{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:49:51Z","timestamp":1791946191401,"version":"4.3.4"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"am","delay-in-days":285,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005037","name":"Bo\u011fazi\u00e7i \u00dcniversitesi","doi-asserted-by":"publisher","award":["11662"],"award-info":[{"award-number":["11662"]}],"id":[{"id":"10.13039\/501100005037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2025R338"],"award-info":[{"award-number":["PNURSP2025R338"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012680","name":"The Nathaniel Wharton Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH092580"],"award-info":[{"award-number":["R01 MH092580"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.mito.2025.102057","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:35:36Z","timestamp":1748993736000},"page":"102057","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Mitochondrial health, prenatal distress, and gestational age: investigation of cf-mtDNA and GDF15 in two pregnancy studies from the USA and Turkey"],"prefix":"10.1016","volume":"84","author":[{"given":"Qiuhan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Hollis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameera","family":"Abuaish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Monk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Aysimi","family":"Duman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Trumpff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mito.2025.102057_b0005","first-page":"487","article-title":"Depression and anxiety in early pregnancy and risk for preeclampsia","volume":"95","author":"Kurki","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mito.2025.102057_b0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1472-6874-10-14","article-title":"A multicentre matched case control study of risk factors for preeclampsia in healthy women in Pakistan","volume":"10","author":"Shamsi","year":"2010","journal-title":"BMC Womens Health"},{"issue":"4","key":"10.1016\/j.mito.2025.102057_b0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1047-2797(02)00419-2","article-title":"Does stress influence early pregnancy loss?","volume":"13","author":"Nelson","year":"2003","journal-title":"Ann. Epidemiol."},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0020","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/s41598-017-01792-3","article-title":"The association between psychological stress and miscarriage: a systematic review and meta-analysis","volume":"7","author":"Qu","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.mito.2025.102057_b0025","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/AOG.0000000000001287","article-title":"Measures of maternal stress and mood in relation to preterm birth","volume":"127","author":"Hoffman","year":"2016","journal-title":"Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.mito.2025.102057_b0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200594","article-title":"Is the risk of low birth weight or preterm labor greater when maternal stress is experienced during pregnancy? A systematic review and meta-analysis of cohort studies","volume":"13","author":"Lima","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.mito.2025.102057_b0035","article-title":"Knobil and Neill's physiology of reproduction","author":"Knobil","year":"2006","journal-title":"Gulf Professional Publishing"},{"issue":"2","key":"10.1016\/j.mito.2025.102057_b0040","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/ajcn\/56.2.334","article-title":"Total energy expenditure of healthy Swedish women during pregnancy and lactation","volume":"56","author":"Forsum","year":"1992","journal-title":"Am. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.mito.2025.102057_b0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/ajcn\/69.2.299","article-title":"Adjustments in energy expenditure and substrate utilization during late pregnancy and lactation","volume":"69","author":"Butte","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.mito.2025.102057_b0050","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/ajcn\/79.6.1078","article-title":"Energy requirements during pregnancy based on total energy expenditure and energy deposition","volume":"79","author":"Butte","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.mito.2025.102057_b0055","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/nutrit\/nuaa093","article-title":"Energy expenditure during pregnancy: a systematic review","volume":"79","author":"Savard","year":"2021","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.mito.2025.102057_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2022.105951","article-title":"The energetic cost of allostasis and allostatic load","volume":"146","author":"Bobba-Alves","year":"2022","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.mito.2025.102057_b0065","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.psyneuen.2006.12.012","article-title":"Prenatal stress increases HPA axis activity and impairs maternal care in lactating female offspring: implications for postpartum mood disorder","volume":"32","author":"Bosch","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.mito.2025.102057_b0070","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/652630","article-title":"Perinatal stress, fatigue, depressive symptoms, and immune modulation in late pregnancy and one month postpartum","volume":"2014","author":"Cheng","year":"2014","journal-title":"Scientific World J."},{"key":"10.1016\/j.mito.2025.102057_b0075","article-title":"Stress-related mental health disorders and inflammation in pregnancy: the current landscape and the need for further investigation","volume":"13","author":"Ravi","year":"2022","journal-title":"Front. Psych."},{"key":"10.1016\/j.mito.2025.102057_b0080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yfrne.2018.01.001","article-title":"An energetic view of stress: focus on mitochondria","volume":"49","author":"Picard","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mito.2025.102057_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2018.01.012","article-title":"A mitochondrial health index sensitive to mood and caregiving stress","author":"Picard","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.mito.2025.102057_b0090","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2147\/NDT.S188964","article-title":"Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder","author":"Zv\u011b\u0159ov\u00e1","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.mito.2025.102057_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2018.05.040","article-title":"The association between cortisol, oxytocin and immune cell mitochondrial oxygen consumption in postpartum women with childhood maltreatment","author":"Boeck","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.mito.2025.102057_b0100","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1038\/tp.2014.44","article-title":"Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression","volume":"4","author":"Karabatsiakis","year":"2014","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0105","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.1038\/s41598-018-26867-7","article-title":"Targeting the association between telomere length and immuno-cellular bioenergetics in female patients with Major Depressive Disorder","volume":"8","author":"Boeck","year":"2018","journal-title":"Sci. Rep."},{"issue":"40","key":"10.1016\/j.mito.2025.102057_b0110","doi-asserted-by":"crossref","first-page":"24778","DOI":"10.1073\/pnas.2005885117","article-title":"Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells","volume":"117","author":"Gumpp","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.mito.2025.102057_b0115","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.mito.2013.05.005","article-title":"Mitochondrial respiration in blood platelets of depressive patients","volume":"13","author":"Hroudov\u00e1","year":"2013","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2025.102057_b0120","doi-asserted-by":"crossref","unstructured":"Trumpff, C., Monzel, A., Sandi, C., Menon, V., Klein, H.-U., Fujita, M., et al., 2023. Psychosocial experiences are associated with human brain mitochondrial biology. bioRxiv. 2023.10.06.559575.","DOI":"10.1101\/2023.10.06.559575"},{"key":"10.1016\/j.mito.2025.102057_b0125","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cobeha.2019.04.015","article-title":"Mitochondrial psychobiology: foundations and applications","volume":"28","author":"Picard","year":"2019","journal-title":"Curr. Opin. Behav. Sci."},{"issue":"11","key":"10.1016\/j.mito.2025.102057_b0130","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.3390\/ijms20112770","article-title":"Organization of DNA in mammalian mitochondria","volume":"20","author":"Farge","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mito.2025.102057_b0135","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8060949","article-title":"Mitochondrial nucleoid: shield and switch of the mitochondrial genome","volume":"2017","author":"Lee","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mito.2025.102057_b0140","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mito.2023.05.001","article-title":"MitoQuicLy: a high-throughput method for quantifying cell-free DNA from human plasma, serum, and saliva","volume":"71","author":"Michelson","year":"2023","journal-title":"Mitochondrion"},{"issue":"3","key":"10.1016\/j.mito.2025.102057_b0145","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1111\/brv.12413","article-title":"The diverse origins of circulating cell-free DNA in the human body: a critical re-evaluation of the literature","volume":"93","author":"Aucamp","year":"2018","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.mito.2025.102057_b0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.mito.2021.04.002","article-title":"Stress and circulating cell-free mitochondrial DNA: a systematic review of human studies, physiological considerations, and technical recommendations","volume":"59","author":"Trumpff","year":"2021","journal-title":"Mitochondrion"},{"issue":"6","key":"10.1016\/j.mito.2025.102057_b0155","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jcrc.2013.05.006","article-title":"Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: time course and the association with clinical status","volume":"28","author":"Yamanouchi","year":"2013","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.mito.2025.102057_b0160","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1479-5876-10-130","article-title":"Plasma nuclear and mitochondrial DNA levels as predictors of outcome in severe sepsis patients in the emergency room","volume":"10","author":"Kung","year":"2012","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mito.2025.102057_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1382003","article-title":"Cell-free DNA in patients with sepsis: long term trajectory and association with 28-day mortality and sepsis-associated acute kidney injury","volume":"15","author":"Dennhardt","year":"2024","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.mito.2025.102057_b0170","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrc3066","article-title":"Cell-free nucleic acids as biomarkers in cancer patients","volume":"11","author":"Schwarzenbach","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"18","key":"10.1016\/j.mito.2025.102057_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814163","article-title":"The diagnostic, prognostic, and therapeutic potential of cell-free DNA with a special focus on COVID-19 and other viral infections","volume":"24","author":"Hovhannisyan","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mito.2025.102057_b0180","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3389\/fimmu.2019.00502","article-title":"Cell-free DNA as a biomarker in autoimmune rheumatic diseases","volume":"10","author":"Duvvuri","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.mito.2025.102057_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11020151","article-title":"Circulating free DNA and its emerging role in autoimmune diseases","volume":"11","author":"Mondelo-Macia","year":"2021","journal-title":"J. Pers. Med."},{"issue":"12","key":"10.1016\/j.mito.2025.102057_b0190","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41423-023-01086-x","article-title":"Mitochondrial DNA-triggered innate immune response: mechanisms and diseases","volume":"20","author":"Hu","year":"2023","journal-title":"Cell. Mol. Immunol."},{"issue":"7","key":"10.1016\/j.mito.2025.102057_b0195","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1038\/s41386-017-0001-9","article-title":"Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder","volume":"43","author":"Lindqvist","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.mito.2025.102057_b0200","doi-asserted-by":"crossref","first-page":"e971","DOI":"10.1038\/tp.2016.236","article-title":"Increased plasma levels of circulating cell-free mitochondrial DNA in suicide attempters: associations with HPA-axis hyperactivity","volume":"6","author":"Lindqvist","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.mito.2025.102057_b0205","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.psyneuen.2019.03.026","article-title":"Acute psychological stress increases serum circulating cell-free mitochondrial DNA","volume":"106","author":"Trumpff","year":"2019","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0210","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41398-018-0264-x","article-title":"Cell-free DNA release under psychosocial and physical stress conditions","volume":"8","author":"Hummel","year":"2018","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.mito.2025.102057_b0215","article-title":"Circulating cell-free mitochondrial DNA in pregnancy","volume":"37","author":"Bradshaw","year":"2022","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.mito.2025.102057_b0220","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejogrb.2020.04.037","article-title":"Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator","volume":"251","author":"McElwain","year":"2020","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.mito.2025.102057_b0225","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mito.2014.10.006","article-title":"GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases","volume":"20","author":"Fujita","year":"2015","journal-title":"Mitochondrion"},{"issue":"10","key":"10.1016\/j.mito.2025.102057_b0230","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease","volume":"17","author":"Wang","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"10.1016\/j.mito.2025.102057_b0235","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/bio.2015.0032","article-title":"A novel approach to high-quality postmortem tissue procurement: the GTEx project","volume":"13","author":"Carithers","year":"2015","journal-title":"Biopreserv. Biobank"},{"issue":"4","key":"10.1016\/j.mito.2025.102057_b0240","doi-asserted-by":"crossref","DOI":"10.1210\/endrev\/bnaa007","article-title":"GDF15: a hormone conveying somatic distress to the brain","volume":"41","author":"Lockhart","year":"2020","journal-title":"Endocr. Rev."},{"issue":"4","key":"10.1016\/j.mito.2025.102057_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113960","article-title":"Activation of GFRAL<sup>+<\/sup> neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor","volume":"43","author":"Engstr\u00f6m Ruud","year":"2024","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.mito.2025.102057_b0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0248980","article-title":"Growth differentiation factor 15 increases in both cerebrospinal fluid and serum during pregnancy","volume":"16","author":"Andersson-Hall","year":"2021","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.mito.2025.102057_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107902","article-title":"GDF15 deficiency hinders human trophoblast invasion to mediate pregnancy loss through downregulating Smad1\/5 phosphorylation","volume":"26","author":"Zeng","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.mito.2025.102057_b0260","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cyto.2016.05.002","article-title":"Serum levels of GDF15 are reduced in preeclampsia and the reduction is more profound in late-onset than early-onset cases","volume":"83","author":"Chen","year":"2016","journal-title":"Cytokine"},{"issue":"16","key":"10.1016\/j.mito.2025.102057_b0265","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020302","article-title":"Circulating growth differentiation factor 15 is increased preceding preeclampsia diagnosis: implications as a disease biomarker","volume":"10","author":"Cruickshank","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.mito.2025.102057_b0270","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.preghy.2018.10.003","article-title":"Maternal serum mitochondrial DNA (mtDNA) levels are elevated in preeclampsia \u2013 a matched case-control study","volume":"14","author":"Marschalek","year":"2018","journal-title":"Pregnancy Hypertens."},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0275","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/HYPERTENSIONAHA.109.130583","article-title":"Circulating and placental growth-differentiation factor 15 in preeclampsia and in pregnancy complicated by diabetes mellitus","volume":"54","author":"Sugulle","year":"2009","journal-title":"Hypertension"},{"issue":"7996","key":"10.1016\/j.mito.2025.102057_b0280","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41586-023-06921-9","article-title":"GDF15 linked to maternal risk of nausea and vomiting during pregnancy","volume":"625","author":"Fejzo","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.mito.2025.102057_b0285","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55164","article-title":"The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling","volume":"9","author":"Worth","year":"2020","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jagp.2022.08.003","article-title":"Late-life depression is associated with increased levels of GDF-15, a pro-aging Mitokine","volume":"31","author":"Mastrobattista","year":"2023","journal-title":"Am. J. Geriatr. Psychiatry"},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0295","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41398-023-02696-9","article-title":"Metabolic features of treatment-refractory major depressive disorder with suicidal ideation","volume":"13","author":"Pan","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"12","key":"10.1016\/j.mito.2025.102057_b0300","doi-asserted-by":"crossref","first-page":"e689","DOI":"10.1038\/tp.2015.185","article-title":"Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders","volume":"5","author":"Frye","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.mito.2025.102057_b0305","article-title":"Psychobiological regulation of plasma and saliva GDF15 dynamics in health and mitochondrial diseases","author":"Huang","year":"2024","journal-title":"bioRxiv"},{"issue":"7","key":"10.1016\/j.mito.2025.102057_b0310","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1176\/appi.ajp.2015.15091171","article-title":"Distress during pregnancy: epigenetic regulation of placenta glucocorticoid-related genes and fetal neurobehavior","volume":"173","author":"Monk","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.mito.2025.102057_b0315","article-title":"Multilevel impact of prenatal risk and protective factors on stress biology and infant development: study protocol of BABIP prospective birth cohort from Turkey","volume":"1","author":"Duman","year":"2020","journal-title":"Brain Behav. Immun. Health"},{"issue":"2","key":"10.1016\/j.mito.2025.102057_b0320","doi-asserted-by":"crossref","first-page":"R445","DOI":"10.1152\/ajpregu.00324.2019","article-title":"Cell-free mitochondrial DNA increases in maternal circulation during healthy pregnancy: a prospective, longitudinal study","volume":"318","author":"Cushen","year":"2020","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"5","key":"10.1016\/j.mito.2025.102057_b0325","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12799","article-title":"Plasma proteomic signature of age in healthy humans","volume":"17","author":"Tanaka","year":"2018","journal-title":"Aging Cell"},{"issue":"12","key":"10.1016\/j.mito.2025.102057_b0330","first-page":"4781","article-title":"The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women","volume":"85","author":"Moore","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.mito.2025.102057_b0335","doi-asserted-by":"crossref","first-page":"E303","DOI":"10.1152\/ajpendo.00134.2023","article-title":"Cross-species comparison of pregnancy-induced GDF15","volume":"325","author":"Klein","year":"2023","journal-title":"Am. J. Phys. Endocrinol. Metab."},{"key":"10.1016\/j.mito.2025.102057_b0340","article-title":"Growth differentiation factor 15 during pregnancy and postpartum as captured in blood, cerebrospinal fluid and placenta: a cohort study on associations with maternal mental health","author":"H\u00f8gh","year":"2024","journal-title":"Psychoneuroendocrinology"},{"issue":"12","key":"10.1016\/j.mito.2025.102057_b0345","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/s41591-019-0673-2","article-title":"Undulating changes in human plasma proteome profiles across the lifespan","volume":"25","author":"Lehallier","year":"2019","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0350","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/emph\/eoae008","article-title":"Nausea, vomiting and conflict in pregnancy: the adaptive significance of growth-differentiation factor 15","volume":"12","author":"Crespi","year":"2024","journal-title":"Evol. Med. Public Health"},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0355","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/cen.14433","article-title":"Growth-differentiation-factor 15 levels in obese and healthy pregnancies: relation to insulin resistance and insulin secretory function","volume":"95","author":"Andersson-Hall","year":"2021","journal-title":"Clin. Endocrinol."},{"issue":"5","key":"10.1016\/j.mito.2025.102057_b0360","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cmet.2024.02.016","article-title":"The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging","volume":"36","author":"Pham","year":"2024","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0365","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/ppul.26197","article-title":"Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates","volume":"58","author":"Almudares","year":"2023","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.mito.2025.102057_b0370","doi-asserted-by":"crossref","first-page":"123","DOI":"10.12688\/wellcomeopenres.14818.1","article-title":"Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: a nested case-control study","volume":"3","author":"Petry","year":"2018","journal-title":"Wellcome Open Res."},{"issue":"10","key":"10.1016\/j.mito.2025.102057_b0375","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvad120","article-title":"Cord blood FGF-21 and GDF-15 levels are affected by maternal exposure to moderate to severe Anemia and Malaria","volume":"7","author":"Hjort","year":"2023","journal-title":"J. Endocr. Soc."},{"issue":"10","key":"10.1016\/j.mito.2025.102057_b0380","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/met.2015.0095","article-title":"Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies","volume":"13","author":"Manna","year":"2015","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"10.1016\/j.mito.2025.102057_b0385","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.611929","article-title":"Nutrition and metabolic adaptations in physiological and complicated pregnancy: focus on obesity and gestational diabetes","volume":"11","author":"Parrettini","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.mito.2025.102057_b0390","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mito.2020.12.009","article-title":"Mitochondrial bioenergetics in leukocytes and oxidative stress in blood serum of mild to moderately depressed women","volume":"58","author":"Gumpp","year":"2021","journal-title":"Mitochondrion"},{"issue":"11","key":"10.1016\/j.mito.2025.102057_b0395","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259591","article-title":"Plasma circulating cell-free mitochondrial DNA in depressive disorders","volume":"16","author":"Fernstr\u00f6m","year":"2021","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.mito.2025.102057_b0400","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5830\/CVJA-2016-021","article-title":"Physiological changes in pregnancy","volume":"27","author":"Soma-Pillay","year":"2016","journal-title":"Cardiovasc. J. Afr."},{"issue":"6","key":"10.1016\/j.mito.2025.102057_b0405","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/MED.0b013e32834c800d","article-title":"Placental hormones and the control of maternal metabolism and fetal growth","volume":"18","author":"Newbern","year":"2011","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"issue":"6","key":"10.1016\/j.mito.2025.102057_b0410","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1093\/jalm\/jfac055","article-title":"The common H202D variant in GDF-15 does not affect its bioactivity but can significantly interfere with measurement of its circulating levels","volume":"7","author":"Karusheva","year":"2022","journal-title":"J. Appl. Lab. Med."},{"issue":"27","key":"10.1016\/j.mito.2025.102057_b0415","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2317673121","article-title":"Psychosocial experiences are associated with human brain mitochondrial biology","volume":"121","author":"Trumpff","year":"2024","journal-title":"PNAS"},{"key":"10.1016\/j.mito.2025.102057_b0420","article-title":"A quantitative approach to mapping mitochondrial specialization and plasticity","author":"Monzel","year":"2025","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0425","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Ps"},{"issue":"1","key":"10.1016\/j.mito.2025.102057_b0430","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"issue":"4","key":"10.1016\/j.mito.2025.102057_b0435","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"issue":"6","key":"10.1016\/j.mito.2025.102057_b0440","doi-asserted-by":"crossref","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch. Gen. Psychiat."},{"issue":"3","key":"10.1016\/j.mito.2025.102057_b0445","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl. Psychol. Meas."},{"key":"10.1016\/j.mito.2025.102057_b0450","doi-asserted-by":"crossref","unstructured":"Spielberger, C., Gorsuch, R., Lushene, R., Vagg, P.R., Jacobs, G., 1983. Manual for the State-Trait Anxiety Inventory (Form Y1\u2013Y2).","DOI":"10.1037\/t06496-000"}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724925000546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724925000546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T02:42:20Z","timestamp":1750473740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724925000546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":90,"alternative-id":["S1567724925000546"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2025.102057","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial health, prenatal distress, and gestational age: investigation of cf-mtDNA and GDF15 in two pregnancy studies from the USA and Turkey","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2025.102057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. and Mitochondria Research Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102057"}}