{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:27:29Z","timestamp":1789550849437,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"vor","delay-in-days":370,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Foundation of Natural Science of China","doi-asserted-by":"crossref","award":["31071649"],"award-info":[{"award-number":["31071649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Modern Agro-industry Technology Research System (MATRS)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.micres.2012.11.006","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T08:45:25Z","timestamp":1355215525000},"page":"211-222","source":"Crossref","is-referenced-by-count":71,"title":["The calcineurin-responsive transcription factor Crz1 is required for conidation, full virulence and DMI resistance in Penicillium digitatum"],"prefix":"10.1016","volume":"168","author":[{"given":"Tianyuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuepeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongye","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.micres.2012.11.006_bib0005","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1128\/IAI.00142-06","article-title":"Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain","volume":"74","author":"Bader","year":"2006","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.micres.2012.11.006_bib0010","doi-asserted-by":"crossref","first-page":"7279","DOI":"10.1016\/S0021-9258(17)37280-0","article-title":"A novel protein, Csg2p, is required for Ca2+ regulation in Saccharomyces cerevisiae","volume":"269","author":"Beeler","year":"1994","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.micres.2012.11.006_bib0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"10.1016\/j.micres.2012.11.006_bib0020","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1094\/PD-75-1098","article-title":"Occurrence of Penicillium digitatum and P. italicum resistant to benomyl, thiabendazole, and imazalil on citrus fruit from different geographic origins","volume":"75","author":"Bus","year":"1991","journal-title":"Plant Dis"},{"issue":"3","key":"10.1016\/j.micres.2012.11.006_bib0025","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.fgb.2008.11.010","article-title":"MoCRZ1, a gene encoding a calcineurin-responsive transcription factor, regulates fungal growth and pathogenicity of Magnaporthe oryzae","volume":"46","author":"Choi","year":"2009","journal-title":"Fungal Genet Biol"},{"issue":"7","key":"10.1016\/j.micres.2012.11.006_bib0030","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/EC.00086-08","article-title":"Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus","volume":"7","author":"Cramer","year":"2008","journal-title":"Eukaryot Cell"},{"issue":"4","key":"10.1016\/j.micres.2012.11.006_bib0035","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/emboj\/21.4.546","article-title":"Calcineurin is essential for survival during membrane stress in Candida albicans","volume":"21","author":"Cruz","year":"2002","journal-title":"EMBO J"},{"issue":"3","key":"10.1016\/j.micres.2012.11.006_bib0040","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1083\/jcb.124.3.351","article-title":"Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases","volume":"124","author":"Cunningham","year":"1994","journal-title":"J Cell Biol"},{"issue":"4","key":"10.1016\/j.micres.2012.11.006_bib0045","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0006-291X(03)01552-3","article-title":"Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress","volume":"311","author":"Cyert","year":"2003","journal-title":"Biochem Biophys Res Co"},{"issue":"11","key":"10.1016\/j.micres.2012.11.006_bib0050","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1091\/mbc.E06-06-0526","article-title":"Real-time monitoring of calcineurin activity in living cells: evidence for two distinct Ca2+-dependent pathways in fission yeast","volume":"17","author":"Deng","year":"2006","journal-title":"Mol Biol Cell"},{"issue":"10","key":"10.1016\/j.micres.2012.11.006_bib0055","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1094\/PD-78-0971","article-title":"Reduction of imazalil effectiveness against citrus green mold in California packinghouses by resistant biotypes of Penicillium digitatum","volume":"78","author":"Eckert","year":"1994","journal-title":"Plant Dis"},{"issue":"1","key":"10.1016\/j.micres.2012.11.006_bib0060","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1365-2958.2002.03165.x","article-title":"Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling","volume":"46","author":"Edlind","year":"2002","journal-title":"Mol Microbiol"},{"issue":"19","key":"10.1016\/j.micres.2012.11.006_bib0065","doi-asserted-by":"crossref","first-page":"16216","DOI":"10.1074\/jbc.M101504200","article-title":"The yeast plasma membrane protein Alr1 controls Mg2+ homeostasis and is subject to Mg2+-dependent control of its synthesis and degradation","volume":"276","author":"Graschopf","year":"2001","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.micres.2012.11.006_bib0070","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1128\/EC.5.3.469-479.2006","article-title":"Regulation of salt tolerance by Torulaspora delbrueckii calcineurin target Crz1p","volume":"5","author":"Hernandez-Lopez","year":"2006","journal-title":"Eukaryot Cell"},{"issue":"20","key":"10.1016\/j.micres.2012.11.006_bib0075","doi-asserted-by":"crossref","first-page":"18078","DOI":"10.1074\/jbc.M212900200","article-title":"Zinc finger protein Prz1 regulates Ca2+ but not Cl\u2212 homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeast","volume":"278","author":"Hirayama","year":"2003","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.micres.2012.11.006_bib0080","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1094\/PHYTO.1999.89.9.716","article-title":"Sensitivity of Penicillium digitatum and P. italicum to postharvest citrus fungicides in California","volume":"89","author":"Holmes","year":"1999","journal-title":"Phytopathology"},{"issue":"1","key":"10.1016\/j.micres.2012.11.006_bib0085","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1564\/15feb12","article-title":"Post-harvest citrus diseases and their control","volume":"15","author":"Ismail","year":"2004","journal-title":"Outlooks Pest Manage"},{"issue":"11","key":"10.1016\/j.micres.2012.11.006_bib0090","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1094\/PDIS-91-11-1502","article-title":"Comparative efficacy of the new postharvest fungicides azoxystrobin, fludioxonil, and pyrimethanil for managing citrus green mold","volume":"91","author":"Kanetis","year":"2007","journal-title":"Plant Dis"},{"issue":"5","key":"10.1016\/j.micres.2012.11.006_bib0095","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/j.1365-2958.2005.05037.x","article-title":"CRZ1, a target of the calcineurin pathway in Candida albicans","volume":"59","author":"Karababa","year":"2006","journal-title":"Mol Microbiol"},{"issue":"11","key":"10.1016\/j.micres.2012.11.006_bib0100","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1094\/PHYTO-97-11-1491","article-title":"Penicillium digitatum suppresses production of hydrogen peroxide in host tissue during infection of citrus fruit","volume":"97","author":"Macarisin","year":"2007","journal-title":"Phytopathology"},{"issue":"24","key":"10.1016\/j.micres.2012.11.006_bib0105","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1101\/gad.11.24.3445","article-title":"Tcn1p\/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae","volume":"11","author":"Matheos","year":"1997","journal-title":"Gene Dev"},{"issue":"5","key":"10.1016\/j.micres.2012.11.006_bib0110","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s004380100474","article-title":"Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene","volume":"265","author":"Mendizabal","year":"2001","journal-title":"Mol Genet Genomics"},{"issue":"4","key":"10.1016\/j.micres.2012.11.006_bib0115","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1128\/AAC.01364-09","article-title":"Roles of Calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata","volume":"54","author":"Miyazaki","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.micres.2012.11.006_bib0120","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/j.1365-2958.2007.05588.x","article-title":"HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans","volume":"63","author":"Munro","year":"2007","journal-title":"Mol Microbiol"},{"issue":"12","key":"10.1016\/j.micres.2012.11.006_bib0125","doi-asserted-by":"crossref","first-page":"7330","DOI":"10.1128\/IAI.72.12.7330-7333.2004","article-title":"The calcineurin target, crz1, functions in azole tolerance but is not required for virulence of Candida albicans","volume":"72","author":"Onyewu","year":"2004","journal-title":"Infect Immun"},{"issue":"31","key":"10.1016\/j.micres.2012.11.006_bib0130","doi-asserted-by":"crossref","first-page":"28694","DOI":"10.1074\/jbc.M101185200","article-title":"Mutation in PMR1, a Ca2+-ATPase in Golgi, confers salt tolerance in Saccharomyces cerevisiae by inducing expression of PMR2, an Na+-ATPase in plasma membrane","volume":"276","author":"Park","year":"2001","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.micres.2012.11.006_bib0135","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST\u00a9) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.micres.2012.11.006_bib0140","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/EC.2.5.937-948.2003","article-title":"Regulation of ENA1 Na+-ATPase gene expression by the Ppz1 protein phosphatase is mediated by the calcineurin pathway","volume":"2","author":"Ruiz","year":"2003","journal-title":"Eukaryot Cell"},{"issue":"4","key":"10.1016\/j.micres.2012.11.006_bib0145","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1046\/j.1365-2958.2003.03495.x","article-title":"Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence","volume":"48","author":"Sanglard","year":"2003","journal-title":"Mol Microbiol"},{"issue":"2","key":"10.1016\/j.micres.2012.11.006_bib0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00294-005-0003-8","article-title":"Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor","volume":"48","author":"Santos","year":"2005","journal-title":"Curr Genet"},{"issue":"4","key":"10.1016\/j.micres.2012.11.006_bib0155","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1128\/EC.00426-07","article-title":"Calcineurin-responsive zinc finger transcription factor CRZ1 of Botrytis cinerea is required for growth, development, and full virulence on bean plants","volume":"7","author":"Schumacher","year":"2008","journal-title":"Eukaryot Cell"},{"issue":"6","key":"10.1016\/j.micres.2012.11.006_bib0160","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/j.1365-2958.2008.06122.x","article-title":"Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA","volume":"67","author":"Soriani","year":"2008","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.micres.2012.11.006_bib0165","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/BJ20080344","article-title":"Two zinc finger transcription factors, CrzA and SltA, are involved in cation homeostasis and detoxification in Aspergillus nidulans","volume":"414","author":"Spielvogel","year":"2008","journal-title":"Biochem J"},{"issue":"7","key":"10.1016\/j.micres.2012.11.006_bib0170","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1101\/gad.13.7.798","article-title":"Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation","volume":"13","author":"Stathopoulos-Gerontides","year":"1999","journal-title":"Gene Dev"},{"issue":"24","key":"10.1016\/j.micres.2012.11.006_bib0175","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1101\/gad.11.24.3432","article-title":"Calcineurin acts through the CRZ1\/TCN1-encoded transcription factor to regulate gene expression in yeast","volume":"11","author":"Stathopoulos","year":"1997","journal-title":"Gene Dev"},{"key":"10.1016\/j.micres.2012.11.006_bib0180","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00253-011-3355-7","article-title":"PdCYP51B, a new putative sterol 14\u03b1-demethylase gene of Penicillium digitatum involved in resistance to imazalil and other fungicides inhibiting ergosterol synthesis","volume":"91","author":"Sun","year":"2011","journal-title":"Appl Microbiol Biot"},{"key":"10.1016\/j.micres.2012.11.006_bib0185","series-title":"DPS data processing system: experimental design, statistical analysis and data mining","author":"Tang","year":"2007"},{"issue":"10","key":"10.1016\/j.micres.2012.11.006_bib0190","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1631\/jzus.B0860006","article-title":"Agrobacterium tumefaciens-mediated genetic transformation of the phytopathogenic fungus Penicillium digitatum","volume":"9","author":"Wang","year":"2008","journal-title":"J Zhejiang Univ Sci B"},{"issue":"1","key":"10.1016\/j.micres.2012.11.006_bib0195","first-page":"95","article-title":"PdMfs1, a major facilitator superfamily transporter from Penicillium digitatum, is partially involved in the imazalil-resistance and pathogenicity","volume":"6","author":"Wang","year":"2012","journal-title":"Afr J Microbiol Res"},{"issue":"4","key":"10.1016\/j.micres.2012.11.006_bib0200","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/EC.00382-06","article-title":"Mg2+ deprivation elicits rapid Ca2+ uptake and activates Ca2+\/calcineurin signaling in Saccharomyces cerevisiae","volume":"6","author":"Wiesenberger","year":"2007","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.micres.2012.11.006_bib0205","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/978-1-4612-3730-3_11","article-title":"Cytochrome P450 of fungi: primary target for azole antifungal agents","volume":"2","author":"Yoshida","year":"1988","journal-title":"Curr Top Med Mycol"},{"issue":"2","key":"10.1016\/j.micres.2012.11.006_bib0210","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0006-2952(87)90694-0","article-title":"Interaction of azole antifungal agents with cytochrome P-45014DM purified from Saccharomyces cerevisiae microsomes","volume":"36","author":"Yoshida","year":"1987","journal-title":"Biochem Pharmacol"},{"issue":"34","key":"10.1016\/j.micres.2012.11.006_bib0215","doi-asserted-by":"crossref","first-page":"31079","DOI":"10.1074\/jbc.M202718200","article-title":"Genome-wide analysis of gene expression regulated by the calcineurin\/Crz1p signaling pathway in Saccharomyces cerevisiae","volume":"277","author":"Yoshimoto","year":"2002","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.micres.2012.11.006_bib0220","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1574-6968.2009.01524.x","article-title":"MgCRZ1, a transcription factor of Magnaporthe grisea, controls growth, development and is involved in full virulence","volume":"293","author":"Zhang","year":"2009","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.micres.2012.11.006_bib0225","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1631\/jzus.2006.AS0362","article-title":"Occurrence of imazalil-resistant biotype of Penicillium digitatum in China and the resistant molecular mechanism","volume":"7","author":"Zhu","year":"2006","journal-title":"J Zhejiang Univ Sci A"}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501312001346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501312001346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T19:37:24Z","timestamp":1643830644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501312001346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0944501312001346"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2012.11.006","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}