{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:51:20Z","timestamp":1785887480014,"version":"3.56.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100015853","name":"Rochester Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP26fk0108750"],"award-info":[{"award-number":["JP26fk0108750"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25fk0108730"],"award-info":[{"award-number":["JP25fk0108730"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23gm1610013"],"award-info":[{"award-number":["JP23gm1610013"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiological Methods"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mimet.2026.107600","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:08:05Z","timestamp":1781737685000},"page":"107600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genome-guided pooled infection and whole-genome sequencing identify clinical Mycobacterium avium complex isolates that persist in a murine infection model"],"prefix":"10.1016","volume":"247","author":[{"given":"Shintaro","family":"Seto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takemasa","family":"Takii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Hijikata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Keicho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mimet.2026.107600_bb0005","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1128\/AAC.04841-14","article-title":"Characterization of mouse models of Mycobacterium avium complex infection and evaluation of drug combinations","volume":"59","author":"Andr\u00e9jak","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.mimet.2026.107600_bb0010","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12864-020-6486-3","article-title":"QuantTB - a method to classify mixed Mycobacterium tuberculosis infections within whole genome sequencing data","volume":"21","author":"Anyansi","year":"2020","journal-title":"BMC Genomics"},{"key":"10.1016\/j.mimet.2026.107600_bb0015","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/molbev\/msu088","article-title":"Automated reconstruction of whole-genome phylogenies from short-sequence reads","volume":"31","author":"Bertels","year":"2014","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.mimet.2026.107600_bb0020","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/ciaa1125","article-title":"Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS\/ERS\/ESCMID\/IDSA clinical practice guideline","volume":"71","author":"Daley","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.mimet.2026.107600_bb0025","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00451-22","article-title":"Novel screening system of virulent strains for the establishment of a Mycobacterium avium complex lung disease mouse model using whole-genome sequencing","volume":"10","author":"Furuuchi","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"10.1016\/j.mimet.2026.107600_bb0030","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03128-25","article-title":"Strain-dependent disease progression and necrotizing granuloma formation in a murine model induced by virulent strains of Mycobacterium avium complex","author":"Hikichi","year":"2026","journal-title":"Microbiol. Spectrum"},{"key":"10.1016\/j.mimet.2026.107600_bb0035","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1183\/09031936.00149212","article-title":"The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study","volume":"42","author":"Hoefsloot","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.mimet.2026.107600_bb0040","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02349-19","article-title":"Synergistic activity of clofazimine and clarithromycin in an aerosol mouse model of Mycobacterium avium infection","volume":"64","author":"Lanoix","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.mimet.2026.107600_bb0045","article-title":"A clofazimine-containing regimen confers improved treatment outcomes in macrophages and in a murine model of chronic progressive pulmonary infection caused by the Mycobacterium avium complex","volume":"11","author":"Lee","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.mimet.2026.107600_bb0050","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1128\/AAC.01240-16","article-title":"Clinical characteristics, treatment outcomes, and resistance mutations associated with macrolide-resistant Mycobacterium avium complex lung disease","volume":"60","author":"Moon","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.mimet.2026.107600_bb0055","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1513\/AnnalsATS.201604-246OC","article-title":"Macrolide-resistant Mycobacterium avium complex lung disease: analysis of 102 consecutive cases","volume":"13","author":"Morimoto","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.mimet.2026.107600_bb0060","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00101-24","article-title":"Transcriptional regulators SP110 and SP140 modulate inflammatory response genes in Mycobacterium tuberculosis-infected human macrophages","volume":"12","author":"Nakamura","year":"2024","journal-title":"Microbiol. Spectrum"},{"key":"10.1016\/j.mimet.2026.107600_bb0065","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.3201\/eid2206.151086","article-title":"Epidemiology of pulmonary nontuberculous mycobacterial disease, Japan","volume":"22","author":"Namkoong","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.mimet.2026.107600_bb0070","article-title":"Triple-antibiotic combination exerts effective activity against Mycobacterium avium subsp. hominissuis biofilm and airway infection in an in vivo murine model","volume":"13","author":"Offman","year":"2024","journal-title":"Antibiotics (Basel, Switzerland)."},{"key":"10.1016\/j.mimet.2026.107600_bb0075","doi-asserted-by":"crossref","first-page":"e0151125","DOI":"10.1128\/aac.01511-25","article-title":"Evaluation of clofazimine-bedaquiline combination as a candidate regimen for macrolide-resistant Mycobacterium avium complex infection","volume":"70","author":"Park","year":"2026","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.mimet.2026.107600_bb0080","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ccm.2023.08.012","article-title":"Global epidemiology of nontuberculous mycobacterial pulmonary disease: a review","volume":"44","author":"Prevots","year":"2023","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.mimet.2026.107600_bb0085","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01853-24","article-title":"The efficacy of a regimen comprising clarithromycin, clofazimine, and bedaquiline in a mouse model of chronic Mycobacterium avium lung infection","volume":"69","author":"Rimal","year":"2025","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.mimet.2026.107600_bb0090","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.052671","article-title":"Immunopathological outcomes are isolate dependent in chronic Mycobacterium avium complex pulmonary disease","volume":"19","author":"Shaw","year":"2026","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.mimet.2026.107600_bb0095","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12866-023-02831-y","article-title":"Virulence of Mycobacterium intracellulare clinical strains in a mouse model of lung infection - role of neutrophilic inflammation in disease severity","volume":"23","author":"Tateishi","year":"2023","journal-title":"BMC Microbiol."}],"container-title":["Journal of Microbiological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167701226002125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167701226002125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:22:33Z","timestamp":1785885753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167701226002125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":19,"alternative-id":["S0167701226002125"],"URL":"https:\/\/doi.org\/10.1016\/j.mimet.2026.107600","relation":{},"ISSN":["0167-7012"],"issn-type":[{"value":"0167-7012","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-guided pooled infection and whole-genome sequencing identify clinical Mycobacterium avium complex isolates that persist in a murine infection model","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mimet.2026.107600","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107600"}}