{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:12:53Z","timestamp":1788361973467,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372292"],"award-info":[{"award-number":["32372292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.micpath.2026.108752","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:05:38Z","timestamp":1785884738000},"page":"108752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Differential pathogenic contributions of tdh\/trh genes in Vibrio parahaemolyticus revealed by rabbit and mice model comparative study"],"prefix":"10.1016","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2185-7447","authenticated-orcid":false,"given":"Gui","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep K.","family":"Malakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108752_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135452","article-title":"Assembly of a multivalent aptamer for efficient inhibition of thermostable direct hemolysin toxicity induced by Vibrio parahaemolyticus","volume":"478","author":"Chen","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.micpath.2026.108752_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.01114","article-title":"Insights into bacteriophage application in controlling species","volume":"7","author":"Letchumanan","year":"2016","journal-title":"Front. Microbiol."},{"issue":"8","key":"10.1016\/j.micpath.2026.108752_bib3","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/s41564-022-01182-0","article-title":"Outbreak dynamics of foodborne pathogen Vibrio parahaemolyticus over a seventeen year period implies hidden reservoirs","volume":"7","author":"Yang","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.micpath.2026.108752_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141650","article-title":"A case-control analysis of traceback investigations for infections (vibriosis) and pre-harvest environmental conditions in Washington State, 2013-2018","volume":"752","author":"Davis","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.micpath.2026.108752_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfoodmicro.2024.110691","article-title":"Recent advances in understanding the fitness and survival mechanisms of Vibrio parahaemolyticus","volume":"417","author":"Liu","year":"2024","journal-title":"Int. J. Food Microbiol."},{"issue":"7\u20138","key":"10.1016\/j.micpath.2026.108752_bib6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s00335-018-9749-4","article-title":"Enterobacteria and host resistance to infection","volume":"29","author":"Kang","year":"2018","journal-title":"Mamm. Genome"},{"issue":"3","key":"10.1016\/j.micpath.2026.108752_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002593","article-title":"Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea","volume":"8","author":"Ritchie","year":"2012","journal-title":"PLoS Pathog."},{"issue":"10","key":"10.1016\/j.micpath.2026.108752_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113261","article-title":"Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus thogenicity","volume":"42","author":"Wu","year":"2023","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.micpath.2026.108752_bib9","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02608-19","article-title":"A novel mouse model of enteric infection reveals that the type III secretion System 2 effector VopC plays a key role in tissue invasion and gastroenteritis","volume":"10","author":"Yang","year":"2019","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.micpath.2026.108752_bib10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/21505594.2017.1388487","article-title":"Galleria mellonella: a model of infection to discern novel mechanisms of pathogenesis of non-toxigenic Vibrio parahaemolyticus strains","volume":"9","author":"P\u00e9rez-Reytor","year":"2018","journal-title":"Virulence"},{"key":"10.1016\/j.micpath.2026.108752_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2025.111162","article-title":"Antibiofilm potential of cumin and lemongrass essential oils against multidrug-resistant Vibrio parahaemolyticus in retailed fish samples","volume":"172","author":"Alasgah","year":"2025","journal-title":"Food Control"},{"key":"10.1016\/j.micpath.2026.108752_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.717147","article-title":"Current perspective on the membrane-damaging action of thermostable direct hemolysin, an atypical bacterial pore-forming toxin","volume":"8","author":"Verma","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.micpath.2026.108752_bib13","article-title":"Genetic and virulence characterisation of isolated from Indian coast","volume":"20","author":"Prabhakaran","year":"2020","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.micpath.2026.108752_bib14","article-title":"The fate of bacteria in human digestive fluids: a new perspective into the pathogenesis of","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2026.108752_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfoodmicro.2024.111025","article-title":"Molecular epidemiology and antimicrobial resistance of isolates from the Pearl River Delta region, China","volume":"429","author":"Wang","year":"2025","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.micpath.2026.108752_bib16","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1099\/mic.0.067637-0","article-title":"Zebrafish as a model for Vibrio parahaemolyticus virulence","volume":"159","author":"Paranjpye","year":"2013","journal-title":"Microbiology-Sgm"},{"key":"10.1016\/j.micpath.2026.108752_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfoodmicro.2024.110993","article-title":"Global phylogeography and genomic characterization of Vibrio parahaemolyticus infections in Jilin province, China (2016-2022)","volume":"428","author":"Zheng","year":"2025","journal-title":"Int. J. Food Microbiol."},{"issue":"5","key":"10.1016\/j.micpath.2026.108752_bib18","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/s41564-019-0368-y","article-title":"Export of a Vibrio parahaemolyticus toxin by the Sec and type III secretion machineries in tandem","volume":"4","author":"Matsuda","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"6","key":"10.1016\/j.micpath.2026.108752_bib19","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1021\/acs.jafc.1c07450","article-title":"Modulation of intestinal barrier, inflammatory response, and Gut microbiota by Pediococcus pentosaceus zy-B alleviates Vibrio parahaemolyticus infection in C57BL\/6J mice","volume":"70","author":"Wang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.micpath.2026.108752_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.anifeedsci.2024.115953","article-title":"Dietary supplementation of micelle silymarin enhances the antioxidant status, innate immunity, growth performance, resistance against infection, and gut morphology in Pacific white shrimp (Litopenaeus vannamei)","volume":"311","author":"Hasanthi","year":"2024","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.micpath.2026.108752_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735432","article-title":"Dietary oregano essential oil improved the growth performance via enhancing the intestinal morphometry and hepato-renal functions of common carp (Cyprinus carpio L.) fingerlings","volume":"526","author":"Abdel-Latif","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.micpath.2026.108752_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2023.109689","article-title":"Duplex electrochemical biosensor for the detection of the and virulence genes of in oysters","volume":"149","author":"Camp\u00e0s","year":"2023","journal-title":"Food Control"},{"issue":"11","key":"10.1016\/j.micpath.2026.108752_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0242156","article-title":"The human health burden of non-typhoidal and foodborne gastroenteritis in Shanghai, east China","volume":"15","author":"Chen","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2026.108752_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.111986","article-title":"Phage controlling method against novel freshwater-derived parahaemolyticus in ready-to-eat crayfish (Procambarus clarkii)","volume":"162","author":"Teng","year":"2022","journal-title":"Food Res. Int."},{"key":"10.1016\/j.micpath.2026.108752_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.dci.2015.10.021","article-title":"Zebrafish as a useful model for zoonotic pathogenicity in fish and human","volume":"55","author":"Zhang","year":"2016","journal-title":"Dev. Comp. Immunol."},{"issue":"11","key":"10.1016\/j.micpath.2026.108752_bib26","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1128\/IAI.00461-10","article-title":"Development of two animal models to study the function of type III secretion systems","volume":"78","author":"Pi\u00f1eyro","year":"2010","journal-title":"Infect. Immun."},{"issue":"6","key":"10.1016\/j.micpath.2026.108752_bib27","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.micpath.2026.108752_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127744","article-title":"Virulence phenotypes differ between toxigenic Vibrio parahaemolyticus isolated from western coasts of Europe","volume":"285","author":"Sor\u00e9e","year":"2024","journal-title":"Microbiol. Res."},{"issue":"4","key":"10.1016\/j.micpath.2026.108752_bib29","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1128\/IAI.01051-09","article-title":"Contribution of Vibrio parahaemolyticus virulence factors to cytotoxicity, enterotoxicity, and lethality in mice","volume":"78","author":"Hiyoshi","year":"2010","journal-title":"Infect. Immun."},{"issue":"9","key":"10.1016\/j.micpath.2026.108752_bib30","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1099\/0022-1317-49-9-801","article-title":"Mechanisms of chloride secretion induced by thermostable direct haemolysin of in human colonic tissue and a human intestinal epithelial cell line","volume":"49","author":"Takahashi","year":"2000","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.micpath.2026.108752_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127838","article-title":"The role of intestinal microbiota and metabolites in intestinal inflammation","volume":"288","author":"Ma","year":"2024","journal-title":"Microbiol. Res."},{"issue":"7","key":"10.1016\/j.micpath.2026.108752_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00251-25","article-title":"Regulatory mechanism for host-cell contact-dependent T3SS gene expression in Vibrio parahaemolyticus","volume":"10","author":"Tandhavanant","year":"2025","journal-title":"mSystems"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102600478X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102600478X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:15:14Z","timestamp":1788358514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240102600478X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":32,"alternative-id":["S088240102600478X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108752","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential pathogenic contributions of tdh\/trh genes in Vibrio parahaemolyticus revealed by rabbit and mice model comparative study","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108752"}}