{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:03:29Z","timestamp":1793048609163,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772736"],"award-info":[{"award-number":["31772736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31502062"],"award-info":[{"award-number":["31502062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Fund for Agro-scientific Research","award":["201303034"],"award-info":[{"award-number":["201303034"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.micres.2017.10.010","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T19:31:21Z","timestamp":1509132681000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Haemophilus parasuis CpxRA two-component system confers bacterial tolerance to environmental stresses and macrolide resistance"],"prefix":"10.1016","volume":"206","author":[{"given":"Qi","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuwang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micres.2017.10.010_bib0005","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1128\/IAI.03056-14","article-title":"The Cpx system regulates virulence gene expression in Vibrio cholerae","volume":"83","author":"Acosta","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micres.2017.10.010_bib0010","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1128\/JB.01957-14","article-title":"The Vibrio cholerae Cpx envelope stress response senses and mediates adaptation to low iron","volume":"197","author":"Acosta","year":"2015","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2017.10.010_bib0015","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1292\/jvms.56.639","article-title":"Pathologic observations of pigs intranasally inoculated with serovar 1, 4 and 5 of Haemophilus parasuis using immunoperoxidase method","volume":"56","author":"Amano","year":"1994","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.micres.2017.10.010_bib0020","doi-asserted-by":"crossref","first-page":"7770","DOI":"10.1128\/AEM.02593-13","article-title":"Induction of the Cpx envelope stress pathway contributes to Escherichia coli tolerance to antimicrobial peptides","volume":"79","author":"Audrain","year":"2013","journal-title":"Appl. Environ. Microb."},{"key":"10.1016\/j.micres.2017.10.010_bib0025","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.mib.2009.07.003","article-title":"Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update","volume":"12","author":"Blair","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0030","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.vetmic.2005.07.007","article-title":"Serological characterization of Haemophilus parasuis isolates from China","volume":"111","author":"Cai","year":"2005","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0035","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tvjl.2007.01.016","article-title":"Serum-resistance in Haemophilus parasuis is associated with systemic disease in swine","volume":"175","author":"Cerda-Cuellar","year":"2008","journal-title":"Vet. J."},{"key":"10.1016\/j.micres.2017.10.010_bib0040","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.vetmic.2011.08.020","article-title":"Electrotransformation of Haemophilus parasuis with in vitro modified DNA based on a novel shuttle vector","volume":"155","author":"Chen","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0045","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-2958.1995.mmi_18030491.x","article-title":"Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses","volume":"18","author":"Cosma","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0050","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.tvjl.2013.08.027","article-title":"Advances in the quest for virulence factors of Haemophilus parasuis","volume":"198","author":"Costa-Hurtado","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.micres.2017.10.010_bib0055","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1297-9716-43-57","article-title":"VtaA8 and VtaA9 from Haemophilus parasuis delay phagocytosis by alveolar macrophages","volume":"43","author":"Costa-Hurtado","year":"2012","journal-title":"Vet. Res."},{"key":"10.1016\/j.micres.2017.10.010_bib0060","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1128\/JB.180.4.831-839.1998","article-title":"CpxP, a stress-combative member of the Cpx regulon","volume":"180","author":"Danese","year":"1998","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2017.10.010_bib0065","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1101\/gad.9.4.387","article-title":"The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP","volume":"9","author":"Danese","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.micres.2017.10.010_bib0070","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.molcel.2009.11.024","article-title":"Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli","volume":"36","author":"Davies","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.micres.2017.10.010_bib0075","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.1073\/pnas.83.16.6164","article-title":"Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides","volume":"83","author":"Davis","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2017.10.010_bib0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fcimb.2016.00011","article-title":"The two-component system CpxRA negatively regulates the locus of enterocyte effacement of enterohemorrhagic Escherichia coli involving sigma(32) and lon protease","volume":"6","author":"De la Cruz","year":"2016","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0085","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1128\/IAI.01213-12","article-title":"The Cpx stress response system potentiates the fitness and virulence of uropathogenic Escherichia coli","volume":"81","author":"Debnath","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micres.2017.10.010_bib0090","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1128\/JB.00372-13","article-title":"Activation of CpxRA in Haemophilus ducreyi primarily inhibits the expression of its targets, including major virulence determinants","volume":"195","author":"Gangaiah","year":"2013","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2017.10.010_bib0095","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/jac\/dkq497","article-title":"Molecular characterization of fluoroquinolone resistance in Haemophilus parasuis isolated from pigs in South China","volume":"66","author":"Guo","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micres.2017.10.010_bib0100","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1128\/AAC.00216-11","article-title":"The expression levels of outer membrane proteins STM1530 and OmpD which are influenced by the CpxAR and BaeSR two-component systems, play important roles in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium","volume":"55","author":"Hu","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micres.2017.10.010_bib0105","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.vetmic.2015.11.020","article-title":"ClpP participates in stress tolerance and negatively regulates biofilm formation in Haemophilus parasuis","volume":"182","author":"Huang","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1574-6968.2011.02436.x","article-title":"Signal integration by the Cpx-envelope stress system","volume":"326","author":"Hunke","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micres.2017.10.010_bib0115","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bbrc.2012.04.003","article-title":"Activation of the Cpx phosphorelay signal transduction system in acidic phospholipid-deficient pgsA mutant cells of Escherichia coli","volume":"421","author":"Itou","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.micres.2017.10.010_bib0120","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nm.2357","article-title":"Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems","volume":"17","author":"Kashyap","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.micres.2017.10.010_bib0125","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1128\/JB.00995-15","article-title":"Functional dissection of the CroRS two-component system required for resistance to cell wall stressors in Enterococcus faecalis","volume":"198","author":"Kellogg","year":"2016","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2017.10.010_bib0130","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2008.09.038","article-title":"Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death","volume":"135","author":"Kohanski","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.micres.2017.10.010_bib0135","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev.micro.112408.134054","article-title":"Bacterial sensor kinases: diversity in the recognition of environmental signals","volume":"64","author":"Krell","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0140","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1128\/JB.01151-13","article-title":"Role of the CpxAR two-component signal transduction system in control of fosfomycin resistance and carbon substrate uptake","volume":"196","author":"Kurabayashi","year":"2014","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2017.10.010_bib0145","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1128\/IAI.00678-10","article-title":"Characterization of the CpxRA regulon in Haemophilus ducreyi","volume":"78","author":"Labandeira-Rey","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micres.2017.10.010_bib0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2165\/00003495-200464020-00004","article-title":"Efflux-mediated drug resistance in bacteria","volume":"64","author":"Li","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.micres.2017.10.010_bib0155","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1128\/JB.02197-12","article-title":"The Cpx stress response confers resistance to some, but not all, bactericidal antibiotics","volume":"195","author":"Mahoney","year":"2013","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2017.10.010_bib0160","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/MMBR.00020-06","article-title":"Stimulus perception in bacterial signal-transducing histidine kinases","volume":"70","author":"Mascher","year":"2006","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.micres.2017.10.010_bib0165","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1128\/JCM.28.12.2711-2716.1990","article-title":"V factor-dependent members of the family Pasteurellaceae in the porcine upper respiratory tract","volume":"28","author":"Moller","year":"1990","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0170","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1099\/mic.0.26229-0","article-title":"Activation of hilA expression at low pH requires the signal sensor CpxA, but not the cognate response regulator CpxR, in Salmonella enterica serovar Typhimurium","volume":"149","author":"Nakayama","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.micres.2017.10.010_bib0175","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1101\/gad.11.9.1169","article-title":"Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system","volume":"11","author":"Pogliano","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.micres.2017.10.010_bib0180","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1128\/jb.179.24.7724-7733.1997","article-title":"Transduction of envelope stress in Escherichia coli by the Cpx two-component system","volume":"179","author":"Raivio","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2017.10.010_bib0185","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/jac\/dkt352","article-title":"Regulation of acrAB expression by cellular metabolites in Escherichia coli","volume":"69","author":"Ruiz","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micres.2017.10.010_bib0190","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.vetmic.2008.11.008","article-title":"Identification of novel potential virulence-associated factors in Haemophilus parasuis","volume":"136","author":"Sack","year":"2009","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0195","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0378-1119(94)90324-7","article-title":"Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum","volume":"145","author":"Schafer","year":"1994","journal-title":"Gene"},{"key":"10.1016\/j.micres.2017.10.010_bib0200","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ijantimicag.2017.03.023","article-title":"Contribution of AcrAB-TolC to multidrug resistance in an Escherichia coli sequence type 131 isolate","volume":"50","author":"Schuster","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micres.2017.10.010_bib0205","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1365-2443.2002.00554.x","article-title":"The Cpx stress response system of Escherichia coli senses plasma membrane proteins and controls HtpX, a membrane protease with a cytosolic active site","volume":"7","author":"Shimohata","year":"2002","journal-title":"Genes Cells"},{"key":"10.1016\/j.micres.2017.10.010_bib0210","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1083\/jcb.200611121","article-title":"SecY alterations that impair membrane protein folding and generate a membrane stress","volume":"176","author":"Shimohata","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.micres.2017.10.010_bib0215","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/j.1365-2958.2010.07527.x","article-title":"Two-component regulatory systems in Pseudomonas aeruginosa: an intricate network mediating fimbrial and efflux pump gene expression","volume":"79","author":"Sivaneson","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2017.10.010_bib0220","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1128\/IAI.00432-10","article-title":"Activation of the CpxRA system by deletion of cpxA impairs the ability of Haemophilus ducreyi to infect humans","volume":"78","author":"Spinola","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micres.2017.10.010_bib0225","doi-asserted-by":"crossref","first-page":"e33777","DOI":"10.1371\/journal.pone.0033777","article-title":"Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044","volume":"7","author":"Srinivasan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micres.2017.10.010_bib0230","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.biochem.69.1.183","article-title":"Two-component signal transduction","volume":"69","author":"Stock","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.micres.2017.10.010_bib0235","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/mbo3.353","article-title":"Molecular and proteome analyses highlight the importance of the Cpx envelope stress system for acid stress and cell wall stability in Escherichia coli","volume":"5","author":"Surmann","year":"2016","journal-title":"MicrobiologyOpen"},{"key":"10.1016\/j.micres.2017.10.010_bib0240","first-page":"200","article-title":"Interaction of Haemophilus parasuis with nasal and tracheal mucosa following intranasal inoculation of cesarean derived colostrum deprived (CDCD) swine","volume":"61","author":"Vahle","year":"1997","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.micres.2017.10.010_bib0245","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1126\/science.1172221","article-title":"Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY","volume":"325","author":"van Stelten","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.micres.2017.10.010_bib0250","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1574-6968.2011.02406.x","article-title":"Just scratching the surface: an expanding view of the Cpx envelope stress response","volume":"326","author":"Vogt","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micres.2017.10.010_bib0255","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1128\/JB.01906-07","article-title":"Signal integration by the two-component signal transduction response regulator CpxR","volume":"190","author":"Wolfe","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2017.10.010_bib0260","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1574-6968.2011.02433.x","article-title":"Serum resistance in Haemophilus parasuis SC096 strain requires outer membrane protein P2 expression","volume":"326","author":"Zhang","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micres.2017.10.010_bib0265","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.rvsc.2014.04.014","article-title":"Biofilm formation in Haemophilus parasuis: relationship with antibiotic resistance, serotype and genetic typing","volume":"97","author":"Zhang","year":"2014","journal-title":"Res. Vet. Sci."}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501317304147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501317304147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T17:40:14Z","timestamp":1603215614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501317304147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":53,"alternative-id":["S0944501317304147"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2017.10.010","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Haemophilus parasuis CpxRA two-component system confers bacterial tolerance to environmental stresses and macrolide resistance","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2017.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}