{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:40:54Z","timestamp":1792233654340,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32430104"],"award-info":[{"award-number":["32430104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2662026DKPY005"],"award-info":[{"award-number":["2662026DKPY005"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFE0106100"],"award-info":[{"award-number":["2024YFE0106100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbiological Research"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.micres.2026.128712","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:02:28Z","timestamp":1788534148000},"page":"128712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Spartin promotes influenza A virus attachment by sustaining the organization of sialic acid clusters"],"prefix":"10.1016","volume":"314","author":[{"given":"Huimin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyu","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-3972","authenticated-orcid":false,"given":"Hongbo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micres.2026.128712_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1190463","article-title":"pH-dependent endocytosis mechanisms for influenza A and SARS-coronavirus","volume":"14","author":"Aganovic","year":"2023","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.micres.2026.128712_bib2","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.bbrc.2005.06.201","article-title":"The Troyer syndrome (SPG20) protein spartin interacts with Eps15","volume":"334","author":"Bakowska","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.micres.2026.128712_bib3","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1091\/mbc.e06-09-0833","article-title":"Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor trafficking","volume":"18","author":"Bakowska","year":"2007","journal-title":"Mol. Biol. Cell."},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib4","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1038\/s41467-025-58935-8","article-title":"Single influenza A viruses induce nanoscale cellular reprogramming at the virus-cell interface","volume":"16","author":"Broich","year":"2025","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.micres.2026.128712_bib5","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41556-023-01178-w","article-title":"The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets","volume":"25","author":"Chung","year":"2023","journal-title":"Nat. Cell. Biol."},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/viro.1994.1615","article-title":"Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates","volume":"205","author":"Connor","year":"1994","journal-title":"Virology"},{"issue":"9","key":"10.1016\/j.micres.2026.128712_bib7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S1473-3099(12)70121-4","article-title":"Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study","volume":"12","author":"Dawood","year":"2012","journal-title":"Lancet Infect. Dis."},{"issue":"10","key":"10.1016\/j.micres.2026.128712_bib8","first-page":"11284","article-title":"A novel mutation in SPART gene causes a severe neurodevelopmental delay due to mitochondrial dysfunction with complex I impairments and altered pyruvate metabolism","volume":"33","author":"Diquigiovanni","year":"2019","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"7","key":"10.1016\/j.micres.2026.128712_bib9","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.230040","article-title":"Mutant SPART causes defects in mitochondrial protein import and bioenergetics reversed by Coenzyme Q","volume":"13","author":"Diquigiovanni","year":"2023","journal-title":"Open. Biol."},{"key":"10.1016\/j.micres.2026.128712_bib10","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.3389\/fimmu.2018.01581","article-title":"Influenza a virus cell entry, replication, virion assembly and movement","volume":"9","author":"Dou","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micres.2026.128712_bib11","first-page":"137","article-title":"Measurement of lateral transport on cell surfaces","volume":"9","author":"Elson","year":"1976","journal-title":"Progress. Clin. Biol. Res."},{"issue":"3","key":"10.1016\/j.micres.2026.128712_bib12","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3390\/biom5031480","article-title":"Characterization of receptor binding profiles of influenza a viruses using an ellipsometry-based label-free glycan microarray assay platform","volume":"5","author":"Fei","year":"2015","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.micres.2026.128712_bib13","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.molcel.2024.02.029","article-title":"Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH","volume":"84","author":"Gahlot","year":"2024","journal-title":"Mol. Cell."},{"issue":"37","key":"10.1016\/j.micres.2026.128712_bib14","doi-asserted-by":"crossref","first-page":"28403","DOI":"10.1074\/jbc.R110.129809","article-title":"Influenza hemagglutinin and neuraminidase membrane glycoproteins","volume":"285","author":"Gamblin","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"38","key":"10.1016\/j.micres.2026.128712_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm6668","article-title":"Apolipoprotein E mediates cell resistance to influenza virus infection","volume":"8","author":"Gao","year":"2022","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.micres.2026.128712_bib16","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.celrep.2018.03.045","article-title":"Genome-wide CRISPR\/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication","volume":"23","author":"Han","year":"2018","journal-title":"Cell. Rep."},{"issue":"7","key":"10.1016\/j.micres.2026.128712_bib17","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.celrep.2017.07.060","article-title":"A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor","volume":"20","author":"Heaton","year":"2017","journal-title":"Cell. Rep."},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib18","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1038\/s41598-020-62074-z","article-title":"The Human Lung Glycome Reveals Novel Glycan Ligands for Influenza A Virus","volume":"10","author":"Jia","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.micres.2026.128712_bib19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.tcb.2018.01.009","article-title":"Clustering on Membranes: Fluctuations and More","volume":"28","author":"Johannes","year":"2018","journal-title":"Trends Cell. Biol."},{"issue":"4","key":"10.1016\/j.micres.2026.128712_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019290","article-title":"SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis","volume":"6","author":"Joshi","year":"2011","journal-title":"PloS. One"},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib21","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1038\/s41467-021-26296-7","article-title":"Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion","volume":"12","author":"Junqueira Alves","year":"2021","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.micres.2026.128712_bib22","doi-asserted-by":"crossref","first-page":"E1645","DOI":"10.1073\/pnas.1514030113","article-title":"Actomyosin dynamics drive local membrane component organization in an in vitro active composite layer","volume":"113","author":"K\u00f6ster","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41572-018-0002-y","article-title":"Influenza","volume":"4","author":"Krammer","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib24","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1038\/s41467-024-49117-z","article-title":"Potential pandemic risk of circulating swine H1N2 influenza viruses","volume":"15","author":"Le Sage","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micres.2026.128712_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198118","article-title":"Swine influenza virus: Current status and challenge","volume":"288","author":"Ma","year":"2020","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib26","first-page":"158","article-title":"The pig as a mixing vessel for influenza viruses: Human and veterinary implications","volume":"3","author":"Ma","year":"2008","journal-title":"J. Mol. Genet. Med. Int. J. Biomed. Res."},{"issue":"35","key":"10.1016\/j.micres.2026.128712_bib27","doi-asserted-by":"crossref","first-page":"33583","DOI":"10.1074\/jbc.M304346200","article-title":"Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling","volume":"278","author":"Morgan","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.micres.2026.128712_bib28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.chom.2012.09.011","article-title":"The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton","volume":"12","author":"Odendall","year":"2012","journal-title":"Cell. host & Microbe"},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib29","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1038\/s41467-025-58834-y","article-title":"The bat influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment","volume":"16","author":"Osman","year":"2025","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.micres.2026.128712_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.15698\/mic2017.12.603","article-title":"Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin","volume":"4","author":"Ring","year":"2017","journal-title":"Microbial cell (Graz Austria)"},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/srep45043","article-title":"Influenza A virus hemagglutinin and neuraminidase act as novel motile machinery","volume":"7","author":"Sakai","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.micres.2026.128712_bib32","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1083\/jcb.129.6.1559","article-title":"Barriers for lateral diffusion of transferrin receptor in the plasma membrane as characterized by receptor dragging by laser tweezers: fence versus tether","volume":"129","author":"Sako","year":"1995","journal-title":"J. Cell. Biol."},{"issue":"2","key":"10.1016\/j.micres.2026.128712_bib33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tibs.2022.08.002","article-title":"Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm","volume":"48","author":"S\u00e1nchez","year":"2023","journal-title":"Trends Biochem. Sci."},{"issue":"21","key":"10.1016\/j.micres.2026.128712_bib34","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1021\/bi00447a018","article-title":"Hemagglutinins from two influenza virus variants bind to sialic acid derivatives with millimolar dissociation constants: a 500-MHz proton nuclear magnetic resonance study","volume":"28","author":"Sauter","year":"1989","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.micres.2026.128712_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000157337","article-title":"Pigs as \u2018Mixing Vessels\u2019 for the Creation of New Pandemic Influenza A Viruses","volume":"2","author":"Scholtissek","year":"2008","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.micres.2026.128712_bib36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coviro.2021.03.001","article-title":"Entry of influenza A virus into host cells - recent progress and remaining challenges","volume":"48","author":"Sempere Borau","year":"2021","journal-title":"Curr. Opin. Virol."},{"issue":"7","key":"10.1016\/j.micres.2026.128712_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008656","article-title":"Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation","volume":"16","author":"Sieben","year":"2020","journal-title":"PLoS. Pathog."},{"issue":"7","key":"10.1016\/j.micres.2026.128712_bib38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1091\/mbc.E18-11-0715","article-title":"Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane","volume":"31","author":"Sil","year":"2020","journal-title":"Mol. Biol. Cell."},{"issue":"5","key":"10.1016\/j.micres.2026.128712_bib39","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jmb.2005.11.002","article-title":"Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities","volume":"355","author":"Stevens","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.micres.2026.128712_bib40","article-title":"Genome-wide CRISPR screen identifies STK11 as a critical regulator of sialic acid clusters important for influenza A virus attachment","author":"Sun","year":"2025","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib41","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1038\/s41467-022-34111-0","article-title":"Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection","volume":"13","author":"Trimarco","year":"2022","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.micres.2026.128712_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2024.151402","article-title":"Actin-membrane linkers: Insights from synthetic reconstituted systems","volume":"103","author":"Tsai","year":"2024","journal-title":"Eur. J. Cell. Biol."},{"issue":"1","key":"10.1016\/j.micres.2026.128712_bib43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tim.2019.08.010","article-title":"Influenza A Virus Hemagglutinin-Neuraminidase-Receptor Balance: Preserving Virus Motility","volume":"28","author":"de Vries","year":"2020","journal-title":"Trends Microbiol."},{"issue":"3","key":"10.1016\/j.micres.2026.128712_bib44","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2314093121","article-title":"Spartin-mediated lipid transfer facilitates lipid droplet turnover","volume":"121","author":"Wan","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6172","key":"10.1016\/j.micres.2026.128712_bib45","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/333426a0","article-title":"Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid","volume":"333","author":"Weis","year":"1988","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.micres.2026.128712_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010257","article-title":"Role of actin filaments and cis binding in cadherin clustering and patterning","volume":"18","author":"Yu","year":"2022","journal-title":"PLoS. Comput. Biol."},{"issue":"11","key":"10.1016\/j.micres.2026.128712_bib47","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.3390\/ijms22116081","article-title":"CMAS and ST3GAL4 Play an Important Role in the Adsorption of Influenza Virus by Affecting the Synthesis of Sialic Acid Receptors","volume":"22","author":"Zhao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.micres.2026.128712_bib48","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.bbrc.2018.04.089","article-title":"Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR\/MAPK pathway","volume":"500","author":"Zhou","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Microbiological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501326002764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944501326002764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:44:22Z","timestamp":1792230262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944501326002764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":48,"alternative-id":["S0944501326002764"],"URL":"https:\/\/doi.org\/10.1016\/j.micres.2026.128712","relation":{},"ISSN":["0944-5013"],"issn-type":[{"value":"0944-5013","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spartin promotes influenza A virus attachment by sustaining the organization of sialic acid clusters","name":"articletitle","label":"Article Title"},{"value":"Microbiological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micres.2026.128712","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128712"}}