{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:03:16Z","timestamp":1789862596856,"version":"4.0.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.micpath.2026.108836","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:26:38Z","timestamp":1789773998000},"page":"108836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Isolation of Bacillus subtilis NJ01 and in silico evaluation of its antimicrobial metabolites as potential inhibitors of the CRN8 effector protein of Phytophthora infestans"],"prefix":"10.1016","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6751-2421","authenticated-orcid":false,"given":"Nafisa","family":"Jakia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-7240","authenticated-orcid":false,"given":"Alomgir","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohana","family":"Mehjabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilan S.","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashed","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Khalekuzzaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Motiur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-2570","authenticated-orcid":false,"given":"Mohammad Nurul","family":"Matin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Asadul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2026.108836_bib1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.plantsci.2017.11.012","article-title":"Emerging microbial biocontrol strategies for plant pathogens","volume":"267","author":"Ab Rahman","year":"2018","journal-title":"Plant Sci."},{"key":"10.1016\/j.micpath.2026.108836_bib2","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.3390\/molecules28186735","article-title":"Bacterial and fungal biocontrol agents for plant disease protection: journey from lab to field, current status, challenges, and global perspectives","volume":"28","author":"Ayaz","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.micpath.2026.108836_bib3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jiph.2016.08.007","article-title":"Antibiotic resistance","volume":"10","author":"Frieri","year":"2017","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.micpath.2026.108836_bib4","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2025.2586882","article-title":"Pathogenicity and virulence of Phytophthora infestans : the ever-evolving threat to food security and its sustainable management strategies","volume":"16","author":"Wang","year":"2025","journal-title":"Virulence"},{"key":"10.1016\/j.micpath.2026.108836_bib5","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.3390\/ijms22095049","article-title":"Nematicidal volatiles from Bacillus atrophaeus GBSC56 promote growth and stimulate induced systemic resistance in tomato against Meloidogyne incognita","volume":"22","author":"Ayaz","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2026.108836_bib6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0031-9422(99)00073-4","article-title":"Phenethyl alcohol glycosides and isopentenol glycoside from fruit of Bupleurum falcatum","volume":"51","author":"Ono","year":"1999","journal-title":"Phytochemistry"},{"key":"10.1016\/j.micpath.2026.108836_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11133732","article-title":"Ameliorative sexual behavior and Phosphodiesterase-5 inhibitory effects of spondias mangifera fruit extract in rodents: in silico, in vitro, and in vivo study","volume":"11","author":"Khalid","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.micpath.2026.108836_bib8","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1104\/pp.112.3.919","article-title":"Induction of defense-related ultrastructural modifications in pea root tissues inoculated with endophytic bacteria","volume":"112","author":"Benhamou","year":"1996","journal-title":"Plant Physiol."},{"key":"10.1016\/j.micpath.2026.108836_bib9","series-title":"Evaluation of the Potential of Five Housekeeping Genes for Identification of Quarantine Pseudomonas syringae","first-page":"73","author":"Lu","year":"2016"},{"key":"10.1016\/j.micpath.2026.108836_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.biocontrol.2015.05.013","article-title":"Microencapsulation of Bacillus subtilis B99-2 and its biocontrol efficiency against Rhizoctonia solani in tomato","volume":"90","author":"Ma","year":"2015","journal-title":"Biol. Control"},{"key":"10.1016\/j.micpath.2026.108836_bib11","first-page":"1","volume":"10","author":"Caulier","year":"2019"},{"key":"10.1016\/j.micpath.2026.108836_bib12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00018-002-8433-7","article-title":"Roles of bacillus endospores in the environment","volume":"59","author":"Nicholson","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.micpath.2026.108836_bib13","first-page":"845","article-title":"MicroReview Bacillus subtilis antibiotics : structures","volume":"56","author":"Stein","year":"2005","journal-title":"Syntheses"},{"key":"10.1016\/j.micpath.2026.108836_bib14","first-page":"1","article-title":"Versatile antagonistic activities of soil-borne bacillus spp . and pseudomonas spp","volume":"9","author":"Caulier","year":"2018","journal-title":"against Phytophthora infestans and Other Potato Pathogens"},{"key":"10.1016\/j.micpath.2026.108836_bib15","author":"Haverkort"},{"key":"10.1016\/j.micpath.2026.108836_bib16","first-page":"2271","volume":"10","author":"Avrova","year":"2008"},{"key":"10.1016\/j.micpath.2026.108836_bib17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.mib.2016.09.002","article-title":"ScienceDirect the cell biology of late blight disease","volume":"34","author":"Whisson","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.micpath.2026.108836_bib18","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1094\/PHYTO-01-15-0005-FI","article-title":"Five reasons to consider Phytophthora infestans a reemerging pathogen","volume":"105","author":"Fry","year":"2015","journal-title":"Phytopathology"},{"key":"10.1016\/j.micpath.2026.108836_bib19","author":"Whisson"},{"key":"10.1016\/j.micpath.2026.108836_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002875","article-title":"The Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cells","volume":"8","author":"Van Damme","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2026.108836_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106785","article-title":"Identification of medicinal plant-based phytochemicals as a potential inhibitor for SARS-CoV-2 main protease ( M pro ) using molecular docking and deep learning methods","volume":"157","author":"Hossain","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.micpath.2026.108836_bib22","author":"Dong"},{"key":"10.1016\/j.micpath.2026.108836_bib23","doi-asserted-by":"crossref","first-page":"8600","DOI":"10.1016\/j.arabjc.2020.09.044","article-title":"Identification and in silico molecular modelling study of newly isolated Bacillus subtilis SI-18 strain against S9 protein of Rhizoctonia solani","volume":"13","author":"Islam","year":"2020","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.micpath.2026.108836_bib24","series-title":"Molecular Modeling and Docking Techniques for Drug Discovery and Design","year":"2025"},{"key":"10.1016\/j.micpath.2026.108836_bib25","first-page":"165","volume":"171","author":"Kapetanovic","year":"2008"},{"key":"10.1016\/j.micpath.2026.108836_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.insi.2025.100049","article-title":"Artificial intelligence (AI) in drug design and discovery: a comprehensive review","volume":"1","author":"Bhat","year":"2025","journal-title":"Silico Res. Biomed."},{"key":"10.1016\/j.micpath.2026.108836_bib27","first-page":"425","article-title":"The BLAST sequence analysis tool","volume":"2","author":"Madden","year":"2013","journal-title":"NCBI Handb"},{"key":"10.1016\/j.micpath.2026.108836_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab1074","article-title":"UFold: fast and accurate RNA secondary structure prediction with deep learning","volume":"50","author":"Fu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2026.108836_bib29","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2026.108836_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"Appl. Crystallogr."},{"key":"10.1016\/j.micpath.2026.108836_bib31","series-title":"Methods Enzymol.","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0076-6879(97)77022-8","article-title":"[20] VERIFY3D: assessment of protein models with three-dimensional profiles","author":"Eisenberg","year":"1997"},{"key":"10.1016\/j.micpath.2026.108836_bib32","doi-asserted-by":"crossref","first-page":"W363","DOI":"10.1093\/nar\/gky473","article-title":"CASTp 3.0: computed atlas of surface topography of proteins","volume":"46","author":"Tian","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2026.108836_bib33","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<490::AID-JCC1>3.0.CO;2-P","article-title":"Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94","volume":"17","author":"Halgren","year":"1996","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.micpath.2026.108836_bib34","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock vina 1.2. 0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.micpath.2026.108836_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108836_bib36","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2026.108836_bib37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.micpath.2026.108836_bib38","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/wcms.1121","article-title":"An overview of the amber biomolecular simulation package","volume":"3","author":"Salomon-Ferrer","year":"2013","journal-title":"Wiley Interdiscip. Rev. Comput. Mol. Sci."},{"key":"10.1016\/j.micpath.2026.108836_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btad350","article-title":"The ACPYPE web server for small-molecule MD topology generation","volume":"39","author":"Kagami","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2026.108836_bib40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/(SICI)1096-987X(20000130)21:2<132::AID-JCC5>3.0.CO;2-P","article-title":"Fast, efficient generation of high\u2010quality atomic charges. AM1\u2010BCC model: I. Method","volume":"21","author":"Jakalian","year":"2000","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.micpath.2026.108836_bib41","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.1021\/jp003020w","article-title":"Structure and dynamics of the TIP3P, SPC, and SPC\/E water models at 298 K","volume":"105","author":"Mark","year":"2001","journal-title":"J. Phys. Chem. A"},{"key":"10.1016\/j.micpath.2026.108836_bib42","series-title":"LINCS: a Linear Constraint Solver for Molecular Simulations","author":"Hess","year":"1997"},{"key":"10.1016\/j.micpath.2026.108836_bib43","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/prot.25534","article-title":"Exploring the conformational landscapes of HIV protease structural ensembles using principal component analysis","volume":"86","author":"Hassan","year":"2018","journal-title":"Proteins: Struct., Funct., Bioinf."},{"key":"10.1016\/j.micpath.2026.108836_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2020.105660","article-title":"Molecular dynamics simulation, free energy landscape and binding free energy computations in exploration the anti-invasive activity of amygdalin against metastasis","volume":"195","author":"Al-Khafaji","year":"2020","journal-title":"Comput. Methods Progr. Biomed."},{"key":"10.1016\/j.micpath.2026.108836_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-49304-w","article-title":"Isolation and evaluation of Qatari soil rhizobacteria for antagonistic potential against phytopathogens and growth promotion in tomato plants","volume":"13","author":"BiBi","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2026.108836_bib46","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1002\/ps.7717","article-title":"Endophytic Bacillus subtilis H17\u201016 effectively inhibits Phytophthora infestans, the pathogen of potato late blight, and its potential application","volume":"79","author":"Zhang","year":"2023","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.micpath.2026.108836_bib47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/12298093.2022.2136333","article-title":"Biological control of oomycete soilborne diseases caused by Phytophthora capsici, Phytophthora infestans, and Phytophthora nicotianae in solanaceous crops","volume":"50","author":"Volynchikova","year":"2022","journal-title":"MYCOBIOLOGY"},{"key":"10.1016\/j.micpath.2026.108836_bib48","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1365-2958.2005.04587.x","article-title":"Bacillus subtilis antibiotics: structures, syntheses and specific functions","volume":"56","author":"Stein","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2026.108836_bib49","series-title":"The Irish Potato Famine Pathogen Phytophthora infestans Translocates the CRN8 Kinase into Host Plant Cells","author":"Van Damme","year":"2012"},{"key":"10.1016\/j.micpath.2026.108836_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2022.127277","article-title":"Pan-genome analysis and molecular docking unveil the biocontrol potential of Bacillus velezensis VB7 against Phytophthora infestans","volume":"268","author":"Kadiri","year":"2023","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.micpath.2026.108836_bib51","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.3390\/molecules28186735","article-title":"Bacterial and fungal biocontrol agents for plant disease protection: journey from lab to field, current status, challenges, and global perspectives","volume":"28","author":"Ayaz","year":"2023","journal-title":"Molecules"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026005620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026005620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:29:46Z","timestamp":1789860586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026005620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":51,"alternative-id":["S0882401026005620"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108836","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation of Bacillus subtilis NJ01 and in silico evaluation of its antimicrobial metabolites as potential inhibitors of the CRN8 effector protein of Phytophthora infestans","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108836","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108836"}}