{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:14:37Z","timestamp":1790331277681,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.mito.2005.04.001","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T12:41:42Z","timestamp":1117024902000},"page":"200-211","source":"Crossref","is-referenced-by-count":45,"title":["The concomitant expression and availability of conventional and alternative, cyanide-insensitive, respiratory pathways in Candida albicans"],"prefix":"10.1016","volume":"5","author":[{"given":"Eva J.","family":"Helmerhorst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Oppenheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2005.04.001_bib1","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.1128\/IAI.71.10.5794-5802.2003","article-title":"Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans","volume":"71","author":"Akhter","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.mito.2005.04.001_bib2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1348-0421.1984.tb00691.x","article-title":"The appearance and characterization of cyanide-resistant respiration in the fungus Candida albicans","volume":"28","author":"Aoki","year":"1984","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.mito.2005.04.001_bib3","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1016\/S0021-9258(19)43948-3","article-title":"Cyanide-insenstive respiration","volume":"248","author":"Bahr","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2005.04.001_bib4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0014-5793(95)00763-Y","article-title":"Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase","volume":"369","author":"Brown","year":"1995","journal-title":"Fed. Eur. Biochem. Soc. Lett."},{"key":"10.1016\/j.mito.2005.04.001_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1177\/10454411990100030701","article-title":"Oral colonization by Candida albicans","volume":"10","author":"Cannon","year":"1999","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.mito.2005.04.001_bib6","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1177\/00220345950740050301","article-title":"Oral Candida: clearance, colonization, or candidiasis?","volume":"74","author":"Cannon","year":"1995","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.mito.2005.04.001_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0014-5793(94)00424-2","article-title":"Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases","volume":"345","author":"Cleeter","year":"1994","journal-title":"Fed. Eur. Biochem. Soc. Lett."},{"key":"10.1016\/j.mito.2005.04.001_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1104\/pp.110.1.1","article-title":"The cyanide-resistant oxidase: to inhibit or not to inhibit, that is the question","volume":"110","author":"Day","year":"1996","journal-title":"Plant Physiol."},{"key":"10.1016\/j.mito.2005.04.001_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1099\/00221287-44-2-149","article-title":"The Crabtree effect: a regulatory system in yeast","volume":"44","author":"De Deken","year":"1966","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.mito.2005.04.001_bib10","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1172\/JCI109958","article-title":"Damage to Candida albicans hyphae and Pseudohyphae by the myeloperoxidase system and oxidative products of neturophil metabolism in vitro","volume":"66","author":"Diamond","year":"1980","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mito.2005.04.001_bib11","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1104\/pp.89.4.1311","article-title":"Monoclonal antibodies to the alternative oxidase of higher plant mitochondria","volume":"89","author":"Elthon","year":"1989","journal-title":"Plant Physiol."},{"key":"10.1016\/j.mito.2005.04.001_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0076-6879(78)53011-5","article-title":"Preparation and properties of complex IV (ferrocytochrome c: oxygen oxidoreductase EC 1.9.3.1)","volume":"53","author":"Errede","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mito.2005.04.001_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0005-2728(94)90160-0","article-title":"Partitioning of electron flux between the respiratory chains of the yeast Candida parapsilosis: parallel working of the two chains","volume":"1184","author":"Guerin","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2005.04.001_bib14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0300-9084(89)90072-2","article-title":"The second respiratory chain of Candida parapsilosis: a comprehensive study","volume":"71","author":"Guerin","year":"1989","journal-title":"Biochimie"},{"key":"10.1016\/j.mito.2005.04.001_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0076-6879(78)53010-3","article-title":"Preparation and properties of dihydroubiquinone:cytochrome c oxidoreductase (complex III)","volume":"53","author":"Hatefi","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mito.2005.04.001_bib16","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1074\/jbc.M008229200","article-title":"Characterization of histatin 5 with resprect to amphipathicity, hydrophobicity and effects on cell and mitochondrial membrane integrity excludes a candidacidal mechanism of pore formation","volume":"276","author":"Helmerhorst","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2005.04.001_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0005-2728(02)00308-0","article-title":"Characterization of the mitochondrial respiratory pathways in Candida albicans","volume":"1556","author":"Helmerhorst","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2005.04.001_bib18","first-page":"1","article-title":"Cyanide-insensitive respiration. An alternative mitochondrial pathway","volume":"4","author":"Henry","year":"1975","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.mito.2005.04.001_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0378-1119(91)90515-D","article-title":"Synthesis and expression of genes encoding tuna, pigeon, and horse cytochromes c in the yeast Saccharomyces cerevisiae","volume":"105","author":"Hickey","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.mito.2005.04.001_bib52","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1006\/abbi.1998.0737","article-title":"Activation of the plant alternative oxidase by high reduction levels of the Q-Pool and pyruvate","volume":"355","author":"Hoefnagel","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mito.2005.04.001_bib20","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1128\/JB.181.13.4098-4102.1999","article-title":"Molecular cloning and functional expression of alternative oxidase from Candida albicans","volume":"181","author":"Huh","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.mito.2005.04.001_bib21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1042\/bj3560595","article-title":"Characterization of the gene family encoding alternative oxidase from Candida albicans","volume":"356","author":"Huh","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2005.04.001_bib53","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0005-2736(78)90304-8","article-title":"Characteristics of proline transport in normal and starved cells of Candida albicans","volume":"514","author":"Jayakumar","year":"1978","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.mito.2005.04.001_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0005-2728(00)00251-6","article-title":"Fungal respiration: a fusion of standard and alternative components","volume":"1504","author":"Joseph-Horne","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2005.04.001_bib23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0005-2728(00)00162-6","article-title":"Diversity and origin of alternative NADH:ubiquinone oxidoreductases","volume":"1459","author":"Kerscher","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2005.04.001_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00399447","article-title":"An alternate respiratory pathway in Candida albicans","volume":"42","author":"Kot","year":"1976","journal-title":"Antonie Van Leeuwenhoek"},{"key":"10.1016\/j.mito.2005.04.001_bib25","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)80358-X","article-title":"Nonfilamentous C. albicans mutants are avirulent","volume":"90","author":"Lo","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mito.2005.04.001_bib26","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1073\/pnas.96.14.8271","article-title":"The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells","volume":"96","author":"Maxwell","year":"1999","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.mito.2005.04.001_bib27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0014-5793(01)03060-5","article-title":"Respiratory chain network in mitochondria of Candida parapsilosis: ADP\/O appraisal of the multiple electron pathways","volume":"508","author":"Milani","year":"2001","journal-title":"Fed. Eur. Biochem. Soc. Lett."},{"key":"10.1016\/j.mito.2005.04.001_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1399-3054.1995.tb05518.x","article-title":"A critique of the use of inhibitors to estimate partitioning of electrons between mitochondrial respiratory pathways in plants","volume":"95","author":"Millar","year":"1995","journal-title":"Physiol. Plant"},{"key":"10.1016\/j.mito.2005.04.001_bib29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1104\/pp.118.2.599","article-title":"The role of the alternative oxidase in stabilizing the in vivo reduction state of the ubiquinone pool and the activation state of the alternative oxidase","volume":"118","author":"Millenaar","year":"1998","journal-title":"Plant Physiol."},{"key":"10.1016\/j.mito.2005.04.001_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-5793(92)80444-L","article-title":"Possible involvement of superoxide anion in the induction of cyanide-resistant respiration in Hansenula anomala","volume":"302","author":"Minagawa","year":"1992","journal-title":"Fed. Eur. Biochem. Soc. Lett."},{"key":"10.1016\/j.mito.2005.04.001_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/10408418509104425","article-title":"Morphogenesis in Candida albicans","volume":"12","author":"Odds","year":"1985","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.mito.2005.04.001_bib32","series-title":"Candida and Candidosis","author":"Odds","year":"1988"},{"issue":"Suppl. 2","key":"10.1016\/j.mito.2005.04.001_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1439-0507.1997.tb00556.x","article-title":"Switch of phenotype as an escape mechanism of the intruder","volume":"40","author":"Odds","year":"1997","journal-title":"Mycoses"},{"key":"10.1016\/j.mito.2005.04.001_bib34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0014-5793(97)01099-5","article-title":"Inhibition of the alternative oxidase stimulates H2O2 production in plant mitochondria","volume":"415","author":"Popov","year":"1997","journal-title":"Fed. Eur. Biochem. Soc. Lett."},{"key":"10.1016\/j.mito.2005.04.001_bib35","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0891-5849(02)01111-5","article-title":"Peroxynitrite reactions and formation in mitochondria","volume":"33","author":"Radi","year":"2002","journal-title":"Free Rad. Biol. Med."},{"key":"10.1016\/j.mito.2005.04.001_bib36","series-title":"Fungi Pathogenic for Humans and Animals","first-page":"723","article-title":"Genetic instability of Candida albicans","author":"Rustchenko","year":"2002"},{"key":"10.1016\/j.mito.2005.04.001_bib37","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1099\/00221287-143-5-1765","article-title":"Variation in assimilating functions occurs in spontaneous Candida albicans mutants having chromosomal alterations","volume":"143","author":"Rustchenko","year":"1997","journal-title":"Microbiology"},{"key":"10.1016\/j.mito.2005.04.001_bib38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1023\/A:1005818507743","article-title":"Characterization of the gene family for alternative oxidase from Arabidopsis thaliana","volume":"35","author":"Saisho","year":"1997","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.mito.2005.04.001_bib39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1084\/jem.152.1.85","article-title":"Macrophage microbicidal activity","volume":"152","author":"Sasada","year":"1980","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mito.2005.04.001_bib40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00408734","article-title":"The alternative respiratory pathway of Candida albicans","volume":"116","author":"Shepherd","year":"1978","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.mito.2005.04.001_bib41","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0005-2728(00)00181-X","article-title":"The mitochondrial cyanide-resistant oxidase: structural conservation amid regulatory diversity","volume":"1459","author":"Siedow","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2005.04.001_bib42","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1590\/S0100-879X1998000600003","article-title":"Alternative oxidase in the branched mitochondrial respiratory network: an overview on structure, function, regulation, and role","volume":"31","author":"Sluse","year":"1998","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.mito.2005.04.001_bib43","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1101\/gr.80202","article-title":"Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans","volume":"12","author":"Steen","year":"2002","journal-title":"Gen. Res."},{"key":"10.1016\/j.mito.2005.04.001_bib44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0001-706X(01)00200-5","article-title":"Candida commensalism and virulence: the evolution of phenotypic plasticity","volume":"81","author":"Soll","year":"2002","journal-title":"Acta Trop."},{"key":"10.1016\/j.mito.2005.04.001_bib45","doi-asserted-by":"crossref","first-page":"8756","DOI":"10.1074\/jbc.273.15.8756","article-title":"A common mechanism for the interaction of nitric oxide with the oxidized binuclear centre and oxygen intermediates of cytochrome c oxidase","volume":"273","author":"Torres","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2005.04.001_bib46","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1104\/pp.002691","article-title":"Induction of mitochondrial alternative oxidase in response to a cell signal pathway down-regulating the cytochrome pathway prevents programmed cell death","volume":"129","author":"Vanlerberghe","year":"2002","journal-title":"Plant Physiol."},{"issue":"Suppl.","key":"10.1016\/j.mito.2005.04.001_bib47","first-page":"G19","article-title":"Control of respiration and aerobic fermentation in Saccharomyces cerevisiae","volume":"35","author":"Von Meyenburg","year":"1969","journal-title":"Antonie van Leeuwenhoek"},{"key":"10.1016\/j.mito.2005.04.001_bib48","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0014-5793(95)00688-6","article-title":"A role for active oxygen species as second messengers in the induction of alternative oxidase gene expression in Petunia hybrida cells","volume":"368","author":"Wagner","year":"1995","journal-title":"Fed. Eur. Biochem. Soc. Lett."},{"key":"10.1016\/j.mito.2005.04.001_bib49","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1023\/A:1027388729586","article-title":"Structure and function of the plant alternative oxidase: its putative role in the oxygen defense mechanism","volume":"17","author":"Wagner","year":"1997","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.mito.2005.04.001_bib50","series-title":"Manual of Clinical Microbiology","first-page":"617","article-title":"Yeasts of medical importance","author":"Warren","year":"1991"},{"key":"10.1016\/j.mito.2005.04.001_bib51","first-page":"2015","article-title":"Relationship between the susceptibility of various bacteria to active oxygen species and to intracellular killing by macrophages","volume":"133","author":"Yamada","year":"1987","journal-title":"J. Gen. Microbiol."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724905000553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724905000553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T05:12:11Z","timestamp":1625980331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724905000553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S1567724905000553"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2005.04.001","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}