{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:00:18Z","timestamp":1793430018456,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011892","name":"Chang Gung Memorial Hospital Kaohsiung Branch","doi-asserted-by":"publisher","award":["CRRPG8K0043"],"award-info":[{"award-number":["CRRPG8K0043"]}],"id":[{"id":"10.13039\/501100011892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-182A-086-MY3"],"award-info":[{"award-number":["NSTC 112-2314-B-182A-086-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.mito.2024.101856","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T07:31:44Z","timestamp":1708759904000},"page":"101856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells"],"prefix":"10.1016","volume":"76","author":[{"given":"Yu-Han","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Lieh","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Jer","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Yu","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wei","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsu-Kung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2024.101856_b0005","doi-asserted-by":"crossref","first-page":"F1477","DOI":"10.1152\/ajprenal.00182.2013","article-title":"TGF-\u03b21 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway","volume":"305","author":"Abe","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.mito.2024.101856_b0010","first-page":"994","article-title":"Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy","volume":"33","author":"Ahmad","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.mito.2024.101856_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112728","article-title":"Mitochondria-derived cell-to-cell communication","volume":"42","author":"Al Amir Dache","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.mito.2024.101856_b0020","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.mito.2024.101856_b0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mito.2024.101856_b0035","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1021\/acsnano.9b08207","article-title":"In vivo tracking of mesenchymal stem cell-derived extracellular vesicles improving mitochondrial function in renal ischemia-reperfusion injury","volume":"14","author":"Cao","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.mito.2024.101856_b0040","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic competition in the tumor microenvironment is a driver of cancer progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.mito.2024.101856_b0045","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/s12967-022-03693-0","article-title":"Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease","volume":"20","author":"Chen","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mito.2024.101856_b0050","doi-asserted-by":"crossref","first-page":"8848","DOI":"10.3390\/ijms24108848","article-title":"Mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment","volume":"24","author":"Clemente-Su\u00e1rez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mito.2024.101856_b0055","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949865","article-title":"Peroxisomal fission is modulated by the mitochondrial rho-GTPases, Miro1 and Miro2","volume":"21","author":"Covill-Cooke","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mito.2024.101856_b0060","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02978-2020","article-title":"Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS","volume":"58","author":"Dutra Silva","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.mito.2024.101856_b0065","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/pro.3839","article-title":"Miro: a molecular switch at the center of mitochondrial regulation","volume":"29","author":"Eberhardt","year":"2020","journal-title":"Protein Sci."},{"key":"10.1016\/j.mito.2024.101856_b0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/bs.mcb.2017.06.004","article-title":"Methods related to studying tau fragmentation","volume":"141","author":"Ferreira","year":"2017","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.mito.2024.101856_b0075","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.bbrc.2006.03.163","article-title":"The atypical rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking","volume":"344","author":"Fransson","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mito.2024.101856_b0080","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/0333102418821661","article-title":"The effects of concurrent coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial","volume":"39","author":"Hajihashemi","year":"2019","journal-title":"Cephalalgia"},{"key":"10.1016\/j.mito.2024.101856_b0085","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00018-015-2087-8","article-title":"Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy","volume":"73","author":"Hamacher-Brady","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mito.2024.101856_b0090","article-title":"Cell-cell communication in kidney fibrosis","volume":"2023","author":"He","year":"2023","journal-title":"Nephrol Dial Transplant."},{"key":"10.1016\/j.mito.2024.101856_b0095","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.stem.2016.08.002","article-title":"Functional impairment in Miro degradation and mitophagy is a shared feature in familial and sporadic Parkinson\u2019s disease","volume":"19","author":"Hsieh","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mito.2024.101856_b0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-32899-5","article-title":"PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability","volume":"13","author":"Hurrell","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mito.2024.101856_b0105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41439-018-0026-6","article-title":"Mitochondrial DNA 3243A>T mutation in a patient with MELAS syndrome","volume":"5","author":"Ikeda","year":"2018","journal-title":"Hum. Genome Var."},{"key":"10.1016\/j.mito.2024.101856_b0110","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jacc.2020.12.060","article-title":"Mitochondria-rich extracellular vesicles from autologous stem cell-derived cardiomyocytes restore energetics of ischemic myocardium","volume":"77","author":"Ikeda","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mito.2024.101856_b0115","doi-asserted-by":"crossref","first-page":"E8844","DOI":"10.1073\/pnas.1721136115","article-title":"Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models","volume":"115","author":"Lee","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.mito.2024.101856_b0120","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9537504","article-title":"mitochondrial transfer of Wharton\u2019s jelly mesenchymal stem cells eliminates mutation burden and rescues mitochondrial bioenergetics in rotenone-stressed MELAS fibroblasts","volume":"2019","author":"Lin","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mito.2024.101856_b0125","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mito.2015.02.006","article-title":"Mitochondrial transfer from Wharton\u2019s jelly-derived mesenchymal stem cells to mitochondria-defective cells recaptures impaired mitochondrial function","volume":"22","author":"Lin","year":"2015","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2024.101856_b0130","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091920","article-title":"5-aza-2\u2019-deoxycytidine induces a RIG-I-related innate immune response by modulating mitochondria stress in neuroblastoma","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mito.2024.101856_b0135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41392-020-00440-z","article-title":"Intercellular mitochondrial transfer as a means of tissue revitalization","volume":"6","author":"Liu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.mito.2024.101856_b0140","doi-asserted-by":"crossref","first-page":"321","DOI":"10.15252\/embj.201696380","article-title":"Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution","volume":"37","author":"L\u00f3pez-Dom\u00e9nech","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.mito.2024.101856_b0145","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jconrel.2023.01.059","article-title":"Mechanisms behind therapeutic potentials of mesenchymal stem cell mitochondria transfer\/delivery","volume":"354","author":"Malekpour","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.mito.2024.101856_b0150","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1242\/dev.138289","article-title":"A new mode of mitochondrial transport and polarized sorting regulated by Dynein, Milton and Miro","volume":"143","author":"Melkov","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.mito.2024.101856_b0155","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1164\/rccm.201701-0170OC","article-title":"Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer","volume":"196","author":"Morrison","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mito.2024.101856_b0160","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nrd.2018.174","article-title":"Mitochondria as a therapeutic target for common pathologies","volume":"17","author":"Murphy","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mito.2024.101856_b0165","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.celrep.2018.03.098","article-title":"MIRO-1 determines mitochondrial shape transition upon GPCR activation and Ca2+ stress","volume":"23","author":"Nemani","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.mito.2024.101856_b0170","doi-asserted-by":"crossref","first-page":"E3631","DOI":"10.1073\/pnas.1402449111","article-title":"Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease","volume":"111","author":"Nguyen","year":"2014","journal-title":"PNAS"},{"key":"10.1016\/j.mito.2024.101856_b0175","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12929-023-00979-3","article-title":"Extracellular release in the quality control of the mammalian mitochondria","volume":"30","author":"Pan","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.mito.2024.101856_b0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001166","article-title":"Neural stem cells traffic functional mitochondria via extracellular vesicles","volume":"19","author":"Peruzzotti-Jametti","year":"2021","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mito.2024.101856_b0185","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms9472","article-title":"Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs","volume":"6","author":"Phinney","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mito.2024.101856_b0190","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/jcmm.17105","article-title":"Wharton\u2019s jelly-derived stromal cells and their cell therapy applications in allogeneic haematopoietic stem cell transplantation","volume":"26","author":"Pochon","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mito.2024.101856_b0195","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbagen.2009.07.007","article-title":"Functional complementation of mitochondrial DNAs: mobilizing mitochondrial genetics against dysfunction","volume":"1800","author":"Schon","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2024.101856_b0200","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011304","article-title":"Mitochondrial trafficking in neurons","volume":"5","author":"Schwarz","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mito.2024.101856_b0205","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrn3156","article-title":"Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration","volume":"13","author":"Sheng","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mito.2024.101856_b0210","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1073\/pnas.0510511103","article-title":"Mitochondrial transfer between cells can rescue aerobic respiration","volume":"103","author":"Spees","year":"2006","journal-title":"PNAS"},{"key":"10.1016\/j.mito.2024.101856_b0215","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/EBC20160090","article-title":"Origins of mtDNA mutations in ageing","volume":"61","author":"Szczepanowska","year":"2017","journal-title":"Essays Biochem."},{"key":"10.1016\/j.mito.2024.101856_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.870193","article-title":"Human mesenchymal stromal cells release functional mitochondria in extracellular vesicles","volume":"10","author":"Thomas","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mito.2024.101856_bib256","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1177\/0271678X20928147","article-title":"Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1","volume":"41","author":"Tseng","year":"2021","journal-title":"J Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mito.2024.101856_b0225","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1159\/000445592","article-title":"Exogenous HGF prevents cardiomyocytes from apoptosis after hypoxia via up-regulating cell autophagy","volume":"38","author":"Wang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.mito.2024.101856_b0230","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.cell.2011.10.018","article-title":"PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility","volume":"147","author":"Wang","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.mito.2024.101856_b0235","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1096\/fj.08-106468","article-title":"VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase","volume":"22","author":"Wright","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.mito.2024.101856_b0240","article-title":"Tunneling nanotube-mediated mitochondrial transfer rescues nucleus pulposus cells from mitochondrial dysfunction and apoptosis","volume":"2022","author":"Yang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mito.2024.101856_b0245","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1074\/jbc.275.6.4251","article-title":"Modification defect at anticodon wobble nucleotide of mitochondrial tRNAs (leu) (UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes","volume":"275","author":"Yasukawa","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2024.101856_b0250","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.stemcr.2016.08.009","article-title":"iPSC-MSCs with high intrinsic MIRO1 and sensitivity to TNF-\u03b1 yield efficacious mitochondrial transfer to rescue anthracycline-induced cardiomyopathy","volume":"7","author":"Zhang","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.mito.2024.101856_b0255","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12929-021-00725-7","article-title":"Mesenchymal stem\/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications","volume":"28","author":"Zhuang","year":"2021","journal-title":"J. Biomed. Sci."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156772492400014X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156772492400014X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T21:45:12Z","timestamp":1738100712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156772492400014X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":51,"alternative-id":["S156772492400014X"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2024.101856","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2024.101856","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. and Mitochondria Research Society. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101856"}}