{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:03:06Z","timestamp":1789833786801,"version":"4.0.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019398","name":"Capital Medical University Affiliated Beijing Friendship Hospital","doi-asserted-by":"publisher","award":["yyqdkt2019-6"],"award-info":[{"award-number":["yyqdkt2019-6"]}],"id":[{"id":"10.13039\/501100019398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.micpath.2026.108775","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:50:53Z","timestamp":1786690253000},"page":"108775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Prediction of the SREBP1\u2013ISYNA1\u2013inositol axis in butyrate-induced pyroptosis and lipid metabolic dysregulation in periodontitis"],"prefix":"10.1016","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-0264","authenticated-orcid":false,"given":"Juan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaining","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanxin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.micpath.2026.108775_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s40496-020-00256-4","article-title":"Periodontitis: a host mediated disruption of microbial homeostasis","volume":"7","author":"Yu","year":"2020","journal-title":"Curr Oral Health Rep"},{"issue":"2","key":"10.1016\/j.micpath.2026.108775_bib2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1128\/iai.32.2.458-463.1981","article-title":"Butyrate and propionate: important components of toxic dental plaque extracts","volume":"32","author":"Singer","year":"1981","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.micpath.2026.108775_bib3","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2019.1651158","article-title":"Gingival epithelial barrier: regulation by beneficial and harmful microbes","volume":"7","author":"Takahashi","year":"2019","journal-title":"Tissue Barriers"},{"issue":"5","key":"10.1016\/j.micpath.2026.108775_bib4","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/odi.12574","article-title":"Programmed cell death in periodontitis: recent advances and future perspectives","volume":"23","author":"Song","year":"2017","journal-title":"Oral Dis."},{"issue":"1","key":"10.1016\/j.micpath.2026.108775_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010372","article-title":"Pyroptosis-mediated periodontal disease","volume":"23","author":"Sordi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.micpath.2026.108775_bib6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"issue":"7661","key":"10.1016\/j.micpath.2026.108775_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.micpath.2026.108775_bib8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/jre.12137","article-title":"Effect of non-surgical periodontal treatment on short chain fatty acid levels in gingival crevicular fluid of patients with generalized aggressive periodontitis","volume":"49","author":"Lu","year":"2014","journal-title":"J. Periodontal. Res."},{"issue":"6","key":"10.1016\/j.micpath.2026.108775_bib9","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1002\/jcb.26641","article-title":"Butyrate and docosahexaenoic acid interact in alterations of specific lipid classes in differentiating colon cancer cells","volume":"119","author":"Tylichov\u00e1","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"20","key":"10.1016\/j.micpath.2026.108775_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222010937","article-title":"Butyrate alters pyruvate flux and induces lipid accumulation in cultured colonocytes","volume":"22","author":"Bekebrede","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6197","key":"10.1016\/j.micpath.2026.108775_bib11","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.1254790","article-title":"Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon","volume":"345","author":"Reboldi","year":"2014","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.micpath.2026.108775_bib12","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/jcpe.13162","article-title":"Butyrate rather than LPS subverts gingival epithelial homeostasis by downregulation of intercellular junctions and triggering pyroptosis","volume":"46","author":"Liu","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.micpath.2026.108775_bib13","article-title":"Periodontal inflammation-triggered by periodontal ligament stem cell pyroptosis exacerbates periodontitis","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.micpath.2026.108775_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.953277","article-title":"Pyroptosis in periodontitis: from the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects","volume":"12","author":"Xu","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2026.108775_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101781","article-title":"Pyroptosis-induced inflammation and tissue damage","volume":"69","author":"Vasudevan","year":"2023","journal-title":"Semin. Immunol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108775_bib16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41467-023-44669-y","article-title":"Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death","volume":"15","author":"Ma","year":"2024","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.micpath.2026.108775_bib17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/jre.13242","article-title":"Lipotoxicity: the missing link between diabetes and periodontitis?","volume":"59","author":"Sun","year":"2024","journal-title":"J. Periodontal. Res."},{"issue":"22","key":"10.1016\/j.micpath.2026.108775_bib18","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2014681118","article-title":"Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation","volume":"118","author":"Hao","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.micpath.2026.108775_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/nu13103666","article-title":"Modulation of adipocyte metabolism by microbial short-chain fatty acids","volume":"13","author":"May","year":"2021","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.micpath.2026.108775_bib20","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1093\/jn\/133.11.3509","article-title":"Acetate and butyrate are the major substrates for de novo lipogenesis in rat colonic epithelial cells","volume":"133","author":"Zambell","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.micpath.2026.108775_bib21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.phrs.2019.04.002","article-title":"Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: molecular mechanisms and therapeutic applications","volume":"144","author":"He","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.micpath.2026.108775_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116142","article-title":"PLCE1 enhances mitochondrial dysfunction to promote GSDME-mediated pyroptosis in doxorubicin-induced cardiotoxicity","volume":"223","author":"Tuersuntuoheti","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108775_bib23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41467-021-27692-9","article-title":"Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry","volume":"13","author":"Santa Cruz Garcia","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026005012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026005012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:18:57Z","timestamp":1789831137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026005012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":23,"alternative-id":["S0882401026005012"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108775","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of the SREBP1\u2013ISYNA1\u2013inositol axis in butyrate-induced pyroptosis and lipid metabolic dysregulation in periodontitis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108775","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108775"}}