{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:19:23Z","timestamp":1791289163232,"version":"4.3.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.mito.2012.10.007","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T21:48:39Z","timestamp":1350510519000},"page":"607-616","source":"Crossref","is-referenced-by-count":20,"title":["Endurance training and chronic intermittent hypoxia modulate in vitro salicylate-induced hepatic mitochondrial dysfunction"],"prefix":"10.1016","volume":"12","author":[{"given":"A.","family":"Ascens\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.O.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lumini-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Marques-Aleixo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"dos Passos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rocha-Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.G.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Torrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2012.10.007_bb0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijcard.2006.04.076","article-title":"Exercise-induced cardioprotection \u2014 biochemical, morphological and functional evidence in whole tissue and isolated mitochondria","volume":"117","author":"Ascensao","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0025","doi-asserted-by":"crossref","first-page":"860","DOI":"10.2174\/138945011795529001","article-title":"Mitochondria as a target for exercise-induced cardioprotection","volume":"12","author":"Ascensao","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.mito.2012.10.007_bb0030","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijcard.2011.05.060","article-title":"Exercise as a beneficial adjunct therapy during doxorubicin treatment-role of mitochondria in cardioprotection","volume":"156","author":"Ascensao","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0255","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mito.2012.10.007_bb0105","doi-asserted-by":"crossref","first-page":"33864","DOI":"10.1074\/jbc.M502391200","article-title":"Oxidative stress is responsible for mitochondrial permeability transition induction by salicylate in liver mitochondria","volume":"280","author":"Battaglia","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2012.10.007_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2005.10.004","article-title":"Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it","volume":"6","author":"Begriche","year":"2006","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2012.10.007_bb0175","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.freeradbiomed.2007.08.015","article-title":"Systemic and mitochondrial adaptive responses to moderate exercise in rodents","volume":"44","author":"Boveris","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2012.10.007_bb0185","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2012.10.007_bb0125","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0006-291X(89)92174-8","article-title":"Cyclosporin A-sensitive and insensitive mechanisms produce the permeability transition in mitochondria","volume":"163","author":"Broekemeier","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2012.10.007_bb0210","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.freeradbiomed.2004.10.016","article-title":"Mitochondrial H(+) leak and ROS generation: an odd couple","volume":"38","author":"Brookes","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2012.10.007_bb0145","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mito.2012.10.007_bb0085","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1042\/bj0830596","article-title":"The effect of salicylate on adenosine\u2013triphosphatase activity of rat-liver mitochondria","volume":"83","author":"Charnock","year":"1962","journal-title":"Biochem. J."},{"issue":"Pt 2","key":"10.1016\/j.mito.2012.10.007_bb0245","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/0264-6021:3410233","article-title":"The mitochondrial permeability transition pore and its role in cell death","volume":"341","author":"Crompton","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2012.10.007_bb0260","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1113\/jphysiol.2010.202036","article-title":"Cyclophilin-D is dispensable for atrophy and mitochondrial apoptotic signalling in denervated muscle","volume":"589","author":"Daussin","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0035","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.cr.7290184","article-title":"Intermittent hypoxia attenuates ischemia\/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2\/Bax expression","volume":"13","author":"Dong","year":"2003","journal-title":"Cell Res."},{"key":"10.1016\/j.mito.2012.10.007_bb0115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0076-6879(67)10010-4","article-title":"Mitochondrial respiratory control and the polarographic measurement of ADP\/O ratios","volume":"10","author":"Estabrook","year":"1967","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mito.2012.10.007_bb0130","doi-asserted-by":"crossref","first-page":"12662","DOI":"10.1074\/jbc.273.20.12662","article-title":"Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain complex i","volume":"273","author":"Fontaine","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2012.10.007_bb0170","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1152\/japplphysiol.01164.2002","article-title":"Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis","volume":"94","author":"Gauthier","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0005","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/sj.ijo.0802628","article-title":"Effects of introducing physical training in the course of a 16-week high-fat diet regimen on hepatic steatosis, adipose tissue fat accumulation, and plasma lipid profile","volume":"28","author":"Gauthier","year":"2004","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.mito.2012.10.007_bb0090","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF01868640","article-title":"Salicylates and proton transport through lipid bilayer membranes: a model for salicylate-induced uncoupling and swelling in mitochondria","volume":"115","author":"Gutknecht","year":"1990","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.mito.2012.10.007_bb0240","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0008-6363(03)00533-9","article-title":"Mitochondrial permeability transition pore opening during myocardial reperfusion\u2014a target for cardioprotection","volume":"61","author":"Halestrap","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mito.2012.10.007_bb0075","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1161\/CIRCULATIONAHA.106.634386","article-title":"What price pain relief?","volume":"113","author":"Hochman","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.mito.2012.10.007_bb0150","series-title":"Methods in Enzymology","first-page":"380","article-title":"Measurement of protein thiol groups and GSH in plasma","author":"Hu","year":"1990"},{"key":"10.1016\/j.mito.2012.10.007_bb0010","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/hep.23711","article-title":"Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease","volume":"52","author":"Johnson","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.mito.2012.10.007_bb0080","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s10067-008-0952-7","article-title":"Utility of published guidelines on the use of nonsteroidal anti-inflammatory drugs in the elderly","volume":"27","author":"Juby","year":"2008","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.mito.2012.10.007_bb0120","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF01868720","article-title":"Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state","volume":"49","author":"Kamo","year":"1979","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.mito.2012.10.007_bb0045","doi-asserted-by":"crossref","first-page":"H224","DOI":"10.1152\/ajpheart.00689.2006","article-title":"Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia","volume":"292","author":"Kolar","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0135","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/bj0520527","article-title":"The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase","volume":"52","author":"Krebs","year":"1952","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2012.10.007_bb0230","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1472-8206.2008.00608.x","article-title":"Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies","volume":"22","author":"Labbe","year":"2008","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.mito.2012.10.007_bb0215","doi-asserted-by":"crossref","first-page":"575","DOI":"10.7150\/ijbs.7.575","article-title":"Mammalian sirtuins and energy metabolism","volume":"7","author":"Li","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mito.2012.10.007_bb0220","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0092-8674(00)81590-1","article-title":"Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis","volume":"94","author":"Li","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mito.2012.10.007_bb0140","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mito.2010.07.005","article-title":"Endurance training reverts heart mitochondrial dysfunction, permeability transition and apoptotic signaling in long-term severe hyperglycemia","volume":"11","author":"Lumini-Oliveira","year":"2011","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2012.10.007_bb0195","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1743-7075-7-36","article-title":"Differential regulation of PGC-1alpha expression in rat liver and skeletal muscle in response to voluntary running","volume":"7","author":"Matiello","year":"2010","journal-title":"Nutr. Metab. (Lond.)"},{"key":"10.1016\/j.mito.2012.10.007_bb0265","doi-asserted-by":"crossref","first-page":"R1250","DOI":"10.1152\/ajpregu.00841.2010","article-title":"Hypercholesterolemia increases mitochondrial oxidative stress and enhances the MPT response in the porcine myocardium: beneficial effects of chronic exercise","volume":"301","author":"McCommis","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0205","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1042\/bst0311300","article-title":"Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling","volume":"31","author":"Miwa","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mito.2012.10.007_bb0190","doi-asserted-by":"crossref","first-page":"R505","DOI":"10.1152\/ajpregu.00208.2003","article-title":"Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer","volume":"286","author":"Navarro","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0250","doi-asserted-by":"crossref","first-page":"40184","DOI":"10.1074\/jbc.M111.243469","article-title":"Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore","volume":"286","author":"Nguyen","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2012.10.007_bb0235","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/toxsci\/kfg045","article-title":"Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition","volume":"73","author":"Oh","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.mito.2012.10.007_bb0180","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2174\/138945011795528912","article-title":"Mitochondria as a drug target in health and disease","volume":"12","author":"Oliveira","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.mito.2012.10.007_bb0200","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1023\/A:1010700515071","article-title":"Dietary fat type and regular exercise affect mitochondrial composition and function depending on specific tissue in the rat","volume":"33","author":"Quiles","year":"2001","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.mito.2012.10.007_bb0055","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1113\/jphysiol.2009.171868","article-title":"The muscle\u2013liver axis: does aerobic fitness induce intrahepatic protection against non-alcoholic fatty liver disease?","volume":"587","author":"Romijn","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0070","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s004210170010","article-title":"Effect of high altitude (7,620m) exposure on glutathione and related metabolism in rats","volume":"84","author":"Singh","year":"2001","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.lfs.2009.11.003","article-title":"Endurance exercise causes mitochondrial and oxidative stress in rat liver: effects of a combination of mitochondrial targeting nutrients","volume":"86","author":"Sun","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.mito.2012.10.007_bb0060","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1095-6433(00)00344-5","article-title":"The effects of endurance training and exhaustive exercise on mitochondrial enzymes in tissues of the rat (Rattus norvegicus)","volume":"128","author":"Terblanche","year":"2001","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.mito.2012.10.007_bb9000","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1113\/jphysiol.2009.169060","article-title":"Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury","volume":"587","author":"Thyfault","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.mito.2012.10.007_bb0095","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0022-3565(25)20745-5","article-title":"The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury","volume":"278","author":"Trost","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mito.2012.10.007_bb0100","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1006\/taap.1997.8313","article-title":"Role of the mitochondrial permeability transition in salicylate toxicity to cultured rat hepatocytes: implications for the pathogenesis of Reye's syndrome","volume":"147","author":"Trost","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.mito.2012.10.007_bb0050","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s13105-011-0115-1","article-title":"Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity","volume":"68","author":"Urdampilleta","year":"2012","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.mito.2012.10.007_bb0110","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/bj0040127","article-title":"The Biuret reaction and the cold nitric acid test in the recognition of protein","volume":"4","author":"Van Norman","year":"1909","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2012.10.007_bb0155","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tibs.2010.07.003","article-title":"Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling","volume":"35","author":"Verdin","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mito.2012.10.007_bb0225","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0006-2952(97)00342-0","article-title":"Biochemical pharmacology of nonsteroidal anti-inflammatory drugs","volume":"55","author":"Wu","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mito.2012.10.007_bb0165","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00395-011-0159-y","article-title":"Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats","volume":"106","author":"Xu","year":"2011","journal-title":"Basic Res. Cardiol."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724912002280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724912002280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T17:17:54Z","timestamp":1744564674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724912002280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1567724912002280"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2012.10.007","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}