{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:29:41Z","timestamp":1785544181857,"version":"3.56.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.mito.2024.101947","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T17:32:10Z","timestamp":1723656730000},"page":"101947","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Activation of multifunctional DNA repair APE1\/Ref-1 enzyme by the dietary phytochemical Ferulic acid protects human neuroblastoma SH-SY5Y cells against A\u03b2(25\u201335)-induced oxidative stress and inflammatory responses"],"prefix":"10.1016","volume":"79","author":[{"given":"Sharanjot","family":"Kaur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harkomal","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monisha","family":"Dhiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Mantha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mito.2024.101947_b0005","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"issue":"10","key":"10.1016\/j.mito.2024.101947_b0010","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/gerona\/glp074","article-title":"Nitric oxide activity and isoenzyme expression in the senescence-accelerated mouse p8 model of Alzheimer's disease: effects of anti-amyloid antibody and antisense treatments","volume":"64","author":"Ali","year":"2009","journal-title":"J. Gerontol. Ser. A: Biomed. Sci. Med. Sci."},{"issue":"3","key":"10.1016\/j.mito.2024.101947_b0015","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/sj.cdd.4401150","article-title":"Potentiation of Fas-mediated apoptosis by attenuated production of mitochondria-derived reactive oxygen species","volume":"10","author":"Aronis","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mito.2024.101947_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13041-016-0280-9","article-title":"The anti-inflammatory role of extranuclear apurinic\/apyrimidinic endonuclease 1\/redox effector factor-1 in reactive astrocytes","volume":"9","author":"Baek","year":"2016","journal-title":"Mol. Brain"},{"key":"10.1016\/j.mito.2024.101947_b0025","doi-asserted-by":"crossref","first-page":"701282","DOI":"10.3389\/fimmu.2021.701282","article-title":"Activation of NLRP3 inflammasome and onset of Alzheimer\u2019s disease","volume":"12","author":"Bai","year":"2021","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.mito.2024.101947_b0030","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.3390\/app11093729","article-title":"PC12 and THP-1 cell lines as neuronal and microglia model in neurobiological research","volume":"11","author":"Balon","year":"2021","journal-title":"Appl. Sci."},{"issue":"11","key":"10.1016\/j.mito.2024.101947_b0035","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1093\/nar\/gkv433","article-title":"Mitochondrial translocation of APE1 relies on the MIA pathway","volume":"43","author":"Barchiesi","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"6645","key":"10.1016\/j.mito.2024.101947_b0040","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/42257","article-title":"Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E","volume":"388","author":"Barger","year":"1997","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.mito.2024.101947_b0045","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1093\/nar\/gkp275","article-title":"Identification of Apurinic\/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA","volume":"37","author":"Barnes","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.mito.2024.101947_b0050","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1089\/ars.2008.2198","article-title":"Transcriptional regulatory functions of mammalian AP-endonuclease (APE1\/Ref-1), an essential multifunctional protein","volume":"11","author":"Bhakat","year":"2009","journal-title":"Antioxid. Redox Signal."},{"issue":"12","key":"10.1016\/j.mito.2024.101947_b0055","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S1471-4914(01)02173-6","article-title":"Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid \u03b2-peptide","volume":"7","author":"Butterfield","year":"2001","journal-title":"Trends Mol. Med."},{"issue":"8","key":"10.1016\/j.mito.2024.101947_b0060","first-page":"924","article-title":"Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease","volume":"1801","author":"Butterfield","year":"2010","journal-title":"Biochim. et Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"issue":"21","key":"10.1016\/j.mito.2024.101947_b0065","doi-asserted-by":"crossref","first-page":"10075","DOI":"10.1073\/pnas.89.21.10075","article-title":"Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta\/A4 amyloid protein precursor","volume":"89","author":"Buxbaum","year":"1992","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.mito.2024.101947_b0070","first-page":"141","article-title":"Brain interleukin-1 beta in Alzheimer's disease and vascular dementia","volume":"16","author":"Cacabelos","year":"1994","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.mito.2024.101947_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108398","article-title":"The pathomimetic oA\u03b225\u201335 model of Alzheimer\u2019s disease: Potential for screening of new therapeutic agents","volume":"245","author":"Canet","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.mito.2024.101947_b0080","doi-asserted-by":"crossref","first-page":"687","DOI":"10.18240\/ijo.2023.05.03","article-title":"Protective effects of ferulic acid against ionizing radiation-induced oxidative damage in rat lens through activating Nrf2 signal pathway","volume":"16","author":"Chen","year":"2023","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.mito.2024.101947_b0085","doi-asserted-by":"crossref","first-page":"102675","DOI":"10.1016\/j.dnarep.2019.102675","article-title":"Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway","volume":"82","author":"Codrich","year":"2019","journal-title":"DNA Repair"},{"key":"10.1016\/j.mito.2024.101947_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-017-1020-5","article-title":"DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6","volume":"14","author":"Coutinho","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mito.2024.101947_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-016-0207-9","article-title":"Drug development in Alzheimer\u2019s disease: the path to 2025","volume":"8","author":"Cummings","year":"2016","journal-title":"Alzheimers Res. Ther."},{"issue":"9","key":"10.1016\/j.mito.2024.101947_b0100","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41573-020-0072-x","article-title":"Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing","volume":"19","author":"Cunnane","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mito.2024.101947_b0105","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbi.2016.12.014","article-title":"Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-\u03b2 and cognitive function in APP\/PS1 mice","volume":"61","author":"Dempsey","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.mito.2024.101947_b0110","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1159\/000485287","article-title":"Mitochondria-targeted antioxidant mito-tempo protects against aldosterone-induced renal injury in vivo","volume":"44","author":"Ding","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.mito.2024.101947_b0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","article-title":"Identification of ROS using oxidized DCFDA and flow-cytometry","volume":"II","author":"Eruslanov","year":"2010","journal-title":"Advanced Protocols in Oxidative Stress"},{"issue":"2","key":"10.1016\/j.mito.2024.101947_b0120","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4049\/jimmunol.139.2.459","article-title":"Visualization and characterization of interleukin 1 receptors in brain","volume":"139","author":"Farrar","year":"1987","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.mito.2024.101947_b0125","doi-asserted-by":"crossref","first-page":"e0159051","DOI":"10.1371\/journal.pone.0159051","article-title":"PA6 stromal cell co-culture enhances SH-SY5Y and VSC4. 1 neuroblastoma differentiation to mature phenotypes","volume":"11","author":"Ferguson","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.mito.2024.101947_b0130","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1159\/000255051","article-title":"Increased serum IL-1\u03b2 level in Alzheimer\u2019s disease and mild cognitive impairment","volume":"28","author":"Forlenza","year":"2010","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"s1","key":"10.1016\/j.mito.2024.101947_b0135","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.3233\/JAD-161086","article-title":"Phytochemical ginkgolide B attenuates amyloid-\u03b2 1\u201342 induced oxidative damage and altered cellular responses in human neuroblastoma SH-SY5Y cells","volume":"60","author":"Gill","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mito.2024.101947_b0140","series-title":"Seminars in Immunopathology, 37","first-page":"607","article-title":"\u03b2-amyloid, microglia, and the inflammasome in Alzheimer\u2019s disease","author":"Gold","year":"2015"},{"issue":"19","key":"10.1016\/j.mito.2024.101947_b0145","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.86.19.7606","article-title":"Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells","volume":"86","author":"Goldgaber","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1\u20132","key":"10.1016\/j.mito.2024.101947_b0150","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jneuroim.2007.03.023","article-title":"Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: Autoantibodies to A\u03b2 (25\u201335) oligomers, S100b and neurotransmitters","volume":"186","author":"Gruden","year":"2007","journal-title":"J. Neuroimmunol."},{"issue":"5","key":"10.1016\/j.mito.2024.101947_b0155","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/archneur.60.5.729","article-title":"Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment","volume":"60","author":"Guillozet","year":"2003","journal-title":"Arch. Neurol."},{"issue":"5580","key":"10.1016\/j.mito.2024.101947_b0160","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.mito.2024.101947_b0165","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1385\/NMM:4:1-2:21","article-title":"Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"4","author":"Hashimoto","year":"2003","journal-title":"NeuroMol. Med."},{"issue":"10","key":"10.1016\/j.mito.2024.101947_b0170","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.neurobiolaging.2007.12.005","article-title":"Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice","volume":"30","author":"Hauptmann","year":"2009","journal-title":"Neurobiol. Aging"},{"issue":"10","key":"10.1016\/j.mito.2024.101947_b0175","first-page":"6559","article-title":"APE1 inhibits foam cell formation from macrophages via LOX1 suppression","volume":"12","author":"Hu","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"12","key":"10.1016\/j.mito.2024.101947_b0180","doi-asserted-by":"crossref","first-page":"e8310","DOI":"10.1371\/journal.pone.0008310","article-title":"Mitochondrial mislocalization underlies A\u03b242-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease","volume":"4","author":"Iijima-Ando","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2024.101947_b0185","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fncel.2020.00198","article-title":"Overview of general and discriminating markers of differential microglia phenotypes","volume":"14","author":"Jurga","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.mito.2024.101947_b0190","first-page":"C641","article-title":"Mitochondria and neuronal activity","volume":"292","author":"Kann","year":"2007","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"5","key":"10.1016\/j.mito.2024.101947_b0195","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0955-2863(01)00215-7","article-title":"Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies","volume":"13","author":"Kanski","year":"2002","journal-title":"J. Nutr. Biochem."},{"issue":"6","key":"10.1016\/j.mito.2024.101947_b0200","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/jnr.23565","article-title":"Ginkgolide B revamps neuroprotective role of apurinic\/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against A\u03b225\u201335-induced neurotoxicity in human neuroblastoma cells","volume":"93","author":"Kaur","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mito.2024.101947_b0205","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/978-981-13-1123-9_25","article-title":"Ferulic Acid: A natural antioxidant with application towards neuroprotection against Alzheimer\u2019s disease","author":"Kaur","year":"2018","journal-title":"Functional Food and Human Health"},{"issue":"1","key":"10.1016\/j.mito.2024.101947_b0210","doi-asserted-by":"crossref","first-page":"306","DOI":"10.31788\/RJC.2020.1315596","article-title":"Phytochemical ginkgolide b protects cultured neuroblastoma sh-sy5y cells against a\u03b2 (25\u201335) induced oxidative stress responses by maintaining the mitochondrial integrity","volume":"13","author":"Kaur","year":"2020","journal-title":"Rasayan J. Chem."},{"key":"10.1016\/j.mito.2024.101947_b0215","doi-asserted-by":"crossref","first-page":"121134","DOI":"10.1016\/j.lfs.2022.121134","article-title":"A cross-sectional study to correlate antioxidant enzymes, oxidative stress and inflammation with prevalence of hypertension","volume":"313","author":"Kaur","year":"2023","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.mito.2024.101947_b0220","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2174\/1874467211205010036","article-title":"APE1\/Ref-1role in redox signaling: translational applications of targeting the redox function of the DNA repair\/redox protein APE1\/Ref-1","volume":"5","author":"Kelley","year":"2012","journal-title":"Curr. Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.mito.2024.101947_b0225","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1447-0594.2010.00687.x","article-title":"Effect of ferulic acid and Angelica archangelica extract on behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies","volume":"11","author":"Kimura","year":"2011","journal-title":"Geriatr. Gerontol. Int."},{"issue":"3","key":"10.1016\/j.mito.2024.101947_b0230","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jnr.10391","article-title":"In vivo conversion of racemized \u03b2-amyloid ([D-Ser26] A\u03b21\u201340) to truncated and toxic fragments ([D-Ser26] A\u03b225\u201335\/40) and fragment presence in the brains of Alzheimer\u2019s patients","volume":"70","author":"Kubo","year":"2002","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.mito.2024.101947_b0235","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3233\/ADR-200211","article-title":"Effects of ferulic acid and Angelica archangelica extract (Feru-guard\u00ae) on mild cognitive impairment: A multicenter, randomized, double-blind, placebo-controlled prospective trial","volume":"4","author":"Kudoh","year":"2020","journal-title":"J. Alzheimer\u2019s Dis. Rep."},{"issue":"7427","key":"10.1016\/j.mito.2024.101947_b0240","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11588","article-title":"The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP","volume":"492","author":"Lee","year":"2012","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mito.2024.101947_b0245","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s13273-021-00219-5","article-title":"Ferulic acid exhibits anti-inflammatory effects by inducing autophagy and blocking NLRP3 inflammasome activation","volume":"18","author":"Liu","year":"2022","journal-title":"Mol. Cell. Toxicol."},{"issue":"14","key":"10.1016\/j.mito.2024.101947_b0250","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1002\/jnr.21346","article-title":"Oxidative damage in mild cognitive impairment and early Alzheimer's disease","volume":"85","author":"Lovell","year":"2007","journal-title":"J. Neurosci. Res."},{"issue":"8\u20139","key":"10.1016\/j.mito.2024.101947_b0255","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.mad.2011.08.003","article-title":"Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain","volume":"132","author":"Lovell","year":"2011","journal-title":"Mech. Ageing Dev."},{"issue":"6","key":"10.1016\/j.mito.2024.101947_b0260","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/jnc.14945","article-title":"Soluble A\u03b2 oligomers and protofibrils induce NLRP3 inflammasome activation in microglia","volume":"155","author":"Lu\u010di\u016bnait\u0117","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2024.101947_b0265","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molimm.2020.12.038","article-title":"Functional crosstalk between long non-coding RNAs and the NLRP3 inflammasome in the regulation of diseases","volume":"131","author":"Luo","year":"2021","journal-title":"Mol. Immunol."},{"issue":"6","key":"10.1016\/j.mito.2024.101947_b0270","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/jnr.23018","article-title":"Proteomic study of amyloid beta (25\u201335) peptide exposure to neuronal cells: Impact on APE1\/Ref-1's protein\u2013protein interaction","volume":"90","author":"Mantha","year":"2012","journal-title":"J. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.mito.2024.101947_b0275","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neulet.2009.09.039","article-title":"APE1\/Ref-1 in Alzheimer's disease: an immunohistochemical study","volume":"466","author":"Marcon","year":"2009","journal-title":"Neurosci. Lett."},{"issue":"5","key":"10.1016\/j.mito.2024.101947_b0280","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/ana.410360510","article-title":"Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease","volume":"36","author":"Mecocci","year":"1994","journal-title":"Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society"},{"issue":"20","key":"10.1016\/j.mito.2024.101947_b0285","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1523\/JNEUROSCI.5047-06.2007","article-title":"Connecting TNF-\u03b1 signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid \u03b2 protein","volume":"27","author":"Medeiros","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mito.2024.101947_b0290","doi-asserted-by":"crossref","first-page":"617588","DOI":"10.3389\/fnagi.2021.617588","article-title":"Mitochondrial dysfunction and oxidative stress in Alzheimer\u2019s disease","volume":"13","author":"Misrani","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"10.1016\/j.mito.2024.101947_b0295","doi-asserted-by":"crossref","first-page":"e55774","DOI":"10.1371\/journal.pone.0055774","article-title":"Ferulic acid is a nutraceutical \u03b2-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice","volume":"8","author":"Mori","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2024.101947_b0300","first-page":"1","article-title":"Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease","volume":"2","author":"Morris","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.mito.2024.101947_b0305","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12035-010-8141-5","article-title":"Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer\u2019s disease\u2014therapeutic aspects","volume":"41","author":"M\u00fcller","year":"2010","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.mito.2024.101947_b0310","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.mito.2024.101947_b0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/NEN.0b013e3181919a48","article-title":"Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship","volume":"68","author":"Nelson","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"3","key":"10.1016\/j.mito.2024.101947_b0320","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/JAD-1999-1301","article-title":"Increased expression but reduced activity of antioxidant enzymes in Alzheimer's disease","volume":"1","author":"Omar","year":"1999","journal-title":"J. Alzheimers Dis."},{"issue":"7","key":"10.1016\/j.mito.2024.101947_b0325","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/sj.emboj.7600614","article-title":"Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space","volume":"24","author":"Otera","year":"2005","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.mito.2024.101947_b0330","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/ijms20010017","article-title":"Effect of inflammatory mediators lipopolysaccharide and lipoteichoic acid on iron metabolism of differentiated SH-SY5Y cells alters in the presence of BV-2 microglia","volume":"20","author":"Pandur","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.mito.2024.101947_b0335","doi-asserted-by":"crossref","first-page":"e430","DOI":"10.1038\/cddis.2012.171","article-title":"JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry","volume":"3","author":"Perelman","year":"2012","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.mito.2024.101947_b0340","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1046\/j.1471-4159.1995.64010253.x","article-title":"Structure-activity analyses of \u03b2-amyloid peptides: contributions of the \u03b225\u201335 region to aggregation and neurotoxicity","volume":"64","author":"Pike","year":"1995","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.mito.2024.101947_b0345","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.55.8.1158","article-title":"Documented head injury in early adulthood and risk of Alzheimer\u2019s disease and other dementias","volume":"55","author":"Plassman","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2024.101947_b0350","doi-asserted-by":"crossref","first-page":"100063","DOI":"10.1016\/j.hsr.2022.100063","article-title":"A critical appraisal on ferulic acid: biological profile, biopharmaceutical challenges and nano formulations","volume":"5","author":"Raj","year":"2022","journal-title":"Health Sci. Rev."},{"key":"10.1016\/j.mito.2024.101947_b0355","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s11011-017-0093-2","article-title":"Curcumin revitalizes Amyloid beta (25\u201335)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2","volume":"32","author":"Sarkar","year":"2017","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.mito.2024.101947_b0360","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41531-017-0032-2","article-title":"Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson\u2019s disease","volume":"3","author":"Sarkar","year":"2017","journal-title":"Nature Partner Journal-Parkinson's Disease"},{"key":"10.1016\/j.mito.2024.101947_b0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.02.030","article-title":"Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology","volume":"42","author":"Scheff","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"12","key":"10.1016\/j.mito.2024.101947_b0370","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1089\/ars.2010.3445","article-title":"Apoptosis-inducing factor: structure, function, and redox regulation","volume":"14","author":"Sevrioukova","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"6","key":"10.1016\/j.mito.2024.101947_b0375","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.freeradbiomed.2008.06.003","article-title":"Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain","volume":"45","author":"Shao","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2024.101947_b0380","first-page":"e53193","article-title":"Differentiation of the SH-SY5Y human neuroblastoma cell line","volume":"108","author":"Shipley","year":"2016","journal-title":"JoVE J. Visual. Experim."},{"issue":"1","key":"10.1016\/j.mito.2024.101947_b0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-6-1","article-title":"Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia","volume":"6","author":"Sondag","year":"2009","journal-title":"J. Neuroinflammation"},{"issue":"6718","key":"10.1016\/j.mito.2024.101947_b0390","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/17135","article-title":"Molecular characterization of mitochondrial apoptosis-inducing factor","volume":"397","author":"Susin","year":"1999","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mito.2024.101947_b0395","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1089\/ars.2008.2194","article-title":"The many functions of APE1\/Ref-1: not only a DNA repair enzyme","volume":"11","author":"Tell","year":"2009","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.mito.2024.101947_b0400","doi-asserted-by":"crossref","first-page":"e22640","DOI":"10.1002\/jbt.22640","article-title":"Organophosphate-pesticides induced survival mechanisms and APE1-mediated Nrf2 regulation in non-small-cell lung cancer cells","volume":"35","author":"Thakur","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"02","key":"10.1016\/j.mito.2024.101947_b0405","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1142\/S0192415X15500214","article-title":"Ferulic acid reverses the cognitive dysfunction caused by amyloid \u03b2 peptide 1\u201340 through anti-oxidant activity and cholinergic activation in rats","volume":"43","author":"Tsai","year":"2015","journal-title":"Am. J. Chin. Med."},{"issue":"5","key":"10.1016\/j.mito.2024.101947_b0410","first-page":"1","article-title":"Molecular mechanisms that influence the macrophage M1\u2013M2 polarization balance","volume":"614","author":"Wang","year":"2014","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.mito.2024.101947_b0415","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.bbadis.2013.10.015","article-title":"Oxidative stress and mitochondrial dysfunction in Alzheimer's disease","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. et Biophys. Acta (BBA)-Mol. Basis Disease"},{"issue":"4","key":"10.1016\/j.mito.2024.101947_b0420","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s12035-020-02204-w","article-title":"Protective activity of A\u03b2 on cell cultures (PC12 and THP-1 after differentiation) preincubated with lipopolysaccharide (LPS)","volume":"58","author":"Wiatrak","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.mito.2024.101947_b0425","doi-asserted-by":"crossref","first-page":"775490","DOI":"10.3389\/fvets.2021.775490","article-title":"Antioxidant effects and potential molecular mechanism of action of limonium aureum extract based on systematic network pharmacology","volume":"1538","author":"Yang","year":"2022","journal-title":"Front. Veterin. Sci."},{"issue":"39","key":"10.1016\/j.mito.2024.101947_b0430","doi-asserted-by":"crossref","first-page":"37768","DOI":"10.1074\/jbc.M304914200","article-title":"Human apurinic\/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis","volume":"278","author":"Yoshida","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.mito.2024.101947_b0435","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1523\/JNEUROSCI.3699-09.2010","article-title":"Expression of \u03b2-amyloid induced age-dependent presynaptic and axonal changes in Drosophila","volume":"30","author":"Zhao","year":"2010","journal-title":"J. Neurosci."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724924001053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724924001053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T04:24:12Z","timestamp":1731558252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724924001053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":87,"alternative-id":["S1567724924001053"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2024.101947","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of multifunctional DNA repair APE1\/Ref-1 enzyme by the dietary phytochemical Ferulic acid protects human neuroblastoma SH-SY5Y cells against A\u03b2(25\u201335)-induced oxidative stress and inflammatory responses","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2024.101947","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. and Mitochondria Research Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101947"}}