{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:30:13Z","timestamp":1793205013225,"version":"4.5.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002714","name":"University of Freiburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002714","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.micres.2026.128607","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:17:00Z","timestamp":1782850620000},"page":"128607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Regulation of cyanobacterial type IV pilus-dependent functions by interaction between a c-di-GMP receptor and two transcription factors"],"prefix":"10.1016","volume":"311","author":[{"given":"Thomas","family":"Wallner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenliu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherihan","family":"Samir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Sabatine","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Cai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2974-9483","authenticated-orcid":false,"given":"Khaled A.","family":"Selim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0935-8415","authenticated-orcid":false,"given":"Annegret","family":"Wilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micres.2026.128607_bib1","unstructured":"Agostinelli, C., Lund, U., 2023. R package circular: Circular Statistics (version 0.5-0). \u3008https:\/\/CRAN.R-project.org\/package=circular\u3009."},{"key":"10.1016\/j.micres.2026.128607_bib2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3389\/fmicb.2018.01121","article-title":"Homeostasis of Second Messenger Cyclic-di-AMP Is Critical for Cyanobacterial Fitness and Acclimation to Abiotic Stress","volume":"9","author":"Agostoni","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ymeth.2012.07.018","article-title":"The bacterial two-hybrid system based on adenylate cyclase reconstitution in Escherichia coli","volume":"58","author":"Battesti","year":"2012","journal-title":"Methods"},{"key":"10.1016\/j.micres.2026.128607_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137652","article-title":"AQUA Cloning: A Versatile and Simple Enzyme-Free Cloning Approach","volume":"10","author":"Beyer","year":"2015","journal-title":"PLoS. One"},{"key":"10.1016\/j.micres.2026.128607_bib5","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1046\/j.1365-2958.2000.02068.x","article-title":"Type IV pilus biogenesis and motility in the cyanobacterium Synechocystis sp. PCC6803","volume":"37","author":"Bhaya","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib6","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1128\/JB.183.20.6140-6143.2001","article-title":"Novel Motility Mutants of Synechocystis Strain PCC 6803 Generated by In Vitro Transposon Mutagenesis","volume":"183","author":"Bhaya","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2026.128607_bib7","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1128\/JB.00573-06","article-title":"Phototaxis and Impaired Motility in Adenylyl Cyclase and Cyclase Receptor Protein Mutants of Synechocystis sp. strain PCC 6803","volume":"188","author":"Bhaya","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2026.128607_bib8","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1365-2958.2009.06739.x","article-title":"Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress","volume":"72","author":"Boehm","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib9","doi-asserted-by":"crossref","first-page":"17084","DOI":"10.1073\/pnas.0406134101","article-title":"Structural basis of activity and allosteric control of diguanylate cyclase","volume":"101","author":"Chan","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2026.128607_bib10","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.bpj.2015.01.042","article-title":"Maintenance of Motility Bias during Cyanobacterial Phototaxis","volume":"108","author":"Chau","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.micres.2026.128607_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1128\/JB.00333-15","article-title":"Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms","volume":"198","author":"Chou","year":"2016","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2026.128607_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00344-19","article-title":"Factors Controlling Floc Formation and Structure in the Cyanobacterium Synechocystis sp. PCC 6803","author":"Conradi","year":"2019","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2026.128607_bib13","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1099\/mic.0.2008\/020222-0","article-title":"The cyanobacterial homologue of the RNA chaperone Hfq is essential for motility of Synechocystis sp. PCC 6803","volume":"154","author":"Dienst","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.micres.2026.128607_bib14","article-title":"Myxococcus xanthus PilB interacts with c-di-GMP and modulates motility and biofilm formation","volume":"205","author":"Dye Keane","year":"2023","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2026.128607_bib15","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.1073\/pnas.1504228112","article-title":"Three cyanobacteriochromes work together to form a light color-sensitive input system for c-di-GMP signaling of cell aggregation","volume":"112","author":"Enomoto","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2026.128607_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/femsml\/uqad019","article-title":"Control of light-dependent behaviour in cyanobacteria by the second messenger cyclic di-GMP","volume":"4","author":"Enomoto","year":"2023","journal-title":"Microlife"},{"key":"10.1016\/j.micres.2026.128607_bib17","first-page":"30540","article-title":"Inactivation of the Open Reading Frame slr0399 in Synechocystis sp. PCC 6803 Functionally Complements Mutations near the QA Niche of Photosystem II","volume":"274","author":"Ermakova-Gerdes","year":"1999","journal-title":"A POSSIBLE ROLE Slr0399 A CHAPERONE QUINONE Bind. J. Biol. Chem."},{"key":"10.1016\/j.micres.2026.128607_bib18","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41592-022-01507-1","article-title":"TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines","volume":"19","author":"Ershov","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.micres.2026.128607_bib19","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1562\/2005-06-28-RA-592","article-title":"Phototaxis in the Cyanobacterium Synechocystis sp. PCC 6803: Role of Different Photoreceptors","volume":"81","author":"Fiedler","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.micres.2026.128607_bib20","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.tim.2021.12.014","article-title":"New views on PII signaling: from nitrogen sensing to global metabolic control","volume":"30","author":"Forchhammer","year":"2022","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/brv.12020","article-title":"Biological roles of cAMP: variations on a theme in the different kingdoms of life","volume":"88","author":"Gancedo","year":"2013","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.micres.2026.128607_bib22","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1128\/MMBR.00035-12","article-title":"Type IV Pilin Proteins: Versatile Molecular Modules","volume":"76","author":"Giltner","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.micres.2026.128607_bib23","series-title":"Molecular cloning: a laboratory manual","author":"Green","year":"2012"},{"issue":"10","key":"10.1016\/j.micres.2026.128607_bib24","article-title":"Preprint] PII signal transduction superfamily acts as a valve plug to control bicarbonate and ammonia homeostasis among different bacterial phyla","volume":"08","author":"Haffner","year":"2023","journal-title":"bioRxiv 2023"},{"key":"10.1016\/j.micres.2026.128607_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113261","article-title":"Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signaling cascade","volume":"28","author":"Haffner","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.micres.2026.128607_bib26","doi-asserted-by":"crossref","unstructured":"Hahn, J., Celma, L., Elshereef, A.A., Samir, S., Dubnau, E., Selim, K.A., Dubnau, D. 2025. [Preprint] c-di-GMP-Dependent Regulation of Motility by comFB and comFC. bioRxiv. 2025.07.11.664319. https:\/\/doi.org\/10.1101\/2025.07.11.664319.","DOI":"10.1101\/2025.07.11.664319"},{"key":"10.1016\/j.micres.2026.128607_bib27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrmicro2109","article-title":"Principles of c-di-GMP signalling in bacteria","volume":"7","author":"Hengge","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib28","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.tim.2021.02.003","article-title":"High-specificity local and global c-di-GMP signaling","volume":"29","author":"Hengge","year":"2021","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/femsml\/uqad015","article-title":"Recent advances and perspectives in nucleotide second messenger signaling in bacteria","volume":"4","author":"Hengge","year":"2023","journal-title":"Microlife"},{"key":"10.1016\/j.micres.2026.128607_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.793336","article-title":"c-di-GMP Homeostasis Is Critical for Heterocyst Development in Anabaena sp. PCC 7120","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib31","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2328","article-title":"Phototaxis Assays of Synechocystis sp. PCC 6803 at Macroscopic and Microscopic Scales","volume":"7","author":"Jakob","year":"2017","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.micres.2026.128607_bib32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrmicro.2016.190","article-title":"Cyclic di-GMP: second messenger extraordinaire","volume":"15","author":"Jenal","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib33","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101759118","article-title":"Mechanotaxis directs Pseudomonas aeruginosa twitching motility","volume":"118","author":"K\u00fchn","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2026.128607_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1112307","article-title":"Regulation of pSYSA defense plasmid copy number in Synechocystis through RNase E and a highly transcribed asRNA","volume":"14","author":"Kaltenbrunner","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib35","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1073\/pnas.95.10.5752","article-title":"A bacterial two-hybrid system based on a reconstituted signal transduction pathway","volume":"95","author":"Karimova","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2026.128607_bib36","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/dnares\/dsu018","article-title":"Comparative Analysis of the Primary Transcriptome of Synechocystis sp. PCC 6803","volume":"21","author":"Kopf","year":"2014","journal-title":"DNA Res."},{"key":"10.1016\/j.micres.2026.128607_bib37","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/s41467-021-21306-0","article-title":"A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis","volume":"12","author":"Kr\u00fcger","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micres.2026.128607_bib38","doi-asserted-by":"crossref","DOI":"10.1093\/femsml\/uqad024","article-title":"Structural and functional diversity of bacterial cyclic nucleotide perception by CRP proteins","volume":"4","author":"Krol","year":"2023","journal-title":"Microlife"},{"key":"10.1016\/j.micres.2026.128607_bib39","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/mmi.12730","article-title":"Accumulation of the Type IV prepilin triggers degradation of SecY and YidC and inhibits synthesis of Photosystem II proteins in the cyanobacterium Synechocystis PCC 6803","volume":"93","author":"Linhartov\u00e1","year":"2014","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib40","doi-asserted-by":"crossref","DOI":"10.1093\/femsml\/uqad008","article-title":"Roles of second messengers in the regulation of cyanobacterial physiology: the carbon-concentrating mechanism and beyond","volume":"4","author":"Mantovani","year":"2023","journal-title":"Microlife"},{"key":"10.1016\/j.micres.2026.128607_bib41","doi-asserted-by":"crossref","first-page":"7885","DOI":"10.1038\/s41598-024-58354-7","article-title":"The redox-sensitive R-loop of the carbon control protein SbtB contributes to the regulation of the cyanobacterial CCM","volume":"14","author":"Mantovani","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micres.2026.128607_bib42","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.str.2009.06.010","article-title":"Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX","volume":"17","author":"Navarro","year":"2009","journal-title":"Struct"},{"key":"10.1016\/j.micres.2026.128607_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.108041","article-title":"The structural basis for high-affinity c-di-GMP binding to the GSPII-B domain of the traffic ATPase PilF from Thermus thermophilus","volume":"301","author":"Nei\u00dfner","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micres.2026.128607_bib44","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/acssynbio.8b00437","article-title":"Expanding the Potential of CRISPR-Cpf1-Based Genome Editing Technology in the Cyanobacterium Anabaena PCC 7120","volume":"8","author":"Niu","year":"2019","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.micres.2026.128607_bib45","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/mmi.14768","article-title":"Minor pilins are involved in motility and natural competence in the cyanobacterium Synechocystis sp. PCC 6803","volume":"116","author":"Oeser","year":"2021","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib46","first-page":"21","article-title":"Function of cAMP as a Mat-Forming Factor in the Cyanobacterium Spirulina platensis","volume":"33","author":"Ohmori","year":"1992","journal-title":"Plant. Cell. Physiol."},{"key":"10.1016\/j.micres.2026.128607_bib47","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1073\/pnas.1502025112","article-title":"Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa","volume":"112","author":"Persat","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2026.128607_bib48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2199-10-79","article-title":"Analysis of current and alternative phenol based RNA extraction methodologies for cyanobacteria","volume":"10","author":"Pinto","year":"2009","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.micres.2026.128607_bib49","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1099\/mic.0.031823-0","article-title":"An RNA helicase, CrhR, regulates the low-temperature-inducible expression of heat-shock genes groES, groEL1 and groEL2 in Synechocystis sp. PCC 6803","volume":"156","author":"Prakash","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.micres.2026.128607_bib50","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/mmi.12066","article-title":"The response threshold of Salmonella PilZ domain proteins is determined by their binding affinities for c-di-GMP","volume":"86","author":"Pultz","year":"2012","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.00043-12","article-title":"Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger","volume":"77","author":"R\u00f6mling","year":"2013","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.micres.2026.128607_bib52","unstructured":"R_Core_Team, 2023. R: A Language and Environment for Statistical Computing. \u3008https:\/\/www.R-project.org\u3009."},{"key":"10.1016\/j.micres.2026.128607_bib53","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1099\/mic.0.058958-0","article-title":"6S RNA - an old issue became blue-green","volume":"158","author":"Rediger","year":"2012","journal-title":"Microbiol. Read."},{"key":"10.1016\/j.micres.2026.128607_bib54","first-page":"1","article-title":"Generic Assignments, Strain Histories and Properties of Pure Cultures of Cyanobacteria","volume":"111","author":"Rippka","year":"1979","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib55","doi-asserted-by":"crossref","first-page":"15528","DOI":"10.1073\/pnas.1018949108","article-title":"Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions","volume":"108","author":"Roelofs","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2026.128607_bib56","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2513041122","article-title":"ComFB, a widespread family of c-di-NMP receptor proteins","volume":"122","author":"Samir","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2026.128607_bib57","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41421-025-00816-x","article-title":"The second messenger c-di-AMP controls natural competence via ComFB signaling protein","volume":"11","author":"Samir","year":"2025","journal-title":"Cell. Discov."},{"key":"10.1016\/j.micres.2026.128607_bib58","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1365-2958.2012.08106.x","article-title":"Light-induced alteration of c-di-GMP level controls motility of Synechocystis sp. PCC 6803","volume":"85","author":"Savakis","year":"2012","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib59","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an Open Source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.micres.2026.128607_bib60","doi-asserted-by":"crossref","first-page":"7239","DOI":"10.1038\/s41467-023-42823-0","article-title":"Structures of the DarR transcription regulator reveal unique modes of second messenger and DNA binding","volume":"14","author":"Schumacher","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micres.2026.128607_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2024.102453","article-title":"PII-like signaling proteins: a new paradigm in orchestrating cellular homeostasis","volume":"79","author":"Selim","year":"2024","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib62","doi-asserted-by":"crossref","first-page":"E4861","DOI":"10.1073\/pnas.1803790115","article-title":"PII-like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response","volume":"115","author":"Selim","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2026.128607_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55495-y","article-title":"Tuning the in vitro sensing and signaling properties of cyanobacterial PII protein by mutation of key residues","volume":"9","author":"Selim","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micres.2026.128607_bib64","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/febs.14989","article-title":"Interaction of N-acetyl-l-glutamate kinase with the PII signal transducer in the non-photosynthetic alga Polytomella parva: Co-evolution towards a hetero-oligomeric enzyme","volume":"287","author":"Selim","year":"2020","journal-title":"FEBS J."},{"key":"10.1016\/j.micres.2026.128607_bib65","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk0568","article-title":"Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB","volume":"7","author":"Selim","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.micres.2026.128607_bib66","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205882120","article-title":"Carbon signaling protein SbtB possesses atypical redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA","volume":"120","author":"Selim","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micres.2026.128607_bib67","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41564-020-00809-4","article-title":"Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus","volume":"6","author":"Shyp","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib68","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00436-18","article-title":"Sycrp2 Is Essential for Twitching Motility in the Cyanobacterium Synechocystis sp. Strain PCC 6803","volume":"200","author":"Song","year":"2018","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micres.2026.128607_bib69","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/oxfordjournals.pcp.a029534","article-title":"An adenylate cyclase, Cya1, Regulates Cell Motility in the Cyanobacterium Synechocystis sp. PCC 6803","volume":"40","author":"Terauchi","year":"1999","journal-title":"Plant. Cell. Physiol."},{"key":"10.1016\/j.micres.2026.128607_bib70","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2958.2003.03980.x","article-title":"Blue light stimulates cyanobacterial motility via a cAMP signal transduction system","volume":"52","author":"Terauchi","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0378-1119(82)90015-4","article-title":"The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers","volume":"19","author":"Vieira","year":"1982","journal-title":"Gene"},{"key":"10.1016\/j.micres.2026.128607_bib72","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1039\/c9pp00489k","article-title":"The cyanobacterial phytochrome 2 regulates the expression of motility-related genes through the second messenger cyclic di-GMP","volume":"19","author":"Wallner","year":"2020","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.micres.2026.128607_bib73","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbabio.2019.04.007","article-title":"A novel Ca(2+)-binding protein influences photosynthetic electron transport in Anabaena sp. PCC 7120","volume":"1860","author":"Walter","year":"2019","journal-title":"Biochim. Biophys. Acta - Bioenerg."},{"key":"10.1016\/j.micres.2026.128607_bib74","article-title":"Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micres.2026.128607_bib75","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03028-22","article-title":"Structural Basis of Dual Specificity of Sinorhizobium meliloti Clr, a cAMP and cGMP Receptor Protein","volume":"14","author":"Werel","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.micres.2026.128607_bib76","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-1119(85)90120-9","article-title":"Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors","volume":"33","author":"Yanisch-Perron","year":"1985","journal-title":"Gene"},{"key":"10.1016\/j.micres.2026.128607_bib77","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1074\/jbc.275.9.6241","article-title":"Identification and Characterization of a Novel cAMP Receptor Protein in the Cyanobacterium Synechocystis sp. PCC 6803","volume":"275","author":"Yoshimura","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micres.2026.128607_bib78","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1046\/j.1365-2958.2002.02790.x","article-title":"Screening for the target gene of cyanobacterial cAMP receptor protein SYCRP1","volume":"43","author":"Yoshimura","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micres.2026.128607_bib79","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221874120","article-title":"A c-di-GMP binding effector controls cell size in a cyanobacterium","volume":"120","author":"Zeng","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501326001710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501326001710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:06:56Z","timestamp":1783919216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501326001710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":79,"alternative-id":["S0944501326001710"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2026.128607","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of cyanobacterial type IV pilus-dependent functions by interaction between a c-di-GMP receptor and two transcription factors","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2026.128607","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"128607"}}