{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:44:57Z","timestamp":1762101897433,"version":"3.41.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.mito.2016.08.002","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T12:11:45Z","timestamp":1470399105000},"page":"177-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations"],"prefix":"10.1016","volume":"30","author":[{"given":"Sandipan","family":"Datta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Tomilov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino","family":"Cortopassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2016.08.002_bb0005","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cmet.2009.01.012","article-title":"Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation","volume":"9","author":"Acin-Perez","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.mito.2016.08.002_bb0010","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1001\/archneur.62.5.730","article-title":"Severe impairment of complex I-driven adenosine triphosphate synthesis in Leber hereditary optic neuropathy cybrids","volume":"62","author":"Baracca","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.mito.2016.08.002_bb0015","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/pr.58.3.5","article-title":"Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use","volume":"58","author":"Bender","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.mito.2016.08.002_bb0020","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/jm060653b","article-title":"Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors","volume":"50","author":"Chappie","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.mito.2016.08.002_bb0025","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/1531-8249(200008)48:2<188::AID-ANA8>3.0.CO;2-P","article-title":"The epidemiology of pathogenic mitochondrial DNA mutations","volume":"48","author":"Chinnery","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mito.2016.08.002_bb0030","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/sj.bjp.0703717","article-title":"Mechanism of action of the hypnotic zolpidem in vivo","volume":"131","author":"Crestani","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mito.2016.08.002_bb0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0014-5793(94)00971-6","article-title":"Functional alterations of the mitochondrially encoded ND4 subunit associated with Leber's hereditary optic neuropathy","volume":"352","author":"Degli Esposti","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mito.2016.08.002_bb0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cellsig.2004.09.009","article-title":"cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases","volume":"17","author":"Feliciello","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mito.2016.08.002_bb0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.survophthal.2009.10.002","article-title":"The neuro-ophthalmology of mitochondrial disease","volume":"55","author":"Fraser","year":"2010","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.mito.2016.08.002_bb0050","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.bbrc.2010.09.089","article-title":"A sensitive, simple assay of mitochondrial ATP synthesis of cultured mammalian cells suitable for high-throughput analysis","volume":"401","author":"Fujikawa","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2016.08.002_bb0055","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.biocel.2011.06.005","article-title":"Progesterone synthesis by human placental mitochondria is sensitive to PKA inhibition by H89","volume":"43","author":"Gomez-Concha","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mito.2016.08.002_bb0060","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1086\/519394","article-title":"Clinical expression of Leber hereditary optic neuropathy is affected by the mitochondrial DNA-haplogroup background","volume":"81","author":"Hudson","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mito.2016.08.002_bb0065","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.2814477","article-title":"Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation","volume":"246","author":"King","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.mito.2016.08.002_bb0070","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/cr.2008.12","article-title":"Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytes","volume":"18","author":"Li","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.mito.2016.08.002_bb0075","first-page":"481","article-title":"Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy","volume":"59","author":"Mackey","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mito.2016.08.002_bb0080","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5301\/ejo.5000055","article-title":"Meta-analysis of the prevalence of Leber hereditary optic neuropathy mtDNA mutations in Europe","volume":"22","author":"Mascialino","year":"2012","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.mito.2016.08.002_bb0090","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.002295","article-title":"Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination","volume":"10","author":"Moorthy","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.mito.2016.08.002_bb0095","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1136\/jmg.31.4.280","article-title":"Leber's hereditary optic neuropathy: correlations between mitochondrial genotype and visual outcome","volume":"31","author":"Oostra","year":"1994","journal-title":"J. Med. Genet."},{"issue":"Pt 2","key":"10.1016\/j.mito.2016.08.002_bb0100","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/brain\/118.2.319","article-title":"The clinical features of Leber's hereditary optic neuropathy defined by the presence of a pathogenic mitochondrial DNA mutation","volume":"118","author":"Riordan-Eva","year":"1995","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.08.002_bb0110","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ajo.2005.11.007","article-title":"Influence of mutation type on clinical expression of Leber hereditary optic neuropathy","volume":"141","author":"Spruijt","year":"2006","journal-title":"Am J. Ophthalmol."},{"key":"10.1016\/j.mito.2016.08.002_bb0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.55782\/ane-2010-1769","article-title":"Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats","volume":"70","author":"Torremans","year":"2010","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.mito.2016.08.002_bb0120","first-page":"1107","article-title":"Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484","volume":"60","author":"Torroni","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mito.2016.08.002_bb0125","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1152\/physiol.00004.2013","article-title":"cAMP and mitochondria","volume":"28","author":"Valsecchi","year":"2013","journal-title":"Physiology (Bethesda)"}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724916301301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724916301301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T15:18:22Z","timestamp":1749050302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724916301301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":23,"alternative-id":["S1567724916301301"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2016.08.002","relation":{},"ISSN":["1567-7249"],"issn-type":[{"type":"print","value":"1567-7249"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2016.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}