{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:01:28Z","timestamp":1784199688796,"version":"3.55.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["456368804"],"award-info":[{"award-number":["456368804"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019147","name":"Universit\u00e4tsmedizin G\u00f6ttingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003385","name":"Georg-August-Universit\u00e4t G\u00f6ttingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mitochondrion"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.mito.2026.102147","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:38:41Z","timestamp":1773419921000},"page":"102147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Quantitative imaging of mitochondrial redox conditions at the single-organelle level"],"prefix":"10.1016","volume":"89","author":[{"given":"Steffen","family":"P\u00f6schel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-1994","authenticated-orcid":false,"given":"Michael","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mito.2026.102147_b0005","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1523\/JNEUROSCI.4468-06.2007","article-title":"Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation","volume":"27","author":"Abramov","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mito.2026.102147_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1465531","article-title":"Quantitative, real-time imaging of spreading depolarization-associated neuronal ROS production","volume":"18","author":"Ackermann","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mito.2026.102147_b0015","doi-asserted-by":"crossref","first-page":"e461","DOI":"10.1038\/cddis.2012.213","article-title":"Computational classification of mitochondrial shapes reflects stress and redox state","volume":"4","author":"Ahmad","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mito.2026.102147_b0020","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28","volume":"26","author":"Alexander","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mito.2026.102147_b0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s10541-005-0102-7","article-title":"Mitochondrial metabolism of reactive oxygen species","volume":"70","author":"Andreyev","year":"2005","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.mito.2026.102147_b0030","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1046\/j.1525-1373.1999.d01-141.x","article-title":"Mechanisms of DNA oxidation","volume":"222","author":"Aust","year":"1999","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.mito.2026.102147_b0035","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1590\/S0100-879X2002000900008","article-title":"Myocardial antioxidant and oxidative stress changes due to sex hormones","volume":"35","author":"Barp","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.mito.2026.102147_b0040","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3064016","article-title":"Increased mitochondrial mass and cytosolic redox imbalance in hippocampal astrocytes of a mouse model of Rett syndrome: subcellular changes revealed by ratiometric imaging of JC-1 and roGFP1 fluorescence","volume":"2017","author":"Bebensee","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mito.2026.102147_b0045","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0891-5849(02)01356-4","article-title":"Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males","volume":"34","author":"Borr\u00e1s","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102147_b0050","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj1340707","article-title":"The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen","volume":"134","author":"Boveris","year":"1973","journal-title":"Biochem. J"},{"key":"10.1016\/j.mito.2026.102147_b0055","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.exger.2010.01.003","article-title":"The sites and topology of mitochondrial superoxide production","volume":"45","author":"Brand","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mito.2026.102147_b0060","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nm.3520","article-title":"Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo","volume":"20","author":"Breckwoldt","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.mito.2026.102147_b0065","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0891-5849(94)00198-S","article-title":"Superoxide and hydrogen peroxide in relation to mammalian cell proliferation","volume":"18","author":"Burdon","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102147_b0070","series-title":"Techniques to Investigate Mitochondrial Function in Neurons","first-page":"179","article-title":"Live imaging of mitochondrial ROS production and dynamic redox balance in neurons","author":"Can","year":"2017"},{"key":"10.1016\/j.mito.2026.102147_b0075","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fphys.2019.00479","article-title":"Neuronal redox-imbalance in Rett syndrome affects mitochondria as well as cytosol, and is accompanied by intensified mitochondrial O2 consumption and ROS release","volume":"10","author":"Can","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mito.2026.102147_b0080","first-page":"51","article-title":"Redox-sensitive green fluorescent protein: probes for dynamic intracellular redox responses A review","volume":"476","author":"Cannon","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mito.2026.102147_b0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.mito.2026.102147_b0090","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cell.2010.02.026","article-title":"Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations","volume":"141","author":"Chen","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.mito.2026.102147_b0095","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.mito.2026.102147_b0100","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.mito.2026.102147_b0105","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cub.2005.02.064","article-title":"Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission","volume":"15","author":"De Vos","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mito.2026.102147_b0110","doi-asserted-by":"crossref","first-page":"13695","DOI":"10.3390\/ijms232213695","article-title":"Deciphering the roles & regulation of estradiol signaling during female mini-puberty: Insights from mouse models","volume":"23","author":"Devillers","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mito.2026.102147_b0115","doi-asserted-by":"crossref","first-page":"42373","DOI":"10.1074\/jbc.M112.413674","article-title":"Electron microscopic analysis of a spherical mitochondrial structure","volume":"287","author":"Ding","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102147_b0120","doi-asserted-by":"crossref","first-page":"22284","DOI":"10.1074\/jbc.M312847200","article-title":"Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators","volume":"279","author":"Dooley","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102147_b0125","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.bbapap.2014.02.006","article-title":"Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation","volume":"1844","author":"Dr\u00f6se","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2026.102147_b0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1113\/jphysiol.1992.sp019114","article-title":"Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors","volume":"450","author":"Duchen","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.mito.2026.102147_b0135","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/088307389000500311","article-title":"Rett syndrome: a mitochondrial disease?","volume":"5","author":"Eeg-Olofsson","year":"1990","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.mito.2026.102147_b0140","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.3390\/cells9122539","article-title":"Overshooting subcellular redox-responses in Rett-mouse hippocampus during neurotransmitter stimulation","volume":"9","author":"Festerling","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mito.2026.102147_b0145","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.pneurobio.2006.07.001","article-title":"Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration","volume":"79","author":"Foster","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.mito.2026.102147_b0150","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1016\/j.neuroimage.2010.11.031","article-title":"Dynamic, semi-quantitative imaging of intracellular ROS levels and redox status in rat hippocampal neurons","volume":"54","author":"Funke","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.mito.2026.102147_b0155","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-bioeng-071516-044730","article-title":"Label-free optical metabolic imaging in cells and tissues","volume":"25","author":"Georgakoudi","year":"2023","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.mito.2026.102147_b0160","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.1073\/pnas.77.11.6715","article-title":"Maternal inheritance of human mitochondrial DNA","volume":"77","author":"Giles","year":"1980","journal-title":"PNAS"},{"key":"10.1016\/j.mito.2026.102147_b0165","first-page":"956","article-title":"Mitochondrial proteome changes in Rett syndrome","volume":"12","author":"Golubiani","year":"2023","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.mito.2026.102147_b0170","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nature09536","article-title":"Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1","volume":"468","author":"Guzman","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102147_b0175","doi-asserted-by":"crossref","first-page":"13044","DOI":"10.1074\/jbc.M312846200","article-title":"Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators","volume":"279","author":"Hanson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102147_b0180","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: a theory based on free radical and radiation chemistry","volume":"11","author":"Harman","year":"1956","journal-title":"J. Gerontol."},{"key":"10.1016\/j.mito.2026.102147_b0185","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/S0891-5849(00)00252-5","article-title":"Reactive oxygen species, cell signaling, and cell injury","volume":"28","author":"Hensley","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102147_b0195","doi-asserted-by":"crossref","first-page":"C1176","DOI":"10.1152\/ajpcell.00017.2014","article-title":"Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts","volume":"306","author":"Iqbal","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mito.2026.102147_b0200","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fncel.2014.00056","article-title":"The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome","volume":"8","author":"Janc","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mito.2026.102147_b0205","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.mito.2008.06.001","article-title":"Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress","volume":"8","author":"Jendrach","year":"2008","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mito.2026.102147_b0210","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1096\/fj.03-0971fje","article-title":"Cysteine\/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control","volume":"18","author":"Jones","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.mito.2026.102147_b0215","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1523\/JNEUROSCI.23-01-00269.2003","article-title":"Hydrogen peroxide modulation of synaptic plasticity","volume":"23","author":"Kamsler","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mito.2026.102147_b0220","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00424-011-1012-8","article-title":"Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria","volume":"462","author":"Keil","year":"2011","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1016\/j.mito.2026.102147_b0225","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1016\/S0021-9258(17)39909-X","article-title":"Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide","volume":"252","author":"Kellogg","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102147_b0230","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13125","article-title":"Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain","volume":"5","author":"Khalifa","year":"2017","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.mito.2026.102147_b0235","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.molcel.2011.08.045","article-title":"Fine-tuning of Drp1\/Fis1 availability by AKAP121\/Siah2 regulates mitochondrial adaptation to hypoxia","volume":"44","author":"Kim","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mito.2026.102147_b0240","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S1016-8478(23)13801-5","article-title":"Age-related changes in the activity of antioxidant and redox enzymes in rats","volume":"16","author":"Kim","year":"2003","journal-title":"Mol. Cells"},{"key":"10.1016\/j.mito.2026.102147_b0245","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3109\/02713688209020022","article-title":"Retinal pigment epithelium: ring mitochondria and lesions induced by continuous light","volume":"2","author":"Lauber","year":"1982","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.mito.2026.102147_b0250","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/aja.1000170304","article-title":"Mitochondria (and other cytoplasmatic structures) in tissue cultures","volume":"17","author":"Lewis","year":"1914","journal-title":"Ann. J. Anat."},{"key":"10.1016\/j.mito.2026.102147_b0255","article-title":"Proteomic profile of mouse brain aging contributions to mitochondrial dysfunction, DNA oxidative damage, loss of neurotrophic factor, and synaptic and ribosomal proteins","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mito.2026.102147_b0260","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.mito.2026.102147_b0265","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s43587-023-00527-6","article-title":"The information theory of aging","volume":"3","author":"Lu","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.mito.2026.102147_b0270","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1523\/JNEUROSCI.6566-10.2011","article-title":"Amyloid beta-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide","volume":"31","author":"Ma","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mito.2026.102147_b0275","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1089\/ars.2009.2695","article-title":"Mitochondrial glutathione, a key survival antioxidant","volume":"11","author":"Mar\u00ed","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mito.2026.102147_b0280","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCRESAHA.111.263848","article-title":"Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension","volume":"110","author":"Marsboom","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.mito.2026.102147_b0285","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF02815160","article-title":"Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain","volume":"31","author":"Mecocci","year":"1997","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.mito.2026.102147_b0290","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1089\/ars.2009.2948","article-title":"Fluorescent protein-based redox probes","volume":"13","author":"Meyer","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mito.2026.102147_b0295","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.bbabio.2011.09.018","article-title":"Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. 1966","volume":"1807","author":"Mitchell","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mito.2026.102147_b0300","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1042\/BST20140071","article-title":"Aberrant redox homoeostasis and mitochondrial dysfunction in Rett syndrome","volume":"42","author":"M\u00fcller","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mito.2026.102147_b0305","first-page":"203","article-title":"Advanced ROS\/redox imaging based on genetically-encoded probes, ratiometric 2-photon microscopy and fluorescence-lifetime imaging","volume":"210","author":"M\u00fcller","year":"2014","journal-title":"Acta Physiol."},{"key":"10.1016\/j.mito.2026.102147_b0310","first-page":"114","article-title":"Mitochondrial organization and motility probed by two-photon microscopy in cultured mouse brainstem neurons","volume":"303","author":"M\u00fcller","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mito.2026.102147_b0315","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nature08119","article-title":"A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish","volume":"459","author":"Niethammer","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102147_b0320","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1158\/0008-5472.CAN-09-2572","article-title":"Optical redox ratio differentiates breast cancer cell lines based on estrogen receptor status","volume":"70","author":"Ostrander","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.mito.2026.102147_b0325","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1091\/mbc.e10-06-0551","article-title":"Aberrant mitochondrial fission in neurons induced by protein kinase C\u03b4 under oxidative stress conditions in vivo","volume":"22","author":"Qi","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mito.2026.102147_b0330","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroscience.2013.04.019","article-title":"Role of mitochondrial fission in neuronal injury in pilocarpine-induced epileptic rats","volume":"245","author":"Qiu","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.mito.2026.102147_b0335","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12017-008-8044-z","article-title":"Mitochondrial medicine for aging and neurodegenerative diseases","volume":"10","author":"Reddy","year":"2008","journal-title":"NeuroMol. Med."},{"key":"10.1016\/j.mito.2026.102147_b0340","doi-asserted-by":"crossref","first-page":"25S","DOI":"10.1016\/S0031-6997(25)06795-X","article-title":"Glutathione depletion and susceptibility","volume":"36","author":"Reed","year":"1984","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.mito.2026.102147_b0345","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ymeth.2016.12.015","article-title":"DeconvolutionLab2: an open-source software for deconvolution microscopy","volume":"115","author":"Sage","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.mito.2026.102147_b0350","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fnmol.2017.00115","article-title":"RyR2-mediated Ca2+ release and mitochondrial ROS generation partake in the synaptic dysfunction caused by amyloid beta peptide oligomers","volume":"10","author":"SanMartin","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mito.2026.102147_b0355","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1212\/WNL.52.7.1417","article-title":"The effect of estrogen replacement on early Parkinson's disease","volume":"52","author":"Saunders-Pullman","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.mito.2026.102147_b0360","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102147_b0365","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mito.2026.102147_b0370","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1126\/science.1106653","article-title":"Extension of murine life span by overexpression of catalase targeted to mitochondria","volume":"308","author":"Schriner","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.mito.2026.102147_b0375","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1089\/ars.2015.6266","article-title":"Dissecting redox biology using fluorescent protein sensors","volume":"24","author":"Schwarzl\u00e4nder","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mito.2026.102147_b0380","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2818.2008.02030.x","article-title":"Confocal imaging of glutathione redox potential in living plant cells","volume":"231","author":"Schwarzl\u00e4nder","year":"2008","journal-title":"J. Microsc."},{"key":"10.1016\/j.mito.2026.102147_b0385","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0968-0004(00)01735-7","article-title":"Mitochondrial filaments and clusters as intracellular power-transmitting cables","volume":"26","author":"Skulachev","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mito.2026.102147_b0390","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1023\/B:MCBI.0000009880.94044.49","article-title":"Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis","volume":"256\u2013257","author":"Skulachev","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.mito.2026.102147_b0395","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/j.1471-4159.1991.tb02017.x","article-title":"Selective increase of iron in substantia nigra zona compacta of parkinsonian brains","volume":"56","author":"Sofic","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2026.102147_b0400","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nm.2313","article-title":"Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity","volume":"17","author":"Song","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.mito.2026.102147_b0405","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1355616","article-title":"Protein oxidation and aging","volume":"257","author":"Stadtman","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.mito.2026.102147_b0410","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.116.309551","article-title":"Redox imaging using cardiac myocyte-specific transgenic biosensor mice","volume":"119","author":"Swain","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.mito.2026.102147_b0415","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/excr.2001.5447","article-title":"Role of the mitochondrial permeability transition and cytochrome C release in hydrogen peroxide-induced apoptosis","volume":"274","author":"Takeyama","year":"2002","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mito.2026.102147_b0420","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.2174\/138161211798764942","article-title":"Females live longer than males: role of oxidative stress","volume":"17","author":"Vina","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mito.2026.102147_b0425","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/ars.2015.6587","article-title":"Redox-indicator mice stably expressing genetically-encoded neuronal roGFP: Versatile tools to decipher subcellular redox dynamics in neuropathophysiology","volume":"25","author":"Wagener","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mito.2026.102147_b0430","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0169-328X(01)00029-8","article-title":"Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice","volume":"89","author":"Warita","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.mito.2026.102147_b0435","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1471-4159.1984.tb09728.x","article-title":"Lipid peroxidation in vivo induced by reversible global ischemia in rat brain","volume":"42","author":"Watson","year":"1984","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2026.102147_b0440","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/CIRCRESAHA.109.206334","article-title":"Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells","volume":"106","author":"Waypa","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.mito.2026.102147_b0445","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nature09472","article-title":"Quantitative reactivity profiling predicts functional cysteines in proteomes","volume":"468","author":"Weerapana","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.mito.2026.102147_b0450","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1165\/rcmb.2005-0337OC","article-title":"Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction","volume":"34","author":"Weissmann","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.mito.2026.102147_b0455","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.freeradbiomed.2014.07.045","article-title":"Response properties of the genetically encoded optical H2O2 sensor HyPer","volume":"76C","author":"Weller","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mito.2026.102147_b0460","article-title":"Mapping of neuronal redox conditions in a mouse model of Rett syndrome","volume":"5","author":"Woeste","year":"2025","journal-title":"Neuroimage Rep."},{"key":"10.1016\/j.mito.2026.102147_b0465","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1038\/jid.2013.428","article-title":"Real-time monitoring of oxidative stress in live mouse skin","volume":"134","author":"Wolf","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mito.2026.102147_b0470","doi-asserted-by":"crossref","first-page":"18797","DOI":"10.1074\/jbc.270.32.18797","article-title":"Substrate control of free radical generation from xanthine oxidase in the postischemic heart","volume":"270","author":"Xia","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mito.2026.102147_b0475","article-title":"Mitochondrially targeted fluorescent redox sensors","volume":"7","author":"Yang","year":"2017","journal-title":"Interf. Focus"},{"key":"10.1016\/j.mito.2026.102147_b0480","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1471-4159.2006.03767.x","article-title":"Nitric oxide impairs mitochondrial movement in cortical neurons during hypoxia","volume":"97","author":"Zanelli","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mito.2026.102147_b0485","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A","volume":"36","author":"Zuchner","year":"2004","journal-title":"Nat. Genet."}],"container-title":["Mitochondrion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724926000371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567724926000371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:00:53Z","timestamp":1778619653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567724926000371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":96,"alternative-id":["S1567724926000371"],"URL":"https:\/\/doi.org\/10.1016\/j.mito.2026.102147","relation":{},"ISSN":["1567-7249"],"issn-type":[{"value":"1567-7249","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative imaging of mitochondrial redox conditions at the single-organelle level","name":"articletitle","label":"Article Title"},{"value":"Mitochondrion","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mito.2026.102147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102147"}}