas plecoglossicida","volume":"65","author":"Jia","year":"2025","journal-title":"Acta Microbiol. Sin."},{"key":"10.1016\/j.micpath.2026.108677_bib41","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fcimb.2018.00207","article-title":"Integration of transcriptomic and proteomic approaches reveals the temperature-dependent virulence of Pseudomonas plecoglossicida","volume":"8","author":"Huang","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.vetmic.2010.03.009","article-title":"Aeromonas hydrophila PepO outer membrane endopeptidase activates human big endothelin-3 in vitro and induces skin ulcer in goldfish (Carassius auratus)","volume":"145","author":"Abolghait","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2026.111179","article-title":"Effects of dietary fermented sugar kelp (Saccharina latissima) on intestinal histology, antioxidant capacity, and immune-related biomarkers of post-smolt Atlantic salmon (Salmo salar)","volume":"172","author":"Sartipiyarahmadi","year":"2026","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.108460","article-title":"Evaluation of protective effects of heat-inactivated cyprinid herpesvirus-2 (CyHV-2) vaccine against herpesviral hematopoietic necrosis disease (HVHND) in goldfish (Carassius auratus)","volume":"132","author":"Dharmaratnam","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740102","article-title":"PvgAS: a novel two-component system that controls type III and type VI secretion systems and virulence in the fish pathogen Pseudomonas plecoglossicida","volume":"578","author":"Tao","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.micpath.2026.108677_bib46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-2958.2009.06629.x","article-title":"Glycogen contributes to the environmental persistence and transmission of Vibrio cholerae","volume":"72","author":"Bourassa","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.998540","article-title":"Proteomic profiling spotlights the molecular targets and the impact of the natural antivirulent umbelliferone on stress response, virulence factors, and the quorum sensing network of Pseudomonas aeruginosa","volume":"12","author":"Kasthuri","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib48","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s004250050489","article-title":"A unique reaction in a common pathway: mechanism and function of chorismate synthase in the shikimate pathway","volume":"207","author":"Macheroux","year":"1999","journal-title":"Planta"},{"key":"10.1016\/j.micpath.2026.108677_bib49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/20014091096710","article-title":"A metabolic node in action: chorismate-utilizing enzymes in microorganisms","volume":"27","author":"Dosselaere","year":"2001","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib50","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1128\/iai.65.2.452-456.1997","article-title":"Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans","volume":"65","author":"Tacket","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2026.108677_bib51","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ijmm.2015.07.004","article-title":"Safety and immunogenicity of an attenuated Salmonella enterica serovar paratyphi A vaccine candidate","volume":"305","author":"Kuang","year":"2015","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib52","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ymben.2019.08.003","article-title":"Metabolic flux responses to deletion of 20 core enzymes reveal flexibility and limits of E. coli metabolism","volume":"55","author":"Long","year":"2019","journal-title":"Metab. Eng."},{"key":"10.1016\/j.micpath.2026.108677_bib53","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jbiotec.2025.04.008","article-title":"In planta production of the nylon precursor beta-ketoadipate","volume":"404","author":"Kazaz","year":"2025","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.micpath.2026.108677_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1271\/bbb.60437","article-title":"Genetic and biochemical investigations on bacterial catabolic pathways for lignin-derived aromatic compounds","volume":"71","author":"Masai","year":"2007","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.micpath.2026.108677_bib55","doi-asserted-by":"crossref","DOI":"10.1128\/ecosalplus.3.6.1.3","article-title":"Biosynthesis of glutamate, aspartate, asparagine, L-Alanine, and D-Alanine","volume":"1","author":"Reitzer","year":"2004","journal-title":"EcoSal Plus"},{"key":"10.1016\/j.micpath.2026.108677_bib56","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1128\/jb.133.1.139-148.1978","article-title":"gltB gene and regulation of nitrogen metabolism by glutamine synthetase in Escherichia coli","volume":"133","author":"Pahel","year":"1979","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micpath.2026.108677_bib57","doi-asserted-by":"crossref","first-page":"8748","DOI":"10.1073\/pnas.1533395100","article-title":"The speed of the flagellar rotary motor of Escherichia coli varies linearly with protonmotive force","volume":"100","author":"Gabel","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micpath.2026.108677_bib58","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/eva.12466","article-title":"Higher resource level promotes virulence in an environmentally transmitted bacterial fish pathogen","volume":"10","author":"Kinnula","year":"2017","journal-title":"Evol. Appl."},{"key":"10.1016\/j.micpath.2026.108677_bib59","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1128\/AEM.02897-09","article-title":"Requirement of the galU gene for polysaccharide production by and pathogenicity and growth in Planta of Xanthomonas citri subsp","volume":"76","author":"Guo","year":"2010","journal-title":"citri, Appl Environ Microbiol"},{"key":"10.1016\/j.micpath.2026.108677_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1149541","article-title":"Contribution of GalU to biofilm formation, motility, antibiotic and serum resistance, and pathogenicity of Salmonella Typhimurium","volume":"13","author":"Guo","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2026.108677_bib61","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012427","article-title":"Bacterial quorum sensing: its role in virulence and possibilities for its control","volume":"2","author":"Rutherford","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.micpath.2026.108677_bib62","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.vaccine.2018.01.067","article-title":"A live attenuated Vibrio anguillarum vaccine induces efficient immunoprotection in tiger puffer (Takifugu rubripes)","volume":"36","author":"Liu","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2026.108677_bib63","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.fsi.2013.05.022","article-title":"Edwardsiella tarda mutant disrupted in type III secretion system and chorismic acid synthesis and cured of a plasmid as a live attenuated vaccine in turbot","volume":"35","author":"Xiao","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib64","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.crbiot.2020.03.001","article-title":"Restoration of wild-type motility to flagellin-knockout Escherichia coli by varying promoter, copy number and induction strength in plasmid-based expression of flagellin","volume":"2","author":"Thomson","year":"2020","journal-title":"Curr. Res. Biotechnol."},{"key":"10.1016\/j.micpath.2026.108677_bib65","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.semcdb.2015.10.032","article-title":"The flagellum in bacterial pathogens: for motility and a whole lot more","volume":"46","author":"Chaban","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.micpath.2026.108677_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001243","article-title":"The EpsE flagellar clutch is bifunctional and synergizes with EPS biosynthesis to promote Bacillus subtilis biofilm formation","volume":"6","author":"Guttenplan","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.micpath.2026.108677_bib67","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1577\/1548-8667(1999)011<0358:AAMOEI>2.0.CO;2","article-title":"An aroA mutant of Edwardsiella ictaluri is safe and efficacious as a live, attenuated vaccine","volume":"11","author":"Thune","year":"1999","journal-title":"J. Aquat. Anim. Health"},{"key":"10.1016\/j.micpath.2026.108677_bib68","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3390\/vaccines12020162","article-title":"The aroA and luxS double-gene mutant strain has potential to be a live attenuated vaccine against Salmonella typhimurium","volume":"12","author":"Zuo","year":"2024","journal-title":"Vaccines"},{"key":"10.1016\/j.micpath.2026.108677_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738932","article-title":"Oral vaccination with feed-based live attenuated vaccine protects large yellow croaker against Pseudomonas plecoglossicida infection","volume":"563","author":"Huang","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.micpath.2026.108677_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110183","article-title":"Evaluation of protective immune response of live-attenuated candidate vaccines \u0394cpxA and \u0394cpxR against Vibrio alginolyticus in pearl gentian grouper","volume":"159","author":"Zhang","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2026.108677_bib71","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/microorganisms7110569","article-title":"A review of fish vaccine development strategies: conventional methods and modern biotechnological approaches","volume":"7","author":"Ma","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.micpath.2026.108677_bib72","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1016\/j.vaccine.2013.12.026","article-title":"The delicate balance in genetically engineering live vaccines","volume":"32","author":"Galen","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2026.108677_bib73","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.3390\/ani14182692","article-title":"Current challenges of vaccination in fish health management","volume":"14","author":"Kumar","year":"2024","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.micpath.2026.108677_bib74","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/jsfa.13908","article-title":"Limosilactobacillus reuteri RE225 alleviates gout by modulating the TLR4\/MyD88\/NF-\u03baB inflammatory pathway and the Nrf2\/HO-1 oxidative stress pathway, and by regulating gut microbiota","volume":"105","author":"Qin","year":"2025","journal-title":"J. Sci. Food Agric."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026004031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026004031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:36:57Z","timestamp":1786484217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026004031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":74,"alternative-id":["S0882401026004031"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108677","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AroC as a key virulence factor and live-attenuated vaccine target in Pseudomonas plecoglossicida","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108677","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108677"}}