{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:14:30Z","timestamp":1790997270725,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","award":["16-373"],"award-info":[{"award-number":["16-373"]}],"id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.mito.2019.10.005","type":"journal-article","created":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T01:44:11Z","timestamp":1572054251000},"page":"35-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy"],"prefix":"10.1016","volume":"50","author":[{"given":"Nanna Scharff","family":"Poulsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Lindhardt","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa Munkeboe","family":"Hornsyld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sofie Vib\u00e6k","family":"Eisum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freja","family":"Fornander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid Emilie","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads Godtfeldt","family":"Stemmerik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ruiz-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Oliver","family":"Krag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Vissing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.mito.2019.10.005_b0005","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1212\/WNL.0000000000002705","article-title":"A comparison of current serum biomarkers as diagnostic indicators of mitochondrial diseases","volume":"86","author":"Davis","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2019.10.005_b0010","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mito.2014.10.006","article-title":"GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases","volume":"20","author":"Fujita","year":"2015","journal-title":"Mitochondrion"},{"issue":"6235","key":"10.1016\/j.mito.2019.10.005_b0015","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"GTEx Consortium","year":"2015","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.mito.2019.10.005_b0020","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10545-005-4160-1","article-title":"Glutathione deficiency in patients with mitochondrial disease: implications for pathogenesis and treatment","volume":"28","author":"Hargreaves","year":"2005","journal-title":"J. Inherit. Metab. Dis."},{"issue":"10","key":"10.1016\/j.mito.2019.10.005_b0025","doi-asserted-by":"crossref","first-page":"8110","DOI":"10.1007\/s12035-016-0283-7","article-title":"Growth differentiation factor 15 is a novel diagnostic biomarker of mitochondrial diseases","volume":"54","author":"Ji","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mito.2019.10.005_b0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2164-15-91","article-title":"Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies","volume":"15","author":"Kalko","year":"2014","journal-title":"BMC Genomics"},{"issue":"11","key":"10.1016\/j.mito.2019.10.005_b0035","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jacc.2007.04.091","article-title":"Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure","volume":"50","author":"Kempf","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.mito.2019.10.005_b0040","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ymgme.2013.06.022","article-title":"Oxidative stress and Nrf2 signaling in McArdle disease","volume":"110","author":"Kitaoka","year":"2013","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.mito.2019.10.005_b0045","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molmet.2017.12.016","article-title":"Exercise increases circulating GDF15 in humans","volume":"9","author":"Kleinert","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.mito.2019.10.005_b0050","first-page":"69","article-title":"Serum GDF15 levels correlate to mitochondrial disease severity and myocardial strain, but not to disease progression in adult m.3243A>G carriers","volume":"24","author":"Koene","year":"2015","journal-title":"JIMD Rep."},{"key":"10.1016\/j.mito.2019.10.005_b0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bone.2016.02.012","article-title":"Reduced bone mineral density in glycogen storage disease type III: evidence for a possible connection between metabolic imbalance and bone homeostasis","volume":"86","author":"Melis","year":"2016","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.mito.2019.10.005_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148709","article-title":"GDF-15 is elevated in children with mitochondrial diseases and is induced by mitochondrial dysfunction","volume":"11","author":"Montero","year":"2016","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.mito.2019.10.005_b0065","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1016\/j.celrep.2016.11.044","article-title":"Reversal of defective mitochondrial biogenesis in limb-girdle muscular dystrophy 2D by independent modulation of histone and PGC-1\u03b1 acetylation","volume":"17","author":"Pambianco","year":"2016","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.mito.2019.10.005_b0070","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/hmg\/dds415","article-title":"Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition","volume":"22","author":"Percival","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.mito.2019.10.005_b0075","first-page":"11","article-title":"Skeletal muscle: an endocrine organ","volume":"10","author":"Pratesi","year":"2013","journal-title":"Clin. Cases Miner. Bone Metab."},{"issue":"3","key":"10.1016\/j.mito.2019.10.005_b0080","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.ncl.2014.05.001","article-title":"Metabolic and mitochondrial myopathies","volume":"32","author":"Sharp","year":"2014","journal-title":"Neurol. Clin."},{"issue":"1\u20132","key":"10.1016\/j.mito.2019.10.005_b0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1023\/A:1006880529195","article-title":"High resolution respirometry of permeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders","volume":"174","author":"Sperl","year":"1997","journal-title":"Mol. Cell Biochem."},{"issue":"3","key":"10.1016\/j.mito.2019.10.005_b0090","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/ejh.12150","article-title":"Serum hepcidin and growth differentiation factor-15 (GDF-15) levels in polycythemia vera and essential thrombocythemia","volume":"91","author":"Tarkun","year":"2013","journal-title":"Eur. J. Haematol."},{"issue":"5","key":"10.1016\/j.mito.2019.10.005_b0095","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/ana.24506","article-title":"Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders","volume":"78","author":"Yatsuga","year":"2015","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.mito.2019.10.005_b0100","first-page":"543","article-title":"Growth differentiation factor-15\/macrophage inhibitory cytokine-1 induction after kidney and lung injury","volume":"23","author":"Zimmers","year":"2005","journal-title":"Shock Augusta Ga"}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724919301448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724919301448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:23:35Z","timestamp":1761589415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724919301448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":20,"alternative-id":["S1567724919301448"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2019.10.005","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2019.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}