{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:34:23Z","timestamp":1777642463678,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010679","name":"Pasteur Institute of Iran","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010679","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Islamic Development Bank, Jeddah, Saudi Arabia"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiological Methods"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.mimet.2010.07.001","type":"journal-article","created":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T19:16:56Z","timestamp":1278875816000},"page":"334-337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Helicobacter pylori bacterial ghost containing recombinant Omp18 as a putative vaccine"],"prefix":"10.1016","volume":"82","author":[{"given":"Y.","family":"Talebkhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bababeik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Esmaeili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Oghalaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Saberi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Afkhami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mimet.2010.07.001_bb0005","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.copbio.2004.10.004","article-title":"Bacterial ghosts\u2014biological particles as delivery systems for antigens, nucleic acids and drugs","volume":"15","author":"Azimpour Tabrizi","year":"2004","journal-title":"Cur. Opin. Biotechnol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0168-1656(00)00315-1","article-title":"Characterization and immunogenicity of Vibrio cholerae ghosts expressing toxin-coregulated pili","volume":"83","author":"Eko","year":"2000","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0015","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.4049\/jimmunol.173.5.3375","article-title":"A novel recombinant multisubunit vaccine against Chlamydia","volume":"173","author":"Eko","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0020","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3325\/cmj.2009.50.124","article-title":"Serum antibodies positivity to 12 Helicobacter pylori virulence antigens in patients with benign or malignant gastroduodenal diseases\u2014cross-sectional study","volume":"50","author":"Filipec Kanizaj","year":"2009","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.mimet.2010.07.001_bb0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1440-1746.2008.05314.x","article-title":"Asia-Pacific Gastric Cancer Consensus Conference. Asia-Pacific consensus guidelines on gastric cancer prevention","volume":"23","author":"Fock","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0030","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/j.1440-1746.2009.05982.x","article-title":"Second Asia\u2013Pacific Consensus Guidelines for Helicobacter pylori infection","volume":"24","author":"Fock","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0035","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1016\/S0264-410X(00)00107-9","article-title":"Intramuscular immunization with genetically inactivated (ghosts) Actinobacillus pleuropneumoniae serotype 9 protects pigs against homologous aerosol challenge and prevents carrier state","volume":"18","author":"Hensel","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.mimet.2010.07.001_bb0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0168-1656(00)00310-2","article-title":"Improved protection against lung colonization by Actinobacillus pleuropneumoniae ghosts: characterization of a genetically inactivated vaccine","volume":"83","author":"Huter","year":"2000","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0045","series-title":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans: Helicobacter pylori. Schistosomes, Liver Flukes and Helicobacter pylori: Views and Expert Opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","first-page":"177","article-title":"World Health Organization","author":"IARC","year":"1994"},{"key":"10.1016\/j.mimet.2010.07.001_bb0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0168-3659(02)00267-5","article-title":"Bacterial ghosts as vaccine candidates for veterinary applications","volume":"85","author":"Javala","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.mimet.2010.07.001_bb0055","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1016\/j.vaccine.2004.11.078","article-title":"Comparative immunogenicity of the Hepatitis B virus core 149 antigen displayed on the inner and outer membrane of bacterial ghosts","volume":"23","author":"Jechlinger","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.mimet.2010.07.001_bb0060","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3748\/wjg.v8.i2.308","article-title":"A study of recombinant protective H. pylori antigens","volume":"8","author":"Jiang","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0065","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1128\/IAI.69.6.3581-3590.2001","article-title":"Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection","volume":"69","author":"Kotloff","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.mimet.2010.07.001_bb0070","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/CMR.00054-05","article-title":"Pathogenesis of Helicobacter pylori infection","volume":"19","author":"Kusters","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.mimet.2010.07.001_bb0075","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0264-410X(02)00259-1","article-title":"B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LTR192G in H. pylori seronegative individuals","volume":"21","author":"Losonsky","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.mimet.2010.07.001_bb0080","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1053\/j.gastro.2008.05.054","article-title":"Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study","volume":"135","author":"Malfertheiner","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mimet.2010.07.001_bb0085","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0264-410X(02)00635-7","article-title":"Protective immunity against pasteurellosis in cattle, induced by Pasteurella haemolytica ghosts","volume":"21","author":"Marchart","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.mimet.2010.07.001_bb0090","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.2165\/00003495-200464170-00003","article-title":"Basis for the management of drug-resistant Helicobacter pylori infection","volume":"64","author":"M\u00e9graud","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.mimet.2010.07.001_bb0095","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1136\/gut.2005.072009","article-title":"Long term follow up of patients treated for Helicobacter pylori infection","volume":"54","author":"Mera","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.mimet.2010.07.001_bb0100","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1128\/IAI.71.1.109-116.2003","article-title":"Generation of Helicobacter pylori ghosts by PhiX protein E-mediated inactivation and their evaluation as vaccine candidates","volume":"71","author":"Panthel","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.mimet.2010.07.001_bb0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jconrel.2003.09.010","article-title":"Bacterial ghosts as novel advanced drug delivery systems: antiproliferative activity of loaded doxorubicin in human Caco-2 cells","volume":"94","author":"Paukner","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.mimet.2010.07.001_bb0110","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1523-5378.2005.00350.x","article-title":"Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function","volume":"10","author":"Rathinavelu","year":"2005","journal-title":"Helicobacter"},{"key":"10.1016\/j.mimet.2010.07.001_bb0115","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S1286-4579(03)00125-4","article-title":"The quest for a vaccine against Helicobacter pylori: how to move from mouse to man?","volume":"5","author":"Ruggiero","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.mimet.2010.07.001_bb0120","first-page":"115","article-title":"Helicobacter pylori vaccine: mucosal adjuvant and delivery systems","volume":"130","author":"Sijun","year":"2009","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.mimet.2010.07.001_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00535-006-1941-8","article-title":"Prevention of gastric cancer: urgent need to implement Helicobacter pylori eradication therapy as a primary preventive measure in Japan","volume":"42","author":"Sugano","year":"2007","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0130","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.vaccine.2009.10.147","article-title":"Toward the development of a stable, freeze-dried formulation of Helicobacter pylori killed whole cell vaccine adjuvanted with a novel mutant of Escherichia coli heat-labile toxin","volume":"28","author":"Summerton","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.mimet.2010.07.001_bb0135","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1574-695X.2006.00206.x","article-title":"Effectiveness of vaccination with recombinant HpaA from Helicobacter pylori is influenced by host genetic background","volume":"50","author":"Sutton","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0140","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0168-1656(95)00123-9","article-title":"Bacterial ghosts: non-living candidate vaccines","volume":"44","author":"Szostak","year":"1996","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.mimet.2010.07.001_bb0145","doi-asserted-by":"crossref","unstructured":"Talebkhan, Y., Ebrahimzadeh, F., Esmaeili, M., Zamaninia, L., Nahvijou, A., Khedmat, H., Fereidooni, F., Mohagheghi, M., Mohammadi, M., 2010. Helicobacter pylori Omp18 and its application in serologic screening of infection. Cur. Microbiol. doi: 10.1007\/s00284-010-9694-2.","DOI":"10.1007\/s00284-010-9694-2"},{"key":"10.1016\/j.mimet.2010.07.001_bb0150","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1046\/j.1365-2036.2002.01221.x","article-title":"Specific identification of three low molecular weight membrane-associated antigens of Helicobacter pylori","volume":"16","author":"Voland","year":"2002","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.mimet.2010.07.001_bb0155","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1128\/IAI.71.7.3837-3843.2003","article-title":"Antigenic properties of HpaA and Omp18, two outer membrane proteins of Helicobacter pylori","volume":"7","author":"Voland","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.mimet.2010.07.001_bb0160","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1128\/jb.172.7.4109-4114.1990","article-title":"Endogenous transmembrane tunnel formation mediated by phi X174 lysis protein E","volume":"172","author":"Witte","year":"1990","journal-title":"J. Bacteriol."}],"container-title":["Journal of Microbiological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167701210002320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167701210002320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T23:41:57Z","timestamp":1759102917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167701210002320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0167701210002320"],"URL":"https:\/\/doi.org\/10.1016\/j.mimet.2010.07.001","relation":{},"ISSN":["0167-7012"],"issn-type":[{"value":"0167-7012","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helicobacter pylori bacterial ghost containing recombinant Omp18 as a putative vaccine","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mimet.2010.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}