{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:54:45Z","timestamp":1791262485963,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270594"],"award-info":[{"award-number":["82270594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010035","name":"Outstanding Youth Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["2022JJ20092"],"award-info":[{"award-number":["2022JJ20092"]}],"id":[{"id":"10.13039\/501100010035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.micres.2025.128142","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T21:41:31Z","timestamp":1742506891000},"page":"128142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["VacA promotes pyroptosis via TNFAIP3\/TRAF1 signaling to induce onset of atrophic gastritis"],"prefix":"10.1016","volume":"296","author":[{"given":"Shilang","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1387-1126","authenticated-orcid":false,"given":"Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"44","key":"10.1016\/j.micres.2025.128142_bib1","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1038\/sj.onc.1204788","article-title":"Tumor necrosis factor receptor-associated factors (TRAFs)[J]","volume":"20","author":"Bradley","year":"2001","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.micres.2025.128142_bib2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling[J]","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.micres.2025.128142_bib3","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","article-title":"Gasdermin D in pyroptosis[J]","volume":"11","author":"Burdette","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"8","key":"10.1016\/j.micres.2025.128142_bib4","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/s41564-019-0441-6","article-title":"VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1[J]","volume":"4","author":"Capurro","year":"2019","journal-title":"Nat. Microbiol"},{"issue":"12","key":"10.1016\/j.micres.2025.128142_bib5","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJMoa1708423","article-title":"Helicobacter pylori therapy for the prevention of metachronous gastric cancer[J]","volume":"378","author":"Choi","year":"2018","journal-title":"N. Engl. J. Med"},{"issue":"2","key":"10.1016\/j.micres.2025.128142_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41419-020-2339-x","article-title":"PUMA-mediated epithelial cell apoptosis promotes Helicobacter pylori infection-mediated gastritis[J]","volume":"11","author":"Dang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.micres.2025.128142_bib7","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1158\/0008-5472.CAN-17-1887","article-title":"Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism[J]","volume":"78","author":"Deswaerte","year":"2018","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.micres.2025.128142_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020351","article-title":"A20 promotes ripoptosome formation and TNF-induced apoptosis via cIAPs regulation and NIK stabilization in keratinocytes[J]","volume":"9","author":"Feoktistova","year":"2020","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.micres.2025.128142_bib9","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1136\/gutjnl-2020-320839","article-title":"Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis[J]","volume":"69","author":"Ford","year":"2020","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.micres.2025.128142_bib10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1523-5378.2008.00584.x","article-title":"Helicobacter pylori and antrum erosion-specific gene expression patterns: the discriminative role of CXCL13 and VCAM1 transcripts[J]","volume":"13","author":"Galamb","year":"2008","journal-title":"Helicobacter"},{"issue":"3","key":"10.1016\/j.micres.2025.128142_bib11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/apt.14424","article-title":"Reversibility of atrophic gastritis and intestinal metaplasia after Helicobacter pylori eradication - a prospective study for up to 10 years[J]","volume":"47","author":"Hwang","year":"2018","journal-title":"Aliment Pharm. Ther."},{"issue":"23","key":"10.1016\/j.micres.2025.128142_bib12","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/jnci\/87.23.1777","article-title":"Helicobacter pylori and atrophic gastritis: importance of the cagA status[J]","volume":"87","author":"Kuipers","year":"1995","journal-title":"J. Natl. Cancer Inst."},{"issue":"11","key":"10.1016\/j.micres.2025.128142_bib13","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1002\/pmic.200401000","article-title":"Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2[J]","volume":"4","author":"Lee","year":"2004","journal-title":"Proteomics"},{"issue":"Pt 8","key":"10.1016\/j.micres.2025.128142_bib14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1099\/jmm.0.46456-0","article-title":"Gene-expression profiles in gastric epithelial cells stimulated with spiral and coccoid Helicobacter pylori[J]","volume":"55","author":"Liu","year":"2006","journal-title":"J. Med Microbiol"},{"key":"10.1016\/j.micres.2025.128142_bib15","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1038\/ncomms3852","article-title":"TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death[J]","volume":"4","author":"Lu","year":"2013","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.micres.2025.128142_bib16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/gut.38.4.498","article-title":"Induction of gastric epithelial apoptosis by Helicobacter pylori[J]","volume":"38","author":"Moss","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.micres.2025.128142_bib17","first-page":"117","article-title":"Inflammasome activation by helicobacter pylori and its implications for persistence and immunity[J]","volume":"397","author":"Pachathundikandi","year":"2016","journal-title":"Curr. Top. Microbiol Immunol."},{"issue":"7","key":"10.1016\/j.micres.2025.128142_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies[J]","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.micres.2025.128142_bib19","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1053\/j.gastro.2021.06.078","article-title":"AGA clinical practice update on the diagnosis and management of atrophic gastritis: expert review[J]","volume":"161","author":"Shah","year":"2021","journal-title":"Gastroenterology"},{"issue":"7575","key":"10.1016\/j.micres.2025.128142_bib20","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death[J]","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.micres.2025.128142_bib21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: gasdermin-mediated programmed necrotic cell death[J]","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem Sci."},{"issue":"13","key":"10.1016\/j.micres.2025.128142_bib22","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1073\/pnas.93.13.6721","article-title":"The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1\/TRAF2 and inhibits NF-kappaB activation[J]","volume":"93","author":"Song","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.micres.2025.128142_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13045-020-00985-0","article-title":"HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1\/2 pathway[J]","volume":"13","author":"Tan","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"9","key":"10.1016\/j.micres.2025.128142_bib24","doi-asserted-by":"crossref","first-page":"15698","DOI":"10.1002\/jcp.28223","article-title":"Helicobacter pylori-downregulated tumor necrosis factor receptor-associated protein 1 mediates apoptosis of human gastric epithelial cells[J","volume":"234","author":"Teng","year":"2019","journal-title":"J. Cell Physiol."},{"issue":"8037","key":"10.1016\/j.micres.2025.128142_bib25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41586-024-07991-z","article-title":"An ancient ecospecies of Helicobacter pylori[J]","volume":"635","author":"Tourrette","year":"2024","journal-title":"Nature"},{"issue":"9-10","key":"10.1016\/j.micres.2025.128142_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.micinf.2017.06.005","article-title":"Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection[J]","volume":"19","author":"Tran","year":"2017","journal-title":"Microbes Infect."},{"issue":"6","key":"10.1016\/j.micres.2025.128142_bib27","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/hel.12311","article-title":"The Upregulation of TRAF1 Induced by Helicobacter pylori Plays an Antiapoptotic Effect on the Infected Cells[J]","volume":"21","author":"Wan","year":"2016","journal-title":"Helicobacter"},{"issue":"48","key":"10.1016\/j.micres.2025.128142_bib28","doi-asserted-by":"crossref","first-page":"7212","DOI":"10.3748\/wjg.v18.i48.7212","article-title":"Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori[J]","volume":"18","author":"Wang","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.micres.2025.128142_bib29","article-title":"Association between Virulence Factors and TRAF1\/4-1BB\/Bcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori[J]","volume":"2015","author":"Wang","year":"2015","journal-title":"Gastroenterol. Res Pr."},{"key":"10.1016\/j.micres.2025.128142_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101319","article-title":"PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer[J]","volume":"28","author":"Wang","year":"2020","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.micres.2025.128142_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-022-00954-9","article-title":"The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation in Helicobacter pylori-associated gastritis by regulating ROS and autophagy[J]","volume":"21","author":"Yu","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.micres.2025.128142_bib32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12866-021-02262-7","article-title":"Construction and preservation of a stable and highly expressed recombinant Helicobacter pylori vacuolating cytotoxin A with apoptotic activity[J]","volume":"21","author":"Yuan","year":"2021","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.micres.2025.128142_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105933","article-title":"IL-1\u03b2, an important cytokine affecting Helicobacter pylori-mediated gastric carcinogenesis[J]","volume":"174","author":"Yuan","year":"2023","journal-title":"Micro Pathog."},{"issue":"12","key":"10.1016\/j.micres.2025.128142_bib34","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1038\/s41419-017-0011-x","article-title":"Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway[J]","volume":"8","author":"Zhu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.micres.2025.128142_bib35","doi-asserted-by":"crossref","DOI":"10.21037\/pcm-21-12","article-title":"Asbestos-induced chronic inflammation in malignant pleural mesothelioma and related therapeutic approaches-a narrative review[J]","volume":"4","author":"Zolondick","year":"2021","journal-title":"Precis Cancer Med"}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501325000989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501325000989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:42:02Z","timestamp":1762332122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501325000989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":35,"alternative-id":["S0944501325000989"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2025.128142","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VacA promotes pyroptosis via TNFAIP3\/TRAF1 signaling to induce onset of atrophic gastritis","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2025.128142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"128142"}}