{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:36:34Z","timestamp":1793136994424,"version":"4.5.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014862","name":"Yangzhou shi kexue jishu ju","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011791","name":"Jiangsu Province Department of Finance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011791","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007166","name":"JIangsu Education Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.micpath.2026.108888","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:09:02Z","timestamp":1792796942000},"page":"108888","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Collateral sensitivity in bacteria: Phenomenon, mechanisms, modulators and therapeutic prospects"],"prefix":"10.1016","volume":"221","author":[{"given":"Mengjie","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guocai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10325","key":"10.1016\/j.micpath.2026.108888_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.micpath.2026.108888_bib2","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cmi.2015.12.002","article-title":"The negative impact of antibiotic resistance","volume":"22","author":"Friedman","year":"2016","journal-title":"Clin. Microbiol. Infection"},{"issue":"9","key":"10.1016\/j.micpath.2026.108888_bib3","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1473-3099(18)30471-7","article-title":"Antimicrobial resistance: a threat to global health","volume":"18","author":"Jee","year":"2018","journal-title":"Lancet Infect. Dis."},{"issue":"10459","key":"10.1016\/j.micpath.2026.108888_bib4","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","article-title":"Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050","volume":"404","year":"2024","journal-title":"Lancet (London, England)"},{"issue":"9","key":"10.1016\/j.micpath.2026.108888_bib5","article-title":"The mechanism of bacterial resistance and potential bacteriostatic strategies","volume":"11","author":"Zhang","year":"2022","journal-title":"Antibiotics (Basel)"},{"issue":"10","key":"10.1016\/j.micpath.2026.108888_bib6","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.addr.2005.04.003","article-title":"Bacterial resistance to antibiotics: modified target sites","volume":"57","author":"Lambert","year":"2005","journal-title":"Adv Drug Deliver Rev"},{"issue":"6","key":"10.1016\/j.micpath.2026.108888_bib7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.chom.2024.05.015","article-title":"Antibiotic resistance: a key microbial survival mechanism that threatens public health","volume":"32","author":"Abbas","year":"2024","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.micpath.2026.108888_bib8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/jb.64.4.489-499.1952","article-title":"Genetic studies on microbial cross resistance to toxic agents. I. Cross resistance of Escherichia coli to fifteen antibiotics","volume":"64","author":"Szybalski","year":"1952","journal-title":"J. Bacteriol."},{"issue":"5","key":"10.1016\/j.micpath.2026.108888_bib9","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1182\/blood.V87.5.1962.1962","article-title":"Bell PB: novel ex vivo analysis of nonclassical, pleiotropic drug resistance and collateral sensitivity induced by therapy provides a rationale for treatment strategies in chronic lymphocytic leukemia","volume":"87","author":"Bosanquet","year":"1996","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.micpath.2026.108888_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101293","article-title":"Identifying states of collateral sensitivity during the evolution of therapeutic resistance in ewing's sarcoma","volume":"23","author":"Scarborough","year":"2020","journal-title":"iScience"},{"issue":"1\u20132","key":"10.1016\/j.micpath.2026.108888_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.drup.2012.03.002","article-title":"Collateral sensitivity as a strategy against cancer multidrug resistance","volume":"15","author":"Pluchino","year":"2012","journal-title":"Drug Resist Update"},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib12","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1038\/s41467-020-15596-z","article-title":"Exploiting evolutionary steering to induce collateral drug sensitivity in cancer","volume":"11","author":"Acar","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib13","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1038\/s41467-024-49122-2","article-title":"\u03b2-lactamase expression induces collateral sensitivity in Escherichia coli","volume":"15","author":"Herencias","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2026.108888_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100961","article-title":"Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae","volume":"68","author":"Ma","year":"2023","journal-title":"Drug Resist. Updates : reviews and commentaries in antimicrobial and anticancer chemotherapy"},{"issue":"2","key":"10.1016\/j.micpath.2026.108888_bib15","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/lam.13488","article-title":"Insights into collateral susceptibility and collateral resistance in during antimicrobial adaptation","volume":"73","author":"Dawan","year":"2021","journal-title":"Lett. Appl. Microbiol."},{"issue":"2","key":"10.1016\/j.micpath.2026.108888_bib16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/1751-7915.13817","article-title":"Convergent phenotypic evolution towards fosfomycin collateral sensitivity of Pseudomonas aeruginosa antibiotic-resistant mutants","volume":"15","author":"Laborda","year":"2022","journal-title":"Microb. Biotechnol."},{"issue":"8","key":"10.1016\/j.micpath.2026.108888_bib17","article-title":"Ciprofloxacin and tetracycline resistance cause collateral sensitivity to aminoglycosides in Salmonella Typhimurium","volume":"12","author":"Hasan","year":"2023","journal-title":"Antibiotics (Basel, Switzerland)"},{"issue":"4","key":"10.1016\/j.micpath.2026.108888_bib18","article-title":"Inactivation of a new potassium channel increases rifampicin resistance and induces collateral sensitivity to hydrophilic antibiotics in Mycobacterium smegmatis","volume":"11","author":"Do","year":"2022","journal-title":"Antibiotics (Basel)"},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37184-7","article-title":"The evolution of antibiotic resistance is associated with collateral drug phenotypes","volume":"14","author":"Waller","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s42003-020-01313-5","article-title":"Carbapenems drive the collateral resistance to ceftaroline in cystic fibrosis patients with MRSA","volume":"3","author":"Varela","year":"2020","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib21","doi-asserted-by":"crossref","first-page":"8302","DOI":"10.1038\/s41467-023-44077-2","article-title":"Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors","volume":"14","author":"Hsu","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.micpath.2026.108888_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001616","article-title":"Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT","volume":"20","author":"Shafik","year":"2022","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41564-024-01857-w","article-title":"Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics","volume":"10","author":"Sakenova","year":"2025","journal-title":"Nat. Microbiol."},{"issue":"3","key":"10.1016\/j.micpath.2026.108888_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04594-22","article-title":"Alteration of adeS contributes to tigecycline resistance and collateral sensitivity to sulbactam in Acinetobacter baumannii","volume":"11","author":"Yang","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"39","key":"10.1016\/j.micpath.2026.108888_bib25","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2507962122","article-title":"Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus","volume":"122","author":"Card","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micpath.2026.108888_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1361795","article-title":"MSDeepAMR: antimicrobial resistance prediction based on deep neural networks and transfer learning","volume":"15","author":"L\u00f3pez-Cort\u00e9s","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2026.108888_bib27","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.csbj.2024.04.035","article-title":"Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains","volume":"23","author":"Do","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"5\u20136","key":"10.1016\/j.micpath.2026.108888_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10822-023-00505-5","article-title":"TargIDe: a machine-learning workflow for target identification of molecules with antibiofilm activity against Pseudomonas aeruginosa","volume":"37","author":"Carneiro","year":"2023","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"16","key":"10.1016\/j.micpath.2026.108888_bib29","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2303165121","article-title":"Reinforcement learning informs optimal treatment strategies to limit antibiotic resistance","volume":"121","author":"Weaver","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.micpath.2026.108888_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2024.107122","article-title":"Antibiotic combinations prediction based on machine learning to multicentre clinical data and drug interaction correlation","volume":"63","author":"Qin","year":"2024","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib31","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/s41467-023-37357-4","article-title":"Tackling antibiotic resistance by inducing transient and robust collateral sensitivity","volume":"14","author":"Hernando-Amado","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2026.108888_bib32","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73250","article-title":"The population genetics of collateral resistance and sensitivity","volume":"10","author":"Ardell","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.micpath.2026.108888_bib33","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51481","article-title":"Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa","volume":"8","author":"Barbosa","year":"2019","journal-title":"eLife"},{"issue":"9","key":"10.1016\/j.micpath.2026.108888_bib34","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1002\/rnc.6528","article-title":"Scheduling collateral sensitivity-based cycling therapies toward eradication of drug-resistant infections","volume":"33","author":"Tetteh","year":"2023","journal-title":"Int J Robust Nonlin"},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib35","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1038\/s41467-021-25927-3","article-title":"Design principles of collateral sensitivity-based dosing strategies","volume":"12","author":"Aulin","year":"2021","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.micpath.2026.108888_bib36","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.bbapap.2008.11.005","article-title":"Outer membrane permeability and antibiotic resistance","volume":"1794","author":"Delcour","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"10.1016\/j.micpath.2026.108888_bib37","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nrmicro1994","article-title":"The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria","volume":"6","author":"Pag\u00e8s","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.micpath.2026.108888_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005453","article-title":"How beta-lactam antibiotics enter bacteria: a dialogue with the porins","volume":"4","author":"James","year":"2009","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.micpath.2026.108888_bib39","article-title":"Polymyxins and bacterial membranes: a review of antibacterial activity and mechanisms of resistance","volume":"10","author":"Ayoub","year":"2020","journal-title":"Membranes"},{"issue":"10","key":"10.1016\/j.micpath.2026.108888_bib40","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025288","article-title":"Polymyxin: alternative mechanisms of action and resistance","volume":"6","author":"Trimble","year":"2016","journal-title":"Cold Spring Harbor perspectives in medicine"},{"issue":"6","key":"10.1016\/j.micpath.2026.108888_bib41","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41564-018-0164-0","article-title":"Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides","volume":"3","author":"L\u00e1z\u00e1r","year":"2018","journal-title":"Nat. Microbiol."},{"issue":"7","key":"10.1016\/j.micpath.2026.108888_bib42","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1128\/AAC.01107-07","article-title":"Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump","volume":"52","author":"Jeannot","year":"2008","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib43","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1038\/s41467-018-06143-y","article-title":"Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli","volume":"9","author":"Podnecky","year":"2018","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.micpath.2026.108888_bib44","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02370-24","article-title":"Efflux pumps mediate changes to fundamental bacterial physiology via membrane potential","volume":"15","author":"Whittle","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.micpath.2026.108888_bib45","article-title":"Acquisition of tigecycline resistance by carbapenem-resistant Klebsiella pneumoniae confers collateral hypersensitivity to aminoglycosides","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000612","article-title":"Molecular mechanisms of collateral sensitivity to the antibiotic nitrofurantoin","volume":"18","author":"Roemhild","year":"2020","journal-title":"PLoS Biol."},{"issue":"13","key":"10.1016\/j.micpath.2026.108888_bib47","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1042\/BCJ20210160","article-title":"The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN","volume":"478","author":"Day","year":"2021","journal-title":"The Biochemical journal"},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib48","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/s41467-019-08529-y","article-title":"Collateral sensitivity constrains resistance evolution of the CTX-M-15 \u03b2-lactamase","volume":"10","author":"Rosenkilde","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2026.108888_bib49","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65130","article-title":"Collateral sensitivity associated with antibiotic resistance plasmids","volume":"10","author":"Herencias","year":"2021","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009172","article-title":"Mechanisms and therapeutic potential of collateral sensitivity to antibiotics","volume":"17","author":"Roemhild","year":"2021","journal-title":"PLoS Pathog."},{"issue":"8","key":"10.1016\/j.micpath.2026.108888_bib51","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/s41579-022-00700-5","article-title":"The physiology and genetics of bacterial responses to antibiotic combinations","volume":"20","author":"Roemhild","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib52","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1038\/s41467-020-19713-w","article-title":"High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli","volume":"11","author":"Maeda","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.micpath.2026.108888_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007697","article-title":"Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics","volume":"15","author":"Crabb\u00e9","year":"2019","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.micpath.2026.108888_bib54","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ijantimicag.2015.07.017","article-title":"Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii","volume":"46","author":"Garc\u00eda-Quintanilla","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2026.108888_bib55","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/msb.2013.57","article-title":"Bacterial evolution of antibiotic hypersensitivity","volume":"9","author":"L\u00e1z\u00e1r","year":"2013","journal-title":"Mol. Syst. Biol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01634-16","article-title":"Molecular bases determining daptomycin resistance-mediated resensitization to \u03b2-Lactams (Seesaw effect) in methicillin-resistant Staphylococcus aureus","volume":"61","author":"Renzoni","year":"2017","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib57","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/s41467-022-29493-0","article-title":"Collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.micpath.2026.108888_bib58","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.01055-21","article-title":"Collateral sensitivity interactions between antibiotics depend on local abiotic conditions","volume":"6","author":"Allen","year":"2021","journal-title":"mSystems"},{"issue":"6","key":"10.1016\/j.micpath.2026.108888_bib59","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1046\/j.1365-2958.2003.03531.x","article-title":"Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with rob regulatory protein","volume":"48","author":"Rosenberg","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2026.108888_bib60","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47612","article-title":"Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle","volume":"8","author":"Santos-Lopez","year":"2019","journal-title":"eLife"},{"issue":"5","key":"10.1016\/j.micpath.2026.108888_bib61","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/molbev\/msz303","article-title":"Using selection by nonantibiotic stressors to sensitize bacteria to antibiotics","volume":"37","author":"Maltas","year":"2020","journal-title":"Mol. Biol. Evol."},{"issue":"4","key":"10.1016\/j.micpath.2026.108888_bib62","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00441-22","article-title":"Evolutionary instability of collateral susceptibility networks in ciprofloxacin-resistant clinical Escherichia coli strains","volume":"13","author":"S\u00f8rum","year":"2022","journal-title":"mBio"},{"issue":"8","key":"10.1016\/j.micpath.2026.108888_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24086892","article-title":"Collateral sensitivity to fosfomycin of tobramycin-resistant mutants of is contingent on bacterial genomic background","volume":"24","author":"Genova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.micpath.2026.108888_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219879","article-title":"Assessment of phenotype microarray plates for rapid and high-throughput analysis of collateral sensitivity networks","volume":"14","author":"Dunkley","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2026.108888_bib65","article-title":"Prediction of cross-resistance and collateral sensitivity by gene expression profiles and genomic mutations","volume":"7","author":"Horinouchi","year":"2017","journal-title":"Sci Rep-Uk"},{"issue":"10","key":"10.1016\/j.micpath.2026.108888_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000515","article-title":"Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance","volume":"17","author":"Maltas","year":"2019","journal-title":"PLoS Biol."},{"issue":"198","key":"10.1016\/j.micpath.2026.108888_bib67","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2022.0793","article-title":"Sequential antibiotic therapy in the laboratory and in the patient","volume":"20","author":"Nyhoegen","year":"2023","journal-title":"J R Soc Interface"},{"issue":"2","key":"10.1016\/j.micpath.2026.108888_bib68","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03109-23","article-title":"The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection","volume":"15","author":"Vanderwoude","year":"2024","journal-title":"mBio"},{"issue":"204","key":"10.1016\/j.micpath.2026.108888_bib69","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006609","article-title":"Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development","volume":"5","author":"Imamovic","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"40","key":"10.1016\/j.micpath.2026.108888_bib70","doi-asserted-by":"crossref","first-page":"14494","DOI":"10.1073\/pnas.1409800111","article-title":"Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance","volume":"111","author":"Kim","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002970","article-title":"Dynamic collateral sensitivity profiles highlight opportunities and challenges for optimizing antibiotic treatments","volume":"23","author":"Maltas","year":"2025","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib72","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1038\/s41467-023-37624-4","article-title":"Collateral sensitivity profiling in drug-resistant Escherichia coli identifies natural products suppressing cephalosporin resistance","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2026.108888_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106134","article-title":"Assessment of the potential of phage-antibiotic synergy to induce collateral sensitivity in Salmonella typhimurium","volume":"180","author":"Hasan","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2026.108888_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/srep26717","article-title":"Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa","volume":"6","author":"Chan","year":"2016","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.micpath.2026.108888_bib75","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cmi.2024.03.015","article-title":"Phage resistance in Klebsiella pneumoniae and bidirectional effects impacting antibiotic susceptibility","volume":"30","author":"Nang","year":"2024","journal-title":"Clin. Microbiol. Infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"issue":"9","key":"10.1016\/j.micpath.2026.108888_bib76","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1093\/molbev\/msx158","article-title":"Alternative evolutionary paths to bacterial antibiotic resistance cause distinct collateral effects","volume":"34","author":"Barbosa","year":"2017","journal-title":"Mol. Biol. Evol."},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib77","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41467-018-08098-6","article-title":"Antibiotic collateral sensitivity is contingent on the repeatability of evolution","volume":"10","author":"Nichol","year":"2019","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.micpath.2026.108888_bib78","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1016\/S2666-5247(21)00118-X","article-title":"Identification of antibiotic pairs that evade concurrent resistance via a retrospective analysis of antimicrobial susceptibility test results","volume":"2","author":"Beckley","year":"2021","journal-title":"Lancet Microbe"},{"issue":"4","key":"10.1016\/j.micpath.2026.108888_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/jacamr\/dlab175","article-title":"Identification of antibiotic collateral sensitivity and resistance interactions in population surveillance data","volume":"3","author":"Zwep","year":"2021","journal-title":"JAC-antimicrobial resistance"},{"issue":"1","key":"10.1016\/j.micpath.2026.108888_bib80","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s42003-025-09303-1","article-title":"Evolutionary trajectories determine feasibility of collateral sensitivity-based antibiotic treatment strategies in critical bacterial pathogens","volume":"9","author":"Chauhan","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.micpath.2026.108888_bib81","series-title":"ESKAPE Pathogens: Detection, Mechanisms and Treatment Strategies","first-page":"79","article-title":"Mechanistic understanding of antibiotic resistance in ESKAPE pathogens","author":"Ranganathan","year":"2024"},{"key":"10.1016\/j.micpath.2026.108888_bib82","series-title":"Omics Approaches in Biofilm Research: Perspectives and Applications","first-page":"201","article-title":"Metabolomics approaches in understanding the biofilm formation and its inhibitors","author":"Gajendran","year":"2025"},{"key":"10.1016\/j.micpath.2026.108888_bib83","series-title":"Omics Approaches in Biofilm Research: Perspectives and Applications","first-page":"429","article-title":"Omics-based therapeutics against biofilm mechanics","author":"Nagarajan","year":"2025"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026006145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401026006145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:28:54Z","timestamp":1793136534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401026006145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":83,"alternative-id":["S0882401026006145"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108888","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Collateral sensitivity in bacteria: Phenomenon, mechanisms, modulators and therapeutic prospects","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2026.108888","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108888"}}