{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:00:58Z","timestamp":1767999658589,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Micron"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.micron.2023.103559","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T12:11:32Z","timestamp":1697631092000},"page":"103559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cellular evidence of communication strategies for small intestinal high endothelial cells: Ultrastructural insights of nano-scale exosomes and autophagy"],"prefix":"10.1016","volume":"176","author":[{"given":"Ping","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangshuang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Quan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouhai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micron.2023.103559_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.micpath.2018.06.037","article-title":"Characterization of inter-Sertoli cell tight and gap junctions in the testis of turtle: Protect the developing germ cells from an immune response","volume":"123","author":"Ahmed","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micron.2023.103559_bib2","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.3390\/cells11223601","article-title":"Mechanisms of cadmium-induced testicular injury: a risk to male fertility","volume":"11","author":"Ali","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.micron.2023.103559_bib3","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.18632\/aging.204675","article-title":"Cadmium-induced impairment of spermatozoa development by reducing exosomal-MVBs secretion: a novel pathway","volume":"15","author":"Ali","year":"2023","journal-title":"Aging"},{"key":"10.1016\/j.micron.2023.103559_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114889","article-title":"Spectacular role of epididymis and bio-active cargo of nano-scale exosome in sperm maturation: A review","volume":"164","author":"Ali","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.micron.2023.103559_bib5","first-page":"1","article-title":"A new insight of cadmium-induced cellular evidence of autophagic-associated spermiophagy during spermatogenesis","author":"Ali","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.micron.2023.103559_bib6","doi-asserted-by":"crossref","DOI":"10.17582\/journal.pjz\/20190925150957","article-title":"Pathology of induced Velogenic Viscerotropic Newcastle Disease (VVND) in Japanese Quail and Myna","volume":"53","author":"Ayoob","year":"2021","journal-title":"Pak. J. Zool."},{"key":"10.1016\/j.micron.2023.103559_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fimmu.2014.00403","article-title":"Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness","volume":"5","author":"Baixauli","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micron.2023.103559_bib8","first-page":"3997","article-title":"Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells","volume":"121","author":"van Balkom","year":"2013","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"10.1016\/j.micron.2023.103559_bib9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/vim.2009.0113","article-title":"Membrane vesicles released by intestinal epithelial cells infected with rotavirus inhibit T-cell function","volume":"23","author":"Barreto","year":"2010","journal-title":"Viral Immunol."},{"key":"10.1016\/j.micron.2023.103559_bib10","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.chom.2013.05.004","article-title":"Intestinal epithelial autophagy is essential for host defense against invasive bacteria","volume":"13","author":"Benjamin","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micron.2023.103559_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00138","article-title":"Autophagy and stem cells: self-eating for self-renewal","volume":"8","author":"Chang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.micron.2023.103559_bib12","doi-asserted-by":"crossref","first-page":"19242","DOI":"10.18632\/oncotarget.8092","article-title":"Cellular evidence for nano-scale exosome secretion and interactions with spermatozoa in the epididymis of the Chinese soft-shelled turtle, Pelodiscus sinensis","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.micron.2023.103559_bib13","article-title":"Porcine milk-derived exosomes promote proliferation of intestinal epithelial cells","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micron.2023.103559_bib14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1189\/jlb.1210696","article-title":"Intestinal epithelial cell-derived integrin \u03b1\u03b26 plays an important role in the induction of regulatory T cells and inhibits an antigen-specific Th2 response","volume":"90","author":"Chen","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.micron.2023.103559_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tcb.2008.11.003","article-title":"Shedding microvesicles: artefacts no more","volume":"19","author":"Cocucci","year":"2009","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.micron.2023.103559_bib16","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.micron.2023.103559_bib17","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3390\/ijms24021205","article-title":"Taurine alleviates Cadmium-Induced hepatotoxicity by regulating autophagy flux","volume":"24","author":"Duan","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micron.2023.103559_bib18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-0854.2007.00677.x","article-title":"Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells","volume":"9","author":"Fader","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.micron.2023.103559_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2613.2011.00767.x","article-title":"Classification and functions of enteroendocrine cells of the lower gastrointestinal tract","volume":"92","author":"Gunawardene","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.micron.2023.103559_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-5699(99)01575-3","article-title":"Antigen processing and presentation by intestinal epithelial cells\u2013polarity and complexity","volume":"21","author":"Hershberg","year":"2000","journal-title":"Immunol. Today"},{"key":"10.1016\/j.micron.2023.103559_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003261","article-title":"Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense","volume":"9","author":"Hu","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micron.2023.103559_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.fsi.2018.06.044","article-title":"A \u201cLamellar structure\u201d contributes to autophagosome biogenesis and mitophagy in zebrafish hepatocytes","volume":"81","author":"Huang","year":"2018","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.micron.2023.103559_bib23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00360-001-0240-1","article-title":"Seasonal changes in morphology and function of the gastrointestinal tract of free-living alpine marmots (Marmota marmota)","volume":"172","author":"Hume","year":"2002","journal-title":"J. Comp. Physiol. B"},{"key":"10.1016\/j.micron.2023.103559_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13045","article-title":"EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance","volume":"7","author":"Jiang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micron.2023.103559_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms16006","article-title":"Corrigendum: EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance","volume":"8","author":"Jiang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micron.2023.103559_bib26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bcmd.2005.12.001","article-title":"Exosomes biological significance: a concise review","volume":"36","author":"Johnstone","year":"2006","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.micron.2023.103559_bib27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jinf.2013.07.024","article-title":"Exosome release from infected dendritic cells: a clue for a fast spread of prions in the periphery?","volume":"67","author":"Kl\u00f6hn","year":"2013","journal-title":"J. Infect."},{"key":"10.1016\/j.micron.2023.103559_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2645465","article-title":"Tight junction in the intestinal epithelium: its association with diseases and regulation by phytochemicals","volume":"2018","author":"Lee","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.micron.2023.103559_bib29","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s12011-022-03262-y","article-title":"Effect of selenium nanoparticles and chitosan on production performance and antioxidant integrity of heat-stressed broiler","volume":"201","author":"Lochi","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.micron.2023.103559_bib30","article-title":"Impacts of dietary pleurotus eryngii polysaccharide on nutrient digestion, metabolism, and immune response of the small intestine and colon\u2014an iTRAQ\u2010based proteomic analysis","volume":"18","author":"Ma","year":"2018","journal-title":"Proteomics"},{"key":"10.1016\/j.micron.2023.103559_bib31","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1084\/jem.183.3.1161","article-title":"B lymphocytes secrete antigen-presenting vesicles","volume":"183","author":"Raposo","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micron.2023.103559_bib32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.0105-2896.2005.00285.x","article-title":"Lymphocyte homing to the gut: attraction, adhesion, and commitment","volume":"206","author":"Salmi","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micron.2023.103559_bib33","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.4049\/jimmunol.1601537","article-title":"Role of lymphocyte subsets in the immune response to primary B cell\u2013derived exosomes","volume":"199","author":"Saunderson","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.micron.2023.103559_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00935","article-title":"Autophagy and its interaction with intracellular bacterial pathogens","volume":"9","author":"Siqueira","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micron.2023.103559_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102835","article-title":"Melatonin alleviates cadmium-induced nonalcoholic fatty liver disease in ducks by alleviating autophagic flow arrest via PPAR-\u03b1 and reducing oxidative stress","author":"Sun","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.micron.2023.103559_bib36","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.4049\/jimmunol.182.3.1548","article-title":"Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes","volume":"182","author":"Walker","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.micron.2023.103559_bib37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mod.2004.10.009","article-title":"Intestinal growth and differentiation in zebrafish","volume":"122","author":"Wallace","year":"2005","journal-title":"Mech. Dev."},{"key":"10.1016\/j.micron.2023.103559_bib38","article-title":"Exosomes treating osteoarthritis: hope with challenge","author":"Wu","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.micron.2023.103559_bib39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.tvjl.2015.01.013","article-title":"Identification and structural composition of the blood\u2013spleen barrier in chickens","volume":"204","author":"Zhang","year":"2015","journal-title":"Vet. J."}],"container-title":["Micron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968432823001579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968432823001579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T02:10:34Z","timestamp":1760839834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968432823001579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":39,"alternative-id":["S0968432823001579"],"URL":"https:\/\/doi.org\/10.1016\/j.micron.2023.103559","relation":{},"ISSN":["0968-4328"],"issn-type":[{"value":"0968-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular evidence of communication strategies for small intestinal high endothelial cells: Ultrastructural insights of nano-scale exosomes and autophagy","name":"articletitle","label":"Article Title"},{"value":"Micron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micron.2023.103559","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103559"}}