{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:46:35Z","timestamp":1790271995951,"version":"4.1.0"},"reference-count":117,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.mito.2020.08.003","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T11:56:02Z","timestamp":1597924562000},"page":"14-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Mitochondrial abnormalities in neurodegenerative models and possible interventions: Focus on Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease"],"prefix":"10.1016","volume":"55","author":[{"given":"Patcharapong","family":"Pantiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanisa","family":"Thonusin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C.","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2020.08.003_b0005","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1161\/01.STR.26.8.1478","article-title":"Ischemic delayed neuronal death. A mitochondrial hypothesis","volume":"26","author":"Abe","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.mito.2020.08.003_b0010","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/jnc.13024","article-title":"Lipid peroxidation is essential for \u03b1-synuclein-induced cell death","volume":"133","author":"Angelova","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2020.08.003_b0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mito.2020.08.003_b0020","doi-asserted-by":"crossref","unstructured":"Bala, S., Szabo, G., 2018. TFEB, a master regulator of lysosome biogenesis and autophagy, is a new player in alcoholic liver disease. Digestive medicine research 1.","DOI":"10.21037\/dmr.2018.09.03"},{"key":"10.1016\/j.mito.2020.08.003_b0025","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/cns.12547","article-title":"Mitochondrial membrane potential-dependent endoplasmic reticulum fragmentation is an important step in neuritic degeneration","volume":"22","author":"Bao","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.mito.2020.08.003_b0030","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng1769","article-title":"High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease","volume":"38","author":"Bender","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0035","doi-asserted-by":"crossref","first-page":"7495","DOI":"10.1038\/s41598-017-07181-0","article-title":"Mitochondrial division inhibitor-1 is neuroprotective in the A53T-\u03b1-synuclein rat model of Parkinson's disease","volume":"7","author":"Bido","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mito.2020.08.003_b0040","doi-asserted-by":"crossref","DOI":"10.2174\/1570159X18666200122122512","article-title":"Role of oxidative stress and metal toxicity in the progression of Alzheimer's disease","author":"Birla","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.mito.2020.08.003_b0045","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/jcmm.13472","article-title":"Effects of d-galactose-induced ageing on the heart and its potential interventions","volume":"22","author":"Bo-Htay","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mito.2020.08.003_b0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7861\/clinmedicine.16-3-247","article-title":"Drug treatments in Alzheimer's disease","volume":"16","author":"Briggs","year":"2016","journal-title":"Clinical Med. (London, England)"},{"key":"10.1016\/j.mito.2020.08.003_b0055","first-page":"11","article-title":"Disturbed mitochondrial dynamics and neurodegenerative disorders. Nature reviews","volume":"11","author":"Burte","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2020.08.003_b0060","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1007\/s12035-015-9515-5","article-title":"Mechanisms of mitochondrial dysfunction in Alzheimer's disease","volume":"53","author":"Cadonic","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mito.2020.08.003_b0065","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3233\/JAD-160726","article-title":"Mitochondrial aspects of synaptic dysfunction in Alzheimer's disease","volume":"57","author":"Cai","year":"2017","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0070","doi-asserted-by":"crossref","first-page":"e1745","DOI":"10.1212\/WNL.0000000000007231","article-title":"Relative risk for Alzheimer disease based on complete family history","volume":"92","author":"Cannon-Albright","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2020.08.003_b0075","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1080\/21691401.2019.1594858","article-title":"The role of DRP1 in ropivacaine-induced mitochondrial dysfunction and neurotoxicity","volume":"47","author":"Chen","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.mito.2020.08.003_b0080","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/alzrt198","article-title":"Definitions of dementia and predementia states in Alzheimer's disease and vascular cognitive impairment: consensus from the Canadian conference on diagnosis of dementia","volume":"5","author":"Chertkow","year":"2013","journal-title":"Alzheimer's Res. Therapy"},{"key":"10.1016\/j.mito.2020.08.003_b0085","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s10439-011-0454-7","article-title":"The nuts and bolts of low-level laser (light) therapy","volume":"40","author":"Chung","year":"2012","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.mito.2020.08.003_b0090","first-page":"433","article-title":"Polyglutamine (polyQ) disorders: the chromatin connection","volume":"3","author":"Cohen-Carmon","year":"2012","journal-title":"Nucleus (Austin, Tex.)"},{"key":"10.1016\/j.mito.2020.08.003_b0095","doi-asserted-by":"crossref","first-page":"584","DOI":"10.2174\/1570159X14666160104142349","article-title":"Cognitive impairment associated with Parkinson's disease: role of mitochondria","volume":"14","author":"Das","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.mito.2020.08.003_b0100","first-page":"504","article-title":"Parkinson's disease and its management: part 1: disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis","volume":"40","author":"DeMaagd","year":"2015","journal-title":"P & T : a peer-Reviewed J. Formulary Manag."},{"key":"10.1016\/j.mito.2020.08.003_b0105","doi-asserted-by":"crossref","first-page":"9043","DOI":"10.1007\/s12035-018-1041-9","article-title":"Bexarotene modulates retinoid-X-receptor expression and is protective against neurotoxic endoplasmic reticulum stress response and apoptotic pathway activation","volume":"55","author":"Dheer","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mito.2020.08.003_b0110","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1515\/hsz-2012-0119","article-title":"Mitophagy: mechanisms, pathophysiological roles, and analysis","volume":"393","author":"Ding","year":"2012","journal-title":"Biol. Chem."},{"key":"10.1016\/j.mito.2020.08.003_b0115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neulet.2016.10.054","article-title":"Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine","volume":"636","author":"Dong","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mito.2020.08.003_b0120","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3233\/JAD-170045","article-title":"Mouse models of Alzheimer's disease","volume":"57","author":"Esquerda-Canals","year":"2017","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_bib576","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007476","article-title":"Huntington\u2019s Disease","author":"Finkbeiner","year":"2011","journal-title":"Cold Spring Harbor Perspective in Biology"},{"key":"10.1016\/j.mito.2020.08.003_b0125","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuint.2017.02.007","article-title":"Mitophagy in neurodegeneration and aging","volume":"109","author":"Fivenson","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.mito.2020.08.003_b0130","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1242\/jcs.171017","article-title":"Mitochondrial dynamics in neuronal injury, development and plasticity","volume":"130","author":"Flippo","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mito.2020.08.003_b0135","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3233\/JAD-170819","article-title":"Alzheimer's disease, oligomers, and inflammation","volume":"62","author":"Forloni","year":"2018","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0140","doi-asserted-by":"crossref","unstructured":"Gao, J., Wang, L., Liu, J., Xie, F., Su, B., Wang, X., 2017. Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases. Antioxidants (Basel, Switzerland) 6.","DOI":"10.3390\/antiox6020025"},{"key":"10.1016\/j.mito.2020.08.003_b0145","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.bbrc.2017.06.146","article-title":"INT131 increases dendritic arborization and protects against Abeta toxicity by inducing mitochondrial changes in hippocampal neurons","volume":"490","author":"Godoy","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2020.08.003_b0150","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2165\/00003495-200161010-00005","article-title":"Cholinesterase inhibitors for Alzheimer's disease","volume":"61","author":"Grutzendler","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/j.mito.2020.08.003_b0155","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12017-016-8420-z","article-title":"Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice","volume":"18","author":"Hagl","year":"2016","journal-title":"NeuroMol. Med."},{"key":"10.1016\/j.mito.2020.08.003_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1179\/1476830515Y.0000000040","article-title":"Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice","volume":"19","author":"Hagl","year":"2016","journal-title":"Nutritional Neurosci."},{"key":"10.1016\/j.mito.2020.08.003_b0165","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3233\/JAD-132084","article-title":"Rice bran extract compensates mitochondrial dysfunction in a cellular model of early Alzheimer's disease","volume":"43","author":"Hagl","year":"2015","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-160882","article-title":"Recent progress in Alzheimer's disease research, part 1: pathology","volume":"57","author":"Hane","year":"2017","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0175","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22416","article-title":"Neuroprotective effects of mitochondria-targeted curcumin against rotenone-induced oxidative damage in cerebellum of mice","volume":"34","author":"Hasan","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.mito.2020.08.003_b0180","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1089\/ars.2012.4928","article-title":"S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease","volume":"19","author":"Haun","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mito.2020.08.003_b0185","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimer's disease","volume":"21","author":"Hirai","year":"2001","journal-title":"J Neurosci.: Official J. Soc. Neurosci."},{"key":"10.1016\/j.mito.2020.08.003_b0190","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s10495-016-1295-5","article-title":"Mitochondrial dynamics during cell cycling","volume":"21","author":"Horbay","year":"2016","journal-title":"Apoptosis : Int. J. Programmed Cell Death"},{"key":"10.1016\/j.mito.2020.08.003_b0195","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fnmol.2017.00196","article-title":"The truncated C-terminal fragment of mutant ATXN3 disrupts mitochondria dynamics in spinocerebellar ataxia type 3 models","volume":"10","author":"Hsu","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mito.2020.08.003_b0200","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s12640-017-9766-1","article-title":"Huntington's disease and mitochondria","volume":"32","author":"Jodeiri Farshbaf","year":"2017","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.mito.2020.08.003_b0205","first-page":"500","article-title":"Turning on lights to stop neurodegeneration: the potential of near infrared light therapy in Alzheimer's and Parkinson's disease","volume":"9","author":"Johnstone","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mito.2020.08.003_b0210","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1093\/hmg\/ddw312","article-title":"Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease","volume":"25","author":"Kandimalla","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0215","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/hmg\/ddx381","article-title":"Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease","volume":"27","author":"Kandimalla","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0220","first-page":"814","article-title":"Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis","volume":"1862","author":"Kandimalla","year":"2016","journal-title":"BBA"},{"key":"10.1016\/j.mito.2020.08.003_b0225","doi-asserted-by":"crossref","first-page":"12292","DOI":"10.1073\/pnas.1606171113","article-title":"PPARgamma-coactivator-1alpha gene transfer reduces neuronal loss and amyloid-beta generation by reducing beta-secretase in an Alzheimer's disease model","volume":"113","author":"Katsouri","year":"2016","journal-title":"PNAS"},{"key":"10.1016\/j.mito.2020.08.003_b0230","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12868-016-0270-y","article-title":"A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death","volume":"17","author":"Kim","year":"2016","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.mito.2020.08.003_b0235","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1093\/hmg\/ddx226","article-title":"Aqua-soluble DDQ reduces the levels of Drp1 and Abeta and inhibits abnormal interactions between Abeta and Drp1 and protects Alzheimer's disease neurons from Abeta- and Drp1-induced mitochondrial and synaptic toxicities","volume":"26","author":"Kuruva","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0240","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bbrc.2011.11.038","article-title":"CCCP induces autophagy in an AMPK-independent manner","volume":"416","author":"Kwon","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2020.08.003_b0245","doi-asserted-by":"crossref","first-page":"9695412","DOI":"10.1155\/2019\/9695412","article-title":"Mitochondria- and oxidative stress-targeting substances in cognitive decline-related disorders: from molecular mechanisms to clinical evidence","volume":"2019","author":"Lejri","year":"2019","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"10.1016\/j.mito.2020.08.003_b0250","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12693","article-title":"DLP1-dependent mitochondrial fragmentation and redistribution mediate prion-associated mitochondrial dysfunction and neuronal death","volume":"17","author":"Li","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.mito.2020.08.003_b0255","first-page":"9","article-title":"Defining ROS in Biology and Medicine","volume":"1","author":"Li","year":"2016","journal-title":"Reactive Oxygen Species (Apex, N.C.)"},{"key":"10.1016\/j.mito.2020.08.003_b0260","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00115-017-0288-0","article-title":"Epidemiology and causes of Parkinson's disease","volume":"88","author":"Lill","year":"2017","journal-title":"Der Nervenarzt"},{"key":"10.1016\/j.mito.2020.08.003_b0265","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neurobiolaging.2016.10.003","article-title":"Low-level laser therapy for beta amyloid toxicity in rat hippocampus","volume":"49","author":"Lu","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mito.2020.08.003_b0270","first-page":"489","article-title":"Levetiracetam: a review of its use in epilepsy","volume":"71","author":"Lyseng-Williamson","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.mito.2020.08.003_b0275","doi-asserted-by":"crossref","DOI":"10.3791\/60377","article-title":"Labeling and imaging of amyloid plaques in brain tissue using the natural polyphenol curcumin","author":"Maiti","year":"2019","journal-title":"J. Visualized Experiments : JoVE."},{"key":"10.1016\/j.mito.2020.08.003_b0280","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2165\/11319230-000000000-00000","article-title":"Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders","volume":"70","author":"Malykh","year":"2010","journal-title":"Drugs"},{"key":"10.1016\/j.mito.2020.08.003_b0285","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neubiorev.2017.02.001","article-title":"Energy and the Alzheimer brain","volume":"75","author":"Mamelak","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.mito.2020.08.003_b0290","first-page":"5148","article-title":"Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease","volume":"25","author":"Manczak","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0295","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/hmg\/ddy042","article-title":"Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease","volume":"27","author":"Manczak","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0300","doi-asserted-by":"crossref","first-page":"7308","DOI":"10.1093\/hmg\/ddv429","article-title":"Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease","volume":"24","author":"Manczak","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0305","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1111\/jcmm.13330","article-title":"Roles of mitochondrial dynamics modulators in cardiac ischaemia\/reperfusion injury","volume":"21","author":"Maneechote","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mito.2020.08.003_b0310","doi-asserted-by":"crossref","first-page":"9302761","DOI":"10.1155\/2017\/9302761","article-title":"Slower dynamics and aged mitochondria in sporadic Alzheimer's disease","volume":"2017","author":"Martin-Maestro","year":"2017","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"10.1016\/j.mito.2020.08.003_b0315","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-019-01665-y","article-title":"Autophagy induction by bexarotene promotes mitophagy in presenilin 1 familial Alzheimer's disease iPSC-derived neural stem cells","author":"Martin-Maestro","year":"2019","journal-title":"Molecular Neurobiol."},{"key":"10.1016\/j.mito.2020.08.003_b0320","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington's disease: a clinical review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.mito.2020.08.003_b0325","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.bbapap.2019.03.001","article-title":"alpha-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis. Biochimica et biophysica acta","volume":"1867","author":"Mehra","year":"2019","journal-title":"Proteins Proteomics"},{"key":"10.1016\/j.mito.2020.08.003_b0330","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2015.03.036","article-title":"Mitochondrial biology, targets, and drug delivery","volume":"207","author":"Milane","year":"2015","journal-title":"J. Controlled Release : Official J. Controlled Release Society"},{"key":"10.1016\/j.mito.2020.08.003_b0335","doi-asserted-by":"crossref","first-page":"11862","DOI":"10.1523\/JNEUROSCI.1001-15.2015","article-title":"Bexarotene-activated retinoid X receptors regulate neuronal differentiation and dendritic complexity","volume":"35","author":"Mounier","year":"2015","journal-title":"J. Neurosci.: Official J. Soc. Neurosci."},{"key":"10.1016\/j.mito.2020.08.003_b0340","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2007-979603","article-title":"Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer's dementia","volume":"28","author":"Muller","year":"1995","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.mito.2020.08.003_b0345","doi-asserted-by":"crossref","DOI":"10.3390\/cells8090961","article-title":"Dynamics of dynamin-related protein 1 in Alzheimer's disease and other neurodegenerative diseases","volume":"8","author":"Oliver","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mito.2020.08.003_b0350","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.3233\/JAD-190048","article-title":"Molecular basis of Alzheimer's disease: focus on mitochondria","volume":"72","author":"Oliver","year":"2019","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0355","doi-asserted-by":"crossref","unstructured":"Palikaras, K., Tavernarakis, N., 2020. Regulation and roles of mitophagy at synapses. Mechanisms of ageing and development, 111216.","DOI":"10.1016\/j.mad.2020.111216"},{"key":"10.1016\/j.mito.2020.08.003_b0360","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ygcen.2015.10.010","article-title":"Cloning, mRNA expression and transcriptional regulation of five retinoid X receptor subtypes in yellow catfish Pelteobagrus fulvidraco by insulin","volume":"225","author":"Pan","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.mito.2020.08.003_b0365","doi-asserted-by":"crossref","unstructured":"Paulson, H., 2012. Machado-Joseph disease\/spinocerebellar ataxia type 3. Handbook of clinical neurology 103, 437-449.","DOI":"10.1016\/B978-0-444-51892-7.00027-9"},{"key":"10.1016\/j.mito.2020.08.003_b0370","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1007\/s12035-016-9944-9","article-title":"The interaction of mitochondrial biogenesis and fission\/fusion mediated by PGC-1alpha regulates rotenone-induced dopaminergic neurotoxicity","volume":"54","author":"Peng","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mito.2020.08.003_b0375","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1111\/bph.12549","article-title":"Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress","volume":"171","author":"Pfeiffer","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mito.2020.08.003_b0380","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1007\/s11064-008-9729-2","article-title":"Mitochondrial respiratory dysfunction in familiar parkinsonism associated with PINK1 mutation","volume":"33","author":"Piccoli","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mito.2020.08.003_b0385","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13063-017-2414-5","article-title":"Photobiomodulation using low-level laser therapy (LLLT) for patients with chronic traumatic brain injury: a randomized controlled trial study protocol","volume":"19","author":"Poiani","year":"2018","journal-title":"Trials"},{"key":"10.1016\/j.mito.2020.08.003_b0390","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: a systematic review and metaanalysis","volume":"9","author":"Prince","year":"2013","journal-title":"Alzheimer's Dementia : J. Alzheimer's Assoc."},{"key":"10.1016\/j.mito.2020.08.003_b0395","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.bbadis.2016.04.017","article-title":"Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease. Biochimica et biophysica acta","volume":"1863","author":"Pugazhenthi","year":"2017","journal-title":"Molecular Basis Disease"},{"key":"10.1016\/j.mito.2020.08.003_b0400","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"New England J. Med."},{"key":"10.1016\/j.mito.2020.08.003_b0405","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.brainresbull.2009.07.010","article-title":"Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease","volume":"80","author":"Quintanilla","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mito.2020.08.003_b0410","doi-asserted-by":"crossref","unstructured":"Reddy, P.H., 2009. Role of mitochondria in neurodegenerative diseases: mitochondria as a therapeutic target in Alzheimer's disease. CNS Spectrums 14, 8\u201313; discussion 16\u201318.","DOI":"10.1017\/S1092852900024901"},{"key":"10.1016\/j.mito.2020.08.003_b0415","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/hmg\/ddx052","article-title":"Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease","volume":"26","author":"Reddy","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0420","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1136\/jim-2016-000240","article-title":"Protective effects of a natural product, curcumin, against amyloid beta induced mitochondrial and synaptic toxicities in Alzheimer's disease","volume":"64","author":"Reddy","year":"2016","journal-title":"J. Investigative Med.: Official Publication Am. Federation Clin. Res."},{"key":"10.1016\/j.mito.2020.08.003_b0425","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3233\/JAD-170988","article-title":"Synergistic protective effects of mitochondrial division inhibitor 1 and mitochondria-targeted small peptide SS31 in Alzheimer's disease","volume":"62","author":"Reddy","year":"2018","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0430","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1093\/hmg\/ddy154","article-title":"Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease","volume":"27","author":"Reddy","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0435","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3233\/JAD-150757","article-title":"Familial presenilin mutations and sporadic Alzheimer's disease pathology: is the assumption of biochemical equivalence justified?","volume":"50","author":"Roher","year":"2016","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0440","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.5604\/17322693.1224259","article-title":"Endogenous mechanisms of reactive oxygen species (ROS) generation","volume":"70","author":"Sarniak","year":"2016","journal-title":"Postepy Hig. Med. Dosw.(Online)"},{"key":"10.1016\/j.mito.2020.08.003_b0445","first-page":"2095","article-title":"The axonal transport of mitochondria","volume":"125","author":"Saxton","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mito.2020.08.003_b0450","doi-asserted-by":"crossref","unstructured":"Singh, A., Kukreti, R., Saso, L., Kukreti, S., 2019. Oxidative stress: a key modulator in neurodegenerative diseases. Molecules (Basel, Switzerland) 24.","DOI":"10.3390\/molecules24081583"},{"key":"10.1016\/j.mito.2020.08.003_bib577","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1093\/hmg\/ddm213","article-title":"Polyglutamine diseases: emerging concepts in pathogenesis and therapy","volume":"16","author":"Shao","year":"2007","journal-title":"Human molecular genetics"},{"key":"10.1016\/j.mito.2020.08.003_b0455","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/arclin\/acx086","article-title":"The Neuropsychology of Huntington's Disease","volume":"32","author":"Snowden","year":"2017","journal-title":"Arch. Clin. Neuropsychol.: Official J. National Acad. Neuropsychol."},{"key":"10.1016\/j.mito.2020.08.003_b0460","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pbb.2014.02.016","article-title":"Retinoids as potential targets for Alzheimer's disease","volume":"120","author":"Sodhi","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.mito.2020.08.003_b0465","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbabio.2017.01.004","article-title":"Mitochondrial dysfunction and mitochondrial dynamics-the cancer connection","volume":"1858","author":"Srinivasan","year":"2017","journal-title":"Biochim. Biophys. Acta, Bioenerg."},{"key":"10.1016\/j.mito.2020.08.003_b0470","doi-asserted-by":"crossref","unstructured":"Stefanis, L., 2012. \u03b1-Synuclein in Parkinson's disease. Cold Spring Harbor perspectives in medicine 2, a009399.","DOI":"10.1101\/cshperspect.a009399"},{"key":"10.1016\/j.mito.2020.08.003_b0475","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3233\/JAD-140381","article-title":"A cell model for the initial phase of sporadic Alzheimer's disease","volume":"42","author":"Stockburger","year":"2014","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0480","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3233\/JAD-150687","article-title":"A mitochondrial role of SV2a protein in aging and Alzheimer's disease: studies with levetiracetam","volume":"50","author":"Stockburger","year":"2016","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0485","doi-asserted-by":"crossref","first-page":"8075903","DOI":"10.1155\/2016\/8075903","article-title":"Enhanced neuroplasticity by the metabolic enhancer piracetam associated with improved mitochondrial dynamics and altered permeability transition pore function","volume":"2016","author":"Stockburger","year":"2016","journal-title":"Neural Plasticity"},{"key":"10.1016\/j.mito.2020.08.003_b0490","doi-asserted-by":"crossref","first-page":"9338","DOI":"10.1523\/JNEUROSCI.0877-14.2014","article-title":"Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons","volume":"34","author":"Summers","year":"2014","journal-title":"J. Neurosci. : Official J. Soc. Neurosci."},{"key":"10.1016\/j.mito.2020.08.003_b0495","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/bph.12461","article-title":"First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics","volume":"171","author":"Szeto","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mito.2020.08.003_b0500","doi-asserted-by":"crossref","first-page":"9171424","DOI":"10.1155\/2019\/9171424","article-title":"Theories of aging and the prevalence of Alzheimer's disease","volume":"2019","author":"Trevisan","year":"2019","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.mito.2020.08.003_b0505","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1007\/s00394-017-1482-3","article-title":"Chronic treatment with prebiotics, probiotics and synbiotics attenuated cardiac dysfunction by improving cardiac mitochondrial dysfunction in male obese insulin-resistant rats","volume":"57","author":"Tunapong","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.mito.2020.08.003_b0510","doi-asserted-by":"crossref","unstructured":"Tysnes, O.B., Storstein, A., 2017. Epidemiology of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996) 124, 901\u2013905.","DOI":"10.1007\/s00702-017-1686-y"},{"key":"10.1016\/j.mito.2020.08.003_b0515","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3233\/JAD-180065","article-title":"Mitochondrial dysfunction as a predictor and driver of Alzheimer's disease-like pathology in OXYS rats","volume":"63","author":"Tyumentsev","year":"2018","journal-title":"J. Alzheimer's Disease : JAD"},{"key":"10.1016\/j.mito.2020.08.003_b0520","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.2174\/138161282035140911142118","article-title":"Mitochondrial biogenesis: pharmacological approaches","volume":"20","author":"Valero","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mito.2020.08.003_b0525","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10571-017-0554-5","article-title":"Roles of peroxisome proliferator-activated receptor gamma on brain and peripheral inflammation","volume":"38","author":"Villapol","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.mito.2020.08.003_b0530","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tem.2015.12.001","article-title":"Mitochondrial dynamics and metabolic regulation","volume":"27","author":"Wai","year":"2016","journal-title":"Trends Endocrinol. Metabolism: TEM"},{"key":"10.1016\/j.mito.2020.08.003_b0535","article-title":"Synaptosomal mitochondrial dysfunction in 5xFAD mouse model of Alzheimer's disease","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mito.2020.08.003_b0540","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071835","article-title":"Functional mapping of human dynamin-1-like GTPase domain based on x-ray structure analyses","volume":"8","author":"Wenger","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mito.2020.08.003_b0545","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1038\/s41598-017-10422-x","article-title":"Diversity of amyloid-beta proteoforms in the Alzheimer's disease brain","volume":"7","author":"Wildburger","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mito.2020.08.003_b0550","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41598-017-18935-1","article-title":"Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells","volume":"8","author":"Wu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mito.2020.08.003_b0555","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/WNR.0000000000000739","article-title":"Mitochondrial dynamics changes with age in an APPsw\/PS1dE9 mouse model of Alzheimer's disease","volume":"28","author":"Xu","year":"2017","journal-title":"NeuroReport"},{"key":"10.1016\/j.mito.2020.08.003_b0560","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neurobiolaging.2014.08.005","article-title":"Blockage of GSK3beta-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease","volume":"36","author":"Yan","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mito.2020.08.003_b0565","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2016.04.200","article-title":"Energy metabolism and inflammation in brain aging and Alzheimer's disease","volume":"100","author":"Yin","year":"2016","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.mito.2020.08.003_b0570","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/hmg\/ddw045","article-title":"Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease","volume":"25","author":"Yin","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mito.2020.08.003_b0575","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/hmg\/ddz038","article-title":"Cellular \u03b1-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons","volume":"28","author":"Zambon","year":"2019","journal-title":"Hum. Mol. Genet."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724920301720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724920301720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:24:42Z","timestamp":1761589482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724920301720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":117,"alternative-id":["S1567724920301720"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2020.08.003","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial abnormalities in neurodegenerative models and possible interventions: Focus on Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2020.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}