{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:23:26Z","timestamp":1793798606238,"version":"4.6.1"},"reference-count":141,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341119"],"award-info":[{"award-number":["82341119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2025YFC3408504"],"award-info":[{"award-number":["2025YFC3408504"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.micres.2025.128417","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T16:52:09Z","timestamp":1765903929000},"page":"128417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A review of phage therapy for drug-resistant Pseudomonas aeruginosa infections"],"prefix":"10.1016","volume":"305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3536-953X","authenticated-orcid":false,"given":"Xiao","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yigang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/138920110790725410","article-title":"Phage therapy pharmacology","volume":"11","author":"Abedon","year":"2010","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics8030103","article-title":"Synergistic action of phage and antibiotics: parameters to enhance the killing efficacy against mono and dual-species biofilms","volume":"8","author":"Akturk","year":"2019","journal-title":"Antibiotics"},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00029-12","article-title":"Bacteriophages \u03c6MR299-2 and \u03c6NH-4 can eliminate Pseudomonas aeruginosa in the murine lung and on cystic fibrosis lung airway cells","volume":"3","author":"Alemayehu","year":"2012","journal-title":"mBio"},{"key":"10.1016\/j.micres.2025.128417_bib4","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.2147\/IDR.S367460","article-title":"Assessment of phage-mediated inhibition and removal of multidrug-resistant Pseudomonas aeruginosa biofilm on medical implants","volume":"15","author":"Amankwah","year":"2022","journal-title":"Infect. Drug Resist."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib5","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/s41467-024-45785-z","article-title":"Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo","volume":"15","author":"Ashworth","year":"2024","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.micres.2025.128417_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofaa389","article-title":"Lessons learned from the first 10 consecutive cases of intravenous bacteriophage therapy to treat multidrug-resistant bacterial infections at a single center in the United States","volume":"7","author":"Aslam","year":"2020","journal-title":"Open Forum Infect. Dis."},{"issue":"4","key":"10.1016\/j.micres.2025.128417_bib7","article-title":"Pseudomonas aeruginosa ventricular assist device infections: findings from ineffective phage therapies in five cases","volume":"68","author":"Aslam","year":"2024","journal-title":"J. Antimicrob. Agents Chemother."},{"issue":"11","key":"10.1016\/j.micres.2025.128417_bib8","article-title":"Genomics and susceptibility profiles of extensively drug-resistant Pseudomonas aeruginosa isolates from Spain","volume":"61","author":"Barrio-Tofi\u00f1o","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micres.2025.128417_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1199657","article-title":"Case report: analysis of phage therapy failure in a patient with a Pseudomonas aeruginosa prosthetic vascular graft infection","volume":"10","author":"Blasco","year":"2023","journal-title":"Front. Med."},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/BF01569821","article-title":"Pseudomonas aeruginosa Biofilms: role of the alginate exopolysaccharide","volume":"15","author":"Boyd","year":"1995","journal-title":"J. Ind. Microbiol."},{"issue":"9","key":"10.1016\/j.micres.2025.128417_bib11","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1469-0691.2005.01217.x","article-title":"Antimicrobial therapy for pulmonary pathogenic colonisation and infection by Pseudomonas aeruginosa in cystic fibrosis patients","volume":"11","author":"Cant\u00f3n","year":"2005","journal-title":"Clin. Microbiol. Infect."},{"issue":"4","key":"10.1016\/j.micres.2025.128417_bib12","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1097\/MAO.0000000000004417","article-title":"Bacteriophage therapy for chronic mastoiditis","volume":"46","author":"Casazza","year":"2025","journal-title":"J. Otol. Neurotol."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofad051","article-title":"Application of phage therapy in a case of a chronic hip-prosthetic joint infection due to Pseudomonas aeruginosa: an Italian real-life experience and in vitro analysis","volume":"10","author":"Cesta","year":"2023","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.micres.2025.128417_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/srep26717","article-title":"Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa","volume":"6","author":"Chan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micres.2025.128417_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-025-03678-8","article-title":"Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in Cystic Fibrosis","author":"Chan","year":"2025","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1208\/s12248-019-0315-0","article-title":"Bacteriophage PEV20 and ciprofloxacin combination treatment enhances removal of Pseudomonas aeruginosa biofilm isolated from cystic fibrosis and wound patients","volume":"21","author":"Chang","year":"2019","journal-title":"AAPS J."},{"issue":"7","key":"10.1016\/j.micres.2025.128417_bib17","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.cmi.2022.01.006","article-title":"The EFfects of Different Doses of Inhaled Bacteriophage Therapy for Pseudomonas aeruginosa pulmonary infections in mice","volume":"28","author":"Chang","year":"2022","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.micres.2025.128417_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijmmb.2024.100771","article-title":"CRISPR-Cas-assisted phage engineering for personalized antibacterial treatments","volume":"53","author":"Chaudhary","year":"2025","journal-title":"Indian J. Med. Microbiol."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168615","article-title":"Synergy and order effects of antibiotics and phages in killing Pseudomonas aeruginosa biofilms","volume":"12","author":"Chaudhry","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12941-020-00389-5","article-title":"Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review","volume":"19","author":"Chegini","year":"2020","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.5582\/bst.2022.01147","article-title":"Bacteriophage therapy for empyema caused by carbapenem-resistant Pseudomonas aeruginosa[J","volume":"16","author":"Chen","year":"2022","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.micres.2025.128417_bib22","article-title":"Genetic engineering of bacteriophages against infectious diseases","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Microbiol."},{"issue":"8","key":"10.1016\/j.micres.2025.128417_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000799","article-title":"Phage-Antibiotic Synergy (PAS): \u03b2-Lactam and Quinolone antibiotics stimulate virulent phage growth","volume":"2","author":"Comeau","year":"2007","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.micres.2025.128417_bib24","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1080\/07388551.2022.2071671","article-title":"Potential of bacteriophage proteins as recognition molecules for pathogen detection","volume":"43","author":"Costa","year":"2023","journal-title":"Crit. Rev. Biotechnol."},{"issue":"10","key":"10.1016\/j.micres.2025.128417_bib25","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.3390\/v6103778","article-title":"Effect of bacteriophage infection in combination with tobramycin on the emergence of resistance in Escherichia coli and Pseudomonas aeruginosa Biofilms","volume":"6","author":"Coulter","year":"2014","journal-title":"Viruses"},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib26","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/infdis\/jiac368","article-title":"Development of host immune response to bacteriophage in a lung transplant recipient on adjunctive phage therapy for a multidrug-resistant Pneumonia","volume":"227","author":"Dan","year":"2023","journal-title":"J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.micres.2025.128417_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ph14111162","article-title":"Friends or Foes? Rapid determination of dissimilar colistin and ciprofloxacin antagonism of Pseudomonas aeruginosa Phages","volume":"14","author":"Danis-Wlodarczyk","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.micres.2025.128417_bib28","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/s41591-019-0437-z","article-title":"Engineered Bacteriophages for Treatment of A Patient with A Disseminated Drug-Resistant Mycobacterium abscessus","volume":"25","author":"Dedrick","year":"2019","journal-title":"Nat. Med."},{"issue":"7783","key":"10.1016\/j.micres.2025.128417_bib29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41586-019-1742-x","article-title":"Bacteriophage Targeting of Gut Bacterium Attenuates Alcoholic Liver Disease","volume":"575","author":"Duan","year":"2019","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41575-021-00536-z","article-title":"Bacteriophages and Their Potential for Treatment of Gastrointestinal Diseases","volume":"19","author":"Duan","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s42003-023-04609-4","article-title":"YgfB Increases \u03b2-lactam Resistance in Pseudomonas aeruginosa by Counteracting AlpA-mediated ampDh3 Expression","volume":"6","author":"Eggers","year":"2023","journal-title":"Commun. Biol."},{"issue":"9","key":"10.1016\/j.micres.2025.128417_bib32","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/infdis\/jiy678","article-title":"Bacteriophage Therapy Increases Complement-Mediated Lysis of Bacteria and Enhances Bacterial Clearance After Acute Lung Infection With Multidrug-Resistant Pseudomonas aeruginosa","volume":"219","author":"El-Aziz","year":"2019","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ph14030184","article-title":"Synergistic Killing and Re-Sensitization of Pseudomonas aeruginosa to Antibiotics by Phage-Antibiotic Combination Treatment","volume":"14","author":"Engeman","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"11","key":"10.1016\/j.micres.2025.128417_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics10111429","article-title":"Effect of Imipenem and Amikacin Combination against Multi-Drug Resistant Pseudomonas aeruginosa","volume":"10","author":"Farhan","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.micres.2025.128417_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2023.199184","article-title":"Characterization and genomic analysis of a broad-spectrum lytic phage HZ2201 and Its antibiofilm efficacy against Pseudomonas aeruginosa","volume":"335","author":"Fei","year":"2023","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib36","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1038\/s41467-022-31837-9","article-title":"Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection","volume":"13","author":"Ferry","year":"2022","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02573-17","article-title":"Design of a Broad-Range Bacteriophage Cocktail That Reduces Pseudomonas aeruginosa Biofilms and Treats Acute Infections in Two Animal Models","volume":"62","author":"Forti","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01477-23","article-title":"Identification and Impact on Pseudomonas aeruginosa Virulence of Mutations Conferring Resistance to a Phage Cocktail for Phage Therapy","volume":"11","author":"Forti","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"11","key":"10.1016\/j.micres.2025.128417_bib39","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/1348-0421.12846","article-title":"Susceptibility of Pseudomonas aeruginosa Veterinary Isolates to Pbunavirus PB1-like Pphages[J","volume":"64","author":"Fujiki","year":"2020","journal-title":"Microbiol. Immunol."},{"issue":"21","key":"10.1016\/j.micres.2025.128417_bib40","doi-asserted-by":"crossref","first-page":"15628","DOI":"10.3390\/ijms242115628","article-title":"Fitness Trade-Offs between Phage and Antibiotic Sensitivity in Phage-Resistant Variants: Molecular Action and Insights into Clinical Applications for Phage Therapy","volume":"24","author":"Fujiki","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micres.2025.128417_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1401234","article-title":"Using Phage to Drive Selections toward Restoring Antibiotic Sensitivity in Pseudomonas aeruginosa via Chromosomal Deletions","volume":"15","author":"Fujiki","year":"2024","journal-title":"Front. Microbiol."},{"issue":"8","key":"10.1016\/j.micres.2025.128417_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/v17081080","article-title":"Biocontrol of Phage Resistance in Pseudomonas Infections: Insights into Directed Breaking of Spontaneous Evolutionary Selection in Phage Therapy","volume":"17","author":"Fujiki","year":"2025","journal-title":"Viruses"},{"issue":"11","key":"10.1016\/j.micres.2025.128417_bib43","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00728-23","article-title":"Ciprofloxacin in Combination with Bacteriophage Cocktails against Multi-Drug Resistant Pseudomonas aeruginosa in ex vivo Simulated Endocardial Vegetation Models","volume":"67","author":"Ghali","year":"2023","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib44","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/mr.60.3.539-574.1996","article-title":"Microbial Pathogenesis in Cystic Fibrosis: Mucoid Pseudomonas aeruginosa and Burkholderia Cepacia","volume":"60","author":"Govan","year":"1996","journal-title":"Microbiol. Rev."},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib45","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1128\/AEM.67.6.2746-2753.2001","article-title":"Reduction in Exopolysaccharide Viscosity as an Aid to Bacteriophage Penetration through Pseudomonas aeruginosa Biofilms","volume":"67","author":"Hanlon","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"issue":"73, 2022","key":"10.1016\/j.micres.2025.128417_bib46","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-med-080219-122208","article-title":"Phage Therapy for Antibiotic-Resistant Bacterial Infections","volume":"73","author":"Hatfull","year":"2022","journal-title":"Annu. Rev. Med."},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/v10060335","article-title":"Phage Genetic Engineering Using CRISPR\u207bCas Systems","volume":"10","author":"Hatoum-Aslan","year":"2018","journal-title":"Viruses"},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib48","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1111\/jam.15647","article-title":"Bacteriophage-Antibiotic Combination Therapy for Multidrug-Resistant Pseudomonas aeruginosa: In vitro Synergy Testing","volume":"133","author":"Holger","year":"2022","journal-title":"J. Appl. Microbiol."},{"issue":"11","key":"10.1016\/j.micres.2025.128417_bib49","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00578-23","article-title":"Phage-Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in in vitro Static and Dynamic Biofilm Models","volume":"67","author":"Holger","year":"2023","journal-title":"Antimicrob. Agents Chemother."},{"issue":"11","key":"10.1016\/j.micres.2025.128417_bib50","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00578-23","article-title":"Phage-Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in in vitro Static and Dynamic Biofilm Models","volume":"67","author":"Holger","year":"2023","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micres.2025.128417_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123853","article-title":"Optimizing in vitro Phage-Ciprofloxacin Combination Formulation for Respiratory Therapy of Multi-Drug Resistant Pseudomonas aeruginosa Infections","volume":"652","author":"Hong","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/v17010065","article-title":"Are You My Host? An Overview of Methods Used to Link Bacteriophages with Hosts","volume":"17","author":"Hyman","year":"2025","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib53","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-micro-041222-124727","article-title":"Viral genome delivery across bacterial cell surfaces","volume":"78","author":"Iglesias","year":"2024","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micres.2025.128417_bib54","article-title":"Phage-encoded depolymerases as a strategy for combating multidrug-resistant Acinetobacter baumannii","volume":"14","author":"Islam","year":"2024","journal-title":"Front. Cell. Infect. Microbiol. 2024"},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib55","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/ismej.2014.223","article-title":"Lytic Activity by Temperate Phages of Pseudomonas aeruginosa in Long-Term Cystic Fibrosis Chronic Lung Infections","volume":"9","author":"James","year":"2015","journal-title":"ISME J."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1473-3099(18)30482-1","article-title":"Efficacy and Tolerability of a Cocktail of Bacteriophages to Treat Burn Wounds Infected by Pseudomonas aeruginosa (PhagoBurn): a Randomised, Controlled, Double-Blind Phase 1\/2 Trial","volume":"19","author":"Jault","year":"2019","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib57","article-title":"Successful Treatment of a Patient With Chronic Bronchiectasis Using an Induced Native Phage Cocktail: A Case Report","volume":"17","author":"Jernigan","year":"2025","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib58","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1128\/AEM.01797-10","article-title":"Bacteriophage Ecology in Escherichia coli and Pseudomonas aeruginosa Mixed-Biofilm Communities","volume":"77","author":"Kay","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micres.2025.128417_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.639570","article-title":"Immune Response to Therapeutic Staphylococcal Bacteriophages in Mammals: Kinetics of Induction, Immunogenic Structural Proteins, Natural and Induced Antibodies","volume":"12","author":"Ka\u017amierczak","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib60","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10381","article-title":"Phage engineering and phage-assisted CRISPR-Cas delivery to combat multidrug-resistant pathogens","volume":"8","author":"Khambhati","year":"2023","journal-title":"Bioeng. Transl. Med."},{"issue":"9","key":"10.1016\/j.micres.2025.128417_bib61","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202113936","article-title":"Bacterial Lysis, Autophagy and Innate Immune Responses During Adjunctive Phage Therapy in a Child","volume":"13","author":"Khatami","year":"2021","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib62","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5152\/eurasianjmed.2022.21010","article-title":"Isolation and Characterization of Lytic Bacteriophages from Wastewater with Phage Therapy Potentials Against Gram-Negative Bacteria","volume":"54","author":"Khorshidtalab","year":"2022","journal-title":"Eurasia J. Med."},{"issue":"22","key":"10.1016\/j.micres.2025.128417_bib63","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.02085-18","article-title":"Phage-antibiotic synergy via delayed lysis","volume":"84","author":"Kim","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib64","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.1038\/s41467-024-53994-9","article-title":"A Blueprint for Broadly Effective Bacteriophage-Antibiotic Cocktails against Bacterial Infections","volume":"15","author":"Kim","year":"2024","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.micres.2025.128417_bib65","doi-asserted-by":"crossref","DOI":"10.1172\/JCI187996","article-title":"Bacteriophage Therapy for Multidrug-Resistant Infections: Current Technologies and Therapeutic Approaches","volume":"135","author":"Kim","year":"2025","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib66","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1038\/s41467-023-39370-z","article-title":"Personalized Aerosolised Bacteriophage Treatment of a Chronic Lung Infection Due to Multidrug-Resistant Pseudomonas aeruginosa","volume":"14","author":"K\u00f6hler","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib67","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tim.2023.11.005","article-title":"Pseudomonas aeruginosa","volume":"32","author":"Krell","year":"2024","journal-title":"Trends Microbiol."},{"issue":"9","key":"10.1016\/j.micres.2025.128417_bib68","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.4049\/jimmunol.1701745","article-title":"Contribution of the Immune Response to Phage Therapy","volume":"200","author":"Krut","year":"2018","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib69","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2174\/138920110790725401","article-title":"Phage Therapy in Clinical Practice: Treatment of Human Infections","volume":"11","author":"Kutter","year":"2010","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"4","key":"10.1016\/j.micres.2025.128417_bib70","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s15010-019-01319-0","article-title":"Successful Adjunctive Use of Bacteriophage Therapy for Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infection in a Cystic Fibrosis Patient","volume":"47","author":"Law","year":"2019","journal-title":"Infection"},{"key":"10.1016\/j.micres.2025.128417_bib71","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.2147\/IDR.S413900","article-title":"Refractory Pseudomonas aeruginosa Bronchopulmonary Infection After Lung Transplantation for Common Variable Immunodeficiency Despite Maximal Treatment Including IgM\/IgA-Enriched Immunoglobulins and Bacteriophage Therapy","volume":"16","author":"Lev\u00eaque","year":"2023","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.micres.2025.128417_bib72","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejpb.2020.11.019","article-title":"Synergistic Activity of phage PEV20-Ciprofloxacin Combination Powder Formulation-A Proof-of-Principle Study in a P. aeruginosa Lung Infection Model","volume":"158","author":"Lin","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"12","key":"10.1016\/j.micres.2025.128417_bib73","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1016\/j.apsb.2022.05.007","article-title":"Recent advances in bacteriophage-based therapeutics: insight into the post-antibiotic era","volume":"12","author":"Ling","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib74","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s40259-021-00480-z","article-title":"Engineered Bacteriophage Therapeutics: Rationale, Challenges and Future","volume":"35","author":"\u0141obocka","year":"2021","journal-title":"BioDrugs"},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib75","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4161\/bact.1.2.14590","article-title":"Pros and Cons of Phage Therapy","volume":"1","author":"Loc-Carrillo","year":"2011","journal-title":"Bacteriophage"},{"key":"10.1016\/j.micres.2025.128417_bib76","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fpubh.2020.00003","article-title":"Combining Standard Molecular Typing and Whole Genome Sequencing to Investigate Pseudomonas aeruginosa Epidemiology in Intensive Care Units","volume":"8","author":"Magalh\u00e3es","year":"2020","journal-title":"Front. Public Health"},{"issue":"5","key":"10.1016\/j.micres.2025.128417_bib77","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tibtech.2022.08.008","article-title":"Approaches for bacteriophage genome engineering","volume":"41","author":"Mahler","year":"2023","journal-title":"Trends Biotechnol."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib78","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-00449-w","article-title":"Augmenting Phage Therapy Using Green Nanotechnology for Promising Infection Control, Wound Healing and Devoiding Phage Resistance in MDR Pseudomonas aeruginosa","volume":"15","author":"Mani","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib79","doi-asserted-by":"crossref","first-page":"9354","DOI":"10.1038\/s41598-024-59444-2","article-title":"Phage-Antibiotic Combinations to Control Pseudomonas aeruginosa\u2013Candida Two-Species Biofilms","volume":"14","author":"Manohar","year":"2024","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib80","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1128\/AAC.01028-06","article-title":"Phage Therapy of Pseudomonas aeruginosa Infection in a Mouse Burn Wound Model","volume":"51","author":"Mcvay","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micres.2025.128417_bib81","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.coviro.2021.12.003","article-title":"Engineering therapeutic phages for enhanced antibacterial efficacy","volume":"52","author":"Meile","year":"2022","journal-title":"Curr. Opin. Virol."},{"issue":"12","key":"10.1016\/j.micres.2025.128417_bib82","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1038\/s41564-024-01842-3","article-title":"Pseudomonas aeruginosa Faces a Fitness Trade-off between Mucosal Colonization and Antibiotic Tolerance during Airway Infection","volume":"9","author":"Meirelles","year":"2024","journal-title":"Nat. Microbiol."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib83","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s15010-024-02178-0","article-title":"Phage Therapy as a Glimmer of Hope in the Fight Against the Recurrence or Emergence of Surgical Site Bacterial Infections","volume":"52","author":"Moghadam","year":"2024","journal-title":"Infection"},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016963","article-title":"Pulmonary Bacteriophage Therapy on Pseudomonas aeruginosa Cystic Fibrosis Strains: First Steps Towards Treatment and Prevention","volume":"6","author":"Morello","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.micres.2025.128417_bib85","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-0716-3523-0_15","article-title":"Successful Use of Phage and Antibiotics Therapy for the Eradication of Two Bacterial Pathogens from the Respiratory Tract of an Infant","volume":"2734","author":"Morozova","year":"2024","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.micres.2025.128417_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198596","article-title":"Fluctuating Bacteriophage-induced galU Deficiency Region is Involved in Trade-off Effects on the Phage and Fluoroquinolone Sensitivity in Pseudomonas aeruginosa","volume":"306","author":"Nakamura","year":"2021","journal-title":"Virus Res."},{"issue":"8","key":"10.1016\/j.micres.2025.128417_bib87","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00065-23","article-title":"Class-driven synergy and antagonism between a Pseudomonas phage and antibiotics","volume":"91","author":"Nicholls","year":"2023","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.micres.2025.128417_bib88","first-page":"703","article-title":"Synergistic Interaction Between Phage Therapy and Antibiotics Clears Pseudomonas aeruginosa Infection in Endocarditis and Reduces Virulence","volume":"215","author":"Oechslin","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micres.2025.128417_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.107088","article-title":"Phage therapy: a targeted approach to overcoming antibiotic resistance","volume":"197","author":"Olawade","year":"2024","journal-title":"Microb. Pathog."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics10010078","article-title":"Bacteriophage Cocktail-Mediated Inhibition of Pseudomonas aeruginosa Biofilm on Endotracheal Tube Surface","volume":"10","author":"Oliveira","year":"2021","journal-title":"Antibiotics"},{"issue":"9","key":"10.1016\/j.micres.2025.128417_bib91","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.medj.2023.07.002","article-title":"Refractory Pseudomonas aeruginosa Infections Treated with Phage PASA16: A Compassionate Use Case Series","volume":"4","author":"Onallah","year":"2023","journal-title":"Med"},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib92","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jbiosc.2020.02.001","article-title":"Characterization of Pseudomonas Lytic Phages and Their Application as a Cocktail with Antibiotics in Controlling Pseudomonas aeruginosa","volume":"129","author":"Ong","year":"2020","journal-title":"J. Biosci. Bioeng."},{"issue":"10","key":"10.1016\/j.micres.2025.128417_bib93","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3390\/v11100891","article-title":"Bacteriophage Application for Difficult-to-treat Musculoskeletal Infections: Development of a Standardized Multidisciplinary Treatment Protocol","volume":"11","author":"Onsea","year":"2019","journal-title":"Viruses"},{"issue":"10, 2023","key":"10.1016\/j.micres.2025.128417_bib94","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev-virology-012423-110530","article-title":"Developing Phage Therapy That Overcomes the Evolution of Bacterial Resistance","volume":"10","author":"Orom\u00ed-Bosch","year":"2023","journal-title":"Annu. Rev. Virol."},{"issue":"10","key":"10.1016\/j.micres.2025.128417_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics13100916","article-title":"Phage-antibiotic combination therapy against recurrent Pseudomonas Septicaemia in a patient with an arterial stent","volume":"13","author":"Otava","year":"2024","journal-title":"Antibiotics"},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib96","first-page":"120","article-title":"Lytic Bacteriophages Against Bacterial Biofilms Formed by Multidrug-Resistant Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus Isolated from Burn Wounds","volume":"2","author":"Pallavali","year":"2021","journal-title":"PHAGE"},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib97","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3390\/idr16060092","article-title":"Advancing Phage Therapy: A Comprehensive Review of the Safety, Efficacy, and Future Prospects for the Targeted Treatment of Bacterial Infections","volume":"16","author":"Palma","year":"2024","journal-title":"Infect. Dis. Rep."},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib98","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/ph18030343","article-title":"In vitro Interactions Between Bacteriophages and Antibacterial Agents of Various Classes Against Multidrug-Resistant Metallo-\u03b2-Lactamase-Producing Pseudomonas aeruginosa Clinical Isolates","volume":"18","author":"Paranos","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.micres.2025.128417_bib99","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jgar.2024.07.007","article-title":"Phage Therapy for Bone and Joint Infections: A Comprehensive Exploration of Challenges, Dynamics, and Therapeutic Prospects","volume":"39","author":"Peng","year":"2024","journal-title":"J. Glob. Antimicrob. Resist."},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib100","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/femsre\/fuaa017","article-title":"Current Challenges and Future Opportunities of Phage Therapy","volume":"44","author":"Pires","year":"2020","journal-title":"FEMS Microbiol. Rev."},{"issue":"6","key":"10.1016\/j.micres.2025.128417_bib101","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/s41564-024-01705-x","article-title":"Personalized Bacteriophage Therapy Outcomes for 100 Consecutive Cases: a Multicentre, Multinational, Retrospective Observational Study","volume":"9","author":"Pirnay","year":"2024","journal-title":"Nat. Microbiol."},{"issue":"5","key":"10.1016\/j.micres.2025.128417_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/v15051210","article-title":"Successful Bacteriophage-Antibiotic Combination Therapy against Multidrug-Resistant Pseudomonas aeruginosa Left Ventricular Assist Device Driveline Infection","volume":"15","author":"Racenis","year":"2023","journal-title":"Viruses"},{"issue":"ement_2","key":"10.1016\/j.micres.2025.128417_bib103","article-title":"2891. Nebulized Phage Therapy for Patients with Cystic Fibrosis with Chronic Pseudomonas aeruginosa Pulmonary Infection: A Phase 1b\/2a Randomized, Double-Blind, Placebo-Controlled, Multicenter Study","volume":"10","author":"Rappo","year":"2023","journal-title":"Open Forum Infect. Dis."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib104","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s43141-022-00409-1","article-title":"Bacteriophage as a Potential Therapy to Control Antibiotic-Resistant Pseudomonas aeruginosa Infection Through Topical Application onto a Full-Thickness Wound in a Rat Model","volume":"20","author":"Rezk","year":"2022","journal-title":"J. ]. J. Genet. Eng. Biotechnol."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib105","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/antibiotics14020110","article-title":"Genomic Insights into and Lytic Potential of Native Bacteriophages M8-2 and M8-3 Against Clinically Relevant Multidrug-Resistant Pseudomonas aeruginosa","volume":"14","author":"Rodr\u00edguez-Recio","year":"2025","journal-title":"Antibiotics"},{"issue":"5","key":"10.1016\/j.micres.2025.128417_bib106","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41579-020-00477-5","article-title":"Pseudomonas aeruginosa Adaptation and Evolution in Patients with Cystic Fibrosis","volume":"19","author":"Rossi","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.micres.2025.128417_bib107","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1469-0691.2005.01161.x","article-title":"Treatment and Control of Severe Infections Caused by Multiresistant Pseudomonas aeruginosa","volume":"11","author":"Rossolini","year":"2005","journal-title":"Clin. Microbiol. Infect."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib108","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1574-695X.2012.00977.x","article-title":"Synergistic Phage-Antibiotic Combinations for the Control of Escherichia coli Biofilms in vitro","volume":"65","author":"Ryan","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"11","key":"10.1016\/j.micres.2025.128417_bib109","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1164\/rccm.200408-1044SO","article-title":"Pathogen-Host Interactions in Pseudomonas aeruginosa[J","volume":"171","author":"Sadikot","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.micres.2025.128417_bib110","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrmicro3564","article-title":"A Century of the Phage: Past, Present and Future","volume":"13","author":"Salmond","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"issue":"7","key":"10.1016\/j.micres.2025.128417_bib111","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics12071089","article-title":"Bacteriophage-Antibiotic Combination Therapy against Pseudomonas aeruginosa","volume":"12","author":"Santamar\u00eda-Corral","year":"2023","journal-title":"Antibiotics"},{"issue":"12","key":"10.1016\/j.micres.2025.128417_bib112","doi-asserted-by":"crossref","first-page":"O983","DOI":"10.1111\/1469-0691.12712","article-title":"Effectiveness of bacteriophages in the sputum of cystic fibrosis patients","volume":"20","author":"Saussereau","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.micres.2025.128417_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115793","article-title":"Novel Intranasal Phage-CaEDTA-Ceftazidime\/Avibactam Triple Combination Therapy Demonstrates Remarkable Efficacy in Treating Pseudomonas aeruginosa Lung Infection","volume":"168","author":"Shein","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib114","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00253-023-12838-0","article-title":"Chitosan-based matrix as a carrier for bacteriophages","volume":"108","author":"Sikora","year":"2024","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib115","article-title":"Combination of Phage Therapy and Cefiderocol to Successfully Treat Pseudomonas aeruginosa Cranial Osteomyelitis","volume":"4","author":"Simner","year":"2022","journal-title":"JACAntimicrob. Resist."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib116","doi-asserted-by":"crossref","DOI":"10.1136\/bmjresp-2022-001360","article-title":"Single-Arm, Open-Labelled, Safety and Tolerability of Intrabronchial and Nebulised Bacteriophage Treatment in Children with Cystic Fibrosis and Pseudomonas aeruginosa","volume":"10","author":"Singh","year":"2023","journal-title":"BMJ Open Respir. Res."},{"key":"10.1016\/j.micres.2025.128417_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2024.199442","article-title":"Safety and Tolerability of Bronchoscopic and Nebulised Administration of Bacteriophage","volume":"348","author":"Singh","year":"2024","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib118","article-title":"Exploiting Phage-Antibiotic Synergies to Disrupt Pseudomonas aeruginosa PAO1 Biofilms in the Context of Orthopedic Infections","volume":"12","author":"Soir","year":"2024","journal-title":"Microbiol. Spectr."},{"issue":"10","key":"10.1016\/j.micres.2025.128417_bib119","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3390\/antibiotics11101340","article-title":"The Safety and Efficacy of Phage Therapy: A Systematic Review of Clinical and Safety Trials","volume":"11","author":"Stacey","year":"2022","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cell.2022.11.017","article-title":"Phage therapy: From Biological Mechanisms to Future Directions","volume":"186","author":"Strathdee","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib121","doi-asserted-by":"crossref","first-page":"9088","DOI":"10.1038\/s41598-024-59866-y","article-title":"An effective antibiofilm strategy based on bacteriophages armed with silver nanoparticles","volume":"14","author":"Szymczak","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib122","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01359-23","article-title":"Evaluation of the impact of repeated intravenous phage doses on mammalian host-phage interactions","volume":"98","author":"Tan","year":"2024","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib123","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jinf.2021.05.027","article-title":"Successful case of adjunctive intravenous bacteriophage therapy to treat left ventricular assist device infection","volume":"83","author":"Tkhilaishvili","year":"2021","journal-title":"J. Infect."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib124","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics10020175","article-title":"Bacteriophage-Derived Depolymerases against Bacterial Biofilm","volume":"10","author":"Topka-Bielecka","year":"2021","journal-title":"Antibiotics"},{"issue":"7","key":"10.1016\/j.micres.2025.128417_bib125","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00707-23","article-title":"Optimizing bacteriophage treatment of resistant Pseudomonas","volume":"9","author":"Ulrich","year":"2024","journal-title":"mSphere"},{"issue":"8","key":"10.1016\/j.micres.2025.128417_bib126","doi-asserted-by":"crossref","first-page":"7055","DOI":"10.1007\/s11033-023-08557-4","article-title":"Bacteriophage genome engineering for phage therapy to combat bacterial antimicrobial resistance as an alternative to antibiotics","volume":"50","author":"Usman","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"8","key":"10.1016\/j.micres.2025.128417_bib127","doi-asserted-by":"crossref","first-page":"e208","DOI":"10.1016\/S1473-3099(21)00612-5","article-title":"Safety and Efficacy of Phage Therapy in Difficult-to-Treat Infections: a Systematic Review","volume":"22","author":"Uyttebroek","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.micres.2025.128417_bib128","article-title":"Survival Comes at a Cost: A Coevolution of Phage and Its Host Leads to Phage Resistance and Antibiotic Sensitivity of Pseudomonas aeruginosa Multidrug Resistant Strains","volume":"12","author":"Valappil","year":"2021","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.micres.2025.128417_bib129","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4103\/0377-4929.42511","article-title":"Utility of Lytic Bacteriophage in the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Septicemia in Mice","volume":"51","author":"Vinodkumar","year":"2008","journal-title":"Indian J. Pathol. Microbiol."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib130","first-page":"309","article-title":"Use of Bacteriophage in the Treatment of Experimental Animal Bacteremia from Imipenem-Resistant Pseudomonas aeruginosa","volume":"17","author":"Wang","year":"2006","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib131","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01882-23","article-title":"Pharmacokinetics and Safety Evaluation of Intravenously Administered Pseudomonas Phage PA_LZ7 in a Mouse Model","volume":"12","author":"Wang","year":"2024","journal-title":"Microbiol. Spectr."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib132","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/AAC.00635-06","article-title":"Efficacy of Bacteriophage Therapy Against Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice","volume":"51","author":"Watanabe","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"10.1016\/j.micres.2025.128417_bib133","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/thoraxjnl-2016-209265","article-title":"Phage Therapy is Highly Effective Against Chronic Lung Infections with Pseudomonas aeruginosa","volume":"72","author":"Waters","year":"2017","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib134","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1038\/s41467-025-60598-4","article-title":"Phage Therapy with Nebulized Cocktail BX004-A for Chronic Pseudomonas aeruginosa Infections in Cystic Fibrosis: A Randomized First-in-Human Trial","volume":"16","author":"Weiner","year":"2025","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.micres.2025.128417_bib135","doi-asserted-by":"crossref","DOI":"10.3390\/v15020387","article-title":"Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Na\u00efve Mice","volume":"15","author":"Weissfuss","year":"2023","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.micres.2025.128417_bib136","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1038\/s41467-025-59806-y","article-title":"Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa","volume":"16","author":"Weissfuss","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.micres.2025.128417_bib137","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1007\/s00264-024-06295-1","article-title":"Bacteriophage therapy as an innovative strategy for the treatment of periprosthetic joint infection: a systematic review","volume":"48","author":"Yang","year":"2024","journal-title":"Int. Orthop."},{"issue":"12","key":"10.1016\/j.micres.2025.128417_bib138","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.3390\/ph16121638","article-title":"Phage therapy-challenges, opportunities and future prospects","volume":"16","author":"Zalewska-Pi\u0105tek","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"10","key":"10.1016\/j.micres.2025.128417_bib139","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/j.1469-0691.2005.01246.x","article-title":"Treatment of multidrug-resistant Pseudomonas aeruginosa Infections: more attention required to in-vitro studies","volume":"11","author":"Zavascki","year":"2005","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.micres.2025.128417_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163027","article-title":"Graphene oxide affects bacteriophage infection of bacteria by promoting the formation of biofilms","volume":"880","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"13","key":"10.1016\/j.micres.2025.128417_bib141","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1016\/j.watres.2013.05.014","article-title":"Application of bacteriophages to selectively remove Pseudomonas aeruginosa in water and wastewater filtration systems","volume":"47","author":"Zhang","year":"2013","journal-title":"Water Res."}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501325003763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501325003763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:13:14Z","timestamp":1773925994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501325003763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":141,"alternative-id":["S0944501325003763"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2025.128417","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A review of phage therapy for drug-resistant Pseudomonas aeruginosa infections","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2025.128417","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128417"}}