{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:54:01Z","timestamp":1772121241948,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013372","name":"Wellcome Trust Centre for Mitochondrial Research","doi-asserted-by":"publisher","award":["203105\/Z\/16\/Z"],"award-info":[{"award-number":["203105\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/501100013372","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.mito.2022.02.002","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T03:24:25Z","timestamp":1644636265000},"page":"85-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Interactions between nuclear and mitochondrial SNPs and Parkinson\u2019s disease risk"],"prefix":"10.1016","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1242-2927","authenticated-orcid":false,"given":"Sarah J.","family":"Pickett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dasha","family":"Deen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Pyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Santibanez-Koref","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mito.2022.02.002_b0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/bmb\/ldt017","article-title":"Mitochondrial genetics","volume":"106","author":"Chinnery","year":"2013","journal-title":"Br. Med. Bull."},{"issue":"1","key":"10.1016\/j.mito.2022.02.002_b0010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/sim.973","article-title":"Sample size requirements for matched case-control studies of gene-environment interaction","volume":"21","author":"Gauderman","year":"2002","journal-title":"Stat. Med."},{"issue":"6","key":"10.1016\/j.mito.2022.02.002_b0015","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/sj.ejhg.5201425","article-title":"Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians","volume":"13","author":"Ghezzi","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.mito.2022.02.002_b0020","doi-asserted-by":"crossref","first-page":"e0191153","DOI":"10.1371\/journal.pone.0191153","article-title":"Examining the role of common and rare mitochondrial variants in schizophrenia","volume":"13","author":"Gon\u00e7alves","year":"2018","journal-title":"PLoS ONE"},{"issue":"9","key":"10.1016\/j.mito.2022.02.002_b0025","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ng.642","article-title":"Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease","volume":"42","author":"Hamza","year":"2010","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.mito.2022.02.002_b0030","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1086\/498176","article-title":"Identification of an X-chromosomal locus and haplotype modulating the phenotype of a mitochondrial DNA disorder","volume":"77","author":"Hudson","year":"2005","journal-title":"Am. J. Hum. Genet."},{"issue":"22","key":"10.1016\/j.mito.2022.02.002_b0035","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1212\/WNL.0b013e318294b434","article-title":"Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease","volume":"80","author":"Hudson","year":"2013","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.mito.2022.02.002_b0040","doi-asserted-by":"crossref","first-page":"e1004369","DOI":"10.1371\/journal.pgen.1004369","article-title":"Recent mitochondrial DNA mutations increase the risk of developing common late-onset human diseases","volume":"10","author":"Hudson","year":"2014","journal-title":"PLoS Genet."},{"issue":"7607","key":"10.1016\/j.mito.2022.02.002_b0045","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature18303","article-title":"Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease","volume":"534","author":"Hyslop","year":"2016","journal-title":"Nature"},{"issue":"7632","key":"10.1016\/j.mito.2022.02.002_b0050","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature20592","article-title":"Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations","volume":"540","author":"Kang","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mito.2022.02.002_b0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13323-015-0022-2","article-title":"Maternal ancestry and population history from whole mitochondrial genomes","volume":"6","author":"Kivisild","year":"2015","journal-title":"Investig Genet"},{"issue":"4","key":"10.1016\/j.mito.2022.02.002_b0060","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.25564","article-title":"Associations between cerebrovascular risk factors and parkinson disease","volume":"86","author":"Kummer","year":"2019","journal-title":"Ann. Neurol."},{"issue":"11","key":"10.1016\/j.mito.2022.02.002_b0065","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.ajhg.2021.09.015","article-title":"Establishing risk of vision loss in Leber hereditary optic neuropathy","volume":"108","author":"Lopez Sanchez","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mito.2022.02.002_b0070","doi-asserted-by":"crossref","first-page":"43449","DOI":"10.1038\/srep43449","article-title":"MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association","volume":"7","author":"Marom","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.mito.2022.02.002_b0075","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/ana.25367","article-title":"Biallelic COLGALT1 variants are associated with cerebral small vessel disease","volume":"84","author":"Miyatake","year":"2018","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.mito.2022.02.002_b0080","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/acn3.532","article-title":"Phenotypic heterogeneity in m.3243A>G mitochondrial disease: The role of nuclear factors","volume":"5","author":"Pickett","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"3","key":"10.1016\/j.mito.2022.02.002_b0090","doi-asserted-by":"crossref","first-page":"e4913","DOI":"10.1371\/journal.pone.0004913","article-title":"Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder","volume":"4","author":"Rollins","year":"2009","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.mito.2022.02.002_b0095","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1086\/502682","article-title":"The power to detect disease associations with mitochondrial DNA haplogroups","volume":"78","author":"Samuels","year":"2006","journal-title":"Am. J. Hum. Genet."},{"issue":"1815","key":"10.1016\/j.mito.2022.02.002_b0100","first-page":"20151704","article-title":"Mitonuclear linkage disequilibrium in human populations","volume":"282","author":"Sloan","year":"2015","journal-title":"Proc Biol Sci"},{"issue":"2","key":"10.1016\/j.mito.2022.02.002_b0105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/hmg\/ddq469","article-title":"Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21","volume":"20","author":"Spencer","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.mito.2022.02.002_b0110","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/mds.22184","article-title":"Neuronal gene expression correlates of Parkinson's disease with dementia","volume":"23","author":"Stamper","year":"2008","journal-title":"Mov. Disord."},{"issue":"15","key":"10.1016\/j.mito.2022.02.002_b0115","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.3390\/app11156927","article-title":"Genomic Overlap between Platelet Parameters Variability and Age at Onset of Parkinson Disease","volume":"11","author":"Tirozzi","year":"2021","journal-title":"Applied Sciences"},{"issue":"4","key":"10.1016\/j.mito.2022.02.002_b0120","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1212\/WNL.0000000000001744","article-title":"Mitochondrial DNA sequence variation in multiple sclerosis","volume":"85","author":"Tranah","year":"2015","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.mito.2022.02.002_b0125","doi-asserted-by":"crossref","first-page":"E386","DOI":"10.1002\/humu.20921","article-title":"Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation","volume":"30","author":"van Oven","year":"2009","journal-title":"Hum. Mutat."},{"issue":"1","key":"10.1016\/j.mito.2022.02.002_b0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jns.2004.09.027","article-title":"Genetic variants of Complex I in multiple sclerosis","volume":"228","author":"Vyshkina","year":"2005","journal-title":"J. Neurol. Sci."},{"issue":"6442","key":"10.1016\/j.mito.2022.02.002_b0135","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6520","article-title":"Germline selection shapes human mitochondrial DNA diversity","volume":"364","author":"Wei","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.mito.2022.02.002_b0140","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-5956-6-8","article-title":"Proteome analysis of human substantia nigra in Parkinson's disease","volume":"6","author":"Werner","year":"2008","journal-title":"Proteome Sci"},{"issue":"6","key":"10.1016\/j.mito.2022.02.002_b0145","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.stem.2016.04.001","article-title":"Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes","volume":"18","author":"Yamada","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.mito.2022.02.002_b0150","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-020-0812-9","article-title":"Genetic and phenotypic landscape of the mitochondrial genome in the Japanese population","volume":"3","author":"Yamamoto","year":"2020","journal-title":"Commun Biol"},{"issue":"7","key":"10.1016\/j.mito.2022.02.002_b0155","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/s41588-021-00868-1","article-title":"An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank","volume":"53","author":"Yonova-Doing","year":"2021","journal-title":"Nat. Genet."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724922000095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724922000095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:28:11Z","timestamp":1761589691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724922000095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":30,"alternative-id":["S1567724922000095"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2022.02.002","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.01.24.22269732","asserted-by":"object"}]},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interactions between nuclear and mitochondrial SNPs and Parkinson\u2019s disease risk","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2022.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. and Mitochondria Research Society.","name":"copyright","label":"Copyright"}]}}