{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:02:36Z","timestamp":1792803756640,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000764","name":"King&apos;s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.mito.2023.05.002","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T12:46:45Z","timestamp":1683722805000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Serum TCA cycle metabolites in Lewy bodies dementia and Alzheimer's disease: Network analysis and cognitive prognosis"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-6410","authenticated-orcid":false,"given":"Alberto","family":"Jaramillo-Jimenez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3520-7530","authenticated-orcid":false,"given":"Lasse M.","family":"Giil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Germ\u00e1n","family":"Borda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-9899","authenticated-orcid":false,"given":"Diego A.","family":"Tovar-Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re Andre","family":"Kristiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-8083","authenticated-orcid":false,"given":"Per","family":"Bruheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-1971","authenticated-orcid":false,"given":"George E.","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf Kristian","family":"Berge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2023.05.002_b0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1159\/000165917","article-title":"Frequency and case identification of dementia with lewy bodies using the revised consensus criteria","volume":"26","author":"Aarsland","year":"2008","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.mito.2023.05.002_b0010","doi-asserted-by":"crossref","unstructured":"Armstrong, M.J., 2019. Lewy body dementias. 25, 128\u2013146.","DOI":"10.1212\/CON.0000000000000685"},{"key":"10.1016\/j.mito.2023.05.002_b0015","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.mito.2007.06.001","article-title":"Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease","volume":"7","author":"Atamna","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2023.05.002_b0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"10.1016\/j.mito.2023.05.002_b0025","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1749-6632.2000.tb06370.x","article-title":"Inherent abnormalities in energy metabolism in Alzheimer disease: interaction with cerebrovascular compromise","author":"Blass","year":"2000","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.mito.2023.05.002_b0030","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ana.20474","article-title":"Mitochondrial abnormalities in Alzheimer brain: mechanistic implications","volume":"57","author":"Bubber","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mito.2023.05.002_b0035","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1038\/ncomms7791","article-title":"Distinct metabolomic signatures are associated with longevity in humans","volume":"6","author":"Cheng","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mito.2023.05.002_b0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/alz.12180","article-title":"Circulating metabolites are associated with brain atrophy and white matter hyperintensities","volume":"17","author":"de Leeuw","year":"2021","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.mito.2023.05.002_b0045","unstructured":"Diagnostic and statistical manual of mental disorders: DSM-IV, 1994. Fourth edition. Washington, DC: American Psychiatric Association. \u00a91994."},{"key":"10.1016\/j.mito.2023.05.002_b0050","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/mds.21507","article-title":"Clinical diagnostic criteria for dementia associated with Parkinson's disease","volume":"22","author":"Emre","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.mito.2023.05.002_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v048.i04","article-title":"Qgraph: network visualizations of relationships in psychometric data","volume":"48","author":"Epskamp","year":"2012","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.mito.2023.05.002_b0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3758\/s13428-017-0862-1","article-title":"Estimating psychological networks and their accuracy: a tutorial paper","volume":"50","author":"Epskamp","year":"2018","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.mito.2023.05.002_b0065","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.mito.2023.05.002_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1752-0509-5-1","article-title":"Metabolomic correlation-network modules in Arabidopsis based on a graph-clustering approach","volume":"5","author":"Fukushima","year":"2011","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.mito.2023.05.002_b0075","article-title":"Differentiating traits and states identifies the importance of chronic neuropsychiatric symptoms for cognitive prognosis in mild dementia","volume":"13","author":"Giil","year":"2021","journal-title":"Alzheimer's Dement. Diagnosis, Assess. Dis. Monit."},{"key":"10.1016\/j.mito.2023.05.002_b0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jpba.2014.10.010","article-title":"Metabolite profiling for the identification of altered metabolic pathways in Alzheimer's disease","volume":"107","author":"Gonz\u00e1lez-Dom\u00ednguez","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.mito.2023.05.002_b0085","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ebiom.2017.10.027","article-title":"Metabolomics and gene expression analysis reveal down-regulation of the citric acid (TCA) cycle in nondiabetic CKD patients","volume":"26","author":"Hallan","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mito.2023.05.002_b0090","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3758\/s13428-021-01637-y","article-title":"Estimating group differences in network models using moderation analysis","volume":"54","author":"Haslbeck","year":"2022","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.mito.2023.05.002_b0095","first-page":"e12259","article-title":"Blood metabolites predicting mild cognitive impairment in the study of Latinos-investigation of neurocognitive aging (HCHS\/SOL)","volume":"14","author":"He","year":"2022","journal-title":"Alzheimer's Dement. Diagnosis, Assess. Dis. Monit."},{"key":"10.1016\/j.mito.2023.05.002_b0100","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1192\/bjp.140.6.566","article-title":"A new clinical scale for the staging of dementia","volume":"140","author":"Hughes","year":"1982","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.mito.2023.05.002_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11749-009-0138-x","article-title":"Missing data methods in longitudinal studies: a review","volume":"18","author":"Ibrahim","year":"2009","journal-title":"Test"},{"key":"10.1016\/j.mito.2023.05.002_b0110","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1093\/ije\/dyy119","article-title":"Comparison of metabolite networks from four German population-based studies","volume":"47","author":"Iqbal","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.mito.2023.05.002_b0115","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mito.2023.05.002_b0120","article-title":"Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?","volume":"16","author":"Ka","year":"2018","journal-title":"BMC Med."},{"key":"10.1016\/j.mito.2023.05.002_b0125","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1001\/archneur.1988.00520320027010","article-title":"Studies of transketolase abnormality in Alzheimer's disease","volume":"45","author":"Kim","year":"1988","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.mito.2023.05.002_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105973","article-title":"Mitophagy enhancers against phosphorylated Tau-induced mitochondrial and synaptic toxicities in Alzheimer disease","volume":"174","author":"Kshirsagar","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mito.2023.05.002_b0135","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2217\/14622416.9.4.383","article-title":"Analysis of the adult human plasma metabolome","volume":"9","author":"Lawton","year":"2008","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.mito.2023.05.002_b0140","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2012.11.020","article-title":"Apolipoprotein E sets the stage: response to injury triggers neuropathology","volume":"76","author":"Mahley","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.mito.2023.05.002_b0145","first-page":"11","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mito.2023.05.002_b0150","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2023.05.002_b0155","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of alzheimer's disease: report of the NINCDS-ADRDA work group\u22c6 under the auspices of department of health and human services task force on Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2023.05.002_b0160","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bbadis.2009.10.006","article-title":"Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology","volume":"1802","author":"Moreira","year":"2010","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.mito.2023.05.002_b0165","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.3389\/fmed.2021.830723","article-title":"Metabolomics-based frailty biomarkers in older Chinese adults","volume":"8","author":"Pan","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.mito.2023.05.002_b0170","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mito.2023.05.002_b0175","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/14789450.2020.1766975","article-title":"Network-based strategies in metabolomics data analysis and interpretation: from molecular networking to biological interpretation","volume":"17","author":"Perez De Souza","year":"2020","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.mito.2023.05.002_b0180","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/metabo10030103","article-title":"Simultaneous measurement of tricarboxylic acid cycle intermediates in different biological matrices using liquid chromatography\u2013tandem mass spectrometry; quantitation and comparison of TCA cycle intermediates in human serum, plasma, kasumi-1 cell and muri","volume":"10","author":"Rathod","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.mito.2023.05.002_b0185","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.410170505","article-title":"An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain","volume":"17","author":"Rex Sheu","year":"1985","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mito.2023.05.002_b0190","doi-asserted-by":"crossref","unstructured":"R\u00f8st, L.M., Thorfinnsdottir, L.B., Kumar, K., Fuchino, K., Lang\u00f8rgen, I.E., Bartosova, Z., Kristiansen, K.A., Bruheim, P., 2020. Absolute Quantification of the Central Carbon Metabolome in Eight Commonly Applied Prokaryotic and Eukaryotic Model Systems. 10, 74.","DOI":"10.3390\/metabo10020074"},{"key":"10.1016\/j.mito.2023.05.002_b0195","unstructured":"RStudio Team, 2019. RStudio: Integrated Development Environment for R."},{"key":"10.1016\/j.mito.2023.05.002_b0200","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800407","article-title":"The aging metabolome\u2014biomarkers to hub metabolites","volume":"20","author":"Sharma","year":"2020","journal-title":"Proteomics"},{"key":"10.1016\/j.mito.2023.05.002_b0205","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ana.410350311","article-title":"Abnormality of the \u03b1-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease","volume":"35","author":"Sheu","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mito.2023.05.002_b0210","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ana.410350311","article-title":"Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease","volume":"35","author":"Sheu","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mito.2023.05.002_b0215","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3233\/JAD-170274","article-title":"Accuracy of clinical diagnosis of dementia with Lewy bodies versus neuropathology","volume":"59","author":"Skogseth","year":"2017","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.mito.2023.05.002_b0220","first-page":"151","article-title":"The possible involvement of mitochondrial dysfunctions in Lewy body dementia: a systematic review","volume":"30","author":"Spano","year":"2015","journal-title":"Funct. Neurol."},{"key":"10.1016\/j.mito.2023.05.002_b0225","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/bioinformatics\/btn209","article-title":"fdrtooa versatile R package for estimating local and tail area-based false discovery rates","volume":"24","author":"Strimmer","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mito.2023.05.002_b0230","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/elps.201300019","article-title":"Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients","volume":"34","author":"Tsuruoka","year":"2013","journal-title":"Electrophoresis"},{"key":"10.1016\/j.mito.2023.05.002_b0235","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.jclinepi.2008.10.003","article-title":"Longitudinal Tobit regression: a new approach to analyze outcome variables with floor or ceiling effects","volume":"62","author":"Twisk","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.mito.2023.05.002_b0240","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1371\/journal.pmed.0040297","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration","volume":"4","author":"Vandenbroucke","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.mito.2023.05.002_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mito.2023.05.002_b0250","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1093\/gerona\/glab315","article-title":"Metabolomics-based identification of metabolic dysfunction in frailty","volume":"77","author":"Westbrook","year":"2022","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mito.2023.05.002_b0255","doi-asserted-by":"crossref","unstructured":"Wilkins, H.M., Wang, X., Menta, B.W., Koppel, S.J., Bothwell, R., Becker, A.M., Anderson, H., Schwartz, E., Pei, D., Yellapu, N.K., Chalise, P., Gouvion, C.M., Haeri, M., Burns, J.M., Swerdlow, R.H., 2021. Bioenergetic and inflammatory systemic phenotypes in Alzheimer's disease APOE \u03b54-carriers. Aging Cell 20.","DOI":"10.1111\/acel.13356"},{"key":"10.1016\/j.mito.2023.05.002_b0260","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.redox.2017.04.010","article-title":"Platelet cytochrome oxidase and citrate synthase activities in APOE \u03b54 carrier and non-carrier Alzheimer's disease patients","volume":"12","author":"Wilkins","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.mito.2023.05.002_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.00141","article-title":"A role for the krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation","volume":"9","author":"Williams","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mito.2023.05.002_b0270","first-page":"1107","article-title":"Metabolic dysregulation contributes to the progression of Alzheimer's disease","author":"Yan","year":"2020","journal-title":"Front. Neurosci."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724923000399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724923000399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T18:32:17Z","timestamp":1761589937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724923000399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":54,"alternative-id":["S1567724923000399"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2023.05.002","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum TCA cycle metabolites in Lewy bodies dementia and Alzheimer's disease: Network analysis and cognitive prognosis","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2023.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}