{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:24:30Z","timestamp":1793237070158,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112\\u20132314-B-182A-086-MY3"],"award-info":[{"award-number":["NSTC 112\\u20132314-B-182A-086-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 113\\u20132314-B-182A-042"],"award-info":[{"award-number":["NSTC 113\\u20132314-B-182A-042"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 114\\u20132314-B-182A-012"],"award-info":[{"award-number":["NSTC 114\\u20132314-B-182A-012"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011892","name":"Kaohsiung Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG8M1111"],"award-info":[{"award-number":["CMRPG8M1111"]}],"id":[{"id":"10.13039\/501100011892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.mito.2026.102132","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T08:08:59Z","timestamp":1770797339000},"page":"102132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Dysregulated iron homeostasis Drives mitochondrial Injury and ferroptosis susceptibility in MELAS fibroblasts"],"prefix":"10.1016","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1523-6940","authenticated-orcid":false,"given":"Yu-Han","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-An","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ya","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Shiung","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Yu","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wei","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-1319","authenticated-orcid":false,"given":"Tsu-Kung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2026.102132_b0005","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrm1620","article-title":"Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis","volume":"6","author":"Rouault","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mito.2026.102132_b0010","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1021\/cr900006y","article-title":"Metal acquisition and availability in the mitochondria","volume":"109","author":"Atkinson","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.mito.2026.102132_b0015","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1146\/annurev.biochem.76.052705.162653","article-title":"Maturation of iron-sulfur proteins in eukaryotes: mechanisms, connected processes, and diseases","volume":"77","author":"Lill","year":"2008","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.mito.2026.102132_b0020","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mito.2026.102132_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.630771","article-title":"The Role of Mitochondria in Pyroptosis","volume":"8","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mito.2026.102132_b0030","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1016\/j.cell.2022.06.038","article-title":"Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis","volume":"185","author":"Weindel","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.mito.2026.102132_b0035","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of Mitochondria in Ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mito.2026.102132_b0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41420-024-01825-7","article-title":"Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation","volume":"10","author":"Jin","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mito.2026.102132_b0045","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"key":"10.1016\/j.mito.2026.102132_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101263","article-title":"Oxidative stress and regulated cell death in Parkinson's disease","volume":"67","author":"Dion\u00edsio","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mito.2026.102132_b0055","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41419-023-06045-y","article-title":"The diversified role of mitochondria in ferroptosis in cancer","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mito.2026.102132_b0060","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/cells9061505","article-title":"Ferroptosis and Cancer: Mitochondria Meet the \u201cIron Maiden\u201d Cell Death","volume":"9","author":"Battaglia","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mito.2026.102132_b0065","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.mito.2026.102132_b0070","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mito.2026.102132_b0075","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fnmol.2020.00110","article-title":"The potential Value of Targeting Ferroptosis in Early Brain Injury after Acute CNS Disease","volume":"13","author":"Chen","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mito.2026.102132_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216152","article-title":"Ferroptosis: Promising approach for cancer and cancer immunotherapy","volume":"561","author":"Zheng","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mito.2026.102132_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.mito.2026.102132_b0090","article-title":"ATF3 promotes ferroptosis in sorafenib-induced cardiotoxicity by suppressing Slc7a11 expression","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mito.2026.102132_b0095","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0005-2760(82)90150-3","article-title":"Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides","volume":"710","author":"Ursini","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2026.102132_b0100","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1038\/s41598-024-55293-1","article-title":"Apomorphine is a potent inhibitor of ferroptosis independent of dopaminergic receptors","volume":"14","author":"Miyauchi","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mito.2026.102132_b0105","doi-asserted-by":"crossref","first-page":"28097","DOI":"10.1074\/jbc.M115.680090","article-title":"Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons results in Rapid Motor Neuron Degeneration and Paralysis","volume":"290","author":"Chen","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102132_b0110","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","article-title":"Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC","volume":"94","author":"Do Van","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mito.2026.102132_b0115","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1074\/jbc.275.6.4251","article-title":"Modification defect at anticodon wobble nucleotide of mitochondrial tRNAs(Leu)(UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes","volume":"275","author":"Yasukawa","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102132_b0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41439-018-0026-6","article-title":"Mitochondrial DNA 3243A>T mutation in a patient with MELAS syndrome","volume":"5","author":"Ikeda","year":"2018","journal-title":"Hum. Genome Var."},{"key":"10.1016\/j.mito.2026.102132_b0125","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9537504","article-title":"Mitochondrial transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts","volume":"2019","author":"Lin","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mito.2026.102132_b0130","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00018-015-2087-8","article-title":"Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy","volume":"73","author":"Hamacher-Brady","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mito.2026.102132_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101856","article-title":"Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells","volume":"76","author":"Lin","year":"2024","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2026.102132_b0140","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/0333102418821661","article-title":"The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial","volume":"39","author":"Hajihashemi","year":"2019","journal-title":"Cephalalgia"},{"key":"10.1016\/j.mito.2026.102132_b0150","doi-asserted-by":"crossref","first-page":"13843","DOI":"10.1074\/jbc.M808515200","article-title":"Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission","volume":"284","author":"Dagda","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102132_b0155","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1021\/acschemneuro.2c00308","article-title":"Mitochondrial Inhibitor Rotenone Triggers and Enhances Neuronal Ferroptosis following Intracerebral Hemorrhage","volume":"14","author":"Cheng","year":"2023","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.mito.2026.102132_b0160","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1083\/jcb.201708007","article-title":"Superoxide dismutases: dual roles in controlling ROS damage and regulating ROS signaling","volume":"217","author":"Wang","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mito.2026.102132_b0165","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102132_b0170","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molmed.2023.05.013","article-title":"FSP1: a key regulator of ferroptosis","volume":"29","author":"Li","year":"2023","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mito.2026.102132_b0175","doi-asserted-by":"crossref","first-page":"1559S","DOI":"10.3945\/ajcn.117.155804","article-title":"Current understanding of iron homeostasis","volume":"106","author":"Anderson","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.mito.2026.102132_b0180","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41420-022-01297-7","article-title":"Recent progress in ferroptosis: inducers and inhibitors","volume":"8","author":"Du","year":"2022","journal-title":"Cell Death Discov."},{"issue":"2","key":"10.1016\/j.mito.2026.102132_b0185","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s11515-014-1302-6","article-title":"Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition","volume":"9","author":"Zhang","year":"2014","journal-title":"Front Biol (beijing)."},{"key":"10.1016\/j.mito.2026.102132_b0190","doi-asserted-by":"crossref","DOI":"10.1177\/1533033818764470","article-title":"High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines","volume":"17","author":"Bajbouj","year":"2018","journal-title":"Technol. Cancer Res. Treat."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156772492600022X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156772492600022X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:29:49Z","timestamp":1781868589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156772492600022X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"alternative-id":["S156772492600022X"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2026.102132","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated iron homeostasis Drives mitochondrial Injury and ferroptosis susceptibility in MELAS fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2026.102132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. and Mitochondria Research Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102132"}}