{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:09:19Z","timestamp":1790136559418,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005029","name":"Helse Vest Regionalt Helsef\u00f8retak","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.mito.2020.09.005","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T17:41:42Z","timestamp":1600882902000},"page":"95-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Mental health and health related quality of life in mitochondrial POLG disease"],"prefix":"10.1016","volume":"55","author":[{"given":"Omar","family":"Hikmat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente Johanne","family":"Vederhus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete Roineland","family":"Benestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Malen E.","family":"Engeset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Klingenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-8425","authenticated-orcid":false,"given":"Magnhild","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal ME","family":"Tallaksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eylert","family":"Brodtkorb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Bircow","family":"Elgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence A.","family":"Bindoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mito.2020.09.005_b0005","first-page":"13","article-title":"SCL-90: an outpatient psychiatric rating scale\u2013preliminary report","volume":"9","author":"Derogatis","year":"1973","journal-title":"Psychopharmacol. Bull."},{"issue":"Pt 3","key":"10.1016\/j.mito.2020.09.005_b0010","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/brain\/awn007","article-title":"POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection","volume":"131","author":"Engelsen","year":"2008","journal-title":"Brain: A J. Neurol."},{"issue":"1","key":"10.1016\/j.mito.2020.09.005_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1176\/appi.psy.47.1.1","article-title":"Review of the literature on major mental disorders in adult patients with mitochondrial diseases","volume":"47","author":"Fattal","year":"2006","journal-title":"Psychosomatics."},{"key":"10.1016\/j.mito.2020.09.005_b0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/9780470024522.ch4","article-title":"Scores and Measurements: Validity, Reliability, Sensitivity","author":"Fayers","year":"2007","journal-title":"Qual. Life"},{"issue":"1","key":"10.1016\/j.mito.2020.09.005_b0025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12955-017-0625-9","article-title":"Measurement properties and normative data for the Norwegian SF-36: results from a general population survey","volume":"15","author":"Garratt","year":"2017","journal-title":"Health Qual. Life Outcomes"},{"issue":"5684","key":"10.1016\/j.mito.2020.09.005_b0030","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death","volume":"305","author":"Green","year":"2004","journal-title":"Science (New York, NY)."},{"issue":"3","key":"10.1016\/j.mito.2020.09.005_b0035","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1086\/444548","article-title":"Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin","volume":"77","author":"Hakonen","year":"2005","journal-title":"Am. J. Hum. Genet."},{"issue":"5","key":"10.1016\/j.mito.2020.09.005_b0040","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/07853890109002089","article-title":"The RAND-36 measure of health-related quality of life","volume":"33","author":"Hays","year":"2001","journal-title":"Ann. Med."},{"key":"10.1016\/j.mito.2020.09.005_b0045","doi-asserted-by":"crossref","DOI":"10.1002\/jimd.12211","article-title":"Simplifying the clinical classification of polymerase gamma (POLG) disease based on age of onset; studies using a cohort of 155 cases","author":"Hikmat","year":"2020","journal-title":"J. Inherit. Metabol. Dis."},{"issue":"Pt 7","key":"10.1016\/j.mito.2020.09.005_b0050","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/brain\/awl088","article-title":"Phenotypic spectrum associated with mutations of the mitochondrial polymerase gamma gene","volume":"129","author":"Horvath","year":"2006","journal-title":"Brain: A J. Neurol."},{"key":"10.1016\/j.mito.2020.09.005_b0055","doi-asserted-by":"crossref","unstructured":"Hudson G, Chinnery PF. Mitochondrial DNA polymerase-gamma and human disease. Human molecular genetics. 2006;15 Spec No 2:R244-52.","DOI":"10.1093\/hmg\/ddl233"},{"key":"10.1016\/j.mito.2020.09.005_b0060","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.gene.2005.03.029","article-title":"Consequences of mutations in human DNA polymerase gamma","volume":"354","author":"Longley","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.mito.2020.09.005_b0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fgene.2015.00003","article-title":"Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genes","volume":"6","author":"Lu","year":"2015","journal-title":"Frontiers in genetics."},{"issue":"9437","key":"10.1016\/j.mito.2020.09.005_b0070","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(04)16983-3","article-title":"Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study","volume":"364","author":"Luoma","year":"2004","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.mito.2020.09.005_b0075","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00005650-199303000-00006","article-title":"The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs","volume":"31","author":"McHorney","year":"1993","journal-title":"Med. Care"},{"issue":"1","key":"10.1016\/j.mito.2020.09.005_b0080","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00005650-199401000-00004","article-title":"The MOS 36-item Short-Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups","volume":"32","author":"McHorney","year":"1994","journal-title":"Medical Care"},{"issue":"12","key":"10.1016\/j.mito.2020.09.005_b0085","first-page":"1380","article-title":"Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society","volume":"19","author":"Parikh","year":"2017","journal-title":"Genet. Med."},{"issue":"7","key":"10.1016\/j.mito.2020.09.005_b0090","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s11136-009-9506-y","article-title":"Readability estimates for commonly used health-related quality of life surveys. Quality of life research","volume":"18","author":"Paz","year":"2009","journal-title":"Int. J. Quality Life Asp. Treatment, Care Rehabilit."},{"issue":"1","key":"10.1016\/j.mito.2020.09.005_b0095","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41582-018-0101-0","article-title":"POLG-related disorders and their neurological manifestations","volume":"15","author":"Rahman","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.mito.2020.09.005_b0100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ddrr.105","article-title":"Polymerase gamma disease through the ages","volume":"16","author":"Saneto","year":"2010","journal-title":"Dev. Disabilit. Res. Rev."},{"key":"10.1016\/j.mito.2020.09.005_b0105","unstructured":"Siqveland T. MT, Leiknes KA. Assessment of psychometric properties of the Norwegian version of the Symptom Checklist 90 Revised (SCL-90-R) 2016."},{"issue":"Pt 8","key":"10.1016\/j.mito.2020.09.005_b0110","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/brain\/awg170","article-title":"Minimum birth prevalence of mitochondrial respiratory chain disorders in children","volume":"126","author":"Skladal","year":"2003","journal-title":"Brain: A J. Neurol."},{"issue":"5","key":"10.1016\/j.mito.2020.09.005_b0115","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35072063","article-title":"The genetics and pathology of oxidative phosphorylation","volume":"2","author":"Smeitink","year":"2001","journal-title":"Nature Rev. Genet."},{"issue":"2","key":"10.1016\/j.mito.2020.09.005_b0120","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2796.2008.02059.x","article-title":"Disorders from perturbations of nuclear-mitochondrial intergenomic cross-talk","volume":"265","author":"Spinazzola","year":"2009","journal-title":"J. Intern. Med."},{"issue":"1","key":"10.1016\/j.mito.2020.09.005_b0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1172\/JCI115856","article-title":"Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia","volume":"90","author":"Suomalainen","year":"1992","journal-title":"J. Clin. Investigat."},{"issue":"Pt 7","key":"10.1016\/j.mito.2020.09.005_b0130","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/brain\/awl097","article-title":"The spectrum of clinical disease caused by the A467T and W748S POLG mutations: a study of 26 cases","volume":"129","author":"Tzoulis","year":"2006","journal-title":"Brain."},{"issue":"7424","key":"10.1016\/j.mito.2020.09.005_b0135","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nature11707","article-title":"Mitochondrial disorders as windows into an ancient organelle","volume":"491","author":"Vafai","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mito.2020.09.005_b0140","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/humu.10246","article-title":"Digenic progressive external ophthalmoplegia in a sporadic patient: recessive mutations in POLG and C10orf2\/Twinkle","volume":"22","author":"Van Goethem","year":"2003","journal-title":"Human Mutat."},{"key":"10.1016\/j.mito.2020.09.005_b0145","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.pathol.4.110807.092314","article-title":"Mitochondrial energetics and therapeutics","volume":"5","author":"Wallace","year":"2010","journal-title":"Annual Rev. Pathol."},{"issue":"6","key":"10.1016\/j.mito.2020.09.005_b0150","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724920301938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724920301938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:26:11Z","timestamp":1761589571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724920301938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":30,"alternative-id":["S1567724920301938"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2020.09.005","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mental health and health related quality of life in mitochondrial POLG disease","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2020.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}