{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:16:29Z","timestamp":1786994189061,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","award":["CARS-47"],"award-info":[{"award-number":["CARS-47"]}],"id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32373182"],"award-info":[{"award-number":["32373182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.micres.2026.128578","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:06:37Z","timestamp":1781107597000},"page":"128578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Vibrio anguillarum hijacks fish host CypA to activate Ras-MAPK signaling and promote Edwardsiella piscicida entry during co-infection"],"prefix":"10.1016","volume":"311","author":[{"given":"Yifan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junze","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micres.2026.128578_bib1","series-title":"Bacterial fish pathogens","author":"Austin","year":"2016"},{"key":"10.1016\/j.micres.2026.128578_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2105-4-2","article-title":"An automated method for finding molecular complexes in large protein interaction networks","volume":"4","author":"Bader","year":"2003","journal-title":"Bmc Bioinforma."},{"issue":"7","key":"10.1016\/j.micres.2026.128578_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109159","article-title":"Induction of cyclophilin a by influenza a virus infection facilitates Group A Streptococcus coinfection","volume":"35","author":"Bai","year":"2021","journal-title":"Cell. Rep."},{"issue":"11","key":"10.1016\/j.micres.2026.128578_bib4","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.tree.2019.07.012","article-title":"The pathobiome in animal and plant diseases","volume":"34","author":"Bass","year":"2019","journal-title":"Trends Ecol. & Evol."},{"issue":"2","key":"10.1016\/j.micres.2026.128578_bib5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nrmicro.2017.128","article-title":"Pathogenesis of HIV-1 and mycobacterium tuberculosis co-infection","volume":"16","author":"Bell","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"issue":"8","key":"10.1016\/j.micres.2026.128578_bib6","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: A cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.micres.2026.128578_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003057","article-title":"Viral and bacterial interactions in the upper respiratory tract","volume":"9","author":"Bosch","year":"2013","journal-title":"PLOS Pathog."},{"issue":"1","key":"10.1016\/j.micres.2026.128578_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/S2666-5247(20)30009-4","article-title":"Co-infections: Potentially lethal and unexplored in COVID-19","volume":"1","author":"Cox","year":"2020","journal-title":"Lancet Microbe"},{"issue":"7","key":"10.1016\/j.micres.2026.128578_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcb.2005.05.001","article-title":"GDIs: Central regulatory molecules in rho GTPase activation","volume":"15","author":"DerMardirossian","year":"2005","journal-title":"Trends Cell. Biol."},{"issue":"6206","key":"10.1016\/j.micres.2026.128578_bib10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/337476a0","article-title":"Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins","volume":"337","author":"Fischer","year":"1989","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.micres.2026.128578_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2761.2011.01279.x","article-title":"Vibrio anguillarum as a fish pathogen: Virulence factors, diagnosis and prevention","volume":"34","author":"Frans","year":"2011","journal-title":"J. Fish. Dis."},{"issue":"7610","key":"10.1016\/j.micres.2026.128578_bib12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature18850","article-title":"Microbiome-wide association studies link dynamic microbial consortia to disease","volume":"535","author":"Gilbert","year":"2016","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.micres.2026.128578_bib13","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.cell.2007.03.051","article-title":"Binding of Ras to phosphoinositide 3-kinase p110alpha is required for Ras-driven tumorigenesis in mice","volume":"129","author":"Gupta","year":"2007","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.micres.2026.128578_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008790","article-title":"Coinfections in wildlife: Focus on a neglected aspect of infectious disease epidemiology","volume":"16","author":"Hoarau","year":"2020","journal-title":"PLOS Pathog."},{"issue":"5","key":"10.1016\/j.micres.2026.128578_bib15","doi-asserted-by":"crossref","first-page":"e00548","DOI":"10.1128\/JB.00548-18","article-title":"Edwardsiella piscicida enters nonphagocytic cells via a macropinocytosis-involved hybrid mechanism","volume":"201","author":"Hu","year":"2019","journal-title":"J. Bacteriol."},{"issue":"38","key":"10.1016\/j.micres.2026.128578_bib16","doi-asserted-by":"crossref","first-page":"22473","DOI":"10.1074\/jbc.270.38.22473","article-title":"Bridging Ral GTPase to rho pathways: RLIP76, a Ral effector with CDC42\/Rac GTPase-activating protein activity","volume":"270","author":"Jullien-Flores","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.micres.2026.128578_bib17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.137.2.481","article-title":"Regulation of cell motility by mitogen-activated protein kinase","volume":"137","author":"Klemke","year":"1997","journal-title":"J. Cell. Biol."},{"issue":"1","key":"10.1016\/j.micres.2026.128578_bib18","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2019.1621648","article-title":"Edwardsiella piscicida: A versatile emerging pathogen of fish","volume":"10","author":"Leung","year":"2019","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/j.micres.2026.128578_bib19","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2025.2526783","article-title":"Edwardsiella piscicida employs C3 derivative to mediate internalization and infection via the teleost-specific receptor","volume":"16","author":"Li","year":"2025","journal-title":"Virulence"},{"key":"10.1016\/j.micres.2026.128578_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110205","article-title":"Proteomics analysis of extracellular vesicles during Vibrio anguillarum infection in lumpfish (Cyclopterus lumpus)","volume":"160","author":"Machimbirike","year":"2025","journal-title":"Fish. & Shellfish. Immunol."},{"key":"10.1016\/j.micres.2026.128578_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.828078","article-title":"Emerging roles of cyclophilin a in regulating viral cloaking","volume":"13","author":"Mamatis","year":"2022","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.micres.2026.128578_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/nrmicro3231","article-title":"The co-pathogenesis of influenza viruses with bacteria in the lung","volume":"12","author":"McCullers","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.micres.2026.128578_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibs.2011.03.006","article-title":"The Ras-ERK and PI3K-mTOR pathways: Cross-talk and compensation","volume":"36","author":"Mendoza","year":"2011","journal-title":"Trends Biochem. Sci."},{"issue":"10","key":"10.1016\/j.micres.2026.128578_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.410","article-title":"Cyclophilin a: A key player for human disease","volume":"4","author":"Nigro","year":"2013","journal-title":"Cell. Death & Dis."},{"key":"10.1016\/j.micres.2026.128578_bib25","article-title":"Dynamics of co-infection in fish: A review of pathogen-host interaction and clinical outcome","volume":"4","author":"Okon","year":"2023","journal-title":"Fish. Shellfish. Immunol. Rep."},{"key":"10.1016\/j.micres.2026.128578_bib26","article-title":"Edwardsiella piscicida induces largemouth bass PINK1\/parkin-mediated mitophagy for its survival and virulence","author":"Pi","year":"2025","journal-title":"J. Immunol."},{"key":"10.1016\/j.micres.2026.128578_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1515641","article-title":"Editorial: Host-bacteria interactions in fish pathogens","volume":"14","author":"Ramos-Vivas","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micres.2026.128578_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jare.2023.04.007","article-title":"The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT\/MAPK\/NF-\u03baB pathways","volume":"57","author":"Shen","year":"2023","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.micres.2026.128578_bib29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41392-023-01719-7","article-title":"Host cyclophilin a facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions","volume":"8","author":"Sheng","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.micres.2026.128578_bib30","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s00343-023-2363-7","article-title":"Transcriptome analysis reveals immune-related genes in tissues of Vibrio anguillarum-infected turbot Scophthalmus maximus","volume":"42","author":"Song","year":"2024","journal-title":"J. Oceanol. Limnol."},{"issue":"1","key":"10.1016\/j.micres.2026.128578_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: A generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.micres.2026.128578_bib32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13567-022-01057-6","article-title":"Orf1B controls secretion of T3SS proteins and contributes to Edwardsiella piscicida adhesion to epithelial cells","volume":"53","author":"Wang","year":"2022","journal-title":"Vet. Res."},{"key":"10.1016\/j.micres.2026.128578_bib33","first-page":"1","article-title":"The type VI secretion system and associated effector proteins","author":"Wohlfarth","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micres.2026.128578_bib34","doi-asserted-by":"crossref","DOI":"10.1101\/483032","article-title":"A critical role of the T3SS effector EseJ in intracellular trafficking and replication of Edwardsiella piscicida in non-phagocytic cells","author":"Zhang","year":"2018","journal-title":"Pathology"}],"updated-by":[{"DOI":"10.1016\/j.micres.2026.128619","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000}},{"DOI":"10.1016\/j.micres.2026.128619","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000}}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501326001424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501326001424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:11:58Z","timestamp":1783919518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501326001424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":34,"alternative-id":["S0944501326001424"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2026.128578","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vibrio anguillarum hijacks fish host CypA to activate Ras-MAPK signaling and promote Edwardsiella piscicida entry during co-infection","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2026.128578","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"128578"}}