{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:15:08Z","timestamp":1767910508046,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["F-7\/91\/2007"],"award-info":[{"award-number":["F-7\/91\/2007"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Biotechnology, Government of India","award":["BT\/Bio-CARe\/01\/10219\/2013-14"],"award-info":[{"award-number":["BT\/Bio-CARe\/01\/10219\/2013-14"]}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["F. 41-1286\/2012 (SR)"],"award-info":[{"award-number":["F. 41-1286\/2012 (SR)"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.mito.2016.08.005","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T09:47:51Z","timestamp":1471254471000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Melatonin modulates permeability transition pore and 5-hydroxydecanoate induced KATP channel inhibition in isolated brain mitochondria"],"prefix":"10.1016","volume":"31","author":[{"given":"Mohammad","family":"Waseem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heena","family":"Tabassum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhel","family":"Parvez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2016.08.005_bb0005","first-page":"46","article-title":"The effect of permeability transition pore opening on reactive oxygen species production in rat brain mitochondria","volume":"83","author":"Akopova","year":"2011","journal-title":"Ukr. Biokhim. Zh."},{"key":"10.1016\/j.mito.2016.08.005_bb0010","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1096\/fj.03-1031fje","article-title":"Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin","volume":"18","author":"Andrabi","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.mito.2016.08.005_bb9000","first-page":"384","article-title":"Melatonin and ischemic stroke: mechanistic roles and action","volume":"2015","author":"Andrabi","year":"2015","journal-title":"Adv. Pharmacol. Sci."},{"key":"10.1016\/j.mito.2016.08.005_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026012","article-title":"Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin","volume":"6","author":"Barzegar","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2016.08.005_bb0020","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1124\/jpet.106.104125","article-title":"The anti-inflammatory drug, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), uncouples mitochondria and induces mitochondrial permeability transition in human hepatoma cells: protection by albumin","volume":"318","author":"Berson","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mito.2016.08.005_bb0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.mito.2016.08.005_bb0030","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/bs.acc.2014.11.001","article-title":"Manganese superoxide dismutase and oxidative stress modulation","volume":"68","author":"Bresciani","year":"2015","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.mito.2016.08.005_bb0035","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.0022-3042.2001.00671.x","article-title":"Calcium-induced cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane","volume":"80","author":"Brustovetsky","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2016.08.005_bb0040","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.febslet.2009.12.038","article-title":"Interaction of mitochondrial potassium channels with the permeability transition pore","volume":"584","author":"Cheng","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mito.2016.08.005_bb0045","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mito.2011.04.007","article-title":"Modulation of the mitochondrial permeability transition by cyclophilin D: moving closer to F(0)-F(1) ATP synthase?","volume":"12","author":"Chinopoulos","year":"2012","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2016.08.005_bb0050","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ceca.2006.01.001","article-title":"Combined modulation of the mitochondrial ATP-dependent potassium channel and the permeability transition pore causes prolongation of the biphasic calcium dynamics","volume":"39","author":"Dahlem","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mito.2016.08.005_bb0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0005-2728(03)00108-7","article-title":"Mitochondrial potassium transport: the K(+) cycle","volume":"1606","author":"Garlid","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2016.08.005_bb0060","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/bj2740611","article-title":"Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin","volume":"274","author":"Griffiths","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/j.mito.2016.08.005_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.yjmcc.2005.04.002","article-title":"K(ATP) channels and preconditioning: a re-examination of the role of mitochondrial K(ATP) channels and an overview of alternative mechanisms","volume":"39","author":"Hanley","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.mito.2016.08.005_bb0070","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1113\/jphysiol.2002.023960","article-title":"(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart","volume":"542","author":"Hanley","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.mito.2016.08.005_bb0075","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-079X.2009.00707.x","article-title":"Melatonin prevents oxidative stress-mediated mitochondrial permeability transition and death in skeletal muscle cells","volume":"47","author":"Hibaoui","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.mito.2016.08.005_bb0080","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/352244a0","article-title":"ATP-sensitive K+ channel in the mitochondrial inner membrane","volume":"352","author":"Inoue","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.mito.2016.08.005_bb0085","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s12640-013-9419-y","article-title":"Protective effect of melatonin on methamphetamine-induced apoptosis in glioma cell line","volume":"25","author":"Jumnongprakhon","year":"2014","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.mito.2016.08.005_bb0090","first-page":"179","article-title":"Modulation of the permeability transition pore by inhibition of the mitochondrial K(ATP) channel in liver vs. brain mitochondria","volume":"44","author":"Kupsch","year":"2007","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.mito.2016.08.005_bb0095","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1743-7075-9-6","article-title":"d-Lactate altered mitochondrial energy production in rat brain and heart but not liver","volume":"9","author":"Ling","year":"2012","journal-title":"Nutr. Metab. (Lond.)"},{"key":"10.1016\/j.mito.2016.08.005_bb0100","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/jpi.12267","article-title":"Melatonin: an ancient molecule that makes oxygen metabolically tolerable","volume":"59","author":"Manchester","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.mito.2016.08.005_bb0110","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S1471-4914(03)00046-7","article-title":"Mitochondria in cell death: novel targets for neuroprotection and cardioprotection","volume":"9","author":"Mattson","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mito.2016.08.005_bb0115","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/gerona\/62.7.687","article-title":"Melatonin is able to reduce the apoptotic liver changes induced by aging via inhibition of the intrinsic pathway of apoptosis","volume":"62","author":"Molpeceres","year":"2007","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mito.2016.08.005_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/586270","article-title":"Role of melatonin in traumatic brain injury and spinal cord injury","author":"Naseem","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.mito.2016.08.005_bb0125","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.bbabio.2010.02.001","article-title":"The dopamine-D2-receptor agonist ropinirole dose-dependently blocks the Ca2+-triggered permeability transition of mitochondria","volume":"1797","author":"Parvez","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2016.08.005_bb0130","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1128\/AAC.42.4.843","article-title":"Cyclosporin analogs inhibit in vitro growth of Cryptosporidium parvum","volume":"42","author":"Perkins","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.mito.2016.08.005_bb0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2144\/000113610","article-title":"Mitochondrial membrane potential probes and the proton gradient: a practical usage guide","volume":"50","author":"Perry","year":"2011","journal-title":"Biotechniques"},{"key":"10.1016\/j.mito.2016.08.005_bb0140","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s13105-014-0347-y","article-title":"Role of mitochondrial permeability transition pore and mitochondrial ATP-sensitive potassium channels in the protective effects of ischemic preconditioning in isolated hearts from fed and fasted rats","volume":"70","author":"Prendes","year":"2014","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.mito.2016.08.005_bb0145","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s11064-009-9934-7","article-title":"Mitochondrial calcium transport and mitochondrial dysfunction after global brain ischemia in rat hippocampus","volume":"34","author":"Racay","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mito.2016.08.005_bb8000","doi-asserted-by":"crossref","DOI":"10.1007\/s00709-015-0930-2","article-title":"Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson's disease","author":"Rasheed","year":"2016","journal-title":"Protoplasma"},{"key":"10.1016\/j.mito.2016.08.005_bb0150","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/iub.1130","article-title":"What is the nature of the mitochondrial permeability transition pore and what is it not?","volume":"65","author":"Siemen","year":"2013","journal-title":"IUBMB Life"},{"key":"10.1016\/j.mito.2016.08.005_bb0155","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0197-0186(01)00122-X","article-title":"Mitochondrial contributions to tissue damage in stroke","volume":"40","author":"Sims","year":"2002","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.mito.2016.08.005_bb0160","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/sj.bjp.0706214","article-title":"Antidiabetic sulphonylureas activate mitochondrial permeability transition in rat skeletal muscle","volume":"145","author":"Skalska","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mito.2016.08.005_bb0165","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbadis.2012.07.009","article-title":"The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease","volume":"1832","author":"Solesio","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2016.08.005_bb0170","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3164\/jcbn.2008006","article-title":"Flow cytometric analysis of Ca-induced membrane permeability transition of isolated rat liver mitochondria","volume":"42","author":"Umegaki","year":"2008","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.mito.2016.08.005_bb0175","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.bbabio.2012.06.620","article-title":"The mitochondrial permeability transition pore (PTP) - an example of multiple molecular exaptation?","volume":"1817","author":"Vianello","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2016.08.005_bb0180","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1749-6632.2003.tb07530.x","article-title":"Possible mechanism for the neuroprotective effects of l-carnitine on methamphetamine-evoked neurotoxicity","volume":"993","author":"Virmani","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mito.2016.08.005_bb0185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1124\/mol.62.1.22","article-title":"Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811","volume":"62","author":"Waldmeier","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mito.2016.08.005_bb0190","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00709-015-0821-6","article-title":"Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin","volume":"253","author":"Waseem","year":"2015","journal-title":"Protoplasma"},{"key":"10.1016\/j.mito.2016.08.005_bb0195","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0891-5849(03)00142-4","article-title":"Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide","volume":"34","author":"Zhao","year":"2003","journal-title":"Free Radic. Biol. Med."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724916301428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724916301428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T11:22:44Z","timestamp":1568287364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724916301428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":40,"alternative-id":["S1567724916301428"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2016.08.005","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin modulates permeability transition pore and 5-hydroxydecanoate induced KATP channel inhibition in isolated brain mitochondria","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2016.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}