{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:04:03Z","timestamp":1775916243623,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.mito.2005.10.002","type":"journal-article","created":{"date-parts":[[2005,11,15]],"date-time":"2005-11-15T12:14:49Z","timestamp":1132056889000},"page":"426-433","source":"Crossref","is-referenced-by-count":31,"title":["Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS"],"prefix":"10.1016","volume":"5","author":[{"given":"Kazutoshi","family":"Nakano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikako","family":"Tarashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Tachikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Noda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7033","key":"10.1016\/j.mito.2005.10.002_bib14","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mito.2005.10.002_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/00207459808986422","article-title":"Cross cerebro-cellular diaschisis in a patient with MELAS with aphasia but without hemiparesis","volume":"93","author":"Bohnen","year":"1998","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.mito.2005.10.002_bib11","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1210\/jc.2003-031684","article-title":"Dichloroacetate therapy attenuated the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism","volume":"89","author":"Duncan","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mito.2005.10.002_bib15","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1161\/01.STR.27.8.1420","article-title":"Adult-onset MELAS. Evidence for involvement of neurons as well as cerebral vasculature in stroke like episodes","volume":"27","author":"Gilchrist","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.mito.2005.10.002_bib1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/348651a0","article-title":"A mutation in the tRNALeu(UUR) gene associated with the MELAS group of mitochondrial encephalomyopathies","volume":"348","author":"Goto","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.mito.2005.10.002_bib5","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/ana.410370604","article-title":"Low platelet mitochondrial complex I and complex II\/III activities in early untreated Parkinson's disease","volume":"37","author":"Haas","year":"1995","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mito.2005.10.002_bib18","first-page":"812","article-title":"Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome","volume":"59","author":"Iizuki","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2005.10.002_bib7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0022-3476(97)80075-3","article-title":"Concomitant administration of sodium dichloroacetate and vitamin B1 for lactic acidemia in children with MELAS syndrome","volume":"131","author":"Kuroda","year":"1997","journal-title":"J. Pediatr."},{"key":"10.1016\/j.mito.2005.10.002_bib16","first-page":"641","article-title":"A case of MELAS showing CSF pleocytosis associated with stroke-like episodes","volume":"38","author":"Maruyama","year":"1998","journal-title":"Rinsho Shinkeigaku Clin. Neurol."},{"key":"10.1016\/j.mito.2005.10.002_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.braindev.2003.12.009","article-title":"Dichloroacetate treatment for mitochondrial cytopathy: long term effects in MELAS","volume":"26","author":"Mori","year":"2004","journal-title":"Brain Dev."},{"key":"10.1016\/j.mito.2005.10.002_bib12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0387-7604(95)00096-8","article-title":"Long-term therapy with cytochrome c, flavin mononucleotide and thiamine diphosphate for a patient with Kearns-Sayre syndrome","volume":"18","author":"Nakagawa","year":"1996","journal-title":"Brain Dev."},{"key":"10.1016\/j.mito.2005.10.002_bib3","unstructured":"Nakano, K., Nasirian, F.S., Haas, R.H., 1994. Peripheral blood measurements of white cells and platelet mitochondrial electron transport activities. IV International Congress of Inborn Errors of Metabolism (abs), p. 103."},{"key":"10.1016\/j.mito.2005.10.002_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1552-6569.2001.tb00057.x","article-title":"Discordance between cerebral oxygen and glucose metabolism, and hemodynamics in a mitochondrial encephalopathy, lactic acidosis, and stroke-like episode patients","volume":"11","author":"Nariai","year":"2001","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.mito.2005.10.002_bib20","first-page":"109","article-title":"Mitochondrial angiopathy in the cerebral blood vessels of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes)","volume":"40","author":"Ohama","year":"1988","journal-title":"No to Shinkei"},{"key":"10.1016\/j.mito.2005.10.002_bib21","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s002340000335","article-title":"Serial diffusion-weighted imaging in MELAS","volume":"42","author":"Ohshita","year":"2000","journal-title":"Neuroradiology"},{"issue":"3","key":"10.1016\/j.mito.2005.10.002_bib22","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bbrc.2004.11.093","article-title":"Mitochondrial ND5 mutations in idiopathic Parkinson's disease","volume":"326","author":"Parker","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2005.10.002_bib24","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1212\/WNL.40.8.1231","article-title":"Evidence for a defect in NADH:ubiquinone oxidoreductase (complex I) in Huntington's disease","volume":"40","author":"Parker","year":"1990","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2005.10.002_bib23","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1212\/WNL.44.6.1086","article-title":"Reduced platelet cytochrome c oxidase activity in Alzheimer's disease","volume":"44","author":"Parker","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2005.10.002_bib9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archneur.55.6.849","article-title":"Magnetic resonance spectroscopy: use in monitoring MELAS treatment","volume":"55","author":"Pavlakis","year":"1998","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.mito.2005.10.002_bib8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1212\/WNL.50.2.531","article-title":"Effects of dichloroacetate in three patients with MELAS","volume":"50","author":"Saitoh","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2005.10.002_bib4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1212\/WNL.45.2.344","article-title":"Carbidopa\/levodopa and selegilline do not affect platelet mitochondrial function in early parkinsonism","volume":"45","author":"Shults","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2005.10.002_bib6","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1212\/WNL.50.3.793","article-title":"Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkisonian patients","volume":"50","author":"Shults","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2005.10.002_bib13","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0387-7604(97)00573-1","article-title":"Treatment of mitochondrial encephalomyopathy with a combination of cytochrome c and vitamins B1 and B2","volume":"19","author":"Tanaka","year":"1997","journal-title":"Brain Dev."},{"key":"10.1016\/j.mito.2005.10.002_bib2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0022-510X(99)00030-1","article-title":"The mitochondrial DNA A3243G mutation in Portugal: clinical and molecular studies in 5 families","volume":"163","author":"Vilarinho","year":"1999","journal-title":"J. Neurol. Sci."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724905001169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724905001169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T20:44:10Z","timestamp":1554497050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724905001169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S1567724905001169"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2005.10.002","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}