{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:22:56Z","timestamp":1777393376346,"version":"3.51.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Polish National Centre for Science","award":["2014\/15\/B\/NZ2\/02272"],"award-info":[{"award-number":["2014\/15\/B\/NZ2\/02272"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.mito.2016.11.006","type":"journal-article","created":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T12:01:34Z","timestamp":1478952094000},"page":"19-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Investigating Leber's hereditary optic neuropathy: Cell models and future perspectives"],"prefix":"10.1016","volume":"32","author":[{"given":"Elona","family":"Jankauskait\u0117","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Bartnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-1776","authenticated-orcid":false,"given":"Agata","family":"Kodro\u0144","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2016.11.006_bb0005","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1186\/1756-0500-4-557","article-title":"Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration","volume":"4","author":"Angebault","year":"2011","journal-title":"BMC. Res. Notes"},{"key":"10.1016\/j.mito.2016.11.006_bb0010","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/nm.3261","article-title":"Specific elimination of mutant mitochondrial genomes in patient\u2013derived cells by mitoTALENs","volume":"19","author":"Bacman","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.mito.2016.11.006_bb0015","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1126\/science.aab1028","article-title":"A prudent path forward for genomic engineering and germline gene modification","volume":"348","author":"Baltimore","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.mito.2016.11.006_bb0020","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1001\/archneur.62.5.730","article-title":"Severe impairment of complex I\u2013driven adenosine triphosphate synthesis in Leber hereditary optic neuropathy cybrids","volume":"62","author":"Baracca","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.mito.2016.11.006_bb0025","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1136\/jnnp.2003.024372","article-title":"Cell response to oxidative stress induced apoptosis in patients with Leber's hereditary optic neuropathy","volume":"75","author":"Battisti","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.mito.2016.11.006_bb0030","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1093\/nar\/gng100","article-title":"A chemical enucleation method for the transfer of mitochondrial DNA to \u03c10 cells","volume":"31","author":"Bayona-Bafaluy","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mito.2016.11.006_bb0035","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/brain\/awh258","article-title":"Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines","volume":"127","author":"Beretta","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0040","article-title":"Targeted epigenetic remodeling of endogenous loci by CRISPR\/Cas9-based transcriptional activators directly converts fibroblasts to neuronal cells","volume":"9","author":"Black","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mito.2016.11.006_bb0045","first-page":"87","article-title":"Ethics of mitochondrial gene replacement: from bench to bedside","volume":"342","author":"Bredenoord","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.mito.2016.11.006_bb0050","first-page":"381","article-title":"Clustering of Caucasian Leber hereditary optic neuropathy patients containing the 11778 or 14484 mutations on an mtDNA lineage","volume":"60","author":"Brown","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mito.2016.11.006_bb0055","doi-asserted-by":"crossref","first-page":"39831","DOI":"10.1074\/jbc.M006476200","article-title":"Functional analysis of lymphoblast and cybrid mitochondria containing the 3460, 11778, or 14484 Leber's hereditary optic neuropathy mitochondrial DNA mutation","volume":"275","author":"Brown","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2016.11.006_bb0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0925-4439(02)00097-2","article-title":"Respiratory function in cybrid cell lines carrying European mtDNA haplogroups: implications for Leber's hereditary optic neuropathy","volume":"1588","author":"Carelli","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2016.11.006_bb0065","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.preteyeres.2003.10.003","article-title":"Mitochondrial dysfunction as a cause of optic neuropathies","volume":"23","author":"Carelli","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.mito.2016.11.006_bb0070","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/stem.1354","article-title":"Induced pluripotent stem cells with a pathological mitochondrial DNA deletion","volume":"31","author":"Cherry","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.mito.2016.11.006_bb0075","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/1096-8628(20010122)98:3<235::AID-AJMG1086>3.0.CO;2-O","article-title":"Leber hereditary optic neuropathy: does heteroplasmy influence the inheritance and expression of the G11778A mitochondrial DNA mutation?","volume":"98","author":"Chinnery","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.mito.2016.11.006_bb0080","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.crvi.2013.11.011","article-title":"Gene therapy for mitochondrial diseases: Leber hereditary optic neuropathy as the first candidate for a clinical trial","volume":"337","author":"Cwerman-Thibault","year":"2014","journal-title":"C. R. Biol."},{"key":"10.1016\/j.mito.2016.11.006_bb0085","first-page":"1","article-title":"Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss","volume":"2","author":"Cwerman-Thibault","year":"2015","journal-title":"Mol. Ther."},{"key":"10.1016\/j.mito.2016.11.006_bb0090","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/brain\/awh447","article-title":"Isolation of transcriptomal changes attributable to LHON mutations and the cybridization process","volume":"128","author":"Danielson","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0095","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/brain\/awh447","article-title":"Isolation of transcriptomal changes attributable to LHON mutations and the cybridization process","volume":"128","author":"Danielson","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0100","first-page":"9","article-title":"Evidence for detrimental cross interactions between reactive oxygen and nitrogen species in Leber's hereditary optic neuropathy cells","volume":"2015","author":"Fallabela","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.mito.2016.11.006_bb0105","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1093\/nar\/gkv140","article-title":"A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions","volume":"43","author":"Fayzulin","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mito.2016.11.006_bb0110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.gpb.2013.08.003","article-title":"Pluripotency of induced pluripotent stem cells","volume":"11","author":"Feng","year":"2013","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.mito.2016.11.006_bb0115","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ophtha.2015.10.025","article-title":"Gene therapy for Leber hereditary optic neuropathy. Initial results","volume":"123","author":"Feuer","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.mito.2016.11.006_bb0120","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/j.1742-4658.2004.04542.x","article-title":"Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber's hereditary optic neuropathy","volume":"272","author":"Floreani","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.mito.2016.11.006_bb0125","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1074\/jbc.M210285200","article-title":"Leber's hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium","volume":"278","author":"Ghelli","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2016.11.006_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0007922","article-title":"The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2.5-hexanedione toxicity","volume":"4","author":"Ghelli","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2016.11.006_bb0135","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/brain\/awq276","article-title":"Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy","volume":"134","author":"Giordano","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0140","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/brain\/awt343","article-title":"Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy","volume":"137","author":"Giordano","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0145","first-page":"6","article-title":"Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways","volume":"17","author":"Giordano","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mito.2016.11.006_bb0150","first-page":"363","article-title":"The effects of idebenone on mitochondrial bioenergetics","volume":"2012","author":"Giorgio","year":"1817","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2016.11.006_bb0155","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/ana.10354","article-title":"Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy","volume":"52","author":"Guy","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mito.2016.11.006_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0017963","article-title":"QO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels","volume":"6","author":"Haefeli","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2016.11.006_bb0165","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.nbd.2007.07.021","article-title":"Minocycline, a possible neuroprotective agent in Leber's hereditary optic neuropathy (LHON): studies of cybrid cells bearing 11778 mutation","volume":"28","author":"Haroon","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mito.2016.11.006_bb0170","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1101\/gad.248252.114","article-title":"A CRISPR view of development","volume":"28","author":"Harrison","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.mito.2016.11.006_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045182","article-title":"Idebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathy","volume":"7","author":"Heitz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2016.11.006_bb0180","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/brain\/awu005","article-title":"Weighing in on Leber hereditary optic neuropathy: effects of mitochondrial mass","volume":"137","author":"Hirano","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0185","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2014.05.010","article-title":"Development and applications of CRISPR-Cas9 for genome engineering","volume":"157","author":"Hsu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mito.2016.11.006_bb0190","first-page":"75","article-title":"Lymphoblastoid cell lines: a continuous in vitro source of cells to study carcinogen sensitivity and DNA repair","volume":"1","author":"Hussain","year":"2012","journal-title":"Int. J. Mol. Cell Med."},{"key":"10.1016\/j.mito.2016.11.006_bb0195","doi-asserted-by":"crossref","first-page":"305716","DOI":"10.1155\/2015\/305716","article-title":"Efficient mitochondrial genome editing by CRISPR\/Cas9","volume":"2015","author":"Jo","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.mito.2016.11.006_bb0200","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3486","article-title":"TALENs: a widely applicable technology for targeted genome editing","volume":"14","author":"Joung","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.mito.2016.11.006_bb0205","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0002-9394(00)00603-6","article-title":"A case-control study of tobacco and alcohol consumption in Leber hereditary optic neuropathy","volume":"130","author":"Kerrison","year":"2000","journal-title":"Am J. Ophthalmol."},{"key":"10.1016\/j.mito.2016.11.006_bb0210","doi-asserted-by":"crossref","first-page":"C658","DOI":"10.1152\/ajpcell.00224.2006","article-title":"Cell and animal models of mtDNA biology: progress and prospects","volume":"292","author":"Khan","year":"2007","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.mito.2016.11.006_bb0215","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.2814477","article-title":"Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation","volume":"246","author":"King","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.mito.2016.11.006_bb0220","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1093\/brain\/awp158","article-title":"Gene\u2013environment interactions in Leber hereditary optic neuropathy","volume":"132","author":"Kirkman","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0225","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1093\/brain\/awp158","article-title":"Gene\u2013environment interactions in Leber hereditary optic neuropathy","volume":"132","author":"Kirkman","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/brain\/aws279","article-title":"Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy","volume":"136","author":"Klopstock","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0235","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1182\/blood-2016-01-678136","article-title":"Ethical and regulatory aspects of genome editing","volume":"127","author":"Kohn","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.mito.2016.11.006_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(00)00224-2","article-title":"Characterization of a transformed rat retinal ganglion cell line","volume":"86","author":"Krishnamoorthy","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.mito.2016.11.006_bb0245","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1167\/iovs.13-12085","article-title":"A forensic path to RGC-5 cell line identification: lessons learned by misidentification of RGC-5 cells","volume":"54","author":"Krishnamoorthy","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mito.2016.11.006_bb0250","first-page":"379","article-title":"Mechanisms of retinal ganglion specific-cell death in Leber hereditary optic neuropathy","volume":"105","author":"Levin","year":"2007","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.mito.2016.11.006_bb0255","first-page":"1","article-title":"Chronic glutamate toxicity in neurodegenerative diseases \u2014 what is the evidence?","volume":"9","author":"Lewerenz","year":"2005","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mito.2016.11.006_bb0260","doi-asserted-by":"crossref","first-page":"20065","DOI":"10.1073\/pnas.1217113109","article-title":"Mouse mtDNA mutant model of Leber hereditary optic neuropathy","volume":"109","author":"Lin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mito.2016.11.006_bb0265","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1086\/346066","article-title":"The epidemiology of Leber hereditary optic neuropathy in the North East of England","volume":"72","author":"Man","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mito.2016.11.006_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011472","article-title":"Successful amelioration of mitochondrial optic neuropathy using the yeast ND1 gene in a rat animal model","volume":"5","author":"Marella","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2016.11.006_bb0275","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbacli.2014.09.003","article-title":"Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry","volume":"2","author":"Pecina","year":"2014","journal-title":"BBA Clin."},{"key":"10.1016\/j.mito.2016.11.006_bb0280","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1093\/hmg\/ddn303","article-title":"Mitochondrial DNA background modulates the assembly kinetics of OXPHOS complexes in a cellular model of mitochondrial disease","volume":"17","author":"Pello","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2016.11.006_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.06-0789","article-title":"The mutant human ND4 subunit of complex I induces optic neuropathy in the mouse","volume":"48","author":"Qi","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mito.2016.11.006_bb0290","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cell.2015.03.051","article-title":"Selective elimination of mitochondrial mutations in the germline by genome editing","volume":"161","author":"Reddy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.mito.2016.11.006_bb0295","doi-asserted-by":"crossref","first-page":"424","DOI":"10.5966\/sctm.2013-0147","article-title":"Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells","volume":"3","author":"Riazifar","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.mito.2016.11.006_bb0300","first-page":"2285","article-title":"Diabefic-like retinopathy in rats prevented with an aldose reductase inhibitor","volume":"30","author":"Robison","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mito.2016.11.006_bb0305","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1002\/jnr.21167","article-title":"Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies","volume":"85","author":"Swerdlow","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mito.2016.11.006_bb0310","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mito.2016.11.006_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106779","article-title":"Profiling the mitochondrial proteome of Leber's hereditary optic neuropathy (LHON) in Thailand: down-regulation of bioenergetics and mitochondrial protein quality control pathways in fibroblasts with the 11778G>A mutation","volume":"9","author":"Tun","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2016.11.006_bb0320","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1167\/iovs.09-3484","article-title":"Recharacterization of the RGC-5 retinal ganglion cell line","volume":"50","author":"Van Bergen","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mito.2016.11.006_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140919","article-title":"Measurement of systemic mitochondrial function in advanced primary open-angle glaucoma and Leber hereditary optic neuropathy","volume":"10","author":"Van Bergen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2016.11.006_bb0330","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.stem.2014.04.020","article-title":"Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing","volume":"15","author":"Veres","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mito.2016.11.006_bb0335","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s13238-015-0177-x","article-title":"Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos","volume":"6","author":"Wang","year":"2015","journal-title":"Protein Cell"},{"key":"10.1016\/j.mito.2016.11.006_bb0340","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1124\/pr.109.001461","article-title":"Pharmacogenomic discovery using cell-based models","volume":"61","author":"Welsh","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.mito.2016.11.006_bb0345","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.redox.2014.03.006","article-title":"Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies","volume":"2","author":"Wilkins","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.mito.2016.11.006_bb0350","first-page":"334","article-title":"The influence of visible light exposure on cultured RGC-5 cells","volume":"14","author":"Wood","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mito.2016.11.006_bb0355","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1093\/brain\/124.12.2448","article-title":"Neuropathy in diabetic mice overexpressing human aldose reductase and effects of aldose reductase inhibitor","volume":"124","author":"Yagihashi","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.mito.2016.11.006_bb0360","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.stem.2012.05.005","article-title":"Induced pluripotent stem cells: past, present, and future","volume":"10","author":"Yamanaka","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mito.2016.11.006_bb0365","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.preteyeres.2010.11.002","article-title":"Mitochondrial optic neuropathies \u2013 disease mechanisms and therapeutic strategies","volume":"30","author":"Yu-Wai-Man","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.mito.2016.11.006_bb0370","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1196\/annals.1299.037","article-title":"Apoptotic cell death of cybrid bearing Leber's hereditary optic neuropathy mutations is caspase independent","volume":"1010","author":"Zanna","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mito.2016.11.006_bb0375","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s10495-005-0742-5","article-title":"Caspase-independent death of Leber's hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and endonuclease G","volume":"10","author":"Zanna","year":"2005","journal-title":"Apoptosis"}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724916302458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724916302458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T10:38:50Z","timestamp":1568543930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724916302458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":75,"alternative-id":["S1567724916302458"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2016.11.006","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating Leber's hereditary optic neuropathy: Cell models and future perspectives","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2016.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}