{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:02:12Z","timestamp":1781841732374,"version":"3.54.5"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.micres.2024.127983","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T03:58:57Z","timestamp":1732593537000},"page":"127983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Structural insights into the advancements of mobile colistin resistance enzymes"],"prefix":"10.1016","volume":"291","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.micres.2024.127983_bib1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/antibiotics12071117","article-title":"Mobile colistin resistance (mcr) gene-containing organisms in poultry sector in low-and middle-income countries: epidemiology, characteristics, and one health control strategies","volume":"12","author":"Anyanwu","year":"2023","journal-title":"Antibiotics"},{"issue":"4","key":"10.1016\/j.micres.2024.127983_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00540-17","article-title":"Polymyxin combinations combat Escherichia coli harboring mcr-1 and blaNDM-5: preparation for a postantibiotic era","volume":"8","author":"Bulman","year":"2017","journal-title":"Mbio"},{"issue":"6","key":"10.1016\/j.micres.2024.127983_bib3","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s41564-023-01369-z","article-title":"Inhibiting fatty acid synthesis overcomes colistin resistance","volume":"8","author":"Carfrae","year":"2023","journal-title":"Nat. Microbiol."},{"issue":"3","key":"10.1016\/j.micres.2024.127983_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00853-19","article-title":"Identification of novel mobilized colistin resistance gene mcr-9 in a multidrug-resistant, colistin-susceptible Salmonella enterica Serotype Typhimurium isolate","volume":"10","author":"Carroll","year":"2019","journal-title":"Mbio"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s42004-024-01129-y","article-title":"A unified view on enzyme catalysis by cryo-EM study of a DNA topoisomerase","volume":"7","author":"Chang","year":"2024","journal-title":"Commun. Chem."},{"key":"10.1016\/j.micres.2024.127983_bib6","doi-asserted-by":"crossref","first-page":"1153740","DOI":"10.3389\/fmicb.2023.1153740","article-title":"Characterization of two novel colistin resistance gene mcr-1 variants originated from Moraxella spp","volume":"14","author":"Che","year":"2023","journal-title":"Front. Microbiol."},{"issue":"5","key":"10.1016\/j.micres.2024.127983_bib7","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300215R","article-title":"EptA of Riemerella anatipestifer mediates phenotypes involved in colistin resistance and virulence","volume":"37","author":"Chen","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.micres.2024.127983_bib8","series-title":"Metals in Medicine","author":"Dabrowiak","year":"2017"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib9","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1080\/22221751.2020.1754133","article-title":"Colistin and its role in the era of antibiotic resistance: an extended review (2000-2019)","volume":"9","author":"El-Sayed Ahmed","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.micres.2024.127983_bib10","unstructured":"EUCAST. The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Clinical breakpoints for bacteria (v 14.0) 2024."},{"issue":"3","key":"10.1016\/j.micres.2024.127983_bib11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S1473-3099(16)00009-8","article-title":"Colistin resistance gene mcr-1 in extended-spectrum \u03b2-lactamase-producing and carbapenemase-producing gram-negative bacteria in Germany","volume":"16","author":"Falgenhauer","year":"2016","journal-title":"Lancet Infect. Dis."},{"issue":"3","key":"10.1016\/j.micres.2024.127983_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03592-22","article-title":"A single residue within the MCR-1 protein confers anticipatory resilience","volume":"11","author":"Frantz","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"36","key":"10.1016\/j.micres.2024.127983_bib13","doi-asserted-by":"crossref","first-page":"17906","DOI":"10.1073\/pnas.1906958116","article-title":"Horizontal gene transfer overrides mutation in Escherichia coli colonizing the mammalian gut","volume":"116","author":"Fraz\u00e3o","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micres.2024.127983_bib14","doi-asserted-by":"crossref","first-page":"1060519","DOI":"10.3389\/fcimb.2023.1060519","article-title":"More than mcr: canonical plasmid-and transposon-encoded mobilized colistin resistance genes represent a subset of phosphoethanolamine transferases","volume":"13","author":"Gaballa","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.micres.2024.127983_bib15","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/molecules24030653","article-title":"Molecular mechanisms of colistin-induced nephrotoxicity","volume":"24","author":"Gai","year":"2019","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.micres.2024.127983_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005957","article-title":"Dissemination and mechanism for the MCR-1 colistin resistance","volume":"12","author":"Gao","year":"2016","journal-title":"PLOS Pathog."},{"issue":"9","key":"10.1016\/j.micres.2024.127983_bib17","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1093\/jac\/dkaa200","article-title":"A novel colistin adjuvant identified by virtual screening for ArnT inhibitors","volume":"75","author":"Ghirga","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.drudis.2019.07.013","article-title":"Understanding the variability of the S1\u2032 pocket to improve matrix metalloproteinase inhibitor selectivity profiles","volume":"25","author":"Gimeno","year":"2020","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.micres.2024.127983_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.677720","article-title":"Current update on intrinsic and acquired colistin resistance mechanisms in bacteria","volume":"8","author":"Gogry","year":"2021","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/applmicrobiol4010005","article-title":"Occurrence of mobile colistin resistance genes mcr-1\u2013mcr-10 including novel mcr gene variants in different pathotypes of porcine Escherichia coli isolates collected in Germany from 2000 to 2021.","volume":"4","author":"G\u00f6pel","year":"2023","journal-title":"Appl. Microbiol."},{"issue":"6","key":"10.1016\/j.micres.2024.127983_bib21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tim.2008.03.007","article-title":"The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more","volume":"16","author":"Gunn","year":"2008","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micres.2024.127983_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101088","article-title":"Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively","volume":"75","author":"Guo","year":"2024","journal-title":"Drug Resist"},{"key":"10.1016\/j.micres.2024.127983_bib23","doi-asserted-by":"crossref","unstructured":"Guo, Z., Feng, S., Liang, L., Li, J., Zhong, L.-L., Zhao, H., G-b, Tian, Yang, J.-R., 2022. The fitness landscape of the mobilized colistin resistance gene;mcr-1. bioRxiv.","DOI":"10.1101\/2022.07.21.500813"},{"issue":"6","key":"10.1016\/j.micres.2024.127983_bib24","article-title":"Investigation of plasmid-mediated colistin resistance genes (mcr-1\u20138) in Enterobacterales isolates","volume":"16","author":"G\u00fcrb\u00fcz","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.micres.2024.127983_bib25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2306\/scienceasia1513-1874.2022.152","article-title":"Prediction of substrate binding on mobile colistin resistance using in silico approach","volume":"49","author":"Hanpaibool","year":"2022","journal-title":"ScienceAsia"},{"issue":"9","key":"10.1016\/j.micres.2024.127983_bib26","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.1021\/acsomega.2c07165","article-title":"Pyrazolones potentiate colistin activity against MCR-1-producing resistant bacteria: computational and microbiological study","volume":"8","author":"Hanpaibool","year":"2023","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib27","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1038\/s41598-024-67838-5","article-title":"Genomic analysis of carbapenem-and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand","volume":"14","author":"Hatrongjit","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micres.2024.127983_bib28","doi-asserted-by":"crossref","first-page":"39392","DOI":"10.1038\/srep39392","article-title":"Insights into the mechanistic basis of plasmid-mediated colistin resistance from crystal structures of the catalytic domain of MCR-1","volume":"7","author":"Hinchliffe","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib29","doi-asserted-by":"crossref","first-page":"38793","DOI":"10.1038\/srep38793","article-title":"Crystal structure of Escherichia coli originated MCR-1, a phosphoethanolamine transferase for colistin resistance","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micres.2024.127983_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154886","article-title":"Gigantol restores the sensitivity of mcr carrying multidrug-resistant bacteria to colistin","volume":"117","author":"Huang","year":"2023","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.micres.2024.127983_bib31","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ijantimicag.2016.11.029","article-title":"Resistance to polymyxins in gram-negative organisms","volume":"49","author":"Jeannot","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"7873","key":"10.1016\/j.micres.2024.127983_bib32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with alphafold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.micres.2024.127983_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2021.106418","article-title":"Distribution of mcr genes among carbapenem-resistant Enterobacterales clinical isolates: high prevalence of mcr-positive Enterobacter cloacae complex in Seoul, Republic of Korea","volume":"58","author":"Kim","year":"2021","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"7","key":"10.1016\/j.micres.2024.127983_bib34","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/s41592-024-02304-8","article-title":"Data-driven regularization lowers the size barrier of cryo-EM structure determination","volume":"21","author":"Kimanius","year":"2024","journal-title":"Nat. Methods"},{"issue":"15","key":"10.1016\/j.micres.2024.127983_bib35","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.3390\/molecules24152719","article-title":"Design, synthesis and biological evaluation of 1-phenyl-2-(phenylamino) ethanone derivatives as novel MCR-1 inhibitors","volume":"24","author":"Lan","year":"2019","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/s12866-023-03118-y","article-title":"Phenotypic and genotypic characterization of colistin-resistant Escherichia coli with mcr-4, mcr-5, mcr-6, and mcr-9 genes from broiler chicken and farm environment","volume":"23","author":"Lemlem","year":"2023","journal-title":"BMC Microbiol."},{"issue":"12","key":"10.1016\/j.micres.2024.127983_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002433","article-title":"A new variant of the colistin resistance gene MCR-1 with co-resistance to \u03b2-lactam antibiotics reveals a potential novel antimicrobial peptide","volume":"21","author":"Liang","year":"2023","journal-title":"PLOS Biol."},{"issue":"11","key":"10.1016\/j.micres.2024.127983_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01272-17","article-title":"Chromosome-mediated mcr-3 variants in Aeromonas veronii from chicken meat","volume":"61","author":"Ling","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micres.2024.127983_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.119516","article-title":"Global epidemiology and genetic diversity of mcr-positive Klebsiella pneumoniae: a systematic review and genomic analysis","volume":"259","author":"Liu","year":"2024","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.micres.2024.127983_bib40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect. Dis."},{"issue":"4","key":"10.1016\/j.micres.2024.127983_bib41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/cryst8040172","article-title":"Crystal structure of the catalytic domain of MCR-1 (cMCR-1) in complex with d-xylose","volume":"8","author":"Liu","year":"2018","journal-title":"Crystals"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib42","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41467-017-01532-1","article-title":"Persistence and reversal of plasmid-mediated antibiotic resistance","volume":"8","author":"Lopatkin","year":"2017","journal-title":"Nat. Commun."},{"issue":"50","key":"10.1016\/j.micres.2024.127983_bib43","doi-asserted-by":"crossref","first-page":"6874","DOI":"10.1039\/D0CC02520H","article-title":"Resistance to the \u201clast resort\u201d antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes","volume":"56","author":"Lythell","year":"2020","journal-title":"Chem. Comm."},{"key":"10.1016\/j.micres.2024.127983_bib44","doi-asserted-by":"crossref","first-page":"39540","DOI":"10.1038\/srep39540","article-title":"High resolution crystal structure of the catalytic domain of MCR-1","volume":"6","author":"Ma","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.micres.2024.127983_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294820","article-title":"New insights on mcr-1-harboring plasmids from human clinical Escherichia coli isolates","volume":"19","author":"Martino","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.micres.2024.127983_bib46","article-title":"Structural biology of MCR-1-mediated resistance to polymyxin antibiotics","volume":"82","author":"Materon ICPalzkill","year":"2023","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"4","key":"10.1016\/j.micres.2024.127983_bib47","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3390\/microorganisms12040772","article-title":"A review on colistin resistance: an antibiotic of last resort","volume":"12","author":"Mondal","year":"2024","journal-title":"Microorganisms"},{"issue":"3","key":"10.1016\/j.micres.2024.127983_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105903","article-title":"KPC-2-producing Klebsiella pneumoniae ST147 in a neonatal unit: clonal isolates with differences in colistin susceptibility attributed to AcrAB-TolC pump","volume":"55","author":"Naha","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"6","key":"10.1016\/j.micres.2024.127983_bib49","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/QCO.0b013e328332e672","article-title":"Colistin in the 21st century","volume":"22","author":"Nation","year":"2009","journal-title":"Curr. Opin. Infect. Dis."},{"issue":"11","key":"10.1016\/j.micres.2024.127983_bib50","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1038\/s41396-023-01509-7","article-title":"Regulatory fine-tuning of mcr-1 increases bacterial fitness and stabilises antibiotic resistance in agricultural settings","volume":"17","author":"Ogunlana","year":"2023","journal-title":"ISME J."},{"key":"10.1016\/j.micres.2024.127983_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2014.00643","article-title":"Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria","volume":"5","author":"Olaitan","year":"2014","journal-title":"Front. Microbiol."},{"issue":"10","key":"10.1016\/j.micres.2024.127983_bib52","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1093\/jac\/dky262","article-title":"Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes","volume":"73","author":"Partridge","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"issue":"6273","key":"10.1016\/j.micres.2024.127983_bib53","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.aad1172","article-title":"Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation","volume":"351","author":"Petrou","year":"2016","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.micres.2024.127983_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005721","article-title":"Origins of de novo genes in human and chimpanzee","volume":"11","author":"Ruiz-Orera","year":"2016","journal-title":"PLoS Genet"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib55","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1016\/S2666-5247(20)30005-7","article-title":"Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing-based molecular epidemiological study","volume":"1","author":"Shen","year":"2020","journal-title":"Lancet Microbe"},{"issue":"5","key":"10.1016\/j.micres.2024.127983_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00609-23","article-title":"Plasmid-mediated colistin resistance from fresh meat and slaughtered animals in the Czech Republic: nation-wide surveillance 2020\u20132021","volume":"11","author":"Sismova","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib57","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12879-024-09314-z","article-title":"A challenging case of carbapenem resistant Klebsiella pneumoniae related pyogenic liver abscess with capsular polysaccharide hyperproduction: a case report","volume":"24","author":"Sohrabi","year":"2024","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib58","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.drudis.2018.07.004","article-title":"MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance","volume":"24","author":"Son","year":"2019","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib59","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12915-016-0303-0","article-title":"Structure of the catalytic domain of the colistin resistance enzyme MCR-1","volume":"14","author":"Stojanoski","year":"2016","journal-title":"BMC Biol."},{"issue":"17","key":"10.1016\/j.micres.2024.127983_bib60","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1039\/D0OB02566F","article-title":"Catalytic mechanism of the colistin resistance protein MCR-1. Ori","volume":"19","author":"Suard\u00edaz","year":"2021","journal-title":"Biomol. Chem."},{"key":"10.1016\/j.micres.2024.127983_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.02154","article-title":"Pull in and push out: mechanisms of horizontal gene transfer in bacteria","volume":"9","author":"Sun","year":"2018","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib62","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1038\/s41467-020-18939-y","article-title":"Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.micres.2024.127983_bib63","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1128\/mBio.00625-17","article-title":"Deciphering MCR-2 colistin resistance","volume":"8","author":"Sun","year":"2017","journal-title":"Mbio"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib64","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41592-023-02087-4","article-title":"AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination","volume":"21","author":"Terwilliger","year":"2024","journal-title":"Nat. Methods"},{"issue":"7","key":"10.1016\/j.micres.2024.127983_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180347","article-title":"Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada","volume":"12","author":"Tijet","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.micres.2024.127983_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118136","article-title":"Emergence of colistin resistance genes (mcr-1) in Escherichia coli among widely distributed wild ungulates","volume":"291","author":"Torres","year":"2021","journal-title":"Environ. Pollut."},{"issue":"11","key":"10.1016\/j.micres.2024.127983_bib67","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1007\/s11427-018-9363-4","article-title":"Structural and functional insights into MCR-2 mediated colistin resistance","volume":"61","author":"Wang","year":"2018","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.micres.2024.127983_bib68","article-title":"Emergence of colistin resistance gene mcr-8 and its variant in Raoultella ornithinolytica","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micres.2024.127983_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13756-018-0303-7","article-title":"Synergistic effect of eugenol with colistin against clinical isolated colistin-resistant Escherichia coli strains","volume":"7","author":"Wang","year":"2018","journal-title":"Antimicrob. Resist. Infect. Control"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib70","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1038\/s41467-024-48352-8","article-title":"The evolution of antibiotic resistance islands occurs within the framework of plasmid lineages","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micres.2024.127983_bib71","doi-asserted-by":"crossref","first-page":"1122532","DOI":"10.3389\/fcimb.2023.1122532","article-title":"Emergence of high-level colistin resistance mediated by multiple determinants, including mcr-1.1, mcr-8.2 and crrB mutations, combined with tigecycline resistance in an ST656 Klebsiella pneumoniae","volume":"13","author":"Wang","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"18","key":"10.1016\/j.micres.2024.127983_bib72","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1016\/j.jmb.2013.06.029","article-title":"The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin","volume":"425","author":"Wanty","year":"2013","journal-title":"J. Mol. Biol."},{"issue":"2","key":"10.1016\/j.micres.2024.127983_bib73","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1096\/fj.201700705R","article-title":"Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance","volume":"32","author":"Wei","year":"2018","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.micres.2024.127983_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007389","article-title":"Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis","volume":"14","author":"Wei","year":"2018","journal-title":"PLoS Genet"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib75","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jmb.2010.04.057","article-title":"Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase","volume":"400","author":"Wende","year":"2010","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.micres.2024.127983_bib76","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00501-18","article-title":"Colocation of the polymyxin resistance gene mcr-1 and a variant of mcr-3 on a plasmid in an Escherichia coli isolate from a chicken farm","volume":"62","author":"Xiang","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"issue":"12","key":"10.1016\/j.micres.2024.127983_bib77","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1111\/1462-2920.15425","article-title":"Co-production of Tet (X) and MCR-1, two resistance enzymes by a single plasmid","volume":"23","author":"Xu","year":"2021","journal-title":"Environ. Microbiol."},{"issue":"12","key":"10.1016\/j.micres.2024.127983_bib78","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1074\/jbc.RA117.000924","article-title":"Mechanistic insights into transferable polymyxin resistance among gut bacteria","volume":"293","author":"Xu","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.micres.2024.127983_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109135","article-title":"The MCR-3 inside linker appears as a facilitator of colistin resistance","volume":"35","author":"Xu","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.micres.2024.127983_bib80","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ebiom.2018.07.027","article-title":"Spread of MCR-3 colistin resistance in China: an epidemiological, genomic and mechanistic study","volume":"34","author":"Xu","year":"2018","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.micres.2024.127983_bib81","doi-asserted-by":"crossref","first-page":"00117","DOI":"10.1128\/mSphere.00117-20","article-title":"High prevalence of colistin-resistant Escherichia coli with chromosomally carried mcr-1 in healthy residents in Vietnam","volume":"5","author":"Yamaguchi","year":"2020","journal-title":"Msphere"},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib82","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1038\/s41467-017-02149-0","article-title":"Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms","volume":"8","author":"Yang","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib83","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03833-22","article-title":"Distribution and transmission of colistin resistance genes mcr-1 and mcr-3 among nontyphoidal Salmonella isolates in China from 2011 to 2020","volume":"11","author":"Yang","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"5","key":"10.1016\/j.micres.2024.127983_bib84","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01204-16","article-title":"Colistin resistance gene mcr-1 and its variant in Escherichia coli isolates from chickens in China","volume":"61","author":"Yang","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.micres.2024.127983_bib85","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00543-17","article-title":"Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli","volume":"8","author":"Yin","year":"2017","journal-title":"Mbio"},{"issue":"8","key":"10.1016\/j.micres.2024.127983_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135198","article-title":"Polymyxin E induces rapid paenibacillus polymyxa death by damaging cell membrane while Ca2+ can protect cells from damage","volume":"10","author":"Yu","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.micres.2024.127983_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201900038","article-title":"Definition of a family of nonmobile colistin resistance (NMCR-1) determinants suggests aquatic reservoirs for MCR-4","volume":"6","author":"Zhang","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.micres.2024.127983_bib88","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-018-0278-1","article-title":"Action and mechanism of the colistin resistance enzyme MCR-4","volume":"2","author":"Zhang","year":"2019","journal-title":"Commun. Biol."},{"issue":"11","key":"10.1016\/j.micres.2024.127983_bib89","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201900034","article-title":"A genomic, evolutionary, and mechanistic study of MCR-5 action suggests functional unification across the MCR family of colistin resistance","volume":"6","author":"Zhang","year":"2019","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.micres.2024.127983_bib90","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13104-018-3255-3","article-title":"Molecular detection of colistin resistance genes (mcr-1 to mcr-5) in human vaginal swabs","volume":"11","author":"Zhang","year":"2018","journal-title":"BMC Res. Notes"},{"issue":"2","key":"10.1016\/j.micres.2024.127983_bib91","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00775-022-01983-y","article-title":"Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria","volume":"28","author":"Zhang","year":"2023","journal-title":"J. Biol. Inorg. Chem."},{"issue":"11","key":"10.1016\/j.micres.2024.127983_bib92","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2119417119","article-title":"Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver","volume":"119","author":"Zhang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micres.2024.127983_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfoodmicro.2023.110449","article-title":"High prevalence of multidrug-resistant Escherichia coli in retail aquatic products in China and the first report of mcr-1-positive extended-spectrum \u03b2-lactamase-producing E. coli ST2705 and ST10 in fish","volume":"408","author":"Zhang","year":"2024","journal-title":"Int. J. Food Microbiol."},{"issue":"2","key":"10.1016\/j.micres.2024.127983_bib94","doi-asserted-by":"crossref","DOI":"10.1093\/lambio\/ovad025","article-title":"Identification of a novel adjuvant loperamide that enhances the antibacterial activity of colistin against MCR-1-positive pathogens in vitro\/vivo","volume":"76","author":"Zhang","year":"2023","journal-title":"Lett. Appl. Microbiol."},{"issue":"4","key":"10.1016\/j.micres.2024.127983_bib95","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/febs.14719","article-title":"Structural and mechanistic insights into polymyxin resistance mediated by EptC originating from Escherichia coli","volume":"286","author":"Zhao","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.micres.2024.127983_bib96","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.3389\/fmicb.2019.02957","article-title":"Colistin combined with tigecycline: a promising alternative strategy to combat Escherichia coli harboring Bla NDM\u20135 and mcr-1","volume":"10","author":"Zhou","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micres.2024.127983_bib97","series-title":"Comprehensive Coordination Chemistry III","first-page":"680","article-title":"9.20 - Metal complexes as drugs and therapeutic agents","author":"Zhou","year":"2021"},{"issue":"3","key":"10.1016\/j.micres.2024.127983_bib98","doi-asserted-by":"crossref","first-page":"155a","DOI":"10.1016\/j.bpj.2023.11.1057","article-title":"Structural basis of MCR-1-mediated polymyxin resistance","volume":"123","author":"Zinkle","year":"2024","journal-title":"Biophys. J."}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501324003847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501324003847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:04:14Z","timestamp":1769915054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501324003847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":98,"alternative-id":["S0944501324003847"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2024.127983","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural insights into the advancements of mobile colistin resistance enzymes","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2024.127983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"127983"}}