{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:08:38Z","timestamp":1792714118324,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2023704"],"award-info":[{"award-number":["BE2023704"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.micres.2025.128298","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T20:20:35Z","timestamp":1754425235000},"page":"128298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Characterization and therapeutic efficacy of phage p9676 against epidemic ST11-KL64 Klebsiella pneumoniae: Insights from genomic analysis and in vivo studies"],"prefix":"10.1016","volume":"301","author":[{"given":"Yapin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guicai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.micres.2025.128298_bib1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3934\/microbiol.2017.3.649","article-title":"Active bacteriophage biocontrol and therapy on sub-millimeter scales towards removal of unwanted bacteria from foods and microbiomes","volume":"3","author":"Abedon","year":"2017","journal-title":"AIMS Microbiol."},{"key":"10.1016\/j.micres.2025.128298_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198250","article-title":"A single dose of a virulent bacteriophage vb PaeP-SaPL, rescues bacteremic mice infected with multi drug resistant pseudomonas aeruginosa","volume":"292","author":"Alvi","year":"2021","journal-title":"Virus Res."},{"issue":"3","key":"10.1016\/j.micres.2025.128298_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00740-17","article-title":"Capsule production and glucose metabolism dictate fitness during serratia marcescens bacteremia","volume":"8","author":"Anderson","year":"2017","journal-title":"mBio"},{"issue":"12","key":"10.1016\/j.micres.2025.128298_bib4","first-page":"3491","volume":"75","author":"Bortolaia","year":"2020","journal-title":"ResFinder 4. 0 Predict. phenotypes genotypes. J. Antimicrob. Chemother."},{"issue":"21","key":"10.1016\/j.micres.2025.128298_bib5","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01585-18","article-title":"A Smooth-Type, Phage-Resistant klebsiella pneumoniae mutant strain reveals that OmpC is indispensable for infection by phage GH-K3","volume":"84","author":"Cai","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.micres.2025.128298_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2672.2004.02422.x","article-title":"Bacteriophage penetration in vertebrates","volume":"98","author":"Dabrowska","year":"2005","journal-title":"J. Appl. Microbiol."},{"issue":"18","key":"10.1016\/j.micres.2025.128298_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00920-21","article-title":"Novel host recognition mechanism of the K1 Capsule-Specific phage of escherichia coli: capsular polysaccharide as the first receptor and lipopolysaccharide as the secondary receptor","volume":"95","author":"Gong","year":"2021","journal-title":"J. Virol."},{"issue":"7790","key":"10.1016\/j.micres.2025.128298_bib8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41586-019-1894-8","article-title":"The arms race between bacteria and their phage foes","volume":"577","author":"Hampton","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.micres.2025.128298_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100891","article-title":"Opposite evolution of pathogenicity driven by in vivo wzc and wcaj mutations in ST11-KL64 carbapenem-resistant klebsiella pneumoniae","volume":"66","author":"He","year":"2023","journal-title":"Drug Resist Updat"},{"issue":"3","key":"10.1016\/j.micres.2025.128298_bib10","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41564-024-01612-1","article-title":"Carbapenem-resistant klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study","volume":"9","author":"Hu","year":"2024","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.micres.2025.128298_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.991306","article-title":"Hypervirulent carbapenem-resistant klebsiella pneumoniae causing highly fatal meningitis in southeastern China","volume":"10","author":"Huang","year":"2022","journal-title":"Front. Public Health"},{"issue":"3","key":"10.1016\/j.micres.2025.128298_bib12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1046\/j.1365-2672.1998.853541.x","article-title":"Bacteriophage and associated polysaccharide depolymerases--novel tools for study of bacterial biofilms","volume":"85","author":"Hughes","year":"1998","journal-title":"J. Appl. Microbiol."},{"issue":"2","key":"10.1016\/j.micres.2025.128298_bib13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.chom.2019.01.014","article-title":"Phage therapy: a renewed approach to combat Antibiotic-Resistant bacteria","volume":"25","author":"Kortright","year":"2019","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.micres.2025.128298_bib14","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3390\/v5030806","article-title":"Understanding bacteriophage specificity in natural microbial communities","volume":"5","author":"Koskella","year":"2013","journal-title":"Viruses"},{"key":"10.1016\/j.micres.2025.128298_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-60327-164-6_14","article-title":"Phage host range and efficiency of plating","volume":"501","author":"Kutter","year":"2009","journal-title":"Methods Mol. Biol. (Clifton N. J. )"},{"issue":"4","key":"10.1016\/j.micres.2025.128298_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tplants.2020.01.013","article-title":"Phage cocktail therapy: multiple ways to suppress pathogenicity","volume":"25","author":"Liu","year":"2020","journal-title":"Trends Plant Sci."},{"issue":"1","key":"10.1016\/j.micres.2025.128298_bib17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12223-020-00835-z","article-title":"Anti-phage serum antibody responses and the outcome of phage therapy","volume":"66","author":"Lusiak-Szelachowska","year":"2021","journal-title":"Folia Microbiol. (Praha)"},{"key":"10.1016\/j.micres.2025.128298_bib18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cis.2017.05.014","article-title":"Formulation, stabilisation and encapsulation of bacteriophage for phage therapy","volume":"249","author":"Malik","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.micres.2025.128298_bib19","doi-asserted-by":"crossref","first-page":"15573","DOI":"10.1038\/srep15573","article-title":"Genetic analysis of capsular polysaccharide synthesis gene clusters in 79 capsular types of klebsiella spp","volume":"5","author":"Pan","year":"2015","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.micres.2025.128298_bib20","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1128\/JB.06052-11","article-title":"Functional characterization of UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferases of escherichia coli and caulobacter crescentus","volume":"194","author":"Patel","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2025.128298_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.copbio.2020.09.009","article-title":"Phage engineering and the evolutionary arms race","volume":"68","author":"Peng","year":"2021","journal-title":"Curr. Opin. Biotechnol."},{"issue":"6","key":"10.1016\/j.micres.2025.128298_bib22","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/femsre\/fuaa017","article-title":"Current challenges and future opportunities of phage therapy","volume":"44","author":"Pires","year":"2020","journal-title":"FEMS Microbiol. Rev."},{"issue":"12","key":"10.1016\/j.micres.2025.128298_bib23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrmicro3564","article-title":"A century of the phage: past, present and future","volume":"13","author":"Salmond","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.micres.2025.128298_bib24","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1128\/JVI.75.6.2509-2515.2001","article-title":"Bacteriophage K1-5 encodes two different tail fiber proteins, allowing it to infect and replicate on both K1 and K5 strains of escherichia coli","volume":"75","author":"Scholl","year":"2001","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.micres.2025.128298_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00954-17","article-title":"Development and use of personalized Bacteriophage-Based therapeutic cocktails to treat a patient with a disseminated resistant acinetobacter baumannii infection","volume":"61","author":"Schooley","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"10.1016\/j.micres.2025.128298_bib26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jctb.434","article-title":"Bacteriophages: biology and history","volume":"76","author":"Sharp","year":"2001","journal-title":"J. Chem. Technol. Biotechnol."},{"issue":"3","key":"10.1016\/j.micres.2025.128298_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/aac.02071-21","article-title":"Considerations for the use of phage therapy in clinical practice","volume":"66","author":"Suh","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.micres.2025.128298_bib28","first-page":"309","article-title":"Use of bacteriophage in the treatment of experimental animal bacteremia from imipenem-resistant pseudomonas aeruginosa","volume":"17","author":"Wang","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.micres.2025.128298_bib29","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.3389\/fmicb.2019.02768","article-title":"A novel polysaccharide depolymerase encoded by the phage SH-KP152226 confers specific activity against Multidrug-Resistant klebsiella pneumoniae via biofilm degradation","volume":"10","author":"Wu","year":"2019","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.micres.2025.128298_bib30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3201\/eid2602.190594","article-title":"Novel subclone of Carbapenem-Resistant klebsiella pneumoniae sequence type 11 with enhanced virulence and transmissibility, China","volume":"26","author":"Zhou","year":"2020","journal-title":"Emerg. Infect. Dis."}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501325002575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501325002575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T09:35:20Z","timestamp":1772789720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501325002575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":30,"alternative-id":["S0944501325002575"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2025.128298","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization and therapeutic efficacy of phage p9676 against epidemic ST11-KL64 Klebsiella pneumoniae: Insights from genomic analysis and in vivo studies","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2025.128298","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128298"}}