{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:06:25Z","timestamp":1790748385763,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005049","name":"Science and Engineering Research Council","doi-asserted-by":"publisher","award":["261252"],"award-info":[{"award-number":["261252"]}],"id":[{"id":"10.13039\/501100005049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005049","name":"Science and Engineering Research Council","doi-asserted-by":"publisher","award":["2018-03878"],"award-info":[{"award-number":["2018-03878"]}],"id":[{"id":"10.13039\/501100005049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.mito.2018.06.004","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T09:11:06Z","timestamp":1529053866000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Is there a mutation gradient along vertebrate mitochondrial genome mediated by genome replication?"],"prefix":"10.1016","volume":"46","author":[{"given":"Xuhua","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2018.06.004_bb0005","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/genetics\/161.4.1589","article-title":"Mutation patterns of mitochondrial H\u2013 and L-strand DNA in closely related cyprinid fishes","volume":"161","author":"Bielawski","year":"2002","journal-title":"Genetics"},{"key":"10.1016\/j.mito.2018.06.004_bb0010","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0968-0004(03)00132-4","article-title":"The mitochondrial DNA replication bubble has not burst","volume":"28","author":"Bogenhagen","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mito.2018.06.004_bb0015","doi-asserted-by":"crossref","first-page":"50961","DOI":"10.1074\/jbc.M308028200","article-title":"Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone","volume":"278","author":"Bowmaker","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2018.06.004_bb0020","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/molbev\/msl013","article-title":"Spatial covariation of mutation and nonsynonymous substitution rates in vertebrate mitochondrial genomes","volume":"23","author":"Broughton","year":"2006","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.mito.2018.06.004_bb0025","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1073\/pnas.71.11.4617","article-title":"Restriction endonuclease cleavage maps of animal mitochondrial DNAs","volume":"71","author":"Brown","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.mito.2018.06.004_bb0030","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1101\/gad.1352105","article-title":"Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism","volume":"19","author":"Brown","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.mito.2018.06.004_bb0035","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3109\/19401736.2011.653807","article-title":"Complete mitochondrial genome of the red drum, Sciaenops ocellatus (Perciformes, Sciaenidae): absence of the typical conserved motif in the origin of the light-strand replication","volume":"23","author":"Cheng","year":"2012","journal-title":"Mitochondrial DNA"},{"key":"10.1016\/j.mito.2018.06.004_bb0040","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0092-8674(82)90049-6","article-title":"Replication of animal mitochondrial DNA","volume":"28","author":"Clayton","year":"1982","journal-title":"Cell"},{"key":"10.1016\/j.mito.2018.06.004_bb0045","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.cb.07.110191.002321","article-title":"Replication and transcription of vertebrate mitochondrial DNA","volume":"7","author":"Clayton","year":"1991","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/j.mito.2018.06.004_bb0050","series-title":"DNA Replication in Eukaryotic Cells","first-page":"1015","article-title":"Mitochondrial DNA replication","author":"Clayton","year":"1996"},{"key":"10.1016\/j.mito.2018.06.004_bb0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/humrep\/15.suppl_2.11","article-title":"Transcription and replication of mitochondrial DNA","volume":"15","author":"Clayton","year":"2000","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mito.2018.06.004_bb0060","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2105-5-113","article-title":"MUSCLE: a multiple sequence alignment method with reduced time and space complexity","volume":"5","author":"Edgar","year":"2004","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.mito.2018.06.004_bb0065","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mito.2018.06.004_bb0070","doi-asserted-by":"crossref","first-page":"E984","DOI":"10.1002\/humu.21113","article-title":"Pathogenic mitochondrial tRNA mutations\u2013which mutations are inherited and why?","volume":"30","author":"Elson","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.mito.2018.06.004_bb0075","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/genetics\/165.2.735","article-title":"Likelihood analysis of asymmetrical mutation bias gradients in vertebrate mitochondrial genomes","volume":"165","author":"Faith","year":"2003","journal-title":"Genetics"},{"key":"10.1016\/j.mito.2018.06.004_bb0080","series-title":"PHYLIP 3.695 (Phylogeny Inference Package).","author":"Felsenstein","year":"2014"},{"key":"10.1016\/j.mito.2018.06.004_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106654","article-title":"The inversion of the control region in three mitogenomes provides further evidence for an asymmetric model of vertebrate mtDNA replication","volume":"9","author":"Fonseca","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2018.06.004_bb0090","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1021\/bi00462a015","article-title":"A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy","volume":"29","author":"Frederico","year":"1990","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.mito.2018.06.004_bb0095","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molcel.2009.12.021","article-title":"Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication","volume":"37","author":"Fuste","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mito.2018.06.004_bb0100","article-title":"In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication","volume":"10","author":"Fuste","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mito.2018.06.004_bb0105","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/10635150390235520","article-title":"A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood","volume":"52","author":"Guindon","year":"2003","journal-title":"Syst. Biol."},{"key":"10.1016\/j.mito.2018.06.004_bb0110","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1016\/S0021-9258(17)35948-3","article-title":"Both the conserved stem-loop and divergent 5\u2032-flanking sequences are required for initiation at the human mitochondrial origin of light-strand DNA replication","volume":"261","author":"Hixson","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2018.06.004_bb0115","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tibs.2009.03.007","article-title":"Mitochondrial DNA replication and repair: all a flap","volume":"34","author":"Holt","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mito.2018.06.004_bb0120","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012971","article-title":"Human mitochondrial DNA replication","volume":"4","author":"Holt","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mito.2018.06.004_bb0125","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0092-8674(00)80688-1","article-title":"Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA","volume":"100","author":"Holt","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.mito.2018.06.004_bb0130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-59745-251-9_3","article-title":"Multiple alignment of DNA sequences with MAFFT","volume":"537","author":"Katoh","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mito.2018.06.004_bb0135","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1038\/sj.emboj.7600257","article-title":"Reconstitution of a minimal mtDNA replisome in vitro","volume":"23","author":"Korhonen","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.mito.2018.06.004_bb0140","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/dna.2004.23.707","article-title":"Detecting gradients of asymmetry in site-specific substitutions in mitochondrial genomes","volume":"23","author":"Krishnan","year":"2004","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.mito.2018.06.004_bb0145","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.mito.2018.06.004_bb0150","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/oxfordjournals.molbev.a025626","article-title":"Asymmetric substitution patterns in the two DNA strands of bacteria","volume":"13","author":"Lobry","year":"1996","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.mito.2018.06.004_bb0155","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1126\/science.272.5262.745","article-title":"Origin of replication of Mycoplasma genitalium","volume":"272","author":"Lobry","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.mito.2018.06.004_bb0160","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jtbi.2008.04.004","article-title":"GC skew in protein-coding genes between the leading and lagging strands in bacterial genomes: new substitution models incorporating strand bias","volume":"253","author":"Marin","year":"2008","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.mito.2018.06.004_bb0165","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0022-2836(79)90440-6","article-title":"Mechanism of mitochondrial DNA replication in mouse L-cells: localization and sequence of the lighe-strand origin of replication","volume":"135","author":"Martens","year":"1979","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mito.2018.06.004_bb0170","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/PL00006243","article-title":"Synonymous substitution rates in Drosophila: mitochondrial versus nuclear genes","volume":"45","author":"Moriyama","year":"1997","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.mito.2018.06.004_bb0175","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1073\/pnas.84.1.166","article-title":"The guanine and cytosine content of genomic DNA and bacterial evolution","volume":"84","author":"Muto","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mito.2018.06.004_bb0180","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1590\/S1415-47572000000400008","article-title":"Mitochondrial genome organization and vertebrate phylogenetics","volume":"23","author":"Pereira","year":"2000","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.mito.2018.06.004_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010426","article-title":"Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number","volume":"5","author":"Pohjoismaki","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2018.06.004_bb0190","series-title":"Numerical Recipes in C: The Art of Scientifi Computing","author":"Press","year":"1992"},{"key":"10.1016\/j.mito.2018.06.004_bb0195","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/oxfordjournals.molbev.a026011","article-title":"Asymmetrical directional mutation pressure in the mitochondrial genome of mammals","volume":"15","author":"Reyes","year":"1998","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.mito.2018.06.004_bb0200","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1074\/jbc.M411916200","article-title":"Bidirectional replication initiates at sites throughout the mitochondrial genome of birds","volume":"280","author":"Reyes","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2018.06.004_bb0205","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1073\/pnas.69.12.3810","article-title":"Replication of mitochondrial DNA in mouse L cells and their thymidine kinase - derivatives: displacement replication on a covalently-closed circular template","volume":"69","author":"Robberson","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.mito.2018.06.004_bb0210","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1073\/pnas.69.3.737","article-title":"Replication of mitochondrial DNA. Circular replicative intermediates in mouse L cells","volume":"69","author":"Robberson","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.mito.2018.06.004_bb0215","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1073\/pnas.71.11.4447","article-title":"Cleavage of replicating forms of mitochondrial DNA by EcoRI endonuclease","volume":"71","author":"Robberson","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.mito.2018.06.004_bb0220","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mito.2014.05.009","article-title":"GC skew and mitochondrial origins of replication","volume":"17","author":"Sahyoun","year":"2014","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2018.06.004_bb0225","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.bi.57.070188.000333","article-title":"DNA repair enzymes","volume":"57","author":"Sancar","year":"1988","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mito.2018.06.004_bb0230","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.biochem.66.1.409","article-title":"Mitochondrial DNA maintenance in vertebrates","volume":"66","author":"Shadel","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mito.2018.06.004_bb0235","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrg2396","article-title":"Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease","volume":"9","author":"Stewart","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mito.2018.06.004_bb0240","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/geno.1994.1391","article-title":"Strand asymmetry in human mitochondrial DNA mutations","volume":"22","author":"Tanaka","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/j.mito.2018.06.004_bb0245","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1016\/S0021-9258(19)69373-7","article-title":"Mechanism of replication of human mitochondrial DNA. Localization of the 5\u2032 ends of nascent daughter strands","volume":"256","author":"Tapper","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2018.06.004_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-2836(82)90159-0","article-title":"Precise nucleotide location of the 5\u2032 ends of RNA-primed nascent light strands of mouse mitochondrial DNA","volume":"162","author":"Tapper","year":"1982","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mito.2018.06.004_bb0255","series-title":"Handbook of the Biology of Aging","first-page":"173","article-title":"DNA repair and replication in aging organisms and cells","author":"Tice","year":"1985"},{"key":"10.1016\/j.mito.2018.06.004_bb0260","doi-asserted-by":"crossref","first-page":"11122","DOI":"10.1073\/pnas.0805399105","article-title":"Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro","volume":"105","author":"Wanrooij","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.mito.2018.06.004_bb0265","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3109\/19401736.2014.892080","article-title":"Complete mitochondrial genome of Lophius litulon (Lophiiforms, Lophiidae) and comparison of light strand replication origin in Lophiidae","volume":"27","author":"Wei","year":"2016","journal-title":"Mitochondrial DNA"},{"key":"10.1016\/j.mito.2018.06.004_bb0270","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.gene.2004.11.019","article-title":"Mutation and selection on the anticodon of tRNA genes in vertebrate mitochondrial genomes","volume":"345","author":"Xia","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.mito.2018.06.004_bb0275","series-title":"Evolution in the Fast Lane: Rapidly Evolving Genes and Genetic Systems","first-page":"73","article-title":"Rapid evolution of animal mitochondria","author":"Xia","year":"2012"},{"key":"10.1016\/j.mito.2018.06.004_bb0280","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/molbev\/mst064","article-title":"DAMBE5: a comprehensive software package for data analysis in molecular biology and evolution","volume":"30","author":"Xia","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.mito.2018.06.004_bb0285","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/jhered\/esx033","article-title":"DAMBE6: new tools for microbial genomics, Phylogenetics, and molecular evolution","volume":"108","author":"Xia","year":"2017","journal-title":"J. Hered."},{"key":"10.1016\/j.mito.2018.06.004_bb0290","series-title":"Large Sets of Aligned Mammalian, Avian, and Crocodilian Mitochondrial Genes","author":"Xia","year":"2018"},{"key":"10.1016\/j.mito.2018.06.004_bb0295","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF02352297","article-title":"On transition bias in mitochondrial genes of pocket gophers","volume":"43","author":"Xia","year":"1996","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.mito.2018.06.004_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1055-7903(02)00326-3","article-title":"An index of substitution saturation and its application","volume":"26","author":"Xia","year":"2003","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.mito.2018.06.004_bb0305","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/j.1460-2075.1996.tb00676.x","article-title":"RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers","volume":"15","author":"Xu","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.mito.2018.06.004_bb0310","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(02)01075-9","article-title":"Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication","volume":"111","author":"Yang","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.mito.2018.06.004_bb0315","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.molcel.2005.05.002","article-title":"A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA","volume":"18","author":"Yasukawa","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mito.2018.06.004_bb0320","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1038\/sj.emboj.7601392","article-title":"Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand","volume":"25","author":"Yasukawa","year":"2006","journal-title":"EMBO J."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724917303343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724917303343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T20:03:56Z","timestamp":1661457836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724917303343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":64,"alternative-id":["S1567724917303343"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2018.06.004","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is there a mutation gradient along vertebrate mitochondrial genome mediated by genome replication?","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2018.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}