{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:32:21Z","timestamp":1761589941338,"version":"build-2065373602"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.mito.2021.02.015","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T05:22:06Z","timestamp":1615526526000},"page":"131-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Vessel flow void sign and hyperintense vessel sign on FLAIR images distinguish between MELAS and AIS"],"prefix":"10.1016","volume":"58","author":[{"given":"Li","family":"Chong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhenzhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Daokun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Yuankui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Yafang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-8659","authenticated-orcid":false,"given":"Jiang","family":"Haishan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mito.2021.02.015_b0005","first-page":"1119","article-title":"Mitochondrial disorders: analysis of their clinical and imaging characteristics","volume":"14","author":"Barkovich","year":"1993","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.mito.2021.02.015_b0010","doi-asserted-by":"crossref","unstructured":"El-Hattab, A.W., Almannai, M., Scaglia, F., 2017. Arginine and citrulline for the treatment of MELAS syndrome. J. Inborn. Errors. Metab. Screen 5,10.1177\/2326409817697399. doi:10.1177\/2326409817697399.","DOI":"10.1177\/2326409817697399"},{"issue":"1","key":"10.1016\/j.mito.2021.02.015_b0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/01.RES.66.1.8","article-title":"Regulation of large cerebral arteries and cerebral microvascular pressure","volume":"66","author":"Faraci","year":"1990","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.mito.2021.02.015_b0020","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/archneur.55.4.489","article-title":"Prognostic value of proton magnetic resonance spectroscopy in ischemic stroke","volume":"55","author":"Federico","year":"1998","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.mito.2021.02.015_b0025","doi-asserted-by":"crossref","unstructured":"Finsterer, J., Zarrouk-Mahjoub, S., 2016. Mitochondrial vasculopathy due to the m.3243A>G mutation is not restricted to the carotid artery. Mol. Genet. Metab. Rep. 9,34-34. doi:10.1016\/j.ymgmr.2016.10.002.","DOI":"10.1016\/j.ymgmr.2016.10.002"},{"issue":"4","key":"10.1016\/j.mito.2021.02.015_b0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neurad.2013.10.004","article-title":"FLAIR-hyperintense vessel sign, diffusion-perfusion mismatch and infarct growth in acute ischemic stroke without vascular recanalisation therapy","volume":"41","author":"Gawlitza","year":"2014","journal-title":"J. Neuroradiol."},{"issue":"6302","key":"10.1016\/j.mito.2021.02.015_b0035","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/348651a0","article-title":"A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies","volume":"348","author":"Goto","year":"1990","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mito.2021.02.015_b0040","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000340021","article-title":"Distal hyperintense vessels on FLAIR: a prognostic indicator of acute ischemic stroke","volume":"68","author":"Huang","year":"2012","journal-title":"Eur. Neurol."},{"issue":"6","key":"10.1016\/j.mito.2021.02.015_b0045","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1212\/WNL.59.6.816","article-title":"Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome","volume":"59","author":"Iizuka","year":"2002","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.mito.2021.02.015_b0050","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1001\/jama.2019.8286","article-title":"Association between time to treatment with endovascular reperfusion therapy and outcomes in patients with acute ischemic stroke treated in clinical practice","volume":"322","author":"Jahan","year":"2019","journal-title":"JAMA"},{"issue":"6281","key":"10.1016\/j.mito.2021.02.015_b0055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1126\/science.aad9642","article-title":"Hypoxia as a therapy for mitochondrial disease","volume":"352","author":"Jain","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.mito.2021.02.015_b0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jocn.2018.06.015","article-title":"Comparison of magnetic resonance spectroscopy (MRS) with arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic Acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS)","volume":"55","author":"Li","year":"2018","journal-title":"J. Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.mito.2021.02.015_b0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jmri.25354","article-title":"Differential diagnosis of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and ischemic stroke using 3D pseudocontinuous arterial spin labeling","volume":"45","author":"Li","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"issue":"2","key":"10.1016\/j.mito.2021.02.015_b0070","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00062-018-0662-8","article-title":"Reversible dilation of cerebral macrovascular changes in MELAS episodes","volume":"29","author":"Li","year":"2019","journal-title":"Clin. Neuroradiol."},{"key":"10.1016\/j.mito.2021.02.015_b0075","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz, M.F., Puebla, M., Figueroa, X.F., 2015. Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca(2+) signaling. Front. Cell Neurosci. 9,59-59. doi:10.3389\/fncel.2015.00059.","DOI":"10.3389\/fncel.2015.00059"},{"issue":"6","key":"10.1016\/j.mito.2021.02.015_b0080","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archneur.55.6.849","article-title":"Magnetic resonance spectroscopy: use in monitoring MELAS treatment","volume":"55","author":"Pavlakis","year":"1998","journal-title":"Arch. Neurol."},{"issue":"5","key":"10.1016\/j.mito.2021.02.015_b0085","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbagen.2011.04.018","article-title":"Okazawa H (2012) In vivo functional brain imaging and a therapeutic trial of L-arginine in MELAS patients","volume":"1820","author":"Yoneda","year":"2012","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724921000313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724921000313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:26:43Z","timestamp":1761589603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724921000313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":17,"alternative-id":["S1567724921000313"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2021.02.015","relation":{},"ISSN":["1567-7249"],"issn-type":[{"type":"print","value":"1567-7249"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vessel flow void sign and hyperintense vessel sign on FLAIR images distinguish between MELAS and AIS","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2021.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}