{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:21:56Z","timestamp":1775060516665,"version":"3.50.1"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.micres.2021.126725","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T01:33:25Z","timestamp":1613871205000},"page":"126725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Glucose - The X factor for the survival of human fungal pathogens and disease progression in the host"],"prefix":"10.1016","volume":"247","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-1808","authenticated-orcid":false,"given":"Hafsa","family":"Qadri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munazah Fazal","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3297-1402","authenticated-orcid":false,"given":"Manzoor Ahmad","family":"Mir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2242-0551","authenticated-orcid":false,"given":"Abdul Haseeb","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micres.2021.126725_bib0005","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/ijms19010048","article-title":"Carbon catabolite repression in filamentous fungi","volume":"19","author":"Adnan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micres.2021.126725_bib0010","doi-asserted-by":"crossref","first-page":"S445","DOI":"10.1093\/infdis\/jix131","article-title":"Multidrug-resistant candida: epidemiology, molecular mechanisms, and treatment","volume":"216","author":"Arendrup","year":"2017","journal-title":"J. Infectious Diseases"},{"key":"10.1016\/j.micres.2021.126725_bib0015","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1462-5822.2005.00676.x","article-title":"Niche\u2010specific regulation of central metabolic pathways in a fungal pathogen","volume":"8","author":"Barelle","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0020","doi-asserted-by":"crossref","first-page":"ii13","DOI":"10.1093\/jac\/dkw392","article-title":"The current treatment landscape: candidiasis","volume":"71","author":"Bassetti","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micres.2021.126725_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006340","article-title":"Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression","volume":"13","author":"Beattie","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micres.2021.126725_bib0030","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nrg948","article-title":"Candida albicans: a molecular revolution built on lessons from budding yeast","volume":"3","author":"Berman","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.micres.2021.126725_bib0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1439-0434.2003.00807.x","article-title":"Germination and survival of fusarium graminearum macroconidia as affected by environmental factors","volume":"152","author":"Beyer","year":"2004","journal-title":"J. Phytopathol."},{"key":"10.1016\/j.micres.2021.126725_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and multi-national prevalence of fungal diseases\u2014estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J. Fungi"},{"key":"10.1016\/j.micres.2021.126725_bib0045","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1128\/EC.00186-06","article-title":"A glucose sensor in Candida albicans","volume":"5","author":"Brown","year":"2006","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.micres.2021.126725_bib0050","doi-asserted-by":"crossref","first-page":"165rv113","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.micres.2021.126725_bib0055","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.micinf.2011.05.009","article-title":"Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals","volume":"13","author":"Byrnes","year":"2011","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micres.2021.126725_bib0060","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1128\/EC.3.1.190-199.2004","article-title":"Candida albicans lacking the gene encoding the regulatory subunit of protein kinase a displays a defect in hyphal formation and an altered localization of the catalytic subunit","volume":"3","author":"Cassola","year":"2004","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.micres.2021.126725_bib0065","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1128\/CMR.00126-13","article-title":"Cryptococcus gattii infections","volume":"27","author":"Chen","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micres.2021.126725_bib0070","article-title":"Potential antifungal targets based on glucose metabolism pathways of Candida albicans","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0075","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.3390\/ijms20133172","article-title":"Physiologically relevant alternative carbon sources modulate biofilm formation, cell wall architecture, and the stress and antifungal resistance of Candida glabrata","volume":"20","author":"Chew","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micres.2021.126725_bib0080","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/jac\/dkt397","article-title":"Azole-resistant Aspergillus fumigatus with the environmental TR46\/Y121F\/T289A mutation in India","volume":"69","author":"Chowdhary","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micres.2021.126725_bib0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006290","article-title":"Candida auris: a rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally","volume":"13","author":"Chowdhary","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micres.2021.126725_bib0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40560-018-0342-4","article-title":"Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris","volume":"6","author":"Cortegiani","year":"2018","journal-title":"J. Intensive Care"},{"key":"10.1016\/j.micres.2021.126725_bib0095","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/jof3020022","article-title":"Fungal biofilms and polymicrobial diseases","volume":"3","author":"Costa-Orlandi","year":"2017","journal-title":"J. Fungi"},{"key":"10.1016\/j.micres.2021.126725_bib0100","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019752","article-title":"Mechanisms of antifungal drug resistance","volume":"5","author":"Cowen","year":"2015","journal-title":"Cold Spring Harbor Perspectives Med."},{"key":"10.1016\/j.micres.2021.126725_bib0105","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1128\/IAI.66.6.2713-2721.1998","article-title":"Roles of the candida albicansMitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis","volume":"66","author":"Csank","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micres.2021.126725_bib0110","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/CMR.00055-08","article-title":"Pathogenesis of aspergillus fumigatus in invasive aspergillosis","volume":"22","author":"Dagenais","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"issue":"2\u20133","key":"10.1016\/j.micres.2021.126725_bib0115","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.funeco.2008.09.001","article-title":"Utilisation of plant cell-wall polysaccharides and organic phosphorus substrates by isolates of aspergillus and penicillium isolated from soil","volume":"1","author":"Daynes","year":"2008","journal-title":"Fungal Ecol."},{"key":"10.1016\/j.micres.2021.126725_bib0120","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1039\/C2MB25512J","article-title":"Yeast cells with impaired drug resistance accumulate glycerol and glucose","volume":"10","author":"Dikicioglu","year":"2014","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.micres.2021.126725_bib0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081412","article-title":"Identification of glucose transporters in aspergillus nidulans","volume":"8","author":"Dos Reis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.micres.2021.126725_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13068-016-0611-1","article-title":"Identification and characterization of putative xylose and cellobiose transporters in Aspergillus nidulans","volume":"9","author":"Dos Reis","year":"2016","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.micres.2021.126725_bib0135","doi-asserted-by":"crossref","first-page":"45073","DOI":"10.1038\/srep45073","article-title":"The low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans","volume":"7","author":"Dos Reis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micres.2021.126725_bib0140","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/j.1462-5822.2012.01813.x","article-title":"Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen","volume":"14","author":"Ene","year":"2012","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0145","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019695","article-title":"Metabolism in fungal pathogenesis","volume":"4","author":"Ene","year":"2014","journal-title":"Cold Spring Harbor perspectives Med."},{"key":"10.1016\/j.micres.2021.126725_bib0150","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00239-002-2330-4","article-title":"Identification and phylogenetic analysis of a glucose transporter gene family from the human pathogenic yeast candida albicans","volume":"55","author":"Fan","year":"2002","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.micres.2021.126725_bib0155","first-page":"296","article-title":"Weight loss and diabetes are new risk factors for the development of invasive aspergillosis infection in non-immunocompromized humans","volume":"14","author":"Ghanaat","year":"2017","journal-title":"Clin. practice (London, England)"},{"key":"10.1016\/j.micres.2021.126725_bib0160","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrmicro2711","article-title":"Candida albicans morphogenesis and host defence: discriminating invasion from colonization","volume":"10","author":"Gow","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0165","doi-asserted-by":"crossref","first-page":"6924","DOI":"10.1128\/AEM.02061-13","article-title":"Structural features of sugars that trigger or support conidial germination in the filamentous fungus aspergillus niger","volume":"79","author":"Hayer","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0170","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1099\/mic.0.2007\/007641-0","article-title":"Aspergillus flavus: human pathogen, allergen and mycotoxin producer","volume":"153","author":"Hedayati","year":"2007","journal-title":"Microbiology"},{"key":"10.1016\/j.micres.2021.126725_bib0175","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/infdis\/jis473","article-title":"Aspergillus nidulans and chronic granulomatous disease: a unique host\u2013pathogen interaction","volume":"206","author":"Henriet","year":"2012","journal-title":"J. Infectious Diseases"},{"key":"10.1016\/j.micres.2021.126725_bib0180","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1099\/mic.0.27121-0","article-title":"Identification of the dialysable serum inducer of germ-tube formation in Candida albicans","volume":"150","author":"Hudson","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.micres.2021.126725_bib0185","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.archoralbio.2004.04.011","article-title":"Biofilm formation of Candida albicans is variably affected by saliva and dietary sugars","volume":"49","author":"Jin","year":"2004","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.micres.2021.126725_bib0190","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1099\/jmm.0.05060-0","article-title":"Binding of Candida albicans enolase to plasmin (ogen) results in enhanced invasion of human brain microvascular endothelial cells","volume":"52","author":"Jong","year":"2013","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0195","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/mmy\/myx082","article-title":"Deletion of Aspergillus nidulans GDP-mannose transporters affects hyphal morphometry, cell wall architecture, spore surface character, cell adhesion, and biofilm formation","volume":"56","author":"Kadry","year":"2018","journal-title":"Med. Mycol."},{"key":"10.1016\/j.micres.2021.126725_bib0200","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1016\/j.bmc.2012.04.045","article-title":"The biology and chemistry of antifungal agents: a review","volume":"20","author":"Kathiravan","year":"2012","journal-title":"Bioorganic Med. Chem."},{"key":"10.1016\/j.micres.2021.126725_bib0205","doi-asserted-by":"crossref","first-page":"fov068","DOI":"10.1093\/femsyr\/fov068","article-title":"Glucose repression in saccharomyces cerevisiae","volume":"15","author":"Kayikci","year":"2015","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.micres.2021.126725_bib0210","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1378\/chest.08-2859","article-title":"Trends in hospitalizations for AIDS-associated pneumocystis jirovecii pneumonia in the United States (1986 to 2005)","volume":"136","author":"Kelley","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.micres.2021.126725_bib0215","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12275-013-2577-z","article-title":"Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence","volume":"51","author":"Ko","year":"2013","journal-title":"J. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0220","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019273","article-title":"The spectrum of fungi that infects humans","volume":"5","author":"K\u00f6hler","year":"2015","journal-title":"Cold Spring Harbor Perspectives Med."},{"key":"10.1016\/j.micres.2021.126725_bib0225","doi-asserted-by":"crossref","first-page":"S431","DOI":"10.1093\/infdis\/jix179","article-title":"Antifungal resistance: an emerging reality and a global challenge","volume":"216","author":"Kontoyiannis","year":"2017","journal-title":"J. Infectious Diseases"},{"key":"10.1016\/j.micres.2021.126725_bib0230","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/genes9090461","article-title":"Evolutionary emergence of drug resistance in Candida opportunistic pathogens","volume":"9","author":"Ksiezopolska","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.micres.2021.126725_bib0235","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/microorganisms5020032","article-title":"Interaction of Candida species with the skin","volume":"5","author":"K\u00fchbacher","year":"2017","journal-title":"Microorganisms"},{"key":"10.1016\/j.micres.2021.126725_bib0240","first-page":"794","article-title":"Invasive candidiasis","volume":"374","author":"Kullberg","year":"2016","journal-title":"The New England journal of medicine"},{"key":"10.1016\/j.micres.2021.126725_bib0245","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1567-1364.2006.00088.x","article-title":"Do major species concepts support one, two or more species within Cryptococcus neoformans?","volume":"6","author":"Kwon-Chung","year":"2006","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.micres.2021.126725_bib0250","doi-asserted-by":"crossref","first-page":"804","DOI":"10.2307\/1555045","article-title":"(1557) Proposal to conserve the name Cryptococcus gattii against C. hondurianus and C. bacillisporus (Basidiomycota, Hymenomycetes, Tremellomycetidae)","volume":"51","author":"Kwon-Chung","year":"2002","journal-title":"Taxon"},{"key":"10.1016\/j.micres.2021.126725_bib0255","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019760","article-title":"Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis","volume":"4","author":"Kwon-Chung","year":"2014","journal-title":"Cold Spring Harbor Perspectives Med."},{"key":"10.1016\/j.micres.2021.126725_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008582","article-title":"Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality","volume":"16","author":"Lagree","year":"2020","journal-title":"PLos Genet."},{"key":"10.1016\/j.micres.2021.126725_bib0265","doi-asserted-by":"crossref","first-page":"13217","DOI":"10.1073\/pnas.93.23.13217","article-title":"Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus candida albicans","volume":"93","author":"Leberer","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.micres.2021.126725_bib0270","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1046\/j.1365-2958.2001.02672.x","article-title":"Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus candida albicans","volume":"42","author":"Leberer","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0275","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1128\/EC.00242-12","article-title":"Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases","volume":"11","author":"Lee","year":"2012","journal-title":"Eukaryotic cell"},{"key":"10.1016\/j.micres.2021.126725_bib0280","article-title":"The glucose sensor-like protein Hxs1 is a high-affinity glucose transporter and required for virulence in Cryptococcus neoformans","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.micres.2021.126725_bib0285","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1101\/gad.856001","article-title":"Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans","volume":"15","author":"Luberto","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.micres.2021.126725_bib0290","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1172\/JCI18309","article-title":"Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans","volume":"112","author":"Luberto","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.micres.2021.126725_bib0295","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1091\/mbc.e04-09-0780","article-title":"The G protein-coupled receptor Gpr1 and the G\u03b1 protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans","volume":"16","author":"Maidan","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.micres.2021.126725_bib0300","doi-asserted-by":"crossref","first-page":"25468","DOI":"10.1074\/jbc.C114.571778","article-title":"Glucose directly promotes antifungal resistance in the fungal pathogen, Candida spp","volume":"289","author":"Mandal","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micres.2021.126725_bib0305","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12281-010-0035-5","article-title":"Fungal biofilms: relevance in the setting of human disease","volume":"4","author":"Martinez","year":"2010","journal-title":"Curr. Fungal Infection Rep."},{"key":"10.1016\/j.micres.2021.126725_bib0310","first-page":"179","article-title":"Cryptococcosis","volume":"30","author":"Maziarz","year":"2016","journal-title":"Infectious Disease Clinics"},{"key":"10.1016\/j.micres.2021.126725_bib0315","series-title":"Candidemia in Intensive Care Unit: a Nationwide Prospective Observational Survey (GISIA-3 Study) and Review of the European Literature from 2000 Through","first-page":"2013","author":"Montagna","year":"2014"},{"key":"10.1016\/j.micres.2021.126725_bib0320","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3201\/eid2301.161497","article-title":"Invasive infections with multidrug-resistant yeast Candida auris, Colombia","volume":"23","author":"Morales-L\u00f3pez","year":"2017","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/j.micres.2021.126725_bib0325","series-title":"Resistance of Candida glabrata to Drugs and the Host Immune System","author":"Musa","year":"2018"},{"key":"10.1016\/j.micres.2021.126725_bib0330","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/14787210.2017.1364992","article-title":"Candida auris: a worrisome, globally emerging pathogen","volume":"15","author":"Navalkele","year":"2017","journal-title":"Expert Rev. Anti-Infective Therapy"},{"key":"10.1016\/j.micres.2021.126725_bib0335","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.meegid.2015.09.004","article-title":"Growth, biofilm formation, antifungal susceptibility and oxidative stress resistance of Candida glabrata are affected by different glucose concentrations","volume":"40","author":"Ng","year":"2016","journal-title":"Infection Genetics Evolution"},{"key":"10.1016\/j.micres.2021.126725_bib0340","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1128\/IAI.00565-09","article-title":"The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii","volume":"177","author":"Ngamskulrungroj","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micres.2021.126725_bib0345","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00294-009-0268-4","article-title":"Biology and genetics of the pathogenic yeast Candida parapsilosis","volume":"55","author":"Nosek","year":"2009","journal-title":"Curr. Genet."},{"key":"10.1016\/j.micres.2021.126725_bib0350","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0966-842X(03)00117-3","article-title":"Antifungal agents: mechanisms of action","volume":"11","author":"Odds","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0355","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/genetics\/155.2.647","article-title":"Conidial germination in Aspergillus nidulans requires RAS signaling and protein synthesis","volume":"155","author":"Osherov","year":"2000","journal-title":"Genetics"},{"key":"10.1016\/j.micres.2021.126725_bib0360","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1128\/MMBR.63.3.554-569.1999","article-title":"Function and regulation of yeast hexose transporters","volume":"63","author":"\u00d6zcan","year":"1999","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.micres.2021.126725_bib0365","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1016\/j.biortech.2008.01.017","article-title":"Fermentation characteristics of Fusariumoxysporum grown on acetate","volume":"99","author":"Panagiotou","year":"2008","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.micres.2021.126725_bib0370","first-page":"1","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Disease Primers"},{"key":"10.1016\/j.micres.2021.126725_bib0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110550","article-title":"Immune defence to invasive fungal infections: a comprehensive review","volume":"130","author":"Pathakumari","year":"2020","journal-title":"Biomed. Pharmacotherapy"},{"key":"10.1016\/j.micres.2021.126725_bib0380","doi-asserted-by":"crossref","first-page":"63","DOI":"10.15698\/mic2018.02.612","article-title":"Ras signalling in pathogenic yeasts","volume":"5","author":"Pentland","year":"2018","journal-title":"Microbial Cell"},{"key":"10.1016\/j.micres.2021.126725_bib0385","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1099\/jmm.0.018309-0","article-title":"Aspergillus niger: an unusual cause of invasive pulmonary aspergillosis","volume":"59","author":"Person","year":"2010","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0390","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1128\/IAI.00624-06","article-title":"Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans","volume":"74","author":"Petzold","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micres.2021.126725_bib0395","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijantimicag.2011.02.016","article-title":"Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008\u20132009)","volume":"38","author":"Pfaller","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micres.2021.126725_bib0400","series-title":"Mechanisms of Drug Resistance in Fungi and Their Significance in Biofilms. In Antibiofilm Agents","first-page":"45","author":"Prasad","year":"2014"},{"key":"10.1016\/j.micres.2021.126725_bib0405","first-page":"2","article-title":"Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host","author":"Price","year":"2011","journal-title":"MBio"},{"key":"10.1016\/j.micres.2021.126725_bib0410","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jmb.2018.01.005","article-title":"Molecular basis of substrate polyspecificity of the Candida albicans Mdr1p multidrug\/H+ antiporter","volume":"430","author":"Redhu","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.micres.2021.126725_bib0415","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1534\/genetics.116.187872","article-title":"Diverse regulation of the CreA carbon catabolite repressor in Aspergillus nidulans","volume":"203","author":"Ries","year":"2016","journal-title":"Genetics"},{"key":"10.1016\/j.micres.2021.126725_bib0420","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1091\/mbc.e09-01-0002","article-title":"Glucose promotes stress resistance in the fungal pathogen Candida albicans","volume":"20","author":"Rodaki","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.micres.2021.126725_bib0425","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1128\/EC.00138-09","article-title":"Glucose sensing network in candida albicans: a sweet spot for fungal morphogenesis","volume":"8","author":"Sabina","year":"2009","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.micres.2021.126725_bib0430","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.simyco.2014.07.004","article-title":"Phylogeny, identification and nomenclature of the genus Aspergillus","volume":"78","author":"Samson","year":"2014","journal-title":"Studies Mycology"},{"key":"10.1016\/j.micres.2021.126725_bib0435","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbrc.2009.03.134","article-title":"On the biochemical classification of yeast trehalases: Candida albicans contains two enzymes with mixed features of neutral and acid trehalase activities","volume":"383","author":"S\u00e1nchez-Fresneda","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.micres.2021.126725_bib0440","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1128\/EC.1.6.865-874.2002","article-title":"Gpa2, a G-protein \u03b1 subunit required for hyphal development in Candida albicans","volume":"1","author":"S\u00e1nchez-Mart\u00ednez","year":"2002","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.micres.2021.126725_bib0445","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/myc.12330","article-title":"Antifungal drug resistance among Candida species: mechanisms and clinical impact","volume":"58","author":"Sanguinetti","year":"2015","journal-title":"Mycoses"},{"key":"10.1016\/j.micres.2021.126725_bib0450","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2016.14281","article-title":"Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia","volume":"146","author":"Schmiedel","year":"2016","journal-title":"Swiss medical weekly"},{"key":"10.1016\/j.micres.2021.126725_bib0455","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/yea.1514","article-title":"Regulation of sugar transport and metabolism by the Candida albicans Rgt1 transcriptional repressor","volume":"24","author":"Sexton","year":"2007","journal-title":"Yeast"},{"key":"10.1016\/j.micres.2021.126725_bib0460","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/mmy\/myv067","article-title":"Aspergillus and aspergilloses in wild and domestic animals: a global health concern with parallels to human disease","volume":"53","author":"Seyedmousavi","year":"2015","journal-title":"Med. Mycol."},{"key":"10.1016\/j.micres.2021.126725_bib0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep11211","article-title":"Mutational analysis of intracellular loops identify cross talk with nucleotide binding domains of yeast ABC transporter Cdr1p","volume":"5","author":"Shah","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micres.2021.126725_bib0470","series-title":"Is Pulmonary Aspergillosis Common in Diabetes Mellitus Patients?","author":"Shahnazi","year":"2010"},{"key":"10.1016\/j.micres.2021.126725_bib0475","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/21501203.2019.1574927","article-title":"Resistance mechanism and proteins in Aspergillus species against antifungal agents","volume":"10","author":"Shishodia","year":"2019","journal-title":"Mycology"},{"key":"10.1016\/j.micres.2021.126725_bib0480","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fimmu.2019.00066","article-title":"Resistance and tolerance to cryptococcal infection: an intricate balance that controls the development of disease","volume":"10","author":"Shourian","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micres.2021.126725_bib0485","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/jof3010008","article-title":"Candida species biofilms\u2019 antifungal resistance","volume":"3","author":"Silva","year":"2017","journal-title":"J. Fungi"},{"key":"10.1016\/j.micres.2021.126725_bib0490","first-page":"56","article-title":"Candida auris: an emerging fungal pathogen","author":"Spivak","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0495","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1101\/gr.80202","article-title":"Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans","volume":"12","author":"Steen","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/j.micres.2021.126725_bib0500","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1139\/cjm-2017-0749","article-title":"The pathogenicity of Aspergillus fumigatus, drug resistance, and nanoparticle delivery","volume":"64","author":"Szalewski","year":"2018","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0505","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fmicb.2015.00429","article-title":"Cytokines induce effector T-helper cells during invasive aspergillosis; What we have learned about T-helper cells?","volume":"6","author":"Thakur","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0510","series-title":"Evaluation of Proteins Involved in Germination of Toxigenic Aspergillus flavus Conidia and Studies on Phytochemicals as Anti-Aflatoxigenic Agents","author":"Tiwari","year":"2018"},{"key":"10.1016\/j.micres.2021.126725_bib0515","first-page":"32","article-title":"Candida parapsilosis: from genes to the bedside","author":"T\u00f3th","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micres.2021.126725_bib0520","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/CMR.00013-08","article-title":"Candida parapsilosis, an emerging fungal pathogen","volume":"21","author":"Trofa","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micres.2021.126725_bib0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2018.03.019","article-title":"Glucose homeostasis is important for immune cell viability during Candida challenge and host survival of systemic fungal infection","volume":"27","author":"Tucey","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.micres.2021.126725_bib0530","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fmicb.2019.00099","article-title":"Sugar sensing and Signaling in Candida albicans and Candida glabrata","volume":"10","author":"Van Ende","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micres.2021.126725_bib0535","article-title":"Antifungal resistance and new strategies to control fungal infections","volume":"2012","author":"Vandeputte","year":"2012","journal-title":"Int. J. Microbial."},{"key":"10.1016\/j.micres.2021.126725_bib0540","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1574-6968.2000.tb08866.x","article-title":"Molecular cloning and functional characterisation of a glucose transporter, CaHGT1, of Candida albicans","volume":"182","author":"Varma","year":"2000","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micres.2021.126725_bib0545","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.drup.2015.08.001","article-title":"International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus","volume":"21","author":"Verweij","year":"2015","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.micres.2021.126725_bib0550","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1099\/13500872-141-8-1829","article-title":"Unusual effect of myo-inositol on phospholipid biosynthesis in Cryptococcus neoformans","volume":"141","author":"Vincent","year":"1995","journal-title":"Microbiology"},{"key":"10.1016\/j.micres.2021.126725_bib0555","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1128\/EC.00039-10","article-title":"Cryptococcal interactions with the host immune system","volume":"9","author":"Voelz","year":"2010","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.micres.2021.126725_bib0560","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/EC.00252-10","article-title":"Role of glucose in the expression of Cryptococcus neoformans antiphagocytic protein 1","volume":"10","author":"Williams","year":"2011","journal-title":"App1. Eukaryotic Cell"},{"key":"10.1016\/j.micres.2021.126725_bib0565","first-page":"567","article-title":"Reassessment of the effect of glucagon and nucleotides on Candida albicans germ tube formation","volume":"42","author":"Zelada","year":"1996","journal-title":"Cell. Mol. Biol. (Noisy-le-Grand, France)"},{"key":"10.1016\/j.micres.2021.126725_bib0570","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-4889(01)00168-9","article-title":"Interactions between regulatory and catalytic subunits of the Candida albicans cAMP-dependent protein kinase are modulated by autophosphorylation of the regulatory subunit","volume":"1542","author":"Zelada","year":"2002","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Cell Research"},{"key":"10.1016\/j.micres.2021.126725_bib0575","series-title":"Cryptococcal Phosphoglucose Isomerase Is Required for Virulence Factor Production, Cell Wall Integrity, and Stress Resistance","author":"Zhang","year":"2015"}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501321000318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501321000318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:52:45Z","timestamp":1760550765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501321000318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":115,"alternative-id":["S0944501321000318"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2021.126725","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucose - The X factor for the survival of human fungal pathogens and disease progression in the host","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2021.126725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"126725"}}