{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:00:39Z","timestamp":1790996439092,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013306","name":"National Institute of Science Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR8004\/MED\/30\/988\/2013"],"award-info":[{"award-number":["BT\/PR8004\/MED\/30\/988\/2013"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT-BRB-TF-2-2011"],"award-info":[{"award-number":["BT-BRB-TF-2-2011"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.mito.2022.10.001","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T06:48:19Z","timestamp":1665989299000},"page":"38-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["TRPV4 acts as a mitochondrial Ca2+-importer and regulates mitochondrial temperature and metabolism"],"prefix":"10.1016","volume":"67","author":[{"given":"Tusar","family":"Kanta Acharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar Majhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranabir","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Smalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Tae","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart D.","family":"Gundelfinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mito.2022.10.001_b0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-81041-w","article-title":"TRPM8 channel inhibitor-encapsulated hydrogel as a tunable surface for bone tissue engineering","volume":"11","author":"Acharya","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mito.2022.10.001_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep06701","article-title":"A molecular fluorescent probe for targeted visualization of temperature at the endoplasmic reticulum","volume":"4","author":"Arai","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mito.2022.10.001_b0015","doi-asserted-by":"crossref","first-page":"8044","DOI":"10.1039\/C5CC01088H","article-title":"Mitochondria-targeted fluorescent thermometer monitors intracellular temperature gradient","volume":"51","author":"Arai","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.mito.2022.10.001_b0020","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/jcs.02372","article-title":"TRPV4 exhibits a functional role in cell-volume regulation","volume":"118","author":"Becker","year":"2005","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.mito.2022.10.001_b0025","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1021\/bi00303a010","article-title":"Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red","volume":"23","author":"Bernardi","year":"1984","journal-title":"Biochemistry"},{"issue":"7","key":"10.1016\/j.mito.2022.10.001_b0030","first-page":"981","article-title":"4TM-TRPM8 channels are new gatekeepers of the ER-mitochondria Ca2+ transfer, Biochimica et Biophysica Acta (BBA)-Molecular","volume":"1865","author":"Bidaux","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.mito.2022.10.001_b0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1471-4159.1996.66010403.x","article-title":"A reevaluation of the role of mitochondria in neuronal Ca2+ homeostasis","volume":"66","author":"Budd","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2022.10.001_b0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bone.2015.04.015","article-title":"Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease","volume":"80","author":"Carson","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.mito.2022.10.001_b0045","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1242\/jcs.014522","article-title":"The mitochondrial membrane potential and Ca2+ oscillations in smooth muscle","volume":"121","author":"Chalmers","year":"2008","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.mito.2022.10.001_b0050","doi-asserted-by":"crossref","first-page":"e2003992","DOI":"10.1371\/journal.pbio.2003992","article-title":"Mitochondria are physiologically maintained at close to 50 C","volume":"16","author":"Chr\u00e9tien","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mito.2022.10.001_b0055","doi-asserted-by":"crossref","first-page":"32037","DOI":"10.1074\/jbc.M303251200","article-title":"Warm temperatures activate TRPV4 in mouse 308 keratinocytes","volume":"278","author":"Chung","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2022.10.001_b0060","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/emboj\/18.1.96","article-title":"Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria","volume":"18","author":"Csord\u00e1s","year":"1999","journal-title":"EMBO J."},{"issue":"20","key":"10.1016\/j.mito.2022.10.001_b0065","doi-asserted-by":"crossref","first-page":"13843","DOI":"10.1074\/jbc.M808515200","article-title":"Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission","volume":"284","author":"Dagda","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2022.10.001_b0070","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbrc.2019.07.042","article-title":"TRPV4 expresses in bone cell lineages and TRPV4-R616Q mutant causing Brachyolmia in human reveals \u201closs-of-interaction\u201d with cholesterol","volume":"517","author":"Das","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2022.10.001_b0075","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbrc.2022.04.066","article-title":"Cytochrome C interacts with the pathogenic mutational hotspot region of TRPV4 and forms complexes that differ in mutation and metal ion-sensitive manner","volume":"611","author":"Das","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2022.10.001_b0080","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1523\/JNEUROSCI.20-19-07290.2000","article-title":"Stimulation-evoked increases in cytosolic [Ca2+] in mouse motor nerve terminals are limited by mitochondrial uptake and are temperature-dependent","volume":"20","author":"David","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mito.2022.10.001_b0085","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1471-4159.2010.06626.x","article-title":"TRP channels of intracellular membranes","volume":"113","author":"Dong","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2022.10.001_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-7793.1999.001aa.x","article-title":"Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death","volume":"516","author":"Duchen","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.mito.2022.10.001_b0095","doi-asserted-by":"crossref","first-page":"11011","DOI":"10.1073\/pnas.1309531110","article-title":"Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake","volume":"110","author":"Feng","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mito.2022.10.001_b0100","doi-asserted-by":"crossref","first-page":"C1705","DOI":"10.1152\/ajpcell.00245.2002","article-title":"Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line","volume":"283","author":"Fern\u00e1ndez-Fern\u00e1ndez","year":"2002","journal-title":"Am. J. Physiol.-Cell Physiol."},{"issue":"2","key":"10.1016\/j.mito.2022.10.001_b0105","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nprot.2006.478","article-title":"Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts","volume":"2","author":"Frezza","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mito.2022.10.001_b0110","doi-asserted-by":"crossref","first-page":"32591","DOI":"10.1074\/jbc.M109.019687","article-title":"The endoplasmic reticulum of dorsal root ganglion neurons contains functional TRPV1 channels","volume":"284","author":"Gallego-Sand\u00edn","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2022.10.001_b0115","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/19336950.2016.1162365","article-title":"Why individual thermo sensation and pain perception varies? Clue of disruptive mutations in TRPVs from 2504 human genome data","volume":"10","author":"Ghosh","year":"2016","journal-title":"Channels."},{"key":"10.1016\/j.mito.2022.10.001_b0120","first-page":"2097","article-title":"Retinal voltage-dependent anion channel: characterization and cellular localization","volume":"43","author":"Gincel","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.mito.2022.10.001_b0125","doi-asserted-by":"crossref","first-page":"e11654","DOI":"10.1371\/journal.pone.0011654","article-title":"Importance of non-selective cationchannel TRPV4 interaction with cytoskeleton and their reciprocal regulations in culturedcells","volume":"5","author":"Goswami","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mito.2022.10.001_b0130","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1523\/JNEUROSCI.22-15-06408.2002","article-title":"Heat-evoked activation of the ion channel, TRPV4","volume":"22","author":"G\u00fcler","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mito.2022.10.001_b0135","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.mito.2013.03.007","article-title":"Significant changes in mitochondrial distribution in different pain models of mice","volume":"13","author":"Guo","year":"2013","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2022.10.001_b0140","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.neuron.2012.08.019","article-title":"Synaptic energy use and supply","volume":"75","author":"Harris","year":"2012","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.mito.2022.10.001_b0145","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/cells9020317","article-title":"Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis","volume":"9","author":"Haustrate","year":"2020","journal-title":"Cells."},{"key":"10.1016\/j.mito.2022.10.001_b0150","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.febslet.2010.04.017","article-title":"Mitochondrial calcium channels","volume":"584","author":"Hoppe","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mito.2022.10.001_b0155","doi-asserted-by":"crossref","first-page":"15835","DOI":"10.1021\/bi981512h","article-title":"Selective inactivation of \u03b1-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal","volume":"37","author":"Humphries","year":"1998","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.mito.2022.10.001_b0160","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41592-020-0801-4","article-title":"Meltome atlas\u2014thermal proteome stability across the tree of life","volume":"17","author":"Jarzab","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mito.2022.10.001_b0165","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/sj.bjp.0704950","article-title":"Anandamide induces cough in conscious guinea-pigs through VR1 receptors","volume":"137","author":"Jia","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mito.2022.10.001_b0170","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1242\/jeb.195.1.293","article-title":"Are mitochondria subject to evolutionary temperature adaptation?","volume":"195","author":"Johnston","year":"1994","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.mito.2022.10.001_b0175","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/377438a0","article-title":"Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes","volume":"377","author":"Jouaville","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.mito.2022.10.001_b0180","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s41048-018-0054-2","article-title":"Theoretical model and characteristics of mitochondrial thermogenesis","volume":"4","author":"Kang","year":"2018","journal-title":"Biophysics reports."},{"key":"10.1016\/j.mito.2022.10.001_b0185","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ceca.2007.07.001","article-title":"Roles of mitochondria and temperature in the control of intracellular calcium in adult rat sensory neurons","volume":"43","author":"Kang","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mito.2022.10.001_b0190","doi-asserted-by":"crossref","unstructured":"Kim, H. Y., Wang, J., Lu, Y., Chung, J. M. & Chung, K. (2009) Superoxide signaling in pain is independent from nitric oxide signaling, Neuroreport. 20, 1424. https:\/\/dx.doi.org\/10.1097%2FWNR.0b013e328330f68b.","DOI":"10.1097\/WNR.0b013e328330f68b"},{"key":"10.1016\/j.mito.2022.10.001_b0195","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature02246","article-title":"The mitochondrial calcium uniporter is a highly selective ion channel","volume":"427","author":"Kirichok","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.mito.2022.10.001_b0200","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0306-4522(94)90537-1","article-title":"Calcium stores in neurons and glia","volume":"63","author":"Kostyuk","year":"1994","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.mito.2022.10.001_b0205","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1373\/clinchem.2005.050146","article-title":"Automated spectrophotometric analysis of mitochondrial respiratory chain complex enzyme activities in cultured skin fibroblasts","volume":"51","author":"Kramer","year":"2005","journal-title":"Clin. Chem."},{"key":"10.1016\/j.mito.2022.10.001_b0210","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ceca.2012.10.003","article-title":"Motility of astrocytic mitochondria is arrested by Ca2+-dependent interaction between mitochondria and actin filaments","volume":"53","author":"Kremneva","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mito.2022.10.001_b0215","doi-asserted-by":"crossref","unstructured":"Kumar, A., Majhi, R. K., Acharya, T. K., Smalla, K.-H., Gundelfinger, E. D. & Goswami, C. (2018) TRPV4 interacts with mitochondrial proteins and acts as a mitochondrial structure-function regulator, bioRxiv, 330993. https:\/\/doi.org\/10.1101\/330993.","DOI":"10.1101\/330993"},{"key":"10.1016\/j.mito.2022.10.001_b0220","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ygcen.2014.10.004","article-title":"Regulation of TRP channels by steroids: Implications in physiology and diseases","volume":"220","author":"Kumar","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.mito.2022.10.001_b0225","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.bbrc.2016.03.071","article-title":"TRPV4 is endogenously expressed in vertebrate spermatozoa and regulates intracellular calcium in human sperm","volume":"473","author":"Kumar","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2022.10.001_b0230","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbrc.2014.11.077","article-title":"Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4","volume":"456","author":"Kumari","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2022.10.001_b0235","doi-asserted-by":"crossref","first-page":"e2005113","DOI":"10.1371\/journal.pbio.2005113","article-title":"Hot mitochondria?","volume":"16","author":"Lane","year":"2018","journal-title":"PLoS Biol."},{"issue":"23","key":"10.1016\/j.mito.2022.10.001_b0240","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1111\/bph.12987","article-title":"Activation of TRPV1 attenuates high salt-induced cardiac hypertrophy through improvement of mitochondrial function","volume":"172","author":"Lang","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mito.2022.10.001_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-02789-8","article-title":"Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers","volume":"7","author":"Lemieux","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.mito.2022.10.001_b0250","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0092-8674(00)00143-4","article-title":"Vanilloid receptor\u2013related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor","volume":"103","author":"Liedtke","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.mito.2022.10.001_b0255","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1111\/febs.13306","article-title":"Functional expression of TRPV channels in T cells and their implications in immune regulation","volume":"282","author":"Majhi","year":"2015","journal-title":"The FEBS journal."},{"key":"10.1016\/j.mito.2022.10.001_b0260","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4161\/chan.5.4.16969","article-title":"Right time-right location-right move: TRPs find motors for common functions","volume":"5","author":"Majhi","year":"2011","journal-title":"Channels."},{"key":"10.1016\/j.mito.2022.10.001_b0265","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/biof.5520080309","article-title":"Electron microscopic tomography of rat-liver mitochondria and their interactions with the endoplasmic reticulum","volume":"8","author":"Mannella","year":"1998","journal-title":"BioFactors"},{"key":"10.1016\/j.mito.2022.10.001_b0270","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1073\/pnas.051636098","article-title":"Circularly permuted green fluorescent proteins engineered to sense Ca2+","volume":"98","author":"Nagai","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mito.2022.10.001_b0275","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3390\/biology10090927","article-title":"Mitochondrial Heterogeneity in Metabolic Diseases","volume":"10","author":"Ngo","year":"2021","journal-title":"Biology."},{"key":"10.1016\/j.mito.2022.10.001_b0280","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/embor.2012.219","article-title":"The puzzle of TRPV4 channelopathies","volume":"14","author":"Nilius","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mito.2022.10.001_b0285","doi-asserted-by":"crossref","first-page":"11021","DOI":"10.1074\/jbc.M008392200","article-title":"Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1","volume":"276","author":"Olah","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.mito.2022.10.001_b0290","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.201912469","article-title":"Single-cell temperature mapping with fluorescent thermometer nanosheets","volume":"152","author":"Oyama","year":"2020","journal-title":"J. Gen. Physiol."},{"issue":"1700","key":"10.1016\/j.mito.2022.10.001_b0295","first-page":"20150418","article-title":"Calcium and ATP control multiple vital functions in","volume":"371","author":"Petersen","year":"2016","journal-title":"The Royal Society"},{"key":"10.1016\/j.mito.2022.10.001_b0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-019-0535-y","article-title":"Transient heat release during induced mitochondrial proton uncoupling","volume":"2","author":"Rajagopal","year":"2019","journal-title":"Communications biology."},{"key":"10.1016\/j.mito.2022.10.001_b0305","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0076-6879(95)60154-6","article-title":"[29] Mitochondrial membrane potential monitored by JC-1 dye","volume":"260","author":"Reers","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mito.2022.10.001_b0310","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.280.5370.1763","article-title":"Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses","volume":"280","author":"Rizzuto","year":"1998","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.mito.2022.10.001_b0315","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.bbabio.2009.03.015","article-title":"Ca2+ transfer from the ER to mitochondria: when, how and why","volume":"1787","author":"Rizzuto","year":"2009","journal-title":"Biochimica et Biophysica Acta (BBA)-Bioenergetics."},{"issue":"8","key":"10.1016\/j.mito.2022.10.001_b0320","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/ng.166","article-title":"Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia","volume":"40","author":"Rock","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mito.2022.10.001_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2021.102356","article-title":"VDAC regulation of mitochondrial calcium flux: From channel biophysics to disease","volume":"94","author":"Rosencrans","year":"2021","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mito.2022.10.001_b0330","article-title":"Adjustments in the control of mitochondrial respiratory capacity to tolerate temperature fluctuations","volume":"222","author":"Scott","year":"2019","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.mito.2022.10.001_b0335","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/35036318","article-title":"OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity","volume":"2","author":"Strotmann","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mito.2022.10.001_b0340","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neulet.2003.09.041","article-title":"Localization of mechanosensitive channel TRPV4 in mouse skin","volume":"353","author":"Suzuki","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mito.2022.10.001_b0345","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1097\/00001756-199712220-00017","article-title":"Mitochondria buffer Ca2+ entry but notintracellular Ca2+ release in mouse DRG neurones","volume":"8","author":"Svichar","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.mito.2022.10.001_b0350","doi-asserted-by":"crossref","first-page":"15305","DOI":"10.1074\/jbc.275.20.15305","article-title":"Calcium signal transmission between ryanodine receptors and mitochondria","volume":"275","author":"Szalai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2022.10.001_b0355","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1113\/jphysiol.2006.126383","article-title":"Stimulation-induced changes in NADH fluorescence and mitochondrial membrane potential in lizard motor nerve terminals","volume":"579","author":"Talbot","year":"2007","journal-title":"The Journal of physiology."},{"key":"10.1016\/j.mito.2022.10.001_b0360","first-page":"G138","article-title":"The TRPV4 channel is a novel regulator of intracellular Ca2+ in human esophageal epithelial cells, American Journal of Physiology-Gastrointestinal and Liver","volume":"301","author":"Ueda","year":"2011","journal-title":"Physiology."},{"key":"10.1016\/j.mito.2022.10.001_b0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-2395-3-2","article-title":"Mitochondrial and sex steroid hormone crosstalk during aging","volume":"3","author":"Velarde","year":"2014","journal-title":"Longevity & healthspan."},{"key":"10.1016\/j.mito.2022.10.001_b0370","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0143-4160(98)90057-4","article-title":"Neuronal calcium stores","volume":"24","author":"Verkhratsky","year":"1998","journal-title":"Cell Calcium"},{"issue":"4","key":"10.1016\/j.mito.2022.10.001_b0375","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4161\/chan.4.4.12905","article-title":"TRPV4-mediated channelopathies","volume":"4","author":"Verma","year":"2010","journal-title":"Channels"},{"key":"10.1016\/j.mito.2022.10.001_b0380","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4161\/chan.4.4.12905","article-title":"TRPV4-mediated channelopathies","volume":"4","author":"Verma","year":"2010","journal-title":"Channels."},{"key":"10.1016\/j.mito.2022.10.001_b0385","doi-asserted-by":"crossref","first-page":"10380","DOI":"10.1021\/ja063733d","article-title":"Combinatorial synthesis of benzimidazolium dyes and its diversity directed application toward GTP-selective fluorescent chemosensors","volume":"128","author":"Wang","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mito.2022.10.001_b0390","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbrc.2021.03.077","article-title":"Role of the TRPM4 channel in mitochondrial function, calcium release, and ROS generation in oxidative stress","volume":"566","author":"Wang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.mito.2022.10.001_b0395","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/anie.201510003","article-title":"A multisite-binding switchable fluorescent probe for monitoring mitochondrial ATP level fluctuation in live cells","volume":"55","author":"Wang","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"issue":"16","key":"10.1016\/j.mito.2022.10.001_b0400","doi-asserted-by":"crossref","first-page":"13569","DOI":"10.1074\/jbc.M200062200","article-title":"Activation of TRPV4 channels (hVRL-2\/mTRP12) by phorbol derivatives","volume":"277","author":"Watanabe","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2022.10.001_b0405","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nature01807","article-title":"Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels","volume":"424","author":"Watanabe","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.mito.2022.10.001_b0410","doi-asserted-by":"crossref","unstructured":"Whittaker, V. (1968) The morphology of fractions of rat forebrain synaptosomes separated on continuous sucrose density gradients, Biochem. J. 106, 412. https:\/\/dx.doi.org\/10.1042%2Fbj1060412.","DOI":"10.1042\/bj1060412"},{"key":"10.1016\/j.mito.2022.10.001_b0415","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(00)02212-2","article-title":"Trp12, a novel Trp related protein from kidney","volume":"485","author":"Wissenbach","year":"2000","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.mito.2022.10.001_b0420","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-16411-5","article-title":"TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca 2+","volume":"11","author":"Woolums","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mito.2022.10.001_b0425","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/19336950.2016.1249076","article-title":"TRPV3 mutants causing Olmsted Syndrome induce impaired cell adhesion and nonfunctional lysosomes","volume":"11","author":"Yadav","year":"2017","journal-title":"Channels."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156772492200085X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156772492200085X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:56:54Z","timestamp":1778821014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156772492200085X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":85,"alternative-id":["S156772492200085X"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2022.10.001","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRPV4 acts as a mitochondrial Ca2+-importer and regulates mitochondrial temperature and metabolism","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2022.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}