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blindness","volume":"295","author":"Andr\u00e9","year":"2002","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.micpath.2026.108862_bib67","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2018.10.016","article-title":"Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules","volume":"49","author":"Maizels","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.micpath.2026.108862_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1356216","article-title":"IFNs in host defence and parasite immune evasion during Toxoplasma gondii infections","volume":"15","author":"L\u00fcder","year":"2024","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.micpath.2026.108862_bib69","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00504-23","article-title":"IFN-\u03bb3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans","volume":"92","author":"De","year":"2024","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.micpath.2026.108862_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens12020319","article-title":"The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection","volume":"12","author":"Deng","year":"2023","journal-title":"Pathogens"},{"issue":"7","key":"10.1016\/j.micpath.2026.108862_bib71","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nri2314","article-title":"Interferon-inducible antiviral effectors","volume":"8","author":"Sadler","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"10.1016\/j.micpath.2026.108862_bib72","article-title":"Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS 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