{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:06:12Z","timestamp":1793462772967,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["CGZH2023000195"],"award-info":[{"award-number":["CGZH2023000195"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20240207010CX"],"award-info":[{"award-number":["20240207010CX"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016107","name":"Science and Technology Department of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["XZ202301ZY0011G"],"award-info":[{"award-number":["XZ202301ZY0011G"]}],"id":[{"id":"10.13039\/501100016107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20340"],"award-info":[{"award-number":["U22A20340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.micres.2024.128042","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T19:41:15Z","timestamp":1735069275000},"page":"128042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Targeting ClpP: Unlocking a novel therapeutic approach of isochlorogenic acid A for methicillin-resistant Staphylococcus aureus-infected osteomyelitis"],"prefix":"10.1016","volume":"292","author":[{"given":"Yueying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueshan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.micres.2024.128042_bib1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jsb.2012.05.003","article-title":"ClpP: a structurally dynamic protease regulated by AAA+\u2009proteins","volume":"179","author":"Alexopoulos","year":"2012","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.micres.2024.128042_bib2","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.2147\/IDR.S272733","article-title":"Methicillin-Resistant Staphylococcus aureus (MRSA): One Health Perspective Approach to the Bacterium Epidemiology, Virulence Factors, Antibiotic-Resistance, and Zoonotic Impact","volume":"13","author":"Algammal","year":"2020","journal-title":"Infect. Drug Resist"},{"issue":"47","key":"10.1016\/j.micres.2024.128042_bib3","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2109671118","article-title":"Staphylococcal ClpXP protease targets the cellular antioxidant system to eliminate fitness-compromised cells in stationary phase","volume":"118","author":"Alqarzaee","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.micres.2024.128042_bib4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jsps.2014.04.008","article-title":"Drug safety: The concept, inception and its importance in patients' health","volume":"24","author":"Alshammari","year":"2016","journal-title":"Saudi Pharm. J."},{"issue":"3","key":"10.1016\/j.micres.2024.128042_bib5","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1166\/jnn.2020.17170","article-title":"Galleria mellonella Larvae as an In Vivo Model to Evaluate the Toxicity of Polymeric Nanocapsules","volume":"20","author":"C\u00e9","year":"2020","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"3","key":"10.1016\/j.micres.2024.128042_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nchembio.2003","article-title":"Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence","volume":"12","author":"Chen","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.micres.2024.128042_bib7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/21505594.2021.1878688","article-title":"Pathogenicity and virulence of Staphylococcus aureus","volume":"12","author":"Cheung","year":"2021","journal-title":"Virulence"},{"issue":"4","key":"10.1016\/j.micres.2024.128042_bib8","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/ACI.0000000000000665","article-title":"Adverse reactions to vancomycin and cross-reactivity with other antibiotics","volume":"20","author":"De Luca","year":"2020","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"9","key":"10.1016\/j.micres.2024.128042_bib9","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1007\/s00216-012-6050-3","article-title":"Novel peptide-protein assay for identification of antimicrobial peptides by fluorescence quenching","volume":"403","author":"Dobslaff","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.micres.2024.128042_bib10","doi-asserted-by":"crossref","first-page":"W53","DOI":"10.1093\/nar\/gku401","article-title":"ProTox: a web server for the in silico prediction of rodent oral toxicity","volume":"42","author":"Drwal","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.micres.2024.128042_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00575-13","article-title":"Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus","volume":"4","author":"Falugi","year":"2013","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.micres.2024.128042_bib12","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1186\/s12879-017-2621-4","article-title":"Magnetic hyperthermia enhance the treatment efficacy of peri-implant osteomyelitis","volume":"17","author":"Fang","year":"2017","journal-title":"BMC Infect. Dis."},{"issue":"6","key":"10.1016\/j.micres.2024.128042_bib13","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1046\/j.1365-2958.2003.03524.x","article-title":"Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence","volume":"48","author":"Frees","year":"2003","journal-title":"Mol. Microbiol"},{"issue":"5","key":"10.1016\/j.micres.2024.128042_bib14","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1111\/j.1365-2958.2004.04368.x","article-title":"Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus","volume":"54","author":"Frees","year":"2004","journal-title":"Mol. Microbiol"},{"issue":"2","key":"10.1016\/j.micres.2024.128042_bib15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijmm.2013.11.009","article-title":"Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus","volume":"304","author":"Frees","year":"2014","journal-title":"Int J. Med Microbiol"},{"issue":"9","key":"10.1016\/j.micres.2024.128042_bib16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nnano.2007.260","article-title":"Intrinsic peroxidase-like activity of ferromagnetic nanoparticles","volume":"2","author":"Gao","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.micres.2024.128042_bib17","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1038\/ncomms7320","article-title":"AAA+\u2009chaperones and acyldepsipeptides activate the ClpP protease via conformational control","volume":"6","author":"Gersch","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micres.2024.128042_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ncrna.2024.08.006","article-title":"MiR-6721-5p as a natural regulator of Meta-VCL is upregulated in the serum of patients with coronary artery disease","volume":"10","author":"Gholipour","year":"2025","journal-title":"Noncoding RNA Res"},{"key":"10.1016\/j.micres.2024.128042_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114814","article-title":"Isochlorogenic acid A ameliorated lead-induced anxiety-like behaviors in mice by inhibiting ferroptosis-mediated neuroinflammation via the BDNF\/Nrf2\/GPX4 pathways","volume":"190","author":"Guo","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.micres.2024.128042_bib20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fcimb.2020.00107","article-title":"Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus","volume":"10","author":"Guo","year":"2020","journal-title":"Front Cell Infect. Microbiol"},{"issue":"3","key":"10.1016\/j.micres.2024.128042_bib21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1159\/000517718","article-title":"Contribution of the Clp Protease to Bacterial Survival and Mitochondrial Homoeostasis","volume":"31","author":"Illigmann","year":"2021","journal-title":"Micro Physiol."},{"key":"10.1016\/j.micres.2024.128042_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115814","article-title":"Ayanin, a natural flavonoid inhibitor of Caseinolytic protease, is a promising therapeutic agent to combat methicillin-resistant Staphylococcus aureus infections","volume":"217","author":"Jin","year":"2023","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.micres.2024.128042_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114753","article-title":"Myricetin protects mice against MRSA-related lethal pneumonia by targeting ClpP","volume":"192","author":"Jing","year":"2021","journal-title":"Biochem Pharm."},{"issue":"2","key":"10.1016\/j.micres.2024.128042_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02340-21","article-title":"Quercetin Reduces the Virulence of S. aureus by Targeting ClpP to Protect Mice from MRSA-Induced Lethal Pneumonia","volume":"10","author":"Jing","year":"2022","journal-title":"Microbiol Spectr."},{"issue":"1","key":"10.1016\/j.micres.2024.128042_bib25","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/21505594.2022.2051313","article-title":"Nepetin reduces virulence factors expression by targeting ClpP against MRSA-induced pneumonia infection","volume":"13","author":"Jing","year":"2022","journal-title":"Virulence"},{"issue":"5","key":"10.1016\/j.micres.2024.128042_bib26","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1208\/s12249-023-02563-2","article-title":"Topical Nanotherapeutics for Treating MRSA-Associated Skin and Soft Tissue Infection (SSTIs)","volume":"24","author":"Karnam","year":"2023","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.micres.2024.128042_bib27","article-title":"In-silico screening to identify phytochemical inhibitor for hP2X7: A crucial inflammatory cell death mediator in Parkinson's disease","volume":"115","author":"Khan","year":"2024","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.micres.2024.128042_bib28","article-title":"Effects of Traditional Chinese Medicine and its Active Ingredients on Drug-Resistant Bacteria","volume":"13","author":"Li","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.micres.2024.128042_bib29","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jproteome.4c00724","article-title":"Functional and Proteomic Dissection of the Contributions of CodY, SigB and the Hibernation Promoting Factor HPF to Interactions of Staphylococcus aureus USA300 with Human Lung Epithelial Cells","author":"Li","year":"2024","journal-title":"J. Proteome Res"},{"issue":"3","key":"10.1016\/j.micres.2024.128042_bib30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/cid\/cir034","article-title":"HF. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary","volume":"52","author":"Liu","year":"2011","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"10.1016\/j.micres.2024.128042_bib31","article-title":"Efficacy and Safety of Antibiotics in the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections: A Systematic Review and Network Meta-Analysis","volume":"13","author":"Liu","year":"2024","journal-title":"Antibiot. (Basel)"},{"key":"10.1016\/j.micres.2024.128042_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.104915","article-title":"Emerging resistance mechanisms for 4 types of common anti-MRSA antibiotics in Staphylococcus aureus: A comprehensive review","volume":"156","author":"Liu","year":"2021","journal-title":"Micro Pathog."},{"key":"10.1016\/j.micres.2024.128042_bib33","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3389\/fphar.2020.00582","article-title":"Isochlorogenic Acid A Attenuates the Progression of Liver Fibrosis Through Regulating HMGB1\/TLR4\/NF-\u03baB Signaling Pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Front Pharm."},{"issue":"5","key":"10.1016\/j.micres.2024.128042_bib34","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4161\/viru.24930","article-title":"Galleria mellonella larvae as an infection model for group A streptococcus","volume":"4","author":"Loh","year":"2013","journal-title":"Virulence"},{"issue":"20","key":"10.1016\/j.micres.2024.128042_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300247","article-title":"Bacteria-Targeted Combined with Photothermal\/NO Nanoparticles for the Treatment and Diagnosis of MRSA Infection In Vivo","volume":"12","author":"Lv","year":"2023","journal-title":"Adv. Health Mater."},{"key":"10.1016\/j.micres.2024.128042_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ebiom.2016.09.015","article-title":"Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically","volume":"12","author":"Mansour","year":"2016","journal-title":"EBioMedicine"},{"issue":"7","key":"10.1016\/j.micres.2024.128042_bib37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41579-022-00686-0","article-title":"Skeletal infections: microbial pathogenesis, immunity and clinical management","volume":"20","author":"Masters","year":"2022","journal-title":"Nat. Rev. Microbiol"},{"issue":"6","key":"10.1016\/j.micres.2024.128042_bib38","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/mmi.14649","article-title":"ClpP1P2 peptidase activity promotes biofilm formation in Pseudomonas aeruginosa","volume":"115","author":"Mawla","year":"2021","journal-title":"Mol. Microbiol"},{"issue":"10","key":"10.1016\/j.micres.2024.128042_bib39","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.080520697","article-title":"Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections","volume":"97","author":"Mazmanian","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"16","key":"10.1016\/j.micres.2024.128042_bib40","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1128\/JB.00074-06","article-title":"Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair","volume":"188","author":"Michel","year":"2006","journal-title":"J. Bacteriol."},{"issue":"6","key":"10.1016\/j.micres.2024.128042_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100427","article-title":"Staphylococcus aureus in vitro secretion of alpha toxin (hla) correlates with the affiliation to clonal complexes","volume":"9","author":"Monecke","year":"2014","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.micres.2024.128042_bib42","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.micres.2024.128042_bib43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/22221751.2020.1711817","article-title":"The combination of salvianolic acid A with latamoxef completely protects mice against lethal pneumonia caused by methicillin-resistant Staphylococcus aureus","volume":"9","author":"Mu","year":"2020","journal-title":"Emerg. Microbes Infect."},{"issue":"12","key":"10.1016\/j.micres.2024.128042_bib44","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/gtc.12188","article-title":"ClpB chaperone passively threads soluble denatured proteins through its central pore","volume":"19","author":"Nakazaki","year":"2014","journal-title":"Genes Cells"},{"issue":"9","key":"10.1016\/j.micres.2024.128042_bib45","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1038\/nprot.2007.321","article-title":"The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability","volume":"2","author":"Niesen","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.micres.2024.128042_bib46","doi-asserted-by":"crossref","DOI":"10.1111\/wrr.13192","article-title":"Understanding Staphylococcus aureus in hyperglycemia: A review of virulence factor and metabolic adaptations","author":"O'Connor","year":"2024","journal-title":"Wound Repair Regen."},{"issue":"5","key":"10.1016\/j.micres.2024.128042_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/cells13050387","article-title":"Effect of Polyphenols on Inflammation Induced by Membrane Vesicles from Staphylococcus aureus","volume":"13","author":"Oura","year":"2024","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.micres.2024.128042_bib48","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1128\/IAI.66.12.5620-5629.1998","article-title":"Large-scale identification of virulence genes from Streptococcus pneumoniae","volume":"66","author":"Polissi","year":"1998","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.micres.2024.128042_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003994","article-title":"Posttranslational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis","volume":"10","author":"Raju","year":"2014","journal-title":"PLoS Pathog."},{"issue":"4","key":"10.1016\/j.micres.2024.128042_bib50","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1365-2958.2010.07251.x","article-title":"A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development","volume":"77","author":"Rathore","year":"2010","journal-title":"Mol. Microbiol"},{"issue":"1","key":"10.1016\/j.micres.2024.128042_bib51","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1473-3099(12)70238-4","article-title":"The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis","volume":"13","author":"Shallcross","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"8","key":"10.1016\/j.micres.2024.128042_bib52","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.acthis.2012.01.006","article-title":"MTT assay for cell viability: Intracellular localization of the formazan product is in lipid droplets","volume":"114","author":"Stockert","year":"2012","journal-title":"Acta Histochem"},{"issue":"1","key":"10.1016\/j.micres.2024.128042_bib53","doi-asserted-by":"crossref","first-page":"8503","DOI":"10.1038\/s41598-020-65107-9","article-title":"Inhibition of urease activity by different compounds provides insight into the modulation and association of bacterial nickel import and ureolysis","volume":"10","author":"Svane","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.micres.2024.128042_bib54","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1365-2958.2003.03437.x","article-title":"Turnover of FlhD and FlhC, master regulator proteins for Salmonella flagellum biogenesis, by the ATP-dependent ClpXP protease","volume":"48","author":"Tomoyasu","year":"2003","journal-title":"Mol. Microbiol"},{"key":"10.1016\/j.micres.2024.128042_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111933","article-title":"Staphyloxanthin inhibitory potential of thymol impairs antioxidant fitness, enhances neutrophil mediated killing and alters membrane fluidity of methicillin resistant Staphylococcus aureus","volume":"141","author":"Valliammai","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.micres.2024.128042_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1087676","article-title":"Homology modeling, virtual screening, molecular docking, and dynamics studies for discovering Staphylococcus epidermidis FtsZ inhibitors","volume":"10","author":"Vemula","year":"2023","journal-title":"Front Mol. Biosci."},{"issue":"11","key":"10.1016\/j.micres.2024.128042_bib57","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.micinf.2007.06.012","article-title":"Role of ClpP in biofilm formation and virulence of Staphylococcus epidermidis","volume":"9","author":"Wang","year":"2007","journal-title":"Microbes Infect."},{"issue":"1","key":"10.1016\/j.micres.2024.128042_bib58","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1080\/21505594.2021.1962138","article-title":"Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A","volume":"12","author":"Wang","year":"2021","journal-title":"Virulence"},{"key":"10.1016\/j.micres.2024.128042_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114226","article-title":"Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis","volume":"159","author":"Wang","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.micres.2024.128042_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114982","article-title":"Scutellarin potentiates vancomycin against lethal pneumonia caused by methicillin-resistant Staphylococcus aureus through dual inhibition of sortase A and caseinolytic peptidase P","volume":"199","author":"Wang","year":"2022","journal-title":"Biochem Pharm."},{"issue":"1","key":"10.1016\/j.micres.2024.128042_bib61","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.1038\/s41467-022-34753-0","article-title":"Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP","volume":"13","author":"Wei","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micres.2024.128042_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.747760","article-title":"Boosting Synergistic Effects of Short Antimicrobial Peptides With Conventional Antibiotics Against Resistant Bacteria","volume":"12","author":"Wu","year":"2021","journal-title":"Front Microbiol"},{"issue":"W1","key":"10.1016\/j.micres.2024.128042_bib63","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"24","key":"10.1016\/j.micres.2024.128042_bib64","doi-asserted-by":"crossref","first-page":"17643","DOI":"10.1074\/jbc.M113.452714","article-title":"Helix unfolding\/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease","volume":"288","author":"Ye","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micres.2024.128042_bib65","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00808-24","article-title":"Osteomyelitis-relevant antibiotics at clinical concentrations show limited effectivity against acute and chronic intracellular S. aureus infections in osteocytes","author":"Zelmer","year":"2024","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micres.2024.128042_bib66","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3389\/fmicb.2017.01715","article-title":"Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin","volume":"8","author":"Zhang","year":"2017","journal-title":"Front Microbiol"},{"issue":"12","key":"10.1016\/j.micres.2024.128042_bib67","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00291-17","article-title":"Construction of a Gene Knockdown System Based on Catalytically Inactive (\"Dead\") Cas9 (dCas9) in Staphylococcus aureus","volume":"83","author":"Zhao","year":"2017","journal-title":"Appl. Environ. Microbiol"}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501324004439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501324004439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:55:18Z","timestamp":1772351718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501324004439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":67,"alternative-id":["S0944501324004439"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2024.128042","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting ClpP: Unlocking a novel therapeutic approach of isochlorogenic acid A for methicillin-resistant Staphylococcus aureus-infected osteomyelitis","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2024.128042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"128042"}}